期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 256, 期 -, 页码 79-86出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2017.08.008
关键词
Intermittent hypoxia; Cancer; Oxidative stress; Inflammation
资金
- SEPAR [086/2014, 139/2015]
The deleterious effects of intermittent hypoxia (IH) on cancer biology have been primarily evaluated in the context of the aberrant circulation observed in solid tumors which results in recurrent infra-tumoral episodic hypoxia. From those studies, IH has been linked to an accelerated tumor progression, metastasis and resistance to therapies. More recently, the role of IH in cancer has also been studied in the context of obstructive sleep apnea (OSA), since IH is a hallmark characteristic of this condition. Such recent studies are undoubtedly adding more information regarding the role of IH on tumor malignancy. In terms of the IH patterns associated with OSA, this altered oxygenation paradigm has been recently proposed as a determinant factor in fostering cancer incidence and progression from both in vitro and in vivo experimental models. Here, we summarize all the available evidence to date linking IH effects on several types of cancer.
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