Article
Chemistry, Physical
Kamaless Patra, Arindom Bhattacherya, Chenfei Li, Jitendra K. Bera, Han Sen Soo
Summary: In this study, a photocatalytic synthesis method using visible light as the driving force was proposed for the synthesis of quinolines and naphthyridines under ambient and aerobic conditions. The method demonstrated a broad substrate scope and applicability for the synthesis of pharmaceutical ingredients and natural products.
Article
Chemistry, Applied
Kim Christopher C. Aganda, Anna Lee
Summary: A method for synthesizing selenaheterocycles starting from aryl diazonium salts was developed. The one-pot process and subsequent visible-light-mediated silver-catalyzed cyclization allow for the synthesis of selenaheterocycles without the need for a photocatalyst. The reactions are conducted under mild conditions without the use of toxic or sensitive reagents.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Fei Wang, Shun-Yi Wang
Summary: The visible-light-promoted free radical cross-coupling method facilitates the efficient construction of unsymmetrical alkyl-alkyl selenide compounds under mild metal-free conditions, providing a green and simple approach with a wide substrate scope, high yields, and easy operation. Additionally, this strategy can also be applied for the efficient synthesis of aryl-alkyl selenides, heteroaryl-alkyl selenides, and aryl-alkyl sulfides.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Ming Zheng, Jing Hou, Li-Li Hua, Wan-Ying Tang, Le-Wu Zhan, Bin-Dong Li
Summary: This study presents a visible-light-mediated divergent 1,2-silylfunctionalization of alkenes under ambient conditions, yielding a variety of silanes including beta-alkoxy, beta-alkylthio, beta-hydroxy, and beta-indolyl silanes. Vinylsilanes were also successfully prepared without the need for an additional nucleophile.
Article
Chemistry, Organic
Hongyan Zhou, Ganggang Wang, Cunhui Wang, Jingya Yang
Summary: In this study, a visible-light-promoted aerobic oxyphosphorylation of alpha-diazoesters and H-phosphine oxides has been developed. The reaction proceeds smoothly at room temperature using air as the oxygen source and blue-light irradiation. Preliminary mechanistic studies indicate the involvement of a light-triggered radical process. This strategy reveals the previously unknown reactivity of diazo compounds with H-phosphine oxides and has potential value in synthetic applications.
Article
Chemistry, Physical
Davud Karimian, Fatemeh Zangi
Summary: A unique hybrid Polyoxometalate with the ability to absorb visible light and perform photocatalytic activity was synthesized. By utilizing this material, the photooxidation of sulfides under O2 atmosphere was conducted, leading to the synthesis of corresponding sulfoxide products in good to high yields.
CATALYSIS COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Sizhe Li, Weijie Zhang, Song Yang, Fei Chen, Chunyue Pan, Juntao Tang, Kai A. I. Zhang, Guipeng Yu
Summary: The photocatalytic aerobic oxidative cyanation of tertiary amines using phenothiazine-containing conjugated microporous polymers (CMPs) as heterogeneous visible light-active photocatalysts showed superior catalytic activity, extensive substrate adaptability, and outstanding recyclability. Fine molecular engineering with electron-donating and -withdrawing groups on the comonomer compositions allowed for tuning of the pore surface and band gap of CMPs, leading to enhanced photo-induced charge separation and interaction with substrates. The fluorine-substituted CMP-PTZ-3 demonstrated high efficiency, good stability, and regenerability as a pure organic photocatalyst, providing new insights in designing high-performance photocatalysts through molecular engineering strategy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Xue Yang Wang, Qing Bao Zhang, Xiao Ling Jin, Li Zhu Wu, Qiang Liu
Summary: An unprecedented catalytic system has been developed for the one-pot synthesis of oxazole acetals from N-propargylamides and alcohols using diselenides, Selectfluor, and visible light. This system demonstrates excellent compatibility of visible-light promotion with organocatalytic oxidative carbon-oxygen bond formations, using air as the terminal oxidant.
Article
Chemistry, Multidisciplinary
Yubin Ma, Fan Gao, Wanru Xiao, Na Li, Shujun Li, Bing Yu, Xuenian Chen
Summary: In this work, two transition metal-containing Nb/W mixed-addendum POM dimers were synthesized and characterized. POM[Fe] was proven to be an efficient photocatalyst for benzylic C-H oxidation under visible light and using oxygen as an oxidant. The results provide insights into the mechanism and effectiveness of POM[Fe] in the oxidation reaction.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shuyi An, Zhifen Guo, Xin Liu, Yan Che, Hongzhu Xing, Peng Chen
Summary: This study reports the synthesis and characterization of a series of novel lanthanide coordination polymer (Ln-CP) photocatalysts with wide-range visible-light adsorption and excellent chemical stability, which show excellent selectivity and yield for the oxidation of amines and thiols. Mechanism studies indicate these Ln-CPs are highly efficient to activate molecular oxygen into highly reactive oxygen species. The work provides an in-depth understanding of photoinduced oxygen activation based on a CP photocatalyst, showing the great potential of photoactive CPs for green synthesis.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Tao Luo, Yang-Fan Guo, Tian-Tian Xu, Hai Dong
Summary: In this study, a visible-light-promoted desulfurization method was successfully used to synthesize deoxysugars, particularly 1-deoxyglycose, 2,4-deoxyglycosides, and 2-deoxyglycosides with exclusive alpha-configuration. Compared to desulfurization under UV light, this method under visible light is easy to operate, does not require a dedicated photochemical reactor, occurs under mild conditions, and avoids many side reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Qinglong Shi, Meichen Xu, Rui Chang, Devenderan Ramanathan, Beatriz Penin, Ignacio Funes-Ardoiz, Juntao Ye
Summary: A metal-free platform using peptide- or sugar-derived chiral thiols and deuterium oxide enables asymmetric open-shell deuteration at non-benzylic positions. This approach allows for multiple types of deuterofunctionalization reactions of exocyclic olefins and achieves high levels of enantioselectivity and deuterium incorporation.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Gao Yanhua, Zhang Yinpan, Zhang Yan, Song Tao, Yang Yong
Summary: A green and efficient method for alcohol oxidation to carbonyl compounds was reported using surface oxygen vacancies-enriched Nb2O5 as the photocatalyst. The catalytic system exhibited high activity with a wide substrate scope and diverse functional group compatibility under mild reaction conditions and visible-light irradiation. Additionally, the catalyst demonstrated good catalytic stability, allowing for multiple recycles without loss of catalytic activity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qiu-Yue Cheng, Ting Wang, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu
Summary: Visible-light-mediated heterogeneous photocatalysis is a promising method for organic transformations. However, accurately detecting and identifying photogenerated species, especially short-lived radical intermediates, remains challenging. In this work, a hybrid ion emitter integrated with a pico-liter heterogeneous photocatalytic reactor was developed for the rapid identification of transient radical intermediates produced under visible-light irradiation. This novel coupling device provides a powerful tool for exploring complex heterogeneous photochemical processes and their ultrafast initial transformations.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Joel Wellauer, Dragan Miladinov, Thomas Buchholz, Jan Schutz, Rene T. Stemmler, Jonathan A. Medlock, Werner Bonrath, Christof Sparr
Summary: A mild photocatalytic phenol oxygenation process using visible light and pressurized air was described, enabling high yields of products for various applications including vitamin synthesis by controlling key process parameters. The reactor design allows for low organophotocatalyst loadings to generate singlet oxygen, contributing to sustainable synthesis of benzoquinones and p-quinols through efficient aerobic phenol oxygenation.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Wen Li, Feng Wang, Yaocheng Shi, Lei Yu
Summary: Polyaniline-supported tungsten (W@PANI) is an efficient catalyst for the oxidative deoximation reaction, which is crucial in the pharmaceutical industry. The method utilizes a minimal amount of catalytic tungsten (0.048 mol% vs. oxime substrates), resulting in high turnover numbers (TONs) of the catalyst (ca. 10(3) mol/mol) and low metal residues in the product (<0.1 ppm). It is applicable for various substrates, including heterocycles, and has been successfully scaled up for kilogram production.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhigang Zeng, Ying Chen, Xiaoming Zhu, Lei Yu
Summary: Polyanilines (PANIs) are easily prepared from anilines via oxidative polymerization reactions and widely used as supports for nano metal catalysts due to their coordination with metals. Compared to inorganic supports, the nano metals on PANIs are firmly anchored, preventing loss during reactions. Additionally, the chemical features of PANIs can be adjusted, providing tunable catalytic activities. This review aims to summarize recent advances and provide a perspective on PANIs-supported nano metal catalysts.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Wenqiang Ding, Shuang Wang, Jiaxiang Gu, Lei Yu
Summary: Selenium functions as selenoprotein in the human body, with the brain being one of the most abundant organs of selenoprotein. It plays a crucial role in maintaining brain redox homeostasis, regulating signal transduction pathways, and neuroimmune regulation. Nano-selenium has attracted attention due to its high bioavailability and low toxicity, and it has great potential in biomedical applications for the nervous system. Recent research on selenoprotein and nano-selenium has become a new focus in understanding the important functions of selenium in the human nervous system.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Minmeng Zhao, Jiahui Li, Qiao Shi, Haoshu Shan, Long Liu, Tuoyu Geng, Lei Yu, Daoqing Gong
Summary: This study investigated the effects of in ovo feeding of selenized glucose on selenium level and antioxidant capacity in the breast muscle of newborn broilers. The results showed that in ovo injection of SeGlu increased selenium level and enhanced the antioxidant capacity in the breast muscle of hatchlings. This suggests that in ovo feeding of SeGlu can improve the antioxidant capacity in the breast muscle of neonatal broilers.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Ying Chen, Chao Chen, Yonghong Liu, Lei Yu
Summary: Catalyzed by cerium ammonium nitrate (CAN), the oxidative cracking reaction of alkenes occurred to produce carbonyls in good yields under mild conditions. The reaction employed molecular oxygen (O2) as the safe and clean oxidant. The catalyst dosage was reduced to as low as 0.5 mol%, while no additive was required. Thus, it may afford a generally green synthetic approach for introducing oxygen into organic molecules as well as the biomass degradation and the resource recycling from the C=C bond-containing waste polymers. X-ray photoelectron spectroscopy (XPS) analysis and control experiments demonstrated that the process proceeded via a single electron transfer (SET) reaction-initiated free radical reaction mechanism. In the process, both Ce and NO3- acted as the oxygen carrier to promote the oxidation reaction. The application of the abundantly existed nitrate in CAN was found to be the key for reducing the catalyst loading.
CHINESE CHEMICAL LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Huimin Sun, Hongen Cao, Xingyu Chen, Yonghong Liu, Lei Yu
Summary: A novel method for preparing selenium-containing materials via fermentation is reported. This method enables the direct transfer of selenium from its inorganic sources into the target material without using hazardous chemical reagents. The produced selenized flour effectively inhibits the growth of Xoo, the pathogen causing rice bacterial blight disease. Acting as a selenium carrier, the use of edible flour in selenized flour makes it more biocompatible than chemical pesticides. The hydroxyls of starch in selenized flour facilitate the continuous release of its efficacy by adhering onto rice leaves.
Article
Biotechnology & Applied Microbiology
Ming-Xuan Liu, Li Xu, Jia-Yi Jiang, Hai-Chen Dong, Peng-Fei Zhu, Lei Cao, Jing Chen, Xiao-Ling Zhang
Summary: The study proposes the concept of self-escape non-cationic gene carriers for targeted delivery and treatment of hepatocellular carcinoma (HCC) using graphitic carbon nitride nanosheets. These nanocomplexes actively target HCC tissue and disrupt lysosome structure to facilitate their escape. They also promote reversible release of DNA in the acidic microenvironment of HCC tissue and effectively upregulate tumor suppressor protein P53 expression for gene therapy of HCC.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Organic
Xiaoxue Li, Hangzhou Hua, Yonghong Liu, Lei Yu
Summary: Catalyzed by Se/Fe via hybrid mechanisms, the carbon-carbon double bond in alkenes can break to produce carbonyls under mild conditions. Using O-2 as a partial oxidant, the amount of H2O2 employed can be reduced (90 mol% vs 250 mol%) to avoid peroxide residues, making the process safer for operation.
Article
Engineering, Biomedical
Ming-Xuan Liu, Li Xu, Yu-Ting Cai, Ruo-Jia Wang, Ying-Ying Gu, Yan-Chao Liu, Yu-Jin Zou, Yong-Mei Zhao, Jing Chen, Xiao-Ling Zhang
Summary: This study established a safe and effective method to downregulate the expression of HIF-1 alpha in hepatic stellate cells (HSCs) and treat liver fibrosis. By delivering HIF-1 alpha small interfering RNA (HIF-1 alpha-siRNA) via VA-PEG-modified CNs-based nanosheets encapsulated with GQDs, the expression of HIF-1 alpha can be decreased. Additionally, the nanosheets can trigger water splitting under near-infrared (NIR) irradiation, improving the hypoxic liver fibrosis site and achieving better therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Yiyang Zhang, Hong Sun, Yonghuai Yang, Haofei Li, Yaocheng Shi, Lei Yu
Summary: The catalytic activities of palladium nanoparticles on a polyaniline support were improved by tungsten doping, resulting in a significantly increased catalyst turnover number (>10(4)) for the Suzuki-Miyaura coupling reaction. Characterization of the materials showed that tungsten doping improved the micro-morphology, leading to more efficient absorption of reactants. Additionally, tungsten facilitated stabilization of Pd(0) species and the transmetallation step, both crucial for the catalytic reaction. Therefore, Pd/W@PANI engineering material may serve as a highly efficient heterogeneous catalyst in the pharmaceutical industry.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xu Zhang, Zijie Wei, Lei Yu
Summary: We unexpectedly discovered that aldehydes could serve as catalyst precursors for the epoxidation of beta-ionone, resulting in a 83% yield of 5,6-epoxy-beta-ionone. Notably, this reaction took place in water and utilized molecular oxygen (O-2) as a mild, inexpensive, and safe oxidant. To the best of our knowledge, this aerobic epoxidation in water represents a novel reaction, potentially opening up new possibilities for the development of green oxidation methods.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Limei Xian, Qianru Li, Tao Li, Lei Yu
Summary: Selenium is an essential mineral element that improves plant growth and tolerance to abiotic stresses. Selenium biofortification is a key strategy to increase the selenium content in crops for human health improvement. In this study, foliar fertilization with different selenium forms was conducted on wheat, and methylselenized glucose (MSG) was found to be the most effective fertilizer, significantly increasing the selenium content in wheat grains compared to Na2SeO3 application. Due to its high utilization rate and low cost, MSG can be a potential selenium source for biofortification.
CHINESE CHEMICAL LETTERS
(2023)
Article
Materials Science, Biomaterials
Ming-Xuan Liu, Li Xu, Peng-Fei Zhu, Xin Li, Miao Shan, Wei Jin, Jing Chen, Yong Ling, Xiao-Ling Zhang
Summary: Researchers successfully synthesized a fluorescent probe DPABP-BI that can identify lipid droplets (LDs) and track their autophagy process. The probe features red fluorescence emission, large Stokes shift, two-photon excitation, outstanding photostability, and biocompatibility. LDs can be specifically identified through the red fluorescence emission of DPABP-BI, while autophagolysosomes can be visualized through the green fluorescence emission of its acid-hydrolyzed product to track the autophagy dynamic process. Additionally, DPABP-BI enables the specific recognition of fatty substances in zebrafish larvae.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Organic
Meng Xiangkun, Qi Zhengyuan, Yu Lei, Zhang Yiyang
Summary: With the issuance of the national plastic reduction order, the development of biodegradable materials like poly(lactic acid) (PLA) has become a popular topic. This paper discusses various methods for synthesizing PLA, focusing on catalyst design and elucidating related mechanisms. This short review may provide guidance for the design and development of low-toxicity and high-selectivity catalyst systems for application.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Xiaohe Wu, Ying Chen, Yiyang Zhang, Xu Zhang, Lei Yu
Summary: A novel polyaniline-supported iron catalyst (Fe@PANI) was designed and synthesized for the selective oxidation of sulphide to sulfoxide. The material exhibits magnetism and can be recycled without deactivation through magnetic separation. The reaction is practical for large-scale applications due to the use of inexpensive catalyst and mild and green conditions.
MATERIALS ADVANCES
(2023)
