期刊
RUSSIAN CHEMICAL BULLETIN
卷 66, 期 8, 页码 1510-1514出版社
SPRINGER
DOI: 10.1007/s11172-017-1916-3
关键词
erythrocytes; methemoglobin; binuclear tetranitrosyl iron complexes; nitric oxide
资金
- Federal Agency for Scientific Organizations [0089-2014-0037]
The NO-donating and hemolytic activity of the binuclear tetranitrosyl iron complexes (TNIC) with thiolate ligands of the composition [Fe-2(SR)(2)(NO)(4)], where R is pyridin-2-yl and 5-nitropyridin-2-yl, was studied. The NO-donating and hemolytic activities of the com- plex with the nitrosubstituted ligand are approximately two and three times higher than the corresponding characteristics of the complex with unsubstituted 2-mercaptopyridine, respectively. Symbate changes in these parameters confirm the conclusion made earlier on the peroxynitrite-dependent mechanism of erythrocyte hemolysis under the action of TNIC. The NO-donating activity of TNIC with ligands of the 2-mercaptopyridine series, unlike the previously studied complexes containing thioderivatives of other nitrogenous heterocycles as S-ligands, did not decrease with an increase in the concentration of erythrocytes. This allows one to consider them as promising NO-donating substances for the preparation of pharma- cological remedies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据