期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 123, 期 -, 页码 16-41出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2016.08.006
关键词
Amyloid; Fibril; Prion; Blood clotting; LPS; Amplification
资金
- Biotechnology and Biological Sciences Research Council [BB/L025752/1]
- National Research Foundation of South Africa [98953]
- Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM) (BBSRC) [BB/M017702/1]
- BBSRC [BB/M017702/1, BB/L025752/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L025752/1] Funding Source: researchfish
The chief and largely terminal element of normal blood clotting is considered to involve the polymerisation of the mainly alpha-helical fibrinogen to fibrin, with a binding mechanism involving 'knobs and holes' but with otherwise little change in protein secondary structure. We recognise, however, that extremely unusual mutations or mechanical stressing can cause fibrinogen to adopt a conformation containing extensive beta-sheets. Similarly, prions can change morphology from a largely alpha-helical to largely beta-sheet conformation, and the latter catalyses both the transition and the self-organising polymerisation of the beta-sheet structures. Many other proteins can also do this, where it is known as amyloidogenesis. When fibrin is formed in samples from patients harbouring different diseases it can have widely varying diameters and morphologies. We here develop the idea, and summarise the evidence, that in many cases the anomalous fibrin fibre formation seen in such diseases actually amounts to amyloidogenesis. In particular, fibrin can interact with the amyloid-beta (A beta) protein that is misfolded in Alzheimer's disease. Seeing these unusual fibrin morphologies as true amyloids explains a great deal about fibrin(ogen) biology that was previously opaque, and provides novel strategies for treating such coagulopathies. The literature on blood clotting can usefully both inform and be informed by that on prions and on the many other widely recognised (beta-)amyloid proteins. A preprint has been lodged in bioRxiv (Kell and Pretorius, 2016). (C) 2016 The Authors. Published by Elsevier Ltd.
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