Article
Multidisciplinary Sciences
Francesco Morandini, Kevin Perez, Loic Brot, Sidy Mohammed Seck, Laurence Tibere, Jean-Pierre Grill, Enguerran Macia, Philippe Seksik
Summary: This study compared the gut microbiomes of mother and infant pairs from rural and urban areas of Senegal. The results showed that urban mothers had different gut microbiome compositions than rural mothers, while urban infants had delayed gut microbiome maturation and higher susceptibility to infectious diseases. These findings suggest that industrialization is associated with gut microbiome alterations and may be linked to disease.
Article
Microbiology
Louise Margrethe Arildsen Jakobsen, Ulrik Kraemer Sundekilde, Henrik Jorgen Andersen, Witold Kot, Josue Leonardo Castro Mejia, Dennis Sandris Nielsen, Axel Kornerup Hansen, Hanne Christine Bertram
Summary: The study found that a diet high in BMO did not have a significant impact on the gut microbiota and metabolic activity in mice, highlighting the importance of the presence of bifidobacteria for microbial effects of milk oligosaccharides in the gastrointestinal tract.
Article
Multidisciplinary Sciences
Claudie Lamoureux, Charles-Antoine Guilloux, Clemence Beauruelle, Stephanie Gouriou, Sophie Ramel, Anne Dirou, Jean Le Bihan, Krista Revert, Thomas Ropars, Rosyne Lagrafeuille, Sophie Vallet, Rozenn Le Berre, Emmanuel Nowak, Genevieve Hery-Arnaud
Summary: This study described the diversity of anaerobic bacteria in the CF airway microbiota, identifying 31 anaerobic genera and 69 species. Better lung function was significantly associated with higher quantification of Veillonella, raising questions about the potential impact of anaerobes on lung function.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Multidisciplinary Sciences
Christopher J. Stewart
Summary: Breast milk is a complex biofluid that has evolved over millions of years to provide optimal nutrition and bioactive compounds to infants. Human milk oligosaccharides (HMOs) are the fourth most abundant component in breast milk, more abundant than proteins and other nutrients, but they do not directly contribute to infant nutrition. Recent studies have shown that HMOs act as prebiotics, which suggests that they play a crucial role in infant development, indicating the importance of understanding the interaction between diet, microbes, and the host for improving human health.
Article
Immunology
Ayaka Yamazaki, Kohei Ogura, Kana Minami, Kazuhiro Ogai, Tomomi Horiguchi, Shigefumi Okamoto, Kanae Mukai
Summary: This study aimed to investigate the potential changes in the oral microbiome of healthy young adults during different phases of the menstrual cycle. The results showed that the oral microbiome profiles of healthy young females were influenced by their menstrual cycles.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Eric Marietta, Irina Horwath, Stephanie Meyer, Shahryar Khaleghi-Rostamkolaei, Eric Norman, David Luckey, Baskar Balakrishnan, Ashutosh Mangalam, Rok Seon Choung, Veena Taneja, Joseph A. Murray
Summary: This study found that oral administration of P. histicola delayed the onset of T1D in NOD mice by increasing the levels of regulatory T cells in the pancreatic lymph nodes. This preliminary work supports the potential use of P. histicola as a therapy for T1D.
Article
Microbiology
Esther Ndungo, Johanna B. Holm, Syze Gama, Andrea G. Buchwald, Sharon M. Tennant, Miriam K. Laufer, Marcela F. Pasetti, David A. Rasko
Summary: Shigella continues to be a major contributor to diarrheal illness and dysentery in children under 5 in low- and middle-income countries. This study explored the impact of Shigella infection on the developing gastrointestinal microbiome in infants and found temporal changes in the microbiota associated with the infection. These findings highlight the need for further research on the microbial communities associated with disease susceptibility and resolution.
Article
Gastroenterology & Hepatology
Tien S. Dong, Michelle Guan, Emeran A. Mayer, Jean Stains, Cathy Liu, Priten Vora, Jonathan P. Jacobs, Venu Lagishetty, Lin Chang, Robert L. Barry, Arpana Gupta
Summary: The prevalence of obesity has reached its highest levels in the past two decades, with connections to the brain-gut-microbiome axis. This study investigates the relationship between the brain-gut-microbiome axis and obesity in a large cohort, controlling for confounders such as sex, race, and diet. The findings reveal alterations in the brain's reward network, differences in microbial diversity and composition, as well as associations between Prevotella/Bacteroides ratio, fecal tryptophan, and nucleus accumbens centrality. These results suggest potential novel pathways for obesity therapies targeting the BGM axis.
Review
Gastroenterology & Hepatology
Allison Grech, Clare E. Collins, Andrew Holmes, Ravin Lal, Kerith Duncanson, Rachael Taylor, Adrienne Gordon
Summary: This systematic review synthesized evidence on the impact of pre-pregnancy and pregnancy exposures on the early intestinal microbiome. Factors such as maternal antibiotic and probiotic use, dietary intake, pre-pregnancy BMI, gestational weight gain, and diabetes were found to influence microbiome composition and diversity. However, there were limitations in the studies, and standardization and collaboration are crucial for further research in this area.
Article
Genetics & Heredity
Hao Li, Jan P. Meier-Kolthoff, Canxin Hu, Zhongjie Wang, Jun Zhu, Wei Zheng, Yun Tian, Feng Guo
Summary: This study investigates the evolutionary history, host specificity, and biogeographic distribution of Prevotella copri and its related taxa. It found that P. copri in the human gut consists of multiple groups with high genomic divergence and non-strict biogeographic patterns. It also reveals long-term co-evolution between P. copri and higher primates, but also sporadic signals of co-speciation and extensive host jumping. Furthermore, the study highlights extensive horizontal transfer of genes among P. copri groups and species in the same primate host.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Adrian Lopez-Garcia, Rita Benitez, Yolanda Nunez, Emilio Gomez-Izquierdo, Eduardo de Mercado, Juan M. Garcia-Casco, Oscar Gonzalez-Recio, Clemente Lopez-Bote, Jordi Estelle, Cristina Ovilo
Summary: This study suggests that both genetic background and diet composition may have a significant impact on gut microbiota composition in pigs, leading to differences in microorganisms. The application of compositional data analysis has facilitated the identification of microorganisms and ratios related to genetic and dietary changes, potentially advancing our understanding of interactions between pig genetics, environment, and gut microbiota.
Article
Immunology
Fengyuan Qi, Shangrong Fan, Chao Fang, Lan Ge, Jinli Lyu, Zhuoqi Huang, Shaowei Zhao, Yuanqiang Zou, Liting Huang, Xinyang Liu, Yiheng Liang, Yongke Zhang, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Xiaowei Zhang
Summary: This study evaluated the efficacy of oral Chinese-origin Lactobacillus with adjuvant metronidazole in treating Chinese BV patients. The results showed that oral administration of probiotics did not improve cure rates, but it effectively restored vaginal health after cure and mainly acted through the intestine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Chiara-Maria Homann, Connor A. J. Rossel, Sara Dizzell, Liene Bervoets, Julia Simioni, Jenifer Li, Elizabeth Gunn, Michael G. Surette, Russell J. de Souza, Monique Mommers, Eileen K. Hutton, Katherine M. Morrison, John Penders, Niels van Best, Jennifer C. Stearns
Summary: The introduction of solid foods during infancy causes shifts in gut microbial composition. This study found that increased dietary diversity is associated with higher microbial richness and diversity in infants' gut microbiomes. High dietary diversity stabilizes the gut microbiome during the introductory period, while low dietary diversity affects the extent of community structure change.
Article
Immunology
Scott J. J. Dos Santos, Zahra Pakzad, Arianne Y. K. Albert, Chelsea N. N. Elwood, Kirsten Grabowska, Matthew G. G. Links, Jennifer A. A. Hutcheon, Evelyn J. J. Maan, Amee R. R. Manges, Tim J. J. Dumonceaux, Zoe G. Hodgson, Janet Lyons, Sheona M. M. Mitchell-Foster, Soren Gantt, K. S. Joseph, Julie E. E. Van Schalkwyk, Janet E. E. Hill, Deborah M. M. Money
Summary: Birth mode has a significant effect on the composition of neonatal gut microbiome within 10 days postpartum, but this effect is not influenced by maternal vaginal microbiome composition. There is no correlation between the vaginal and stool microbiome communities of newborns. Intrapartum antibiotic administration is associated with lower abundances of specific bacterial strains in infant stool.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Junkui Chen, Zhengpeng Li, Xiaofan Wang, Bin Fan, Feilong Deng, Hongwei D. Yu, Xiaolei Ze, Liying Zhu, Yeshi Yin, Yanhong Chen, Jiangchao Zhao, Yunsheng Yang, Xin Wang
Summary: This study investigated the effects of carbohydrates on the human gut microbiota, and found that IMO, INU, and starch can sustain the growth of Prevotella enterotype. The findings provide insight into the nutritional requirements underlying gut enterotype formation.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Joshua M. Lyte, James Keane, Julia Eckenberger, Nicholas Anthony, Sandip Shrestha, Daya Marasini, Karrie M. Daniels, Valentina Caputi, Annie M. Donoghue, Mark Lyte
Summary: This study reveals significant differences in cecal microbial community structure, tissue neurochemical concentrations, and gut structural morphologies between birds with different corticosterone responses to stress. Unique neurochemical changes in the intestine following stress suggest a potential relationship between the cecal microbiome and overall avian physiology.
Article
Biochemistry & Molecular Biology
Danielle N. Rendina, Gabriele R. Lubach, Mark Lyte, Gregory J. Phillips, Ankush Gosain, Joseph F. Pierre, Roza M. Vlasova, Martin A. Styner, Christopher L. Coe
Summary: This study tracked the assembly of gut microbiota during the initial nursing period and transition to solid food in infant monkeys. The dynamic bacterial community structure reflected different maturational phases, influenced early by breast milk and later by solid foods. Higher abundance of certain microbial taxa during nursing was associated with slower growth trajectories and smaller brain volumes at one year of age.
Article
Surgery
Joseph F. Pierre, Greg J. Phillips, Lawrance C. Chandra, Danielle N. Rendina, Neena F. Thomas-Gosain, Gabriele R. Lubach, Mark Lyte, Christopher L. Coe, Ankush Gosain
Summary: The study found that inclusion of lyticase in the sample preparation process significantly increased fungal ITS reads, enhanced detection of numerous fungal genera in non-human primate fecal samples, and maintained fidelity of microbiome identification and community features.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Margie D. Lee, Ignacio R. Ipharraguerre, Ryan J. Arsenault, Mark Lyte, Joshua M. Lyte, Brooke Humphrey, Roselina Angel, Douglas R. Korver
Summary: This paper is a compilation of talks given by leading international researchers in the field of poultry gut microbiology and microbiome research. The talks cover various aspects such as historical developments, the impact of the microbiome on health, and the mechanisms of host-microbiome interactions, emphasizing the importance of a deeper understanding of host microbiomes.
Article
Microbiology
Alexandra Proctor, Nancy A. Cornick, Chong Wang, Shankumar Mooyottu, Paulo A. Arruda, Kayce Kobs, Gregory J. Phillips
Summary: The study found that piglets develop natural resistance to Clostridioides difficile as they age, with older piglets over 1 week old showing decreased clinical signs of disease. The diversity and complexity of the intestinal microbiota were identified as factors contributing to this resistance, highlighting the potential for new strategies for prevention and treatment of C. difficile infection.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Meghan Wymore Brand, Alexandra L. Proctor, Jesse M. Hostetter, Naihui Zhou, Iddo Friedberg, Albert E. Jergens, Gregory J. Phillips, Michael J. Wannemuehler
Summary: The study evaluated the impact of neonatal colonization with E. coli LF82 on the severity of colitis in mice, showing differential effects on colitic events.
Article
Agriculture, Dairy & Animal Science
Joshua M. Lyte, Diego A. Martinez, Kelsy Robinson, Annie M. Donoghue, Karrie M. Daniels, Mark Lyte
Summary: Microbial endocrinology is the study of neurochemical-based inter kingdom signaling and its impact on host-microbe interaction. Neurochemicals play a crucial role in determining bacterial colonization and interaction with the gut epithelium. However, little is known about the biogeography of neurochemicals in the avian gut. This study aimed to determine the concentrations of stress-related neurochemicals in different regions of the broiler chicken intestinal tract and investigate changes with age. The results showed regional differences in neurochemical concentrations and age-related changes for certain neurochemicals.
Article
Microbiology
Akhil A. Vinithakumari, Piyush Padhi, Belen Hernandez, Susanne Je-Han Lin, Aaron Dunkerson-Kurzhumov, Lucas Showman, Matthew Breitzman, Caroline Stokes, Yousuf Sulaiman, Chandra Tangudu, Deepa A. Kuttappan, Muhammed S. Muyyarikkandy, Auriel A. Willette, Gregory J. Phillips, Vellareddy Anantharam, Ann Perera, Brett A. Sponseller, Anumantha Kanthasamy, Shankumar Mooyottu
Summary: This study reveals the potential mechanistic link between C. difficile infection and alterations in brain dopamine metabolism, which may have an impact on the development and manifestation of neurodevelopmental disorders in infected individuals.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Edward Fox, Mark Lyte
Summary: This study reveals the anatomical relationship between microbes and mucosal elements in the gut, showing that the majority of microbiota are associated with food. It suggests that microbiota may potentially influence behavior through the secretion of bacterial products that interact with gut neurons.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Oncology
Karin Allenspach, Dana C. Borcherding, Chelsea A. Iennarella-Servantez, Allison P. Mosichuk, Todd Atherly, Dipak Kumar Sahoo, Aarti Kathrani, Jan S. Suchodolski, Agnes Bourgois-Mochel, Mariana Rossoni Serao, Nick V. Serao, Auriel Willette, Beatriz Agulla Perez, Vojtech Gabriel, Sichao Mao, Logan Kilburn, Viet Dang, David Borts, Luciana L. Almada, Martin E. Fernandez-Zapico, Gregory J. Phillips, Albert E. Jergens, Jonathan P. Mochel
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Lucas R. Koester, Kris Hayman, Chiron J. Anderson, Bienvenido W. Tibbs-Cortes, Karrie M. Daniels, Faith M. Seggerman, Patrick J. Gorden, Mark Lyte, Stephan Schmitz-Esser
Summary: Mitigating the effects of heat stress on livestock is crucial for their health and performance. One method is to enhance feed palatability by adding artificial sweeteners, although their impact on the rumen microbial communities is not fully understood. This study found that supplementing dairy cattle's diet with a saccharin-based sweetener did not affect their performance during heat stress, but it did lead to changes in the rumen microbial communities. Further research is needed to fully understand the role of artificial sweeteners in mitigating stress conditions for livestock and their effects on microbial communities.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Microbiology
Xinglin Jia, Gregory J. Phillips, Joshua M. Lyte
Summary: Avian pathogenic Escherichia coli, found in the avian intestinal tract, can cause systemic disease in birds and act as a foodborne zoonotic pathogen associated with human disease. This study reports the complete genome sequence of E. coli strain H1998 isolated from a chicken with colisepticemia.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Mathematical & Computational Biology
Peter D. Karp, Suzanne Paley, Markus Krummenacker, Anamika Kothari, Michael J. Wannemuehler, Gregory J. Phillips
Summary: The Pathway Tools (PTools) software is a tool for storing and analyzing genomic and metabolic information, generating metabolic reconstructions based on metagenomes, investigating microbial community properties, and searching for metabolic transformation routes.
FRONTIERS IN BIOINFORMATICS
(2022)