期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 22, 期 22, 页码 17397-17413出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-015-4227-y
关键词
Inland silverside; NSAIDs; Transcriptomics; Microarray; Gene expression; qPCR; Ecotoxicology
资金
- California Department of Fish and Wildlife [E1183010]
- State and Federal Contractors Water Agency [201301957]
- Delta Stewardship Council
Ibuprofen is one of the most commonly detected pharmaceuticals in wastewater effluent; however, the effects of ibuprofen on aquatic organisms are poorly understood. This study presents the transcriptome-wide response of the inland silverside, Menidia beryllina, to chronic exposure to ibuprofen. At the lowest exposure concentration (0.0115 mg/L), we detected a downregulation of many genes involved in skeletal development, aerobic respiration, and immune function. At the highest exposure concentration (1.15 mg/L), we detected increased expression of regulatory genes in the arachidonic acid metabolism pathway and several immune genes involved in an inflammatory response. Additionally, there was differential expression of genes involved in oxidative stress responses and a downregulation of genes involved in osmoregulation. This study provides useful information for monitoring the effects of this common wastewater effluent contaminant in the environment and for the generation of biomarkers of exposure to ibuprofen that may be transferable to other fish species.
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