Article
Clinical Neurology
Samira Zarrabi-Ajami, Hadi Zamanian, Mohammadali Amini-Tehrani, Zahra Farhadidanaloo, Razieh Janati Razavi, Azam Abbasi, Saeideh Darbandi, Pegah Chenari
Summary: This study conducted a cross-cultural validation of the short quality of life scale (SQoL) for multiple sclerosis (MS) patients in the Persian language. The scale's original structure had an acceptable model fit, but a slightly modified structure also had a sound fit and meaningful dimensions. The Persian version of the scale (P-SQoL) showed good reliability and validity. Further cross-cultural investigations are recommended to confirm these findings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-Ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune
Summary: This study assessed the association of HRQOL with disabilities, fatigue, and depression in Japanese subjects with MS. The results showed that HRQOL had relatively close correlations with disabilities and fatigue, and depression had an especially close relationship with HRQOL.
JOURNAL OF NEUROLOGY
(2023)
Review
Public, Environmental & Occupational Health
Guido Camanni, Ornella Ciccone, Alessandro Lepri, Chiara Tinarelli, Chiara Bedetti, Sandra Cicuttin, Nicola Murgia, Sandro Elisei
Summary: This study aims to evaluate the rates of exclusion of people with disabilities (PWDs) from recent biomedical research. The study found a high rate of exclusion of PWDs in clinical trials and the presence of ill-defined exclusion criteria.
Article
Multidisciplinary Sciences
S. Gil-Perotin, L. Bernad, S. Reddam, C. Ferrer-Pardo, S. Navarro-Quevedo, L. Solis-Tarazona
Summary: This study suggests that a set of standardized patient-reported outcomes (PRO) can be used to predict the progression and disability risk in multiple sclerosis (MS) patients. The results demonstrate the associations between baseline clinical and biochemical variables and PRO measures, and highlight the potential of the Modified Fatigue Impact Scale (MFIS) as an effective tool for predicting disability in relapsing MS patients.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Andreia Santos Nascimento, Cindy Vieira Fagundes, Felipe Augusto dos Santos Mendes, Josevan Cerqueira Leal
Summary: Virtual Reality (VR) shows positive effects on fatigue, quality of life, and balance in people with Multiple Sclerosis (MS); VR promotes greater improvement in these aspects compared to conventional exercises; However, VR does not significantly enhance functional mobility in MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Thomas P. Leist, Michele Cole, Sumit Verma, Alex Keenan, Hoa H. Le
Summary: This study examined fatigue in patients with multiple sclerosis (MS) and its associated characteristics through the analysis of a database. The results showed that patients with markers of fatigue had higher prevalence of comorbidities and physical impairments. This study has important implications for optimizing patient care and making informed decisions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Adalet Gocmen, Ozlem Ethemoglu
Summary: This study investigated the impact of sleep disturbance on the quality of life in MS patients and its relationship with demographic and clinical characteristics. The results showed that the quality of life was significantly impaired in MS patients, which was related to progressive MS, chronic fatigue, sleep-disordered breathing, poor sleep quality, comorbid anxiety and depression.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Stephanie Rodgers, Zina-Mary Manjaly, Pasquale Calabrese, Nina Steinemann, Marco Kaufmann, Anke Salmen, Andrew Chan, Juerg Kesselring, Christian P. Kamm, Jens Kuhle, Chiara Zecca, Claudio Gobbi, Viktor von Wyl, Vladeta Ajdacic-Gross
Summary: The study utilized a longitudinal design to analyze the interrelations between fatigue, depression, and health-related quality of life in persons with multiple sclerosis. Results showed that non-somatic depressive symptomatology fully mediated the impact on HRQoL through fatigue, while somatic depressive symptoms did not act as a mediator.
Article
Rehabilitation
Rakel Berriozabalgoitia, Iraia Bidaurrazaga-Letona, Erika Otxoa, Miriam Urquiza, Jon Irazusta, Ana Rodriguez-Larrad
Summary: The study found that overground robotic (OR) training can significantly improve functional mobility and maintain gait speed in individuals with MS, without increasing perceived fatigue. In contrast, the control group demonstrated declines in these areas. Further research is needed to confirm these preliminary results.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Clinical Neurology
Christian Wilson R. Turalde, Adrian Espiritu, Veeda Michelle M. Anlacan
Summary: The study reviewed the efficacy and safety of memantine in multiple sclerosis patients but found no significant improvements in cognitive function, spasticity, fatigue, and disability compared to placebo. Memantine was associated with mild adverse events like dizziness, fatigue, and anxiety. Future research should consider different MS subtypes, co-administration of disease-modifying therapies, longer duration of administration, and more sensitive outcome measures.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Henrik Ahvenjarvi, Marja Niiranen, Sakari Simula, Paivi Hamalainen, Helja-Marja Surcel, Anne M. Remes, Mervi Ryytty, Johanna Kruger
Summary: This study aimed to investigate the effects of demographic and clinical characteristics, as well as lifestyle risk factors on experienced fatigue and health-related quality of life (HRQoL) among different types of relapsing remitting multiple sclerosis (RRMS) patients. The study found that fatigue and HRQoL were negatively correlated, with more severe disease types associated with higher levels of fatigue and lower HRQoL. Age, disease course, and changes in treatment were also associated with worsened fatigue and HRQoL.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Clinical Neurology
Faezeh Khodaie, Naghmeh Abbasi, Amir Hooman Kazemi Motlagh, Baixiao Zhao, Abdorreza Naser Moghadasi
Summary: The review suggests that acupuncture can help improve symptoms and reduce relapses in patients with multiple sclerosis. It has positive effects on regulating the neuro-immune system, improving quality of life, reducing fatigue, improving bladder function, reducing spasms and pain, etc.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Immunology
Safanah AlSaeed, Tamadher Aljouee, Nuha M. Alkhawajah, Rola Alarieh, Hanan AlGarni, Salman Aljarallah, Mohsen Ayyash, Amani Abu-Shaheen
Summary: This study aims to assess the prevalence of depression, anxiety, and fatigue among pwMS who have no physical disability in Saudi Arabia and demonstrate any correlation between these factors and physical activity as well as the QoL. The results revealed that depression, anxiety, and fatigue tend to be correlated and clustered together among pwMS in our cohort.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Laura L. Laslett, Cynthia Honan, Jason A. Turner, Baye Dagnew, Julie A. Campbell, Tiffany K. Gill, Sarah Appleton, Leigh Blizzard, Bruce Taylor, Ingrid van der Mei
Summary: Poor sleep quality is common in people with multiple sclerosis (MS), and strongly associated with worse health-related quality of life. This association is independent of other MS symptoms and does not cluster with other common MS symptoms.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Integrative & Complementary Medicine
Faezeh Khodaie, Abdorreza Naser Moghadasi, Amir Hooman Kazemi, Baixiao Zhao
Summary: This study aimed to investigate the effectiveness of acupuncture combined with amantadine compared with amantadine alone in relieving fatigue symptoms in patients with RRMS. The results showed that acupuncture plus amantadine and routine care was more effective in reducing fatigue and improving quality of life compared to amantadine and routine care alone.
ACUPUNCTURE IN MEDICINE
(2023)