Article
Physiology
Jaime Gallo-Villegas, Leonardo A. Castro-Valencia, Laura Perez, Daniel Restrepo, Oscar Guerrero, Sergio Cardona, Yeliana L. Sanchez, Manuela Yepes-Calderon, Luis H. Valbuena, Miguel Pena, Andres F. Milan, Maria C. Trillos-Almanza, Sergio Granados, Juan C. Aristizabal, Mauricio Estrada-Castrillon, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C. Aguirre-Acevedo, Juan C. Calderon
Summary: This study compared the efficacy of high-intensity, low-volume interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin resistance (IR), muscle mass, muscle activation, and serum musclin in adults with metabolic syndrome. The results showed no significant differences between the two training methods in reducing IR, increasing muscle mass, and improving body composition, although both were effective in improving insulin resistance, muscle mass, and body composition.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Carlos Dellavechia de Carvalho, Rafael Rossi Valentim, Luiz Carlos Carvalho Navegantes, Marcelo Papoti
Summary: This study investigated the physiological and molecular responses of rats to chronic training. The results showed that 5 weeks of running training improved performance and increased resting glycogen levels in the muscles, and the intensity of training did not significantly affect the training outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Aaron Persinger, Matthew Butawan, Martina Faietti, Ashley Pryke, Kyley Rose, Marie van der Merwe, Richard J. Bloomer, Melissa J. Puppa
Summary: Time-restricted feeding (TRF) does not significantly impact muscle metabolic flexibility and running performance, especially in young populations consuming a healthy diet and exercising.
Article
Respiratory System
Lorna E. Latimer, Dumitru Constantin-Teodosiu, Bhavesh Popat, Despina Constantin, Linzy Houchen-Wolloff, Charlotte E. Bolton, Michael C. Steiner, Paul L. Greenhaff
Summary: The study found that aging and COPD do not impair intrinsic mitochondrial function in untrained state, but AET has robust effects on whole-body and muscle mitochondrial responses in HY, significant effects in HO, and deficiencies in COPD. All groups showed strong muscle mRNA responses.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Nutrition & Dietetics
Thiago Santos Rosa, Hugo Luca Correa, Lysleine Alves Deus, Whitley Stone, Andrea Lucena Reis, Andre Bonadias Gadelha, Thais Branquinho de Araujo, Paulo Roberto Silva Junior, Milton Rocha Moraes, Jose Adeirton Bezerra Silva, Carmen Tzanno-Martins, Herbert Gustavo Simoes, Jonato Prestes, Rodrigo Vanerson Passos Neves
Summary: The study compared the effects of dynamic and isometric resistance training on HD patients, finding that dynamic resistance training was more effective in improving glycemic homeostasis, lipid profile, and NO levels, while isometric resistance training only improved strength.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Rita Nogueira-Ferreira, Ines Santos, Rita Ferreira, Dulce Fontoura, Claudia Sousa-Mendes, Ines Falcao-Pires, Andre P. Lourenco, Adelino Leite-Moreira, Iola F. Duarte, Daniel Moreira-Goncalves
Summary: Exercise training has positive effects on the management of metabolic syndrome, improving inflammation, exercise capacity, and muscle metabolism. It reduces muscle atrophy and fibrosis and enhances oxidative metabolism, reducing fatigue susceptibility.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Saeid Shamlou Kazemi, Ali Heidarianpour, Elnaz Shokri
Summary: This study investigates the effects of resistance training (RT) and high-intensity interval training (HIIT) on metabolic indices and serum levels of Sirtuin1 (SIRT1) in postmenopausal women with metabolic syndrome (MetS). The results show that both RT and HIIT significantly improve metabolic indices and increase SIRT1 levels, with HIIT having a greater impact on blood pressure and blood sugar control.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Pediatrics
Meng Cao, Shu Li, Yucheng Tang, Yu Zou
Summary: High-intensity interval training (HIIT) has positive effects on glycolipid metabolism in children with metabolic disorders, showing improvements in TG, TC, LDL-C, HDL-C, BG, BI, and HOMA-IR. HIIT did not have superior effects compared to moderate-intensity training (MIT), but protocols with a WRR of 1:1 and using %MAS as exercise intensity were more effective in reducing TG and LDL-C. Protocols using %HR as exercise intensity were better in increasing HDL-C, decreasing BI, and HOMA-IR compared to MIT.
FRONTIERS IN PEDIATRICS
(2022)
Article
Sport Sciences
Joyce S. Ramos, Lance C. Dalleck, Mackenzie Fennell, Alex Martini, Talita Welmans, Rebecca Stennett, Shelley E. Keating, Robert G. Fassett, Jeff S. Coombes
Summary: This study investigated the effects of different exercise intensities on FFI in adults with MetS. Results suggest that high-intensity interval training may lead to greater improvements in FFI compared to moderate-intensity continuous training, although no significant differences were found between groups. Further research is needed to explore the impact of exercise intensity on FFI in individuals with MetS.
SPORTS MEDICINE-OPEN
(2021)
Article
Cell Biology
Reichelle X. Yeo, Pieter J. Dijkstra, Flavia G. De Carvalho, Fanchao Yi, Maria F. Pino, Steven R. Smith, Lauren M. Sparks
Summary: This study assessed the impact of aerobic training on mitochondrial metabolism of human skeletal muscle cells, and found that aerobic training can improve skeletal muscle mitochondrial capacity without affecting mitochondrial content.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Alfonso Moreno-Cabanas, Juan Fernando Ortega, Felix Morales-Palomo, Miguel Ramirez-Jimenez, Laura Alvarez-Jimenez, Ricardo Mora-Rodriguez
Summary: The study aimed to investigate the effects of substituting parts of aerobic training (AT) with resistance training (RT) on metabolic syndrome (MetS) factors. Results showed that replacing 20% of AT with RT can improve glucose control and muscle strength in MetS individuals, suggesting that resistance training should be included in exercise recommendations for regaining glycemic control in MetS patients.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Health Care Sciences & Services
Jaime Gallo-Villegas, Daniel Restrepo, Laura Perez, Leonardo A. Castro-Valencia, Raul Narvaez-Sanchez, Jorge Osorio, Daniel C. Aguirre-Acevedo, Juan C. Calderon
Summary: This study compared the safety of high-intensity, low-volume interval training (HIIT-low volume) with moderate-intensity continuous aerobic training (MICT) in patients with metabolic syndrome. The results showed that both interventions were safe, but HIIT-low volume should be avoided in patients with venous insufficiency of the lower limbs.
JOURNAL OF PATIENT SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ruonan Shangguan, Zhiqiang Hu, Yuzhen Luo, Min Chen, Xiangdeng Lai, Jingquan Sun, Siyu Chen
Summary: This study investigated the effects of high-intensity interval training (HIIT) of different durations on intramuscular triglyceride abundance, mitochondrial function, and lipid metabolism in SD rats. The results showed that HIIT for 2, 4, and 10 weeks significantly increased intramuscular triglyceride abundance, while lipid metabolism-related proteins exhibited inconsistent changes. Mitochondrial function decreased after 2 and 4 weeks of training but improved after 6 weeks, and intramuscular triglyceride contents declined. Caution should be exercised when considering 2 and 4 weeks of training under similar HIIT protocols, and at least 6 weeks of training is effective for mitochondrial enhancement.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Christina Guluzian, Vincent Giguere
Summary: This study found that increasing ERRa activity can enhance exercise capacity and endurance by reprogramming ERRa global DNA occupancy and muscle transcriptome, thereby improving oxidative fibers, mitochondrial biogenesis, fatty acid oxidation, and lactate homeostasis.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Amanda V. Sardeli, Alex Castro, Victor B. Gadelha, Wellington M. dos Santos, Janet M. Lord, Claudia R. Cavaglieri, Mara Patricia T. Chacon-Mikahil
Summary: Increases in longevity and obesity have led to a higher prevalence of Metabolic Syndrome (MetS) and hypertension. Combined aerobic and resistance exercise training is recommended to maintain good health in older adults and known to generate important metabolic adaptations. The study conducted a metabolomics analysis to investigate the changes in metabolism in response to 16 weeks of CT in non-physically active older women with MetS.
Article
Sport Sciences
Lidia Robles-Gonzalez, Millan Aguilar-Navarro, Alvaro Lopez-Samanes, Carlos Ruiz-Moreno, Alejandro Munoz, David Varillas-Delgado, Jorge Gutierrez-Hellin, Jorn W. Helge, Jonatan R. Ruiz, Francisco J. Amaro-Gahete
Summary: This study found that maximal fat oxidation and the intensity that elicits it remain consistent throughout the day in healthy women, regardless of the time of exercise testing. These results have clinical relevance in understanding the differences between men and women in terms of fat oxidation during exercise.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Raquel Gonzalez-Martos, Raquel Aparicio-Ugarriza, Julian Alcazar, Carmen Ramirez-Castillejo, Dace Reihmane, Adrian Menendez-Rey, Marcela Gonzalez-Gross, Amelia Guadalupe-Grau
Summary: Type 2 diabetes mellitus (T2DM) in old age affects the musculoskeletal system causing loss of muscle mass, strength, and physical function. Stress-inducible proteins named sestrins may serve as novel biomarkers for muscle function. The study aimed to investigate the association between different force-velocity profiles and body composition, physical performance, and glucose control in older adults with T2DM. The results showed that older adults with T2DM exhibited different F-V profiles, which were associated with low levels of Sesn2, impaired body composition, and physical performance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Mikkel Thunestvedt Hansen, Karina Louise Skov Husted, Mathilde Fogelstrom, Tue Romer, Samuel Emil Schmidt, Kasper Sorensen, Jorn Helge
Summary: A model using seismocardiography (SCG) for the prediction of (V) over dotO(2)max was found to accurately predict the maximum oxygen consumption in a healthy adult population.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Anthropology
Dirk L. Christensen, Kate Westgate, Lewis Griffiths, Joseph Sironga, Venance P. Maro, Jorn W. Helge, Steen Larsen, Ib C. Bygbjerg, Kaushik L. Ramaiya, Jorgen Jensen, Soren Brage
Summary: This study aimed to objectively quantify the metabolic intensity of traditional jumping-dance activity performed by Maasai men and assess its associations with habitual physical activity and cardiorespiratory fitness. The findings showed that the intensity of jumping-dance activity was moderate, but on average seven times higher than habitual physical activity.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Kim Z. Rokamp, Flemming Dela, Niels H. Secher, Lars Gronlykke, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard
Summary: This study investigates the impact of the ADRB2 gene polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. The results showed that the insulin, glycerol, and free fatty acid responses to epinephrine were decreased in participants with the Arg16 genotype compared with those with the Gly16 genotype before hypoglycemia, but there was no difference in glucose response. However, there were no differences in response to epinephrine between genotype groups after repetitive hypoglycemia.
Article
Sport Sciences
Isabel Guisado-Cuadrado, Victor M. Alfaro-Magallanes, Nuria Romero-Parra, Beatriz Rael, Amelia Guadalupe-Grau, Ana B. Peinado
Summary: The study examined the influence of ovarian hormones and training characteristics on bone mineral density in well-trained females. Endurance-trained premenopausal females had lower spine BMD compared to resistance-trained premenopausal females. Postmenopausal females and long-term users of oral contraceptives also showed lower BMD levels in the pelvis, spine, and total body.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Arthur Ingersen, Malte Schmucker, Christina Alexandersen, Benjamin Graungaard, Tobias Thorngreen, Jacob Borch, Jens Juul Holst, Jorn Wulff Helge, Flemming Dela
Summary: The study aimed to investigate the interaction of semaglutide treatment and aerobic training on pancreatic β-cell secretory function in patients with type 2 diabetes. The results showed that aerobic training increased insulin secretion, and semaglutide treatment further improved β-cell secretory function. The combination of aerobic training and semaglutide treatment synergistically enhanced β-cell secretory function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ida Bager Christensen, Ida Blom, Tine Lovso Dohlmann, Fabian Finger, Jorn W. Helge, Zachary Gerhart-Hines, Flemming Dela, Steen Larsen
Summary: This study investigated the effects of statin therapy on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue. The results showed that statin treatment was associated with mitochondrial respiratory capacity, but there was no clear link to the inflammatory status of adipose tissue.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Physiology
Christopher T. A. Lewis, Lee Tabrizian, Joachim Nielsen, Jenni Laitila, Thomas N. Beck, Mathilde S. Olsen, Marija M. Ognjanovic, Per Aagaard, Rune Hokken, Simon Laugesen, Arthur Ingersen, Jesper L. Andersen, Casper Soendenbroe, Jorn W. Helge, Flemming Dela, Steen Larsen, Ronni E. Sahl, Tue Romer, Mikkel T. Hansen, Jacob Frandsen, Charlotte Suetta, Julien Ochala
Summary: Lewis et al. investigated the influence of training status on relaxed myosin conformations and found that moderate physical activity leads to a shift in relaxed myosin conformation, resulting in reduced ATP consumption. Their study revealed that physical activity level and training type can influence resting skeletal muscle myosin dynamics, suggesting that environmental stimuli such as exercise can rewire the molecular metabolism of human skeletal muscle through myosin.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Sport Sciences
Ivan Baltasar-Fernandez, Jose Losa-Reyna, Aitor Carretero, Carlos Rodriguez-Lopez, Ana Alfaro-Acha, Amelia Guadalupe-Grau, Ignacio Ara, Luis M. Alegre, Mari Carmen Gomez-Cabrera, Francisco J. Garcia-Garcia, Julian Alcazar
Summary: This study aimed to assess the residual effects of a 12-week concurrent training program in older adults with COPD. The results showed that after 10 months of detraining, the intervention group had improved physical function, health-related quality of life, early rate of force development, and maximum muscle power, while no significant differences were found in peak oxygen uptake, late rate of force development, systemic oxidative damage, and antioxidant capacity. The findings suggest that concurrent training can have positive effects on older adults with COPD.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Endocrinology & Metabolism
Anders Bue Klein, Pablo Ranea-Robles, Trine Sand Nicolaisen, Claudia Gil, Kornelia Johann, Julia Prats Quesada, Nina Pistolevij, Kathrine V. R. Hviid, Line Fich, Simone M. Offersen, Jorn Wulff Helge, Henriette Svarre Nielsen, Jaco Bakker, Maximilian Kleinert, Christoffer Clemmensen
Summary: Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that may play a potential role in pregnancy. While mice and rats have a limited response to pregnancy, macaques and humans exhibit significant increases in GDF15 levels. These species-specific findings provide valuable insights for future research on GDF15 in pregnancy and for developing pharmacological strategies to treat severe nausea and hyperemesis gravidarum (HG).
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Romer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jorn Wulff Helge
Summary: The aim of this study was to investigate the effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in younger and older men. The results showed a positive effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in both young and old trained men, with no sign of attenuated function in adipose tissue with age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Mikkel T. Hansen, Tue Romer, Amalie Hojgaard, Karina Husted, Kasper Sorensen, Samuel E. Schmidt, Flemming Dela, Jorn W. Helge
Summary: This study investigated the validity and reliability of Seismofit in estimating V.O(2)peak in a healthy population. The results showed that Seismofit had a high level of consistency in its estimation, but further improvement is needed in the clinical application due to measurement errors and a MAPE value exceeding 10%.
CARDIOVASCULAR DIGITAL HEALTH JOURNAL
(2023)
Article
Obstetrics & Gynecology
Celia Rodriguez-Longobardo, Amelia Guadalupe-Grau, Miguel Angel Gomez-Ruano, Olga Lopez-Torres
Summary: Lower urinary tract symptoms (LUTS) can be found in young athletes. Early use of pelvic floor muscle training as a preventive strategy may help avoid future pelvic floor dysfunction.
Article
Nutrition & Dietetics
Melike Nur Eroglu, Celia Rodriguez-Longobardo, Ana Ramirez-Adrados, Clara Colina-Coca, Silvia Burgos-Postigo, Olga Lopez-Torres, Valentin E. Fernandez-Elias
Summary: This study evaluated and compared the effects of 24-hour intermittent fasting on the physical performance of female CrossFit athletes. The results showed that fasting did not impair exercise performance or negatively affect physiological parameters in these athletes.