Article
Rheumatology
Eleftheria Pertsinidou, Saedis Saevarsdottir, Vivek Anand Manivel, Lars Klareskog, Lars Alfredsson, Linda Mathsson-Alm, Monika Hansson, Martin Cornillet, Guy Serre, Rikard Holmdahl, Karl Skriner, Per-Johan Jakobsson, Helga Westerlind, Johan Askling, Johan Roennelid
Summary: In early RA patients, ACPA is associated with a lower number of affected joints, while RF is associated with elevated systemic inflammation markers in an ACPA-dependent manner. This finding supports the in vitro models of ACPA and RF in immune complex-induced inflammation. These phenotypic associations are independent of classification criteria.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Yann Nguyen, Carine Salliot, Amandine Gelot, Xavier Mariette, Marie-Christine Boutron-Ruault, Raphaele Seror
Summary: Exposure to passive smoking in childhood and/or adulthood increases the risk of rheumatoid arthritis (RA) by the same order as active smoking.
Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Aase Hensvold, Lars Klareskog
Summary: Recent progress in understanding the etiology and molecular pathogenesis of rheumatoid arthritis (RA) has opened up new opportunities for personalized and targeted prevention strategies, aiming to prevent the disease before onset and understand the molecular pathogenesis of its different variants.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Rheumatology
Nilasha Ghosh, Pankti Reid, Carlos Andres Aude, Jessica Kirschman, Susan Goodman, Vivian P. Bykerk, Amit Lakhanpal, Diviya Rajesh, Karmela K. Chan, William H. Robinson, Anne R. Bass
Summary: In this study, the expansion of ACPA epitopes in CCP+ICI-IA was compared with patients with RA. It was found that patients with ICI-IA had lower ACPA titres and targeted fewer ACPA epitopes compared to longstanding RA patients, and there were no significant differences in the presence of the shared epitope between ICI-IA patients and ICI controls. This suggests that ICI-IA may represent an accelerated model of RA pathogenesis.
Article
Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
Summary: This study identified nine novel autoantibodies in ACPA-negative RA, with anti-PTX3 and anti-DUSP11 showing the highest sensitivity. The combination of these two autoantibodies significantly increased the diagnostic sensitivity in ACPA-negative RA. The novel biomarkers provide potential diagnostic value for ACPA-negative RA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Christine G. Parks, Lauren E. Wilson, Michela Capello, Kevin D. Deane, Samir M. Hanash
Summary: Autoantibodies to tumor-associated antigens (anti-TAA) have the potential to be biomarkers for breast cancer. However, their relationship with systemic autoimmunity as measured by antinuclear antibodies (ANA) is unclear. This study aims to investigate the relationship between anti-TAAs and ANA among women with and without breast cancer.
Article
Rheumatology
Nathalie Luurssen-Masurel, Elise van Mulligen, Angelique Elisabeth Adriana Maria Weel-Koenders, Johanna Maria Wilhelmina Hazes, Pascal Hendrik Pieter de Jong
Summary: This study compared the long-term clinical outcomes of three clinical arthritis phenotypes: undifferentiated arthritis (UA), autoantibody-negative (RA-) and autoantibody-positive RA (RA+). The results showed that there were differences in remission rates and sustained remission rates between these phenotypes. The data confirm that rheumatoid arthritis can be subdivided based on clinical phenotypes and that treatment should be stratified accordingly.
Article
Rheumatology
Michelle D. van den Beukel, Tineke J. van Wesemael, Anna Titia W. Hoogslag, Nicole Borggreven, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, Rene E. M. Toes, Diane van der Woude, Leendert A. Trouw
Summary: It has been found that the presence of anti-malondialdehyde-acetaldehyde adducts and anti-advanced glycation end-products autoantibodies is common in rheumatoid arthritis patients. These autoantibodies are associated with HLA genes, inflammation, and clinical outcomes.
Article
Rheumatology
Bowen Tang, Qianwen Liu, Anna Ilar, Pernilla Wiebert, Sara Hagg, Leonid Padyukov, Lars Klareskog, Lars Alfredsson, Xia Jiang
Summary: This study examined the effects of occupational inhalable exposures on the development of rheumatoid arthritis (RA) and their interactions with smoking and RA-risk genes, specifically in relation to the presence of anticitrullinated protein antibodies (ACPA). The results showed that exposure to any occupational inhalable agents was associated with an increased risk for ACPA-positive RA. Furthermore, there was a significantly elevated risk for ACPA-positive RA among individuals who were exposed to occupational inhalable agents, smoked, and had a high genetic risk score (GRS). Significant interactions were found between occupational inhalable agents and smoking/genetic factors (high GRS or HLA-SE) in ACPA-positive RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Hieronymus T. W. Smeele, Marco W. J. Schreurs, Nathalie Costedoat-Chalumeau, Jerome M. J. Cornette, Radboud J. E. M. Dolhain
Summary: This study found a low prevalence of anti-SSA and anti-SSB autoantibodies in RA patients wishing to conceive or pregnant. Especially for RF-negative patients, the current recommendation to test for anti-SSA and anti-SSB may need to be reconsidered.
Review
Biochemistry & Molecular Biology
Sunhee Jang, Eui-Jong Kwon, Jennifer Jooha Lee
Summary: Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, and recent advancements have shed light on the underlying mechanisms, providing new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Iris Paola Guzman-Guzman, Claudia Isabel Ramirez-Velez, Ramces Falfan-Valencia, Jose Eduardo Navarro-Zarza, Ilse Adriana Gutierrez-Perez, Oscar Zaragoza-Garcia, Monica Ramirez, Natividad Castro-Alarcon, Isela Parra-Rojas
Summary: The SNP of the PADI2 gene plays a crucial role in the pathogenesis and severity of rheumatoid arthritis (RA), with specific genotypes in women from southern Mexico being associated with early disease onset, positive autoantibodies, and radiographic joint damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Ketian Li, Min Wang, Lidan Zhao, Yudong Liu, Xuan Zhang
Summary: This review summarizes the current knowledge about the primary drivers of ACPA(-) RA, focusing on the serological, cellular, and molecular aspects of immune mechanisms. A better understanding of the etiology of ACPA(-) RA will aid in personalized treatment design and improve early treatment and outcomes.
Review
Rheumatology
Kevin D. Deane, V. Michael Holers
Summary: The prevention of RA is a critical topic, involving predicting individuals who may develop clinically apparent RA in the future and discussions on clinical trials for prevention. Studies aimed at delaying or preventing clinically apparent IA/RA onset have gained attention, as making prevention of RA a future public health strategy has become a focus.
ARTHRITIS & RHEUMATOLOGY
(2021)
Letter
Rheumatology
Benoit Thomas P. Gilbert, Axel Finckh, Deshire Alpizar Rodriguez
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Sport Sciences
Denis Mongin, Clovis Chabert, Delphine Sophie Courvoisier, Jeronimo Garcia-Romero, Jose Ramon Alvero-Cruz
Summary: This study proposes a cross-sectional study based on 980 maximal effort tests to investigate the effect of heart rate recovery (HRR) calculation methods on its association with cardiorespiratory fitness (CRF). The results show that there is no significant association between HRR indices based on exponential regression and CRF. However, other HRR indices are associated with CRF when t(0) is at least 1 minute, with the strongest association observed at t(0) = 2 minutes for females and t(0) = 3 minutes for males.
RESEARCH IN SPORTS MEDICINE
(2023)
Review
Rheumatology
Maria F. Ramirez-Flores, Cinthya Cadena-Trejo, Emilio Motte-Garcia, Isaac D. Juarez-Cruz, Maria V. Fernandez-Garcia, Alfonso Gastelum-Strozzi, Deshire Alpizar-Rodriguez, Adolfo Hernandez-Garduno, Ingris Pelaez-Ballestas
Summary: A syndemic framework is used to assess the multidimensionality of diseases and their circumstances, providing important insights in various fields. This study aimed to evaluate the use of this framework in rheumatic and musculoskeletal diseases (RMDs). The results showed limited application of syndemic studies in rheumatology, highlighting the need for further research.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Correction
Rheumatology
Ying-Ying Leung, Tatiana Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lind-Qvist, David Simon, Amara Ezeonyeji, Enrique R. Soriano, Oliver FitzGerald
JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Burkhard Moeller, Joachim Grifka
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Louise Linde, Lykke M. Ornbjerg, Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindstrom, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Bjorn Gudbjornsson, Thorvardur Jon Love, Dan C. Nordstrom, Timo Yli-Kerttula, Lucie Nekvindova, Jiri Vencovsky, Florenzo Iannone, Alberto Cauli, Anne Gitte Loft, Bente Glintborg, Karin Laas, Ziga Rotar, Matija Tomsic, Gary J. Macfarlane, Burkhard Moller, Marleen van de Sande, Catalin Codreanu, Michael J. Nissen, Merih Birlik, Sukran Erten, Maria J. Santos, Elsa Vieira-Sousa, Merete L. Hetland, Mikkel Ostergaard
Summary: In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission and moderate response at 6 months, as well as drug retention at 12 months were identified, indicating potential generalizability from country to disease level.
Article
Health Care Sciences & Services
Frederic Ehrler, Carlotta Tuor, Robin Rey, Remy Trompier, Antoine Berger, Michael Ramusi, Delphine S. Courvoisier, Johan N. Siebert
Summary: This study aims to explore the impact of a mobile app called PIMPmyHospital on the timeliness of accessing laboratory results in emergency departments (EDs), as well as its effectiveness on ED length of stay, technology acceptance, and usability. The study will be conducted in a pediatric ED in Switzerland, with participants including postgraduate residents, pediatric emergency medicine fellows, and registered nurses. The results of the study are expected to be published in a peer-reviewed journal in late 2023.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Rheumatology
Everardo Alvarez-Hernandez, Eduardo Barreira-Mercado, Hilda E. Fragoso-Loyo, Cristina Hernandez-Diaz, Blanca Mota-Mondragon, Sandra Munoz-Lopez, Mario Perez-Cristobal, Nadina Rubio-Perez, Alfonso Torres-Jimenez, Angelica Vargas Guerrero, Monica Vazquez del Mercado, Miguel Angel Villarreal-Alarcon, Cesar Pacheco-Tena, Deshire Alpizar-Rodriguez
Summary: The study aims to describe the distribution of adult and pediatric rheumatologists in Mexico and the factors associated with this distribution. The databases of the Mexican Council of Rheumatology and the Mexican College of Rheumatology for 2020 were reviewed to analyze the number, age, and gender of certified rheumatologists by state. The results show a shortage of rheumatologists in Mexico, with underserved regions in the pediatric area. It is important to implement health policies to achieve a more balanced and efficient regionalization of this specialty and increase the percentage of certified rheumatologists.
REUMATOLOGIA CLINICA
(2023)
Article
Immunology
Axel Finckh, Adrian Ciurea, Catherine E. Raptis, Andrea Rubbert-Roth
Summary: Immune-mediated inflammatory diseases (IMIDs) are a diverse group of diseases characterized by immune dysregulation, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. The prevalence of IMIDs ranges between 5% and 7% in developed countries. The use of immunomodulatory medications in the management of IMIDs can weaken the immune response and increase the risk of severe outcomes from COVID-19, as well as reduce the efficacy of COVID-19 vaccination. This article summarizes the current literature on COVID-19 outcomes, vaccination responses, and the impact of immunomodulatory therapies in patients with rheumatologically dominated IMIDs, and provides vaccination recommendations for individuals with IMID.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Rheumatology
Burkhard Moller, Godehard A. Scholz, Jennifer Amsler, Adrian Ciurea, Raphael Micheroli, Michael J. Nissen, Eleftherios Papagiannoulis, Christoph Blapp, Almut Scherer, Nikhil Yawalkar
Summary: This study compared the effectiveness of the first biologic DMARD (bDMARD) in patients with low and high joint counts. The results showed that bDMARD had similar drug retention rates in patients with low and high joint counts. Furthermore, bDMARD retention was significantly better when administered with conventional synthetic DMARD co-therapy.
Article
Rheumatology
Denis Mongin, Barbara Russo, Alejandro Brigante, Sami Capderou, Delphine S. Courvoisier, Michele Iudici
Summary: This study aimed to assess the time from completion to publication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs) and investigate the factors associated with the time to publication. The results showed that a high proportion of CTDs-RCTs were published beyond 2 years from completion. The time to publication improved over time and was not influenced by the significance of primary outcome results, funder, impact factor of the journal, number of recruiting countries, and comparator.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Maria-Eugenia Zaballa, Javier Perez-Saez, Carlos de Mestral, Nick Pullen, Julien Lamour, Priscilla Turelli, Charlene Raclot, Helene Baysson, Francesco Pennacchio, Jennifer Villers, Julien Duc, Viviane Richard, Roxane Dumont, Claire Semaani, Andrea Jutta Loizeau, Clement Graindorge, Elsa Lorthe, Jean-Francois Balavoine, Didier Pittet, Manuel Schibler, Nicolas Vuilleumier, Francois Chappuis, Omar Kherad, Andrew S. Azman, Klara M. Posfay-Barbe, Laurent Kaiser, Didier Trono, Silvia Stringhini, Idris Guessous
Summary: In Geneva, Switzerland, over 93.8% of the population has developed anti-SARS-CoV-2 antibodies, with 72.4% acquired through infection. However, there is lower neutralization capacity against the Omicron BA.5 subvariant, especially in children under 12 years old. Additional booster doses after vaccination and infection can enhance neutralization capacity.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Adrian Ciurea, Axel Finckh
ANNALS OF THE RHEUMATIC DISEASES
(2023)