期刊
REPRODUCTIVE TOXICOLOGY
卷 73, 期 -, 页码 87-95出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.07.022
关键词
Decidualization; Glyphosate-based herbicide; Implantation sites; Wnt5a; Wnt7a; beta-catenin; Dkk1; sFRP4
资金
- Universidad Nacional del Litoral (Santa Fe, Argentina) (CAI+D program)
- Argentine Council for Scientific and Technological Research (CONICET)
- Argentine Agency for the Promotion of Science and Technology (ANPCyT)
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2 mg/kg of GBH from postnatal day (PND) 1 to PND7. On PND8 and PND21, Wnt5a and beta-catenin expression was evaluated in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and beta-catenin expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, GBH -exposed rats showed increased Wnt5a and p-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and p-catenin expression in subepithelial stroma but decreased beta-catenin expression in glandular epithelium. On GD9, GBH-exposed rats showed decreased Wnt5a and Wnt7a expression in the antimesometrial zone and LE respectively, without changes in p-catenin expression, while Dkk1 and sFRP4 were up- and down-regulated respectively. We concluded that neonatal GBH exposure may lead to embryo losses by disturbing uterine signaling. (C) 2017 Elsevier Inc. All rights reserved.
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