Article
Biochemical Research Methods
Jianjun Jiang, Lehua Cheng, Liang Yan, Mingxia Ge, Liqin Yang, Haoqiang Ying, Qingpeng Kong
Summary: The study identified specific lncRNAs in centenarians related to longevity as well as their regulatory roles in cellular aging processes. These dysregulated lncRNAs in centenarians may serve as potential protective factors in healthy aging.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Cell Biology
Paola Sebastiani, Anthony Federico, Melody Morris, Anastasia Gurinovich, Toshiko Tanaka, Kevin B. Chandler, Stacy L. Andersen, Gerald Denis, Katherine Costello, Luigi Ferrucci, Lori Jennings, David J. Glass, Stefano Monti, Thomas T. Perls
Summary: Using samples from the New England Centenarian Study, researchers characterized the serum proteome of centenarians, their offspring, and age-matched controls. They identified protein signatures associated with longer survival in centenarians and younger individuals and found similarities in aging markers between centenarians and short-lived cohorts. The study provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms to prolong health and support longevity.
Article
Biochemistry & Molecular Biology
Marcello Pinti, Lara Gibellini, Domenico Lo Tartaro, Sara De Biasi, Milena Nasi, Rebecca Borella, Lucia Fidanza, Anita Neroni, Leonarda Troiano, Claudio Franceschi, Andrea Cossarizza
Summary: In this study, we analyzed the levels of 62 cytokines and growth factors in healthy centenarians and middle-aged controls. We found an increase in pro-inflammatory cytokines in centenarians, as well as other cytokines involved in inflammation. Anti-inflammatory cytokines did not show an increase, except for the Th2-shifting cytokine IL-19. Several growth factors involved in regulating immunity were also upregulated in centenarians. Principal component analysis showed that pro and anti-inflammatory cytokines contributed the most to the observed data variability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Fengjiao Liu, Qianyan Huang, Yanting Du, Shunxing Li, Minggang Cai, Xuguang Huang, Fengying Zheng, Luxiu Lin
Summary: More than 80% of primary biomass in marine environments comes from phytoplankton, which absorb trace elements and serve as the main mechanism for trace element sinks. Petroleum hydrocarbons, due to their difficult degradability and bioaccumulation, are significant and priority organic contaminants in marine environments. This study evaluated the ecological risk of accidental and persistent petroleum hydrocarbon contamination by exposing Chlorella pyrenoidosa to short and medium-term petroleum hydrocarbons. The interaction between phytoplankton physiological markers and trace element absorption was explored to understand the effects on primary biomass and trace element sinks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Diego Marcos-Perez, Ander Saenz-Antonanzas, Ander Matheu
Summary: Centenarians are considered models of healthy aging due to their remarkable long life and compression of morbidity. Recent studies have identified the transcription factor REST as a key player in extreme longevity and cognitive activity, acting as an epigenetic regulator of neuronal homeostasis in both human and animal models. This research aims to summarize the genetic and epigenetic factors, as well as molecular pathways associated with centenarians and aging biology, with a focus on the impact of REST in longevity.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Siyao Lu, Ismail Shogo, Qiushi Feng, Wei-Jun Jean Yeung
Summary: This study investigates the degree of successful aging among a large sample of Chinese centenarians. It finds substantial heterogeneity in achieving the criteria of successful aging among centenarians, with social factors significantly associated with their aging performances. Specific subtypes of successful aging may provide insights into the underlying biological-environmental mechanisms of exceptional longevity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Neurosciences
Zhe-Zhe Zhang, Jing Chen, Bao-Ling Luo, Ming-Zhu Ni, Xue Liu, Li-Ping Zeng, Qi-Gang Yang, Fang Wang, Gui-Hai Chen
Summary: Mounting evidence suggests that histone modifications are involved in aging-associated cognitive decline (AACD) and can be transmitted to offspring over multiple generations under conditions of stress. This study investigated the effects of maternal sub-chronic inflammation on AACD and histone modifications in the F1 and F2 generations of mice, and found that gestational inflammatory insults can accelerate AACD in the F2 generation and cause abnormal histone modifications in the hippocampus, primarily transmitted through the paternal lineage.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Michael Wainberg, Grace R. Jacobs, Aristotle N. Voineskos, Shreejoy J. Tripathy
Summary: This study explores the relationship between dimensional psychopathology and neurobiological, familial, and genetic risk factors in a large population of preadolescents. The findings suggest that specific dimensions of psychopathology are associated with decreased functional connectivity in certain brain networks, while family history indicators are associated with all dimensions. These findings are significant for understanding the trajectory of psychopathology during adolescence.
MOLECULAR PSYCHIATRY
(2022)
Article
Environmental Sciences
Zhe Hao, Chuchu Zhang, Bo Lin, Zhuo Chen, Yonghua Li, Xinqing Zou, Hairong Li, Fangqin Zheng, Jing Cao
Summary: This study investigated the presence of toxic and essential trace metals in the fingernails of participants from the Hainan Province, China. The results showed high levels of essential elements Fe and Se, but a lack of toxic element Pb, in the participants. The study highlighted the influence of diet and environment in determining the presence of trace elements in nails, which varied among generations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Geriatrics & Gerontology
Franca Rosa Guerini, Matteo Cesari, Beatrice Arosio
Summary: The COVID-19 pandemic poses a higher risk for older individuals, but some centenarians show remarkable recovery abilities; the human leukocyte antigen (HLA) may play a crucial role in influencing the severity of COVID-19 infection.
Article
Behavioral Sciences
Jing Chen, Zhe-Zhe Zhang, Bao-Ling Luo, Qi-Gang Yang, Ming-Zhu Ni, Qi-Tao Wu, Yun Li, Xue-Wei Li, Gui-Hai Chen
Summary: Anxiety disorder has a high prevalence, and prenatal inflammation exposure during late gestation can increase age-related anxiety-like behaviors in offspring across generations. FABP7 expression in the hippocampus appears to be closely related to these anxiety-like behaviors.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
M. Dolores Merino, Marta Sanchez-Ortega, Elvira Elvira-Flores, Inmaculada Mateo-Rodriguez
Summary: This study investigates the psychological resources and positive personality characteristics of healthy centenarians, revealing that they possess various psychological resources that contribute to healthy aging. The findings also open up new avenues for further research in this field.
JOURNAL OF HAPPINESS STUDIES
(2023)
Article
Economics
Yujia Huo, Jane Golley
Summary: This paper examines gender differences in intergenerational education attainment in China. Using data from the China Family Panel Studies (CFPS) survey in 2016, the study finds that intergenerational 'persistence' is higher for females than males in the entire sample and across different age cohorts. The results suggest that the relatively low upward mobility among females from families with low education levels contributes to this gender difference. These findings provide valuable insights into the unequal transmission of education across generations and its implications for gender inequality in Chinese society.
CHINA ECONOMIC REVIEW
(2022)
Article
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. McCarthy, Cynthia Vied, Gregg D. Stanwood, Chris Schatschneider, Pradeep G. Bhide
Summary: This study reports the effects of aspartame on anxiety-like behavior, neurotransmitter signaling, and gene expression in the amygdala. Mice drinking water with aspartame exhibited anxiety-like behavior and had altered gene expression in the amygdala. The changes in behavior and gene expression were also observed in the offspring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Suey S. Y. Yeung, Michelle Kwan, Jean Woo
Summary: Diet is a key factor in preventing age-related diseases and maintaining overall good health status. Dietary patterns centered on plant-based foods have a beneficial role in healthy aging. There is a knowledge gap between multidimensional concepts of healthy aging and dietary patterns.