期刊
RESEARCH ON CHEMICAL INTERMEDIATES
卷 43, 期 11, 页码 6379-6393出版社
SPRINGER
DOI: 10.1007/s11164-017-2995-3
关键词
N-Heterocyclic carbene; Ag-NHC complexes; Morpholine; Antimicrobial activity; Antibiotic
资金
- Inonu University, Research Project Unit [I.U.A.F:2011/25]
- Dokuz Eylul University [2010.KB.FEN.13]
This article describes synthesis of N-morpholinoethylbenzimidazole (1), 2-morpholinoethyl-substituted benzimidazolium salts (NHC precursors, 2a-c), and their Ag(I) N-heterocyclic carbene (NHC) complexes (3a-c). All compounds were characterized by H-1 and C-13 Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and elemental analysis, and their antimicrobial effects examined. The molecular structure of the NHC precursor 2a (1) was established by single-crystal X-ray diffraction analysis. Minimum Inhibition Concentration (MIC) values were determined to evaluate their antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains and Candida albicans fungal species. All tested samples were compared with silver nitrate. All the compounds exhibited strong antimicrobial activity.
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