Blockade of alcohol escalation and “relapse” drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice

Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice

(2017) Y. Zhou et al.   GENES BRAIN AND BEHAVIOR

Sex- and hormone-dependent alterations in alcohol withdrawal-induced anxiety and corticolimbic endocannabinoid signaling

(2017) Angela M. Henricks et al.   NEUROPHARMACOLOGY

Involvement of Endocannabinoids in Alcohol “Binge” Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists

(2016) Yan Zhou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

FAAHGene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence

(2016) Primavera A. Spagnolo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Sex-dependence of anxiety-like behavior in cannabinoid receptor 1 (Cnr1) knockout mice

(2016) Mallory E. Bowers et al.   BEHAVIOURAL BRAIN RESEARCH

Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala

(2016) Stacey L. Robinson et al.   NEUROPHARMACOLOGY

Chronic ethanol exposure decreases CB1receptor function at GABAergic synapses in the rat central amygdala

(2015) Florence P. Varodayan et al.   ADDICTION BIOLOGY

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

(2015) Luca Carnevali et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Endocannabinoid signalling in reward and addiction

(2015) Loren H. Parsons et al.   NATURE REVIEWS NEUROSCIENCE

Neurobiological Interactions Between Stress and the Endocannabinoid System

(2015) Maria Morena et al.   NEUROPSYCHOPHARMACOLOGY

FAAH genetic variation enhances fronto-amygdala function in mouse and human

(2015) Iva Dincheva et al.   Nature Communications

The alcohol deprivation effect model for studying relapse behavior: A comparison between rats and mice

(2014) Valentina Vengeliene et al.   ALCOHOL

Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice

(2014) Balapal S. Basavarajappa et al.   HIPPOCAMPUS

Changes in Cerebral CB1 Receptor Availability after Acute and Chronic Alcohol Abuse and Monitored Abstinence

(2014) J. Ceccarini et al.   JOURNAL OF NEUROSCIENCE

Alcohol: A stimulant activating brain stress responsive systems with persistent neuroadaptation

(2014) Yan Zhou et al.   NEUROPHARMACOLOGY

Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study

(2013) Jenny Ceccarini et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction

(2013) Leigh V. Panlilio et al.   PHARMACOLOGY & THERAPEUTICS

Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography

(2012) J Hirvonen et al.   MOLECULAR PSYCHIATRY

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury

(2012) M Pardini et al.   Translational Psychiatry

Differential Effects of Single Versus Repeated Alcohol Withdrawal on the Expression of Endocannabinoid System-Related Genes in the Rat Amygdala

(2011) Antonia Serrano et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Persistent Escalation of Alcohol Drinking in C57BL/6J Mice With Intermittent Access to 20% Ethanol

(2011) Lara S. Hwa et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats

(2009) Lily Alvarez-Jaimes et al.   JOURNAL OF NEUROCHEMISTRY

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

FAAH inhibitor, URB-597, promotes extinction and CB1 antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats

(2009) Laurie A. Manwell et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics

(2009) Regina A. Mangieri et al.   PSYCHOPHARMACOLOGY

Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats

(2008) M. Scherma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats

(2008) Marina Rubio et al.   NEUROPHARMACOLOGY

Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat

(2008) Andrea Cippitelli et al.   PSYCHOPHARMACOLOGY

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

(2007) Fabricio A. Moreira et al.   NEUROPHARMACOLOGY