期刊
PROTEIN AND PEPTIDE LETTERS
卷 24, 期 5, 页码 388-396出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866524666170220113312
关键词
Fiber gap; gut microbiota; metabolic disease; microbiota-accessible carbohydrate; host health; protein turnover
资金
- National Basic Research Program of China (973 Program) [2013CB117301]
- National Natural Science Foundation of China [31272448, 31472101, 31420103908, 31528018]
- 111 Project [B16044]
- Beijing Nova program [xx2013055]
- Education Foundation of China Agricultural University 'Dabeinong Education Fund' [1041-415001]
- National Department Public Benefit Research Foundation [201403047]
- developmental fund for animal science by Shenzhen Jinxinnong Feed Co., Ltd
Accumulating evidence is dramatically increasing the access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human diseases. Several functional roles are carried out by a major class of the host's diet, such as fiber. Fiber is the main source of microbiota-accessible carbohydrate in the diet of humans. In the modern diet, it is difficult to intake sufficient dietary fiber as recommended. The low-fiber diet in the modern life, known as fiber gap, can trigger a substantial depletion of the human gut microbiota diversity and beneficial metabolites. The short-chain fatty acids are regarded as one of the major microbial metabolites of dietary fibers, which can improve intestinal mucosal immunity, as well as to be a source of energy for the liver. Thus, the loss of microbiota diversity has a potential negative function to various aspects of host health. Actually, the real fiber gap for ideal health and maintaining microbial diversity might be even more serious than currently appreciated. Herein, we briefly discuss the interactions between gut microbiota and the host diet, focusing specifically on the low-fiber diet. Gut bacteria in the context of the development of host low-fiber diets, which may lead to health and disorders, particularly include metabolic syndrome and obesity-related disease, IBD liver, disease, and colorectal cancer.
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