☆ 4.4 Article

Comorbid diagnoses for youth at clinical high risk of psychosis

SCHIZOPHRENIA RESEARCH (2017)

期刊

SCHIZOPHRENIA RESEARCH

卷 190, 期 -, 页码 90-95

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.schres.2017.03.043

关键词

Clinical high risk; DSM-IV diagnoses; Comorbidity; Anxiety; Depression

类别

Psychiatry

资金

National Institute of Mental Health [U01MH081984]
Commonwealth of Massachusetts [SCDMH82101008006]
[U01 MH081928]
[P50 MH080272]
[R01 MH60720]
[U01 MH082022]
[K24 MH76191]
[U01MH081902]
[P50 MH066286]
[U01MH082004]
[U01MH081988]
[U01MH082022]
[UO1 MH081857-05]

向作者/读者索取更多资源

Protocol

Reagent

摘要

Several studies have demonstrated that youth at clinical high risk (CHR) of developing psychosis have a high prevalence of comorbid psychiatric disorders. Less is known about the impact of comorbid diagnoses on later conversion to psychosis and the change over time. The aim of this study was to determine the frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis. The NAPLS 2 sample consisted of 744 CHR youth and 276 healthy controls. Only 21% of the CHR group did not have a comorbid diagnosis with many have 2-3 DSM-IV comorbid diagnoses. The most common diagnoses were anxiety and depressive disorders, which did improve over time. The only diagnosis at baseline that differentiated the converters from the non-converters was cannabis misuse. Comorbidity, except for cannabis use, was essentially independent of clinical outcome. It is possible that those with comorbid diagnoses are preferentially the help-seeking individuals that present for help in our clinics and research projects and that those who are at risk but do not have a comorbid diagnosis may not be seeking help in the prodromal phase. (C) 2017 Elsevier B.V. All rights reserved.

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