期刊
ENVIRONMENTAL POLLUTION
卷 196, 期 -, 页码 247-256出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2014.09.019
关键词
Antidepressant; Surface water; Climate change; Chiral separation; Rhine river
资金
- Federal Ministry of Transport and Digital Infrastructure (BMVI)
- Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) for the KLIWAS research program
- German Federal Ministry of Education and Research [02WRS1275A]
- EU FP6 Integrated Project ENSEMBLES [505539]
Fate and occurrence of 4 selective serotonin reuptake inhibitors, one serotonin-noradrenergic reuptake inhibitor and one noradrenergic-dopamineric reuptake inhibitor and their human metabolites were determined in a German municipal wastewater treatment plant as well as in the Rhine River and selected tributaries. The enantiomeric fractions of venlafaxine and its metabolites were not altered during wastewater treatment and were similar in all river samples underlining that no appreciable biodegradation occurs. In the Rhine catchment area highest concentrations were detected for venlafaxine, citalopram and their human metabolites. Projected future climate change would lead to an increased portion of treated wastewater in rivers due to reduced discharges during low flow situations by the end of the 21st century. However, the effect of climate change on the pattern and concentrations of antidepressants is predicted to be of minor importance in comparison to altered consumption quantities caused by demographic developments and changes in life styles. (C) 2014 Elsevier Ltd. All rights reserved.
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