标题
Multisite aggregation of p53 and implications for drug rescue
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 13, Pages E2634-E2643
出版商
Proceedings of the National Academy of Sciences
发表日期
2017-03-15
DOI
10.1073/pnas.1700308114
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
- (2016) Andreas C. Joerger et al. Annual Review of Biochemistry
- A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas
- (2016) Alice Soragni et al. CANCER CELL
- Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family
- (2016) Sebastian Kehrloesser et al. CELL DEATH AND DIFFERENTIATION
- Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
- (2016) Dawid Walerych et al. NATURE CELL BIOLOGY
- 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells
- (2016) Matthias R. Bauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Uncovering the Mechanism of Aggregation of Human Transthyretin
- (2015) Lorena Saelices et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In vitro Characterization of the Rapid Cytotoxicity of Anticancer Peptide HPRP-A2 through Membrane Destruction and Intracellular Mechanism against Gastric Cancer Cell Lines
- (2015) Jing Zhao et al. PLoS One
- Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding
- (2015) GuoZhen Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis
- (2015) GuoZhen Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and -synuclein
- (2015) M. Goedert SCIENCE
- The amyloid state and its association with protein misfolding diseases
- (2014) Tuomas P. J. Knowles et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Functional interplay between MDM2, p63/p73 and mutant p53
- (2014) M H Stindt et al. ONCOGENE
- Small molecule induced reactivation of mutant p53 in cancer cells
- (2013) Xiangrui Liu et al. NUCLEIC ACIDS RESEARCH
- A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins
- (2013) Antonios C. Tsolis et al. PLoS One
- The Amyloid State of Proteins in Human Diseases
- (2012) David Eisenberg et al. CELL
- The Use of Therapeutic Peptides to Target and to Kill Cancer Cells
- (2012) R. J. Boohaker et al. CURRENT MEDICINAL CHEMISTRY
- Mutant p53: one name, many proteins
- (2012) W. A. Freed-Pastor et al. GENES & DEVELOPMENT
- Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils
- (2012) Ana P. D. Ano Bom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53
- (2012) Rainer Wilcken et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- First-order rate-determining aggregation mechanism of p53 and its implications
- (2012) G. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
- (2012) R. Wilcken et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides
- (2011) Andreas Vitalis et al. BIOPHYSICAL CHEMISTRY
- Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
- (2011) Jie Xu et al. Nature Chemical Biology
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
- (2010) Sebastian Maurer-Stroh et al. NATURE METHODS
- Protein aggregation diseases: pathogenicity and therapeutic perspectives
- (2010) Adriano Aguzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding
- (2010) Joel L. Kaar et al. PROTEIN SCIENCE
- FoldAmyloid: a method of prediction of amyloidogenic regions from protein sequence
- (2009) S. O. Garbuzynskiy et al. BIOINFORMATICS
- Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
- (2008) F. M. Boeckler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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