Article
Multidisciplinary Sciences
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Summary: This study examined the role of dopamine D-5 receptors in impulse control and found that they are not necessary for impulse control. The results highlight the importance of time series analysis and detailed analysis of the learning process in understanding the behavioral functions of D-5 receptors.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Melissa J. Glenn, Ariel A. Batallan Burrowes, Waylin Yu, Lisa Blackmer-Raynolds, Amanda Norchi, Amanda L. Doak
Summary: Mutations in the DISC1 gene are linked to increased risk of psychological disorders. Knocking out the gene in rats resulted in significant behavioral effects, with females showing hyperactivity and aversion to novelty while males exhibited anxiety and large prepulse inhibition deficits. This suggests gender-specific consequences of DISC1 dysfunction in behavioral deficits.
GENES BRAIN AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Xiaojia Ren, D. Allan Butterfield
Summary: Parkinson's disease (PD) is the second most common age-related neurodegenerative disease globally, impacting quality of life significantly as people live longer. Genetically modified PD rodent models are crucial for studying mechanisms and potential therapies. The MJFF funded the generation of a PINK1 KO rat model for familial PD, aiming to improve understanding of PD etiology and treatment strategies.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Karolina Nizinska, Kinga Szydlowska, Avgoustinos Vouros, Anna Kiryk, Aleksandra Stepniak, Eleni Vasilaki, Katarzyna Lukasiuk
Summary: The study analyzed behavior in a rat model of epilepsy, identifying differences in behavioral impairments between animals with short versus long latency to seizures and low versus high number of seizures. Results suggest that epilepsy intensity and seizure frequency may affect animal behavior, with mild behavioral changes observed overall.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Congyao Zha, Karine Gamache, Oliver M. Hardt, Wayne S. Sossin
Summary: CAPN15 is an intracellular cysteine protease that plays an important role in development. Loss of CAPN15 leads to eye anomalies and brain volumetric changes in mice, and biallelic variants in CAPN15 are associated with developmental delay and neurodevelopmental disorders in humans. In this study, it was found that CAPN15 regulates behavior in adult mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuka Takahashi, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, Chihiro Sato
Summary: Schizophrenia is a severe psychiatric disorder influenced by genetic and environmental factors. Changes in polysialylation of neural cell adhesion molecules have been found in the brains of patients with psychiatric disorders. This study investigates the effects of genetic (G) and environmental (E) factors on polysialylated NCAM expression using a schizophrenia mouse model and acute stress conditions. The study discovers differences in polysialylation and NCAM responses to stress in different brain regions, suggesting the vulnerability of the schizophrenia mouse model to stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Health Care Sciences & Services
Keren Nitzan, Roni Toledano, Shiran Shapira, Nadir Arber, Ravid Doron
Summary: The study found that CD24 knockout mice exhibited better cognitive performance and less anxiety-like behavior compared to wild-type mice, with no effect on depression-like behavior. This phenotype remained constant from childhood to adulthood.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Brian R. Barnett, Sue Y. Yi, McKenzie J. Poetzel, Keith Dodd, Nicholas A. Stowe, John-Paul J. Yu
Summary: NODDI is an emerging MRI DWI technique that allows for non-invasive quantitative assessment of neurite density and morphology, particularly suitable for studying dynamic changes in the developing brain. This advanced method shows enhanced sensitivity and specificity in identifying neurodevelopmental and sex-specific changes in brain microstructure, offering potential applications in psychiatric illness studies.
Article
Biochemistry & Molecular Biology
Judit Garcia-Gonzalez, Bruno de Quadros, William Havelange, Alistair J. Brock, Caroline H. Brennan
Summary: Research has shown that developmental exposure to the synthetic cannabinoid JWH-018 in zebrafish embryos can have long-term behavioral impacts, including decreased anxiety levels. However, the DISC1 gene does not moderate these effects in the process.
Article
Medicine, General & Internal
Idil Memis, Rahul Mittal, Emily Furar, Isaiah White, Rebecca S. Eshraghi, Jeenu Mittal, Adrien A. Eshraghi
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social behavior, stereotypic/repetitive behaviors, and sensory/communication deficits. This study investigated BBB integrity and oxidative stress in Cntnap2(-/-) rats and found increased BBB permeability and oxidative stress in these rats. These findings suggest that Cntnap2(-/-) rats are a relevant model for further exploration of therapeutic interventions for ASD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Suzanne O. Nolan, Samantha L. Hodges, Matthew S. Binder, Gregory D. Smith, James T. Okoh, Taylor S. Jefferson, Brianna Escobar, Joaquin N. Lugo
Summary: This study aimed to investigate the therapeutic efficacy of omega-3 fatty acids for the behavioral and neuroimmune phenotype of the Fmr1 knockout model. The results showed that omega-3 fatty acid supplementation reversed certain behavioral deficits but also had negative effects on other behaviors and immune functions.
Article
Neurosciences
Cong Liu, Qian Hu, Yan Chen, Lingqian Wu, Xionghao Liu, Desheng Liang
Summary: The functions of the brain-enriched protein Stxbp6 have been poorly understood for the past two decades. By generating a global Stxbp6-knockout mouse, researchers found that Stxbp6 loss affects weight gain and alters the expression of genes associated with the nervous system. Additionally, KEGG enrichment analysis suggests potential regulatory pathways of Stxbp6 in the central nervous system, particularly in complement and coagulation cascades.
Article
Multidisciplinary Sciences
Lei Tan, Xiaolong Qi, Weining Kong, Jiachuan Jin, Dan Lu, Xu Zhang, Yue Wang, Siting Wang, Wei Dong, Xudong Shi, Wei Chen, Jianying Wang, Keru Li, Yuan Xie, Lijuan Gao, Feifei Guan, Kai Gao, Chaojun Li, Cheng Wang, Zhibin Hu, Lianfeng Zhang, Xuejiang Guo, Bin Shen, Yuanwu Ma
Summary: We used a modified DddA-derived cytosine base editor to introduce premature stop codons in mitochondrial protein-coding genes, resulting in the depletion of mtProteins in both cell and rat resources. This provides valuable tools for studying mtProtein-coding genes and developing therapeutic strategies.
Article
Biochemistry & Molecular Biology
Eleonora Spekker, Zsuzsanna Bohar, Annamaria Fejes-Szabo, Monika Szucs, Laszlo Vecsei, Arpad Pardutz
Summary: Migraine is a neurological condition that is more common in women than men, possibly related to estrogen. In the experiment, repeated migraine attacks induced by IS treatment activate and sensitize the trigeminal system, leading to changes in pain thresholds and behavior in animals.