Article
Biochemistry & Molecular Biology
Stefanie Trinh, Vanessa Kogel, Lilly Kneisel, Elena Mueller-Limberger, Beate Herpertz-Dahlmann, Cordian Beyer, Jochen Seitz
Summary: The gut microbiota composition plays a causal role in body weight regulation and psychiatric disorders such as anorexia nervosa (AN). Previous research has shown that chronic starvation in an AN animal model leads to changes in the microbiome and reductions in brain volume and astrocytes. This study analyzed whether these alterations are reversible after refeeding. The findings suggest that the microbiome alterations in the ABA model are primarily starvation-related and support the use of this model in investigating the effects of starvation on the microbiota-gut-brain axis in AN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Stein Frostad
Summary: This article discusses the association between anorexia nervosa (AN) and the gut microbiota-brain (GMB) axis, proposing a hypothesis that changes in the GMB axis due to malnutrition drive AN. Malnutrition-induced alterations in gut microbiota may increase sensitivity to anxiety-inducing gastrointestinal hormones, leading to the development and maintenance of AN.
Review
Cell Biology
Qinwen Wang, Qianyue Yang, Xingyin Liu
Summary: The gut microbiota interacts with the brain through the microbiota-gut-brain axis, regulating physiological processes and impacting neurodevelopmental disorders. Researchers have identified three pathways through which the gut microbiota regulates neurodevelopment: the immune pathway, the neuronal pathway, and the endocrine/systemic pathway. This review provides an overview of research advancements in the microbiota-gut-brain axis in neurodevelopmental disorders and discusses the current state and future perspectives in this field.
Article
Gastroenterology & Hepatology
Farnaz Fouladi, Emily C. Bulik-Sullivan, Elaine M. Glenny, Laura M. Thornton, Kylie K. Reed, Stephanie Thomas, Susan Kleiman, Ashlie Watters, Judy Oakes, Eun-Young Huh, Quyen Tang, Jintong Liu, Zorka Djukic, Lauren Harper, Yesel Trillo-Ordonez, Shan Sun, Ivory Blakely, Philip S. Mehler, Anthony A. Fodor, Lisa M. Tarantino, Cynthia M. Bulik, Ian M. Carroll
Summary: This study investigates the composition of gut microbiota in patients with anorexia nervosa (AN) and its influence on the host. The researchers collected fecal samples from AN patients before and after treatment at two different eating disorder units. The results show that the gut microbiota of AN patients remained distinct from non-eating disorder controls even after treatment. The study highlights the important role of gut microbiota in AN patients and its impact on recovery.
Review
Clinical Neurology
Laura Di Lodovico, Stanislas Mondot, Joel Dore, Isabelle Mack, Mouna Hanachi, Philip Gorwood
Summary: Research indicates that alterations in gut microbiota, characterized by a decrease in butyrate-producing species and an increase in mucine-degrading species, may play a role in Anorexia Nervosa. Standardized research methods are recommended to improve comparability among studies and better identify the alterations of gut microbiota in AN.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Alessio Maria Monteleone, Jacopo Troisi, Gloria Serena, Alessio Fasano, Riccardo Dalle Grave, Giammarco Cascino, Francesca Marciello, Simona Calugi, Giovanni Scala, Giulio Corrivetti, Palmiero Monteleone
Summary: Alterations in the gut microbiome and fecal metabolites were found in anorexia nervosa (AN), with differences seen between those with restricting AN (ANR) and binge-purging AN (ANBP) types. ANBP patients showed significant differences in microbial abundances and metabolites compared to ANR patients. Despite small sample size, this study confirms the occurrence of distinct gut dysbiosis in ANR and ANBP, showcasing different connections between gut microorganisms and fecal metabolites in the two AN types.
Article
Microbiology
Stefanie Trinh, Larissa Kaever, Anna Schloesser, Anna Simon, Vanessa Kogel, Clara Voelz, Cordian Beyer, Jochen Seitz
Summary: This study investigated the effect of chronic food starvation, multistrain probiotic supplementation, and refeeding on the gut and gut-associated lymphatic tissue (GALT) using a translational activity-based anorexia (ABA) rat model. The results showed that ABA caused atrophic changes in intestinal morphology and increased GALT formation in the small bowel and colon. The increased GALT in ABA rats could be reversed by multistrain probiotic supplementation and refeeding. These findings highlight the potential role of gut inflammatory alterations in the pathophysiology of AN and suggest probiotics as a beneficial addition to AN treatment.
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Gastroenterology & Hepatology
Yaohui Wei, Sufang Peng, Cheng Lian, Qing Kang, Jue Chen
Summary: The review indicates that gut microbiome plays a crucial role in anorexia nervosa, potentially influencing weight regulation through the microbiota-gut-brain axis. Future research may lead to the development of microbiome-based prevention, diagnostics, and therapies for this disorder.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Ewelina Mlynarska, Joanna Gadzinowska, Julita Tokarek, Joanna Forycka, Aleksandra Szuman, Beata Franczyk, Jacek Rysz
Summary: This review investigates the impact of gut microbiota on the development of depression and the underlying molecular mechanisms. There are two possible pathways in which this interaction might occur, one suggesting that depressive disorder could lead to dysbiosis and the other considering if changes in gut microbiota might cause depressive disorder. The mechanisms responsible for this interaction include the secretion of neurotransmitters, gut peptides, and the activation of the immune system. However, more research is needed to explore the direct mechanisms of the interaction between gut microbiota and mental health.
Review
Microbiology
Xuan Fu, Ti Chen, Jingda Cai, Bo Liu, Yaohui Zeng, Xiaojie Zhang
Summary: Substance addiction is a complex worldwide public health issue that endangers both individuals and society, while the gut microbiome may play a crucial role in the pathogenesis of substance-related disorders.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Psychology, Clinical
Madeline L. West, Susan Hart, Amy Loughman, Felice N. Jacka, Heidi M. Staudacher, Afrouz Abbaspour, Andrea Phillipou, Anu Ruusunen, Tetyana Rocks
Summary: The gut microbiota is believed to be associated with symptoms common in anorexia nervosa, such as depression and gastrointestinal disturbances. However, unique considerations must be addressed when conducting gut microbiota research in individuals with AN.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Endocrinology & Metabolism
Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo
Summary: This review article focuses on the expanded endocannabinoid system (eCBome) and the gut microbiome, which are increasingly attracting attention as sources of chemical signals regulating food intake, energy metabolism, and body weight. The article describes the mechanisms through which these two systems, in interactions with other signaling systems, intervene in eating disorders, based on studies in experimental models or patients. Furthermore, the article discusses the possibility of the involvement of the eCBome-gut microbiome axis in eating disorders, considering the emerging multi-faceted cross-talk mechanisms between these complex systems.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
Sijia Fan, Weiwei Guo, Dan Xiao, Mengyuan Guan, Tiepeng Liao, Sufang Peng, Airong Feng, Ziyi Wang, Hao Yin, Min Li, Jue Chen, Wei Xiong
Summary: Alterations in intestinal microbiota contribute to excessive intake of palatable foods in individuals with overeating disorders. Stress and dieting history lead to changes in the microbiota and intestinal metabolism, resulting in hyperactivation of the gut-brain axis and the development of overeating disorder symptoms.
Review
Nutrition & Dietetics
Jasmine Carter, Jeffery Bettag, Sylvia Morfin, Chandrashekhara Manithody, Aakash Nagarapu, Aditya Jain, Hala Nazzal, Sai Prem, Meghan Unes, Matthew McHale, Chien-Jung Lin, Chelsea Hutchinson, Grace Trello, Arti Jain, Edward Portz, Arun Verma, Marzena Swiderska-Syn, Daniel Goldenberg, Kento Kurashima
Summary: Short bowel syndrome (SBS) is a condition caused by a reduction in the length or functional capacity of the intestine. The gut microbiome plays a significant role in modulating disease progression in SBS patients. The composition and shifts of gut bacteria in SBS and the resulting systemic effects have been extensively studied, revealing the variability and dependence on multiple factors. The bidirectional communication between the gut and the brain, regulated by the microbiome, known as the gut-brain axis (GBA), also has implications in SBS.
Article
Psychiatry
Joanna Popiolek-Kalisz, Mariusz Teter, Gustaw Kozak, Tomasz Powrozek, Radoslaw Mlak, Grzegorz Sobieszek, Hanna Karakula-Juchnowicz, Teresa Malecka-Massalska
Summary: The study found that PA 50kHz is the best BIA parameter to predict muscle strength in anorexia nervosa patients, and it could be useful for assessment before physical activity treatment application.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Oncology
Tomasz Powrozek, Anna Brzozowska, Marcin Mazurek, Monika Prendecka, Iwona Homa-Mlak, Radoslaw Mlak, Teresa Malecka-Massalska
Summary: This study found that the 13041A>G polymorphism in the GPLIN1 gene is associated with adipose tissue loss and malnutrition development in HNC patients after radiation therapy. Men with the AA genotype had lower fat mass after RTH, and had higher risk of fat tissue loss. The presence of the AA genotype may help facilitate early nutritional intervention and supportive treatment for preventing body mass and fat mass loss during treatment.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Agriculture, Dairy & Animal Science
Agnieszka Chalabis-Mazurek, Jose Luis Valverde Piedra, Siemowit Muszynski, Ewa Tomaszewska, Sylwia Szymanczyk, Sylwester Kowalik, Marcin B. Arciszewski, Anna Zacharko-Siembida, Tomasz Schwarz
Summary: This study evaluated the impact of partially substituting wheat and barley with maize or modern rye varieties on the concentration of heavy metals in feed offered to pigs and in pig tissues. The results showed that new rye varieties, especially hybrid variety, could be a potential alternative source of cereal grains for pig nutrition.
Article
Agriculture, Dairy & Animal Science
Janine Donaldson, Sylwester Swiatkiewicz, Anna Arczewka-Wlosek, Siemowit Muszynski, Sylwia Szymanczyk, Marcin Bartlomiej Arciszewski, Anna Zacharko Siembida, Katarzyna Kras, Jose Luis Valverde Piedra, Tomasz Schwarz, Ewa Tomaszewska, Piotr Dobrowolski
Summary: The inclusion of modern hybrid rye in corn-wheat-based diets for broilers improves the structure of the duodenum and ileum, but this effect is mitigated by xylanase supplementation.
Article
Medicine, General & Internal
Edyta Koman-Wierdak, Joanna Rog, Agnieszka Brzozowska, Mario Damiano Toro, Vincenza Bonfiglio, Katarzyna Zaluska-Ogryzek, Hanna Karakula-Juchnowicz, Robert Rejdak, Katarzyna Nowomiejska
Summary: The study measured RNFL and vasculature using OCTA in patients with schizophrenia and bipolar disorder, finding that retinal microvascular dysfunction occurs in the macula but not around the optic disc. OCTA could be an important additional diagnostic tool in detecting psychiatric disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ryszard Sitarz, Alicja Forma, Kaja Karakula, Dariusz Juchnowicz, Jacek Baj, Jacek Bogucki, Hanna Karakula-Juchnowicz
Summary: This study aimed to assess stress coping strategies among Polish students during the COVID-19 lockdown and evaluate the impact of those strategies on depression, stress, and anxiety symptoms. Findings showed that women tended to turn to religion for emotional distress relief, while men were more likely to use substances and humor.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jaromir Jarecki, Teresa Malecka-Masalska, Ewa Kosior-Jarecka, Wojciech Widuchowski, Piotr Krasowski, Martina Gutbier, Maciej Dobrzynski, Tomasz Blicharski
Summary: The aim of this study was to evaluate the levels of MMPs and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The results showed that the levels of MMP3, MMP9, and pro-MMP13 were increased in more advanced stages of osteoarthritis, indicating an underlying inflammatory process.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Paulina Wrobel-Knybel, Michal Flis, Joanna Rog, Baland Jalal, Leszek Wolkowski, Hanna Karakula-Juchnowicz
Summary: This study investigates the prevalence, frequency, and symptomatology of sleep paralysis (SP) as well as the impact of anxiety symptoms, perceived stress, and lifestyle variables on SP. The study finds that SP is associated with PTSD and anxiety symptoms, and factors such as age, BMI, smoking, alcohol consumption, sleep duration, and perceived stress also influence the occurrence and severity of SP. These findings suggest a complex etiology for SP involving psychological and lifestyle factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Health Care Sciences & Services
Iwona Homa-Mlak, Dominika Pigon-Zajac, Pawel Wawrejko, Teresa Malecka-Massalska, Radoslaw Mlak
Summary: According to the World Health Organization, cancer remains one of the main causes of mortality globally. Cancer cachexia is a complex disorder characterized by muscle mass loss and inflammation. miRNAs have potential as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia due to their ability to regulate multiple genes and biological processes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Ryszard Sitarz, Dariusz Juchnowicz, Kaja Karakula, Alicja Forma, Jacek Baj, Joanna Rog, Robert Karpinski, Anna Machrowska, Hanna Karakula-Juchnowicz
Summary: The niacin skin flush test (NSFT) is a simple method for assessing fatty acid content in cell membranes and may serve as an indicator of underlying factors in patients. This paper aims to determine the potential usefulness of NSFT in mental disorder diagnostics and identify factors that may affect its results. Research suggests that NSFT can aid in early intervention, psychiatric staging, and the development of new therapeutic methods based on its mechanisms. It can also contribute to personalized diets for patients and has potential benefits in the subclinical phase of the disease. However, further validation of NSFT is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dariusz Juchnowicz, Michal Dzikowski, Joanna Rog, Napoleon Waszkiewicz, Kaja Hanna Karakula, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakula-Juchnowicz
Summary: This study assessed the utility of complete blood count (CBC) in the prediction of schizophrenia diagnosis and its relationship with oxidative stress (OS). The findings showed that certain CBC parameters were altered in patients with the first episode of psychosis compared to healthy individuals, and there were various associations between OS and CBC. The study also proposed promising CBC models for distinguishing different patient groups.
Meeting Abstract
Psychiatry
K. H. Karakula, A. Forma, R. Sitarz, J. Baj, D. Juchnowicz, J. Bogucki, W. Tuszynska-Bogucka, M. L. Tee, C. A. Tee, J. T. Ly-Uson, M. S. Islam, M. T. Sikder, A. H. El-Monshed, A. Loutfy, M. F. Hussain Qureshi, M. Abbas, S. Taseen, M. Lakhani, S. Jayakumar, S. Ilango, S. Kumar, A. A. Ruiz-Chow, A. Iturbide, D. D. Gonzalez-Mille, H. Karakula-Juchnowicz
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
R. Sitarz, D. Juchnowicz, K. Karakula, A. Forma, J. Baj, J. Rog, R. Karpinski, A. Machrowska, H. Karakula-Juchnowicz
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
A. A. Forma, K. H. Karakula, R. Sitarz, D. Juchnowicz, J. Baj, J. Bogucki, J. Rog, M. L. Tee, C. A. Tee, J. T. Ly-Uson, M. S. Islam, M. T. Sikder, A. H. El-Monshed, A. Loutfy, M. F. H. Qureshi, M. Abbas, S. Taseen, M. Lakhani, C. Wang, X. Wan, Y. Tan, R. Pan, R. Ho, S. Jayakumar, S. Ilango, S. K. Kumar, A. A. Ruiz-Chow, A. Iturbide, D. D. Gonzalez-Mille, L. P. Doan, H. Karakula-Juchnowicz
EUROPEAN PSYCHIATRY
(2023)
