Article
Polymer Science
Wojciech Raj, Krzysztof Jerczynski, Mahdi Rahimi, Ewa Pavlova, Miroslav Slouf, Agata Przekora, Joanna Pietrasik
Summary: In this study, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized, and the anticancer drug DOX was loaded within the micelles. The micelles demonstrated potential as drug delivery systems for cancer treatment, with pH-responsive characteristics. However, increasing the hydrophobic block polymerization degree reduced the cytotoxicity of the micelles.
Article
Polymer Science
Pratiksha Awasthi, Shib Shankar Banerjee
Summary: The researchers successfully developed a biomimetic mechano-adaptive thermoplastic elastomeric material that can improve its mechanical properties through water stimulation. The improved mechanical properties were achieved through the formation of nanosized CaSO4 crystals and strong interactions between the filler particles. This technique allows for reversible changes in the TPE material's dynamic stiffness.
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Polymer Science
Jinlong Qin, Min Sun, Wei Hu, Jiajing Cheng, Zhen Fan, Jianzhong Du
Summary: Immunotherapy plays an important role in cancer treatment, but there are challenges in delivering immunotherapeutic agents and activating them effectively at tumor sites. Hydrogels, combined with immunotherapies, offer a chance to enhance the immune response against tumors with reduced side effects. Stimuli-responsiveness is also applied to optimize pharmacokinetics and improve therapeutic outcomes. This review discusses the opportunities of combining immunotherapy with stimuli-responsive hydrogels, such as light, temperature, ultrasound, and magnetically responsive hydrogels, for effective cancer treatment. It also explores the potential of stimuli-responsive hydrogels as vaccine implants against cancer and Covid-19.
Review
Chemistry, Multidisciplinary
Ivanna Amarsy, Sebastien Papot, Gilles Gasser
Summary: Metal-based prodrugs are developed to overcome the drawbacks of metal-based compounds for biomedical applications, by utilizing tumor-associated stimuli for selective delivery. This field has significant applications in oncology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Rossella Laurano, Monica Boffito, Michela Abrami, Mario Grassi, Alice Zoso, Valeria Chiono, Gianluca Ciardelli
Summary: The study presents a thermo- and pH-responsive hydrogel (P-CHP407) with a significant amount of -COOH groups for controlled and localized drug release, showing enhanced drug delivery kinetics and the potential use as smart delivery systems in the treatment of chronic infected wounds.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Muhammad Asim Raza, Nafisa Gull, Se -Won Lee, Kamala-Kannan Seralathan, Sang Hyun Park
Summary: In this study, chitosan and poly(vinylpyrrolidone) crosslinked hydrogels were prepared for drug delivery systems. The hydrogels exhibited excellent antimicrobial characteristics, biocompatibility, and anti-cancer efficacy, as well as controlled drug release capability.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Hongyue Wang, Lin Wang, Shasha Guo, Zehao Liu, Luqing Zhao, Renzhong Qiao, Chao Li
Summary: An active flavonoid compound, rutin, was incorporated into a guanosine phenylborate hydrogel (GBR) for the treatment of inflammatory bowel disease (IBD). The hydrogel exhibited good stability and injectability, and achieved dual-responsive release in an acidic pH and excessive ROS-containing medium. In vivo studies showed that the GBR hydrogel had higher therapeutic efficacy than free rutin and could suppress the expression of inflammatory cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Wen-Hsin Chang, Yi-Fang Lee, Yen-Wenn Liu, Itamar Willner, Wei-Ching Liao
Summary: A method for synthesizing DNA-based acrylamide hydrogel microcapsules loaded with quantum dots as readout signal is introduced, which can detect cancer-associated microRNAs. The detection sensitivity can be improved by coupling the microcapsules with strand displacement amplification.
Review
Materials Science, Multidisciplinary
Meng Ding, Wei Zhao, Ling-Jie Song, Shi-Fang Luan
Summary: Bacterial biofilm infections pose a long-standing threat to human life and health, with traditional antibiotic therapies proving ineffective in eradicating them. Stimuli-responsive nanocarriers have gained attention for their smart drug release properties, with various stimuli such as enzymes, pH levels, and external triggers proving beneficial for biofilm treatment.
Article
Chemistry, Multidisciplinary
Changhui Liu, Yan Fang, Xuan Zhang, Yub Raj Neupane, Zicheng Jiang, Giorgia Pastorin, Siowling Soh
Summary: This study introduces a novel class of stimuli-responsive attachments that can transform non-responsive drug carriers into stimuli-responsive carriers, enabling targeted release at specific sites. The attachments ensure that carriers are not leaky and can release contents completely by rupturing their shells, offering a general, simple, and effective approach.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Materials Science, Multidisciplinary
Gamze Kocal, Burcu Oktay, Gunes Ozen Eroglu, Serap Erdem Kuruca, Soner Cubuk, Nilhan Kayaman Apohan
Summary: This study successfully prepared mesoporous HAp nanoparticles with fluorescent and pH-responsive properties, and controlled the release rate of anticancer drugs through the design of nanoplatforms. The DOX@HAp/terpolymer nanoparticles exhibited different drug release characteristics under different pH conditions, showing high biocompatibility and inducing apoptosis of cancer cells.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Article
Multidisciplinary Sciences
Youngho Eom, Seon-Mi Kim, Minkyung Lee, Hyeonyeol Jeon, Jaeduk Park, Eun Seong Lee, Sung Yeon Hwang, Jeyoung Park, Dongyeop X. Oh
Summary: Self-repairable materials aim to replicate the curable and resilient properties of biological tissue, but often face challenges due to the conflicting properties of self-healing and toughening. In this study, authors introduced a tough and strong carbonate-type thermoplastic polyurethane elastomer that self-heals at ambient temperature.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Shameer Pillarisetti, Veena Vijayan, Jayakumar Rangasamy, Rizia Bardhan, Saji Uthaman, In-Kyu Park
Summary: We report a multi-stimulus responsive alginate nanogel that responds to changes in pH and redox potential in the tumor microenvironment. Combined with chemotherapy and photodynamic therapy (PDT), this nanogel enhances the therapeutic effect in breast cancer and melanoma by releasing a hydrophobic photosensitizer and a cytotoxic agent.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pervaiz Ali Channar, Mubashir Aziz, Syeda Abida Ejaz, Gul-e-Saba Chaudhry, Amna Saeed, Rabail Ujan, Abbas Hasan, Syeda Rabia Ejaz, Aamer Saeed
Summary: The synthesis of compounds with a thiazolidinone pharmacophore was achieved, and their anticancer activities were evaluated. Compounds 2c and 2d exhibited significant cytotoxicity against MCF-7 and HeLa cell lines by inducing apoptosis. Molecular docking and dynamic simulations provided further support to these findings, and computational studies suggested the potential of these compounds as lead molecules for the development of novel drug candidates for specific cancers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Saira Naseem, Zahid Shafiq, Parham Taslimi, Saghir Hussain, Tugba Taskin-Tok, Dursun Kisa, Aamer Saeed, Ahmed Temirak, Muhammad N. Tahir, Khawar Rauf, Ahmed El-Gokha
Summary: A series of xanthene-based thiazoles were synthesized and characterized. These compounds exhibited high inhibition potential against acetylcholinesterase, butyrylcholinesterase, alpha-amylase, and alpha-glycosidase enzymes at low concentrations. Among them, compounds 3b and 3p showed superior inhibitory potential compared to known commercial inhibitors. Molecular docking studies also revealed important interactions between these compounds and the target enzymes.
ARCHIV DER PHARMAZIE
(2023)
Article
Materials Science, Ceramics
Firdous Bibi, Shahid Iqbal, Ambreen Kalsoom, Muhammad Jamshaid, Adeel Ahmed, Misbah Mirza, Waseem Akhtar Qureshi
Summary: In this study, Nd & Mn co-doped strontium hexa-ferrite Sr1-xNdxFe12-yMnyO19 nanoparticles were synthesized using a simple micro-emulsion method. The co-doped materials exhibited improved structural, magnetic, and photo-catalytic properties compared to the bare material. The narrow band gap and defect structure of the co-doped nanoparticles contributed to their enhanced photo-catalytic activity. The results demonstrate the potential applications of these co-doped nanoparticles in various electrical and magnetic materials, as well as in the remediation of toxic contaminants.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Haya A. Abubshait, Muhammad Saad, Shahid Iqbal, Samar A. Abubshait, Ali Bahadur, Muhammad Raheel, Fwzah H. Alshammari, Norah Alwadai, Hamad Alrbyawi, Mohammed A. S. Abourehab, Eslam B. Elkaeed, Muhammad Abdul Qayyum, H. H. Somaily
Summary: In this study, Co-doped ZnO nanoparticles were synthesized using polyvinyl alcohol hydrogel as a platform for the degradation of methyl orange dye. The Co-doped ZnO nanoparticles exhibited excellent photocatalytic activity due to the doping of a low-cost transition metal. The photocatalytic efficiency of the prepared composite was greatly enhanced, and it showed better degradation performance compared to the pure Co-doped ZnO nanoparticles.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Komal Aroosh, Mohsin Javed, Nadia Hussain, Ahmad Alhujaily, Shahid Iqbal, Mohammed T. T. Alotaibi, Muhammad Faizan, Muhammad Shuaib Khan, Ali Bahadur, Muhammad Abdul Qayyum, Nasser S. S. Awwad, Yosef Jazaa, Foziah F. F. Al-Fawzan, Eslam B. B. Elkaeed
Summary: This study presents the synthesis of a 2D heterojunction tellurium-doped zinc oxide composite with sulfur-doped graphitic carbon nitride using a low-cost coprecipitation technique. The synthesized photocatalysts were characterized using SEM-EDX, FTIR, and XRD, which confirmed the alteration in the ZnO structure due to tellurium incorporation. The results showed improved photocatalytic degradation behavior and adsorption efficiency for heavy metals by the synthesized materials.
ADSORPTION SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Shahid Iqbal, Sajid Rashid Ahmad
Summary: The Hindu Kush Himalayan (HKH) region, housing the world's largest glaciers outside the polar region, is a crucial freshwater source for millions of people downstream. This study employed advanced geospatial techniques to assess the velocity variation of glaciers in the Hunza Basin. By analyzing satellite images, the study successfully computed the surface ice velocity of the glaciers from 2013 to 2020. The results revealed that glacier velocity increases with altitude but decreases at the terminus, with tributary glaciers significantly contributing to the mainstream glacier velocity.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2023)
Article
Chemistry, Multidisciplinary
Shoaib Khan, Shahid Iqbal, Muhammad Taha, Rafaqat Hussain, Fazal Rahim, Mazloom Shah, Nasser S. Awwad, Hala A. Ibrahium, Mohammed Issa Alahmdi, Ayed A. Dera, Hayat Ullah, Ali Bahadur, Samar O. Aljazzar, Eslam B. Elkaeed, Muhammad Rauf
Summary: The clinical significance of benzimidazole-containing drugs has increased, and research interest in these moieties is strong due to their diverse biological features. This study aimed to synthesize a new series of benzimidazole analogs and evaluate their inhibitory activity against alpha-amylase and alpha-glucosidase. Most of the derivatives showed promising activity, with analog 2 displaying the best inhibitory activity. The structure-activity relationship (SAR) was determined by examining the substitution effects, and molecular docking provided insights into the interactions between the active substances and the targeted enzymes.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Shaker S. Adam, Sumbleen Sikander, M. Tariq Qamar, Shahid Iqbal, Ahmed Khalil, Amel Musa Taha, Obadah S. Abdel-Rahman, Eslam B. Elkaeed
Summary: Water pollution caused by pesticide use in agriculture is a major concern. Photocatalytic removal of pesticides using metallic oxide photocatalysts shows promise. In this study, Orthorhombic MoO3 modified with cobalt oxide was used to remove imidacloprid and imidacloprid-containing insecticides. The synthesized composites showed improved absorption properties in the visible light spectrum and reduced recombination of photoexcitons. The photocatalytic removal of imidacloprid and Greeda under natural sunlight irradiation achieved high removal rates (98% and 93%, respectively) using the 10% Co3O4-MoO3 composite.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
M. Tariq Qamar, Shahid Iqbal, M. Aslam, Ahmad Alhujaily, Anum Bilal, Komal Rizwan, Hafiz Muhammad Umer Farooq, Tahir Ali Sheikh, Ali Bahadur, Nasser S. Awwad, Hala A. Ibrahium, Rasmiah S. Almufarij, Eslam B. Elkaeed
Summary: In this study, economical indoor white light was used as the illumination source for the photocatalytic removal of organic toxins from contaminated water. CeO2 was doped with Ni, Cu, and Fe to enhance its catalytic activity. Fe-doped CeO2 exhibited the highest photocatalytic activity among all the materials tested. The antifungal properties of the doped CeO2 nanoparticles were also assessed, and Fe-doped CeO2 nanoparticles showed outstanding antifungal properties compared to other doped CeO2 nanoparticles.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Maryam Ramzan, Mohsin Javed, Shahid Iqbal, Ahmad Alhujaily, Qaiser Mahmood, Komal Aroosh, Ali Bahadur, Muhammad Abdul Qayyum, Nasser S. Awwad, Hala A. Ibrahium, Murefah Mana Al-Anazy, Eslam B. Elkaeed
Summary: This research synthesized pure nickel sulfide nanoparticles and a series of Te-doped NiS nanoparticles, as well as a series of S-g-C3N4/Te@NiS nanocomposites, through a hydrothermal route. The synthesized materials were characterized using XRD, FTIR, and SEM-EDX techniques. The photocatalytic activity tests showed that 1%Te@NiS nanoparticles exhibited excellent dye degradation capacity under sunlight. The S-g-C3N4/1%Te@NiS nanocomposites with different amounts of S-g-C3N4 showed enhanced antifungal ability and excellent antibacterial and photocatalytic efficiency.
Article
Engineering, Electrical & Electronic
Muhammad Amjad, Ayesha Mohyuddin, Mohsin Javed, Shahid Iqbal, Rabia Liaquat, Mohammed T. Alotaibi, Wajad Ulfat, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Murefah Mana Al-Anazy, Eslam B. Elkaeed
Summary: Researchers developed a biodegradable starch-based polymer and silver blend nanocomposite for efficient removal of hazardous organic dyes from industrial wastewater.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Asma Khan, Hongli Wen, Shahid Iqbal, Mujaddad-ur Rehman, Mazloom Shah, Muhammad Raheel, Farhan Ahmad Khan, Rashid Khan, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Foziah F. Al-Fawzan, Eslam B. Elkaeed
Summary: Organic-inorganic hybrid perovskite materials have limitations due to stability and toxicity issues, but the lead-free hybrid bismuth-based compound TBI shows excellent light-absorbing properties and phase stability, making it a potential absorber for photovoltaic and solar cell applications.
Article
Chemistry, Multidisciplinary
Shoaib Khan, Shahid Iqbal, Wajid Rehman, Nadia Hussain, Rafaqat Hussain, Mazloom Shah, Farhan Ali, Ahmed M. Fouda, Yousaf Khan, Ayed A. Dera, Mohammed Issa Alahmdi, Ali Bahadur, Hanan A. Al-ghulikah, Eslam B. Elkaeed
Summary: Different synthetic methods have been developed recently to investigate the biological significances of bis-benzimidazole analogs. This study aimed to synthesize a new series of bis-benzimidazole analogs using a fast and efficient method. Spectroscopic techniques were used to confirm the synthesized scaffolds, and molecular docking was performed to analyze the binding interactions. The derivatives were evaluated for their inhibitory activity against α-amylase and α-glucosidase through SAR study. Compound 9 exhibited excellent activity compared to the referenced drug acarbose.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Arifa Shaukat, Muhammad Akhyar Farrukh, Kok-Keong Chong, Rabia Nawaz, Muhammad Tariq Qamar, Shahid Iqbal, Nasser S. Awwad, Hala A. Ibrahium
Summary: FeSnO2 nanocomposites were synthesized using green method with aqueous leaf extracts of Lawsonia inermis and Phyllanthus embilica plants. The role of polyphenols and the reduction potentials for the synthesis of FeSnO2 were highlighted. Various analytical techniques were used to examine the synthesized materials, and the sample prepared using the leaf extract of Lawsonia inermis showed the best photocatalytic activity of 84%.
Article
Materials Science, Multidisciplinary
Tanzeela Fazal, Shahid Iqbal, Mujaddad-ur Rehman, Azam Hayat, Mazloom Shah, Sajid Mahmood, Khurram Shoaib, Ahmad Alhujaily, Bibi Nazia Murtaza, Sedra tul Muntaha, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Foziah F. Al-Fawzan, Eslam B. Elkaeed
Summary: Biological production of nanomaterials is an environmentally friendly and stable approach. In this study, silver iron oxide nanoparticles were synthesized using Escherichia coli bacterium, showing antimicrobial and photocatalytic degradation properties, as well as hydrogen generation potential.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Article
Chemistry, Applied
Xiaodan Wu, Zihan Wang, Guansong Shao, Bingyang Qin, Ying Wang, Tao Wang, Zhiguo Liu, Yujie Fu
Summary: In this study, a new type of cellulose-based ionic imprinting adsorbent was developed for the selective removal of cobalt ions. The adsorbent exhibited excellent adsorption performance, high cycling stability, and preferential selectivity for cobalt ions. The simple preparation method and promising application prospects make it a promising candidate for water treatment.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Article
Chemistry, Applied
Chandirasekar Shanmugam, Vanitha Marimuthu, Nagappan Rajendiran
Summary: In this study, monodispersed gold and silver nanoparticles were synthesized using cholic acid functionalized star poly(DL-lactide) as a capping and reducing agent. The synthesized materials were found to be effective heterogeneous catalysts for the reduction reaction.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Article
Chemistry, Applied
Bianca-Iulia Ciubotaru, Mirela-Fernanda Zaltariov, Mihaela Dascalu, Adrian Bele, Alexandra Bargan, Maria Cazacu
Summary: Porous networks were obtained using polysiloxanes pendant functionalized with aminopropyl groups. The addition of certain substances, such as ammonium bicarbonate and acetic acid, promoted the porosity and covalent cross-linking of the polymer. The resulting materials exhibited high dielectric permittivity and significant electrical output signal when subjected to compression, making them suitable for capacitive pressure sensors.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Article
Chemistry, Applied
Mohamed A. Zein, Basim H. Asghar, Abdulaziz M. Almohyawi, Norah F. Alqahtani, Ahmed Alharbi, J. Alkabli, Reda F. M. Elshaarawy, Lamia A. Ismail
Summary: In this study, new amphiphilic chitosan-thyme extract-nanosilver nanocomposites were prepared, which synergistically inhibited bacterial biofilm formation and bacterial proliferation. The nanocomposites disrupted bacterial cell membranes, causing cell death, and prevented biofilm formation. In addition, the nanocomposites exhibited good biocompatibility, making them potential candidates for biomedical applications.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Review
Chemistry, Applied
Norah F. Alqahtani
Summary: This review explores the potential of Imidazolium-based ionic liquids (ImILs) in improving the solubility, stability, and functionality of chitosan, and provides an overview of the types and preparation methods of functionalized imidazolium ionic liquids (FImILs). Additionally, it discusses the various opportunities offered by FImIL-chitosan derivatives.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Article
Chemistry, Applied
Olesya N. Zabegaeva, Alexey F. Kosolapov, Sergei L. Semjonov, Mariam G. Ezernitskaya, Egor S. Afanasyev, Ivan A. Godovikov, Alexander Chuchalov, Dmitriy A. Sapozhnikov
Summary: Polyimides are commonly used as primary protective coatings for optical fibers in high-temperature applications. However, the manufacturing process is complicated due to certain drawbacks. This study shows the potential use of polyamide-imides as highly reliable protective coatings for optical fibers.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
Article
Chemistry, Applied
Luis Miguel Nunez Tapia, Pascal Thebault, Laurent Bischoff, Alain Ledoux, Florian Defontaine, Olivier Lesouhaitier, Fabrice Burel
Summary: A water soluble cationic bis-cyclocarbonate was prepared through a three steps procedure, and non-isocyanate polyurethanes were prepared in acetonitrile with high yields. The resulting materials exhibited good thermal properties and hydrophilic properties. The polyurethane thermoset showed high inhibition towards bacteria, and the bis-cyclocarbonate oligomer was found to be harmless to organisms.
REACTIVE & FUNCTIONAL POLYMERS
(2024)
