Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

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Metabolic Interactions in the Tumor Microenvironment

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Mitochondrial respiratory gene expression is suppressed in many cancers

(2017) Ed Reznik et al.   eLife

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

(2017) Lan-Feng Dong et al.   eLife

Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer

(2016) Anton M.F. Kalsbeek et al.   Aging-US

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region

(2016) Viktor M. Pastukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

(2016) Xiaoran Li et al.   Oncotarget

Gene expression in normal-appearing tissue adjacent to prostate cancers are predictive of clinical outcome: evidence for a biologically meaningful field effect

(2016) Cristina Magi-Galluzzi et al.   Oncotarget

Mitochondrial DNA copy number variation across human cancers

(2016) Ed Reznik et al.   eLife

Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis

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The Molecular Taxonomy of Primary Prostate Cancer

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Reprint of: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

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Genomic Predictors of Outcome in Prostate Cancer

(2015) Peter J. Boström et al.   EUROPEAN UROLOGY

How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

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Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer

(2015) Huakang Tu et al.   Oncotarget

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

(2014) Caleb F. Davis et al.   CANCER CELL

Peripheral Blood Mitochondrial DNA Copy Number Is Associated with Prostate Cancer Risk and Tumor Burden

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Simultaneous quantification of mitochondrial DNA copy number and deletion ratio: A multiplex real-time PCR assay

(2014) Nicole R. Phillips et al.   Scientific Reports

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

(2014) Young Seok Ju et al.   eLife

Reduced Mitochondrial DNA Content Associates with Poor Prognosis of Prostate Cancer in African American Men

(2013) Shahriar Koochekpour et al.   PLoS One

Number matters: control of mammalian mitochondrial DNA copy number

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells

(2008) Akihiro Naito et al.   CANCER SCIENCE

Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2

(2008) L Moro et al.   CELL DEATH AND DIFFERENTIATION

Increased distributional variance of mitochondrial DNA content associated with prostate cancer cells as compared with normal prostate cells

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