Article
Medicine, Research & Experimental
Ahmet Arisoy, Abdullah Yilgor, Ibrahim H. Uney
Summary: Patients with COPD are at a higher risk of developing peripheral neuropathy, especially motor neuropathy. The Global Initiative for Chronic Obstructive Lung Disease classifies these neuropathies as group D. Various factors may contribute to the accelerated development of neuropathy.
MEDICAL SCIENCE MONITOR
(2021)
Article
Respiratory System
Vasiliy V. Polosukhin, Sergey S. Gutor, Rui-Hong Du, Bradley W. Richmond, Pierre P. Massion, Pingsheng Wu, Justin M. Cates, Kim L. Sandler, Stephen Rennard, Timothy S. Blackwell
Summary: In patients with COPD, thickening of epithelial and subepithelial tissue, mucus plugging, reduced collagen density in the airway wall, and loss of radial alveolar attachments were associated with airflow limitation. The major determinant of airflow limitation related to small airways was found to be the loss of alveolar attachments, which may be mediated by neutrophilic inflammation. Additionally, quantitative analysis of CT scans found an association between the extent of emphysema and loss of alveolar attachments.
Article
Cardiac & Cardiovascular Systems
Howraman Meteran, Simon Francis Thomsen, Martin R. Miller, Jacob Hjelmborg, Torben Sigsgaard, Vibeke Backer
Summary: The spirometric definition of airway obstruction affects the association between COPD and comorbidities, with COPD only being significantly associated with heart failure. Respiratory symptoms (RS) seem to have a stronger association with comorbidities compared to airway obstruction.
RESPIRATORY MEDICINE
(2021)
Review
Respiratory System
Vishanna Balbirsingh, Andrea S. Mohammed, Alice M. Turner, Michael Newnham
Summary: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular disease (CVD), and the relationship between the two involves shared risk factors, pathophysiology, high prevalence, adverse effects of COPD, and medication interactions. Improved diagnosis and treatment could lead to better outcomes for COPD patients with CVD, which is often underdiagnosed.
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Review
Medicine, Research & Experimental
Michael C. Ferrera, Wassim W. Labaki, MeiLan K. Han
Summary: COPD is a common respiratory disorder with high morbidity and mortality, often underdiagnosed until clinical advancement. Research focuses on early changes for better diagnosis and identifying patients for early intervention. Treatment options have significantly expanded in the past 20 years with new medications and procedures.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Medicine, General & Internal
Aleksandra Undrunas, Piotr Kasprzyk, Aleksandra Rajca, Krzysztof Kuziemski, Witold Rzyman, Tomasz Zdrojewski
Summary: This study aimed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in the largest Polish lung cancer screening program and found that COPD is significantly under-diagnosed in this cohort. Most diagnosed cases were in the initial stage, highlighting the potential benefits of combined lung cancer and COPD screening.
Article
Plant Sciences
Vahideh Ghorani, Mohammad Reza Khazdair, Majid Mirsadraee, Omid Rajabi, Mohammad Hossein Boskabady
Summary: The study suggests that Zataria multiflora may have therapeutic effects on chronic obstructive pulmonary disease (COPD) patients by reducing inflammatory cytokines, improving pulmonary function test values, and alleviating respiratory symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Article
Physiology
Ruixue Hou, Fangfang Miao, Di Jin, Qingfang Duan, Cheng Yin, Qunpeng Feng, Tianlong Wang
Summary: This study aimed to compare the prevalence of postoperative respiratory failure in COPD patients according to disease severity after general anesthesia. The results indicated that the preoperative arterial oxygen tension in COPD patients was associated with the risk of postoperative respiratory failure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Rukiye Ciftci, Ahmet Kurtoglu, Ozgur Eken, Dilber Durmaz, Serdar Eler, Nebahat Eler, Monira I. Aldhahi
Summary: The aim of this study was to investigate the factors influencing the shuttle walking test (SWT) in patients with chronic obstructive pulmonary disease (COPD). The study included 29 patients with COPD and a healthy group of 34 women. The results showed that COPD patients had lower walking distance, speed, and SWT levels compared to the healthy group. Heart rate, perceived exertion, and dyspnea levels were significantly affected by the SWT in COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Tim Raveling, Judith Vonk, Fransien M. Struik, Roger Goldstein, Huib A. M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman
Summary: Chronic non-invasive ventilation (NIV) can improve arterial blood gases and health-related quality of life in stable COPD patients, while also benefiting post-exacerbation COPD patients in terms of blood gases and admission-free survival. However, the overall impact on exercise capacity and mortality remains uncertain across both populations.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Fredrik Nyman
Summary: This article uses an ethnographic approach to study chronic obstructive pulmonary disease (COPD) and finds that patients face complicated cognitive and emotional experiences, requiring holistic solutions that consider psychological processes, contextual factors, and subjective age. The article also highlights the importance of a gerontological perspective in understanding COPD.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Einar M. H. Martinsen, Tomas M. L. Eagan, Elise O. Leiten, Ingvild Haaland, Gunnar R. Husebo, Kristel S. Knudsen, Christine Drengenes, Walter Sanseverino, Andreu Paytuvi-Gallart, Rune Nielsen
Summary: The study revealed differences in taxonomic composition and diversity between oral and pulmonary mycobiomes in participants with COPD and controls, with more Candida found in oral samples. Malassezia and Sarocladium were frequently found in pulmonary samples. There were no consistent differences in terms of differential abundance/distribution between study groups, but sample type affected beta diversity.
Article
Environmental Sciences
Zihui Wang, Yumin Zhou, Yongbo Zhang, Xiaoliang Huang, Xianzhong Duan, Duohong Chen, Yubo Ou, Longhui Tang, Shiliang Liu, Wei Hu, Chenghao Liao, Yijia Zheng, Long Wang, Min Xie, Jinzhen Zheng, Sha Liu, Ming Luo, Fan Wu, Zhishan Deng, Heshen Tian, Jieqi Peng, Huajing Yang, Shan Xiao, Xinwang Wang, Nanshan Zhong, Pixin Ran
Summary: In Guangdong, the reduction in PM2.5, PM10, and SO2 concentrations may lead to a decrease in attributable hospital admissions for AECOPD, while ozone (O-3) has emerged as an important risk factor.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Binwei Hao, Ruiting Sun, Xiaotong Guo, Lili Zhang, Jieda Cui, Yumin Zhou, Wei Hong, Yanan Zhang, Jinxi He, Xiaoming Liu, Bing Li, Pixin Ran, Juan Chen
Summary: NOX4-mediated ROS production alters TGF-beta(1) induced cell differentiation and collagen I protein synthesis in HBSMCs through the p38MAPK/Akt signaling pathway in a Smad-dependent manner.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Oncology
Huanhuan Fan, Fan Wu, Jing Liu, Weifeng Zeng, Silan Zheng, Heshen Tian, Haiqing Li, Huajing Yang, Zihui Wang, Zhishan Deng, Jieqi Peng, Youlan Zheng, Shan Xiao, Guoping Hu, Yumin Zhou, Pixin Ran
Summary: Individuals with prior pulmonary tuberculosis have an increased risk and high prevalence of chronic obstructive pulmonary disease (COPD). Future studies are needed to identify the underlying mechanisms for tuberculosis-associated COPD and therapeutic strategies.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Toxicology
Jinding Pu, Juan Xu, Lu Chen, Hongbin Zhou, Weitao Cao, Binwei Hao, Naijian Li, Jianxiong Wu, JinZhen Zheng, Wei Hong, Bing Li, Pixin Ran
Summary: Research has shown that biomass smoke exposure may induce Th17 responses through activation of dendritic cells and lead to the development of chronic obstructive pulmonary disease in a rat model. By studying the role of antigen-presenting cells and the effect of biomass-related particulate matter, it was found that biomass smoke activates lung dendritic cells via the Toll-like receptor 2 pathway.
TOXICOLOGY LETTERS
(2021)
Article
Respiratory System
Jinglong Chen, Changbin Jiang, Youlan Zheng, Dongxing Zhao, Fan Wu, Zhuxiang Zhao, Jun Zhao, Qing Li, Bing Li, Gongyong Peng, Yumin Zhou, Pixin Ran
Summary: Individuals with COPD exposed to biomass smoke showed different pulmonary and non-pulmonary changes compared to healthy individuals, with COPD patients exhibiting more severe disease progression.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Dongxing Zhao, Asghar Abbasi, Richard Casaburi, Alessandra Adami, Nicholas B. Tiller, Wei Yuan, Christopher Yee, Nicholas G. Jendzjowsky, David M. MacDonald, Ken M. Kunisaki, William W. Stringer, Janos Porszasz, Barry J. Make, Russell P. Bowler, Harry B. Rossiter
Summary: The study found that in COPD patients, a heart rate recovery <= 10 bt/min after a 6-minute walk test is associated with more severe pulmonary impairment, airway wall thickening, worsened dyspnea, and decreased quality of life, and may predict future exacerbations.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Shuyun Chen, Xiaochen Li, Zihui Wang, Yumin Zhou, Dongxing Zhao, Zhuxiang Zhao, Sha Liu, Pixin Ran
Summary: The handheld expiratory flowmeter showed good validity as a screening tool for COPD in Chinese primary care settings, with a high correlation with conventional spirometry measurements. The cut-off point for FEV1/FEV6 was found to be 0.77, with a sensitivity of 71.2% and specificity of 89.8%.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Oncology
Erkang Yi, Jiahuan Zhang, Mengning Zheng, Yi Zhang, Chunxiao Liang, Binwei Hao, Wei Hong, Biting Lin, Jinding Pu, Zhiwei Lin, Peiyu Huang, Bing Li, Yumin Zhou, Pixin Ran
Summary: IL6-AS1 is upregulated in chronic obstructive pulmonary disease and promotes inflammation by enhancing the expression of inflammatory factors. It acts as an endogenous sponge in the cytoplasm to stabilize IL-6 mRNA, and in the nucleus, it recruits early B-cell factor 1 to promote IL-6 transcription.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Mi Gao, Chunxiao Liang, Wei Hong, Xiaoyuan Yu, Yumin Zhou, Ruiting Sun, Haiqing Li, Haichao Huang, Xuhong Gan, Ze Yuan, Jiahuan Zhang, Juan Chen, Qiudi Mo, Luyao Wang, Biting Lin, Bing Li, Pixin Ran
Summary: Exposure to biomass-related PM2.5 may lead to mitochondrial dysfunction in human airway epithelial cells, resulting in altered mitochondrial metabolism and dynamics. Mitochondria targeted peptide could alleviate these effects.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cardiac & Cardiovascular Systems
Jieqi Peng, Fan Wu, Heshen Tian, Huajing Yang, Youlan Zheng, Zhishan Deng, Zihui Wang, Shan Xiao, Xiang Wen, Peiyu Huang, Lifei Lu, Cuiqiong Dai, Ningning Zhao, Suyin Huang, Pixin Ran, Yumin Zhou
Summary: In a study of 1327 subjects, the prevalence of IOS-SAD in a community-based population was 32.9%, with the IOS-SAD group exhibiting increased airway resistance and poorer lung function compared to the non-SAD group. Risk factors for SAD included older age, higher BMI, smoking, childhood cough, and asthma.
RESPIRATORY MEDICINE
(2021)
Article
Respiratory System
Weifeng Zou, Dong Ye, Sha Liu, Jinxing Hu, Tao Zhu, Fang He, Pixin Ran
Summary: Inhibition of GSK-3 beta weakens the PM2.5-induced inflammatory response by regulating the JNK/NF-kappa B signaling pathway in bronchial epithelial cells. The use of GSK-3 beta inhibitors TDZD-8 and SB216763 significantly suppressed the effects of PM2.5 on inflammation, with TDZD-8 showing greater differences in inflammation-related cytokine levels compared to SB216763. JNK inhibitor SP600125 also reduced the level of NF-kappa B phosphorylation induced by PM2.5.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Clinical Neurology
Riken Chen, Yitao Zhang, Yateng Luo, Donghao Wang, Zhenzhen Zheng, Xiaofen Su, Kang Wu, Wei Fu, Dongxing Zhao, Nuofu Zhang
Summary: By comparing different questionnaires, this study found that the NoSAS score combined with ESS has high accuracy and specificity in diagnosing OSAHS.
Letter
Critical Care Medicine
Yating Chen, Riken Chen, Yiqi Lin, Jianxiong Lai, Jiahe Wang, Xiaofeng Zhu, Yinghua Liu, Zhuofan Zhang, Yuhan Yang, Dongxing Zhao
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Yating Chen, Jingcun Wang, Shenyu Wen, Donghao Wang, Qiming Gan, Yiqi Lin, Jianxiong Lai, Haojie Zhang, Yanyan Zhou, Dongxing Zhao
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Naijian Li, Zhouli Dai, Zhang Wang, Zhishan Deng, Jiahuan Zhang, Jinding Pu, Weitao Cao, Tianhui Pan, Yumin Zhou, Zhaowei Yang, Jing Li, Bing Li, Pixin Ran
Summary: The gut microbiome of COPD patients differs from healthy controls, with distinct microbial diversity, Prevotella-dominated gut enterotype, and lower levels of short-chain fatty acids. Transplantation of fecal microbiota from COPD patients into mice led to elevated lung inflammation, while exposure to biomass fuel smoke exacerbated lung function decline, emphysematous changes, airway remodeling, and mucus hypersecretion in a COPD-like manner.
RESPIRATORY RESEARCH
(2021)