Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

(2016) Sungmin Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling

(2016) Alan S. Liu et al.   Scientific Reports

A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size

(2015) Xuan Cao et al.   BIOPHYSICAL JOURNAL

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Traction microscopy to identify force modulation in subresolution adhesions

(2015) Sangyoon J Han et al.   NATURE METHODS

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

(2015) Chiara Bonfanti et al.   Nature Communications

A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells

(2015) Vivek B. Shenoy et al.   Interface Focus

Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations

(2014) A.S. Abhilash et al.   BIOPHYSICAL JOURNAL

Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers

(2014) Hailong Wang et al.   BIOPHYSICAL JOURNAL

Rheology of Semiflexible Bundle Networks with Transient Linkers

(2014) Kei W. Müller et al.   PHYSICAL REVIEW LETTERS

Active mechanics and dynamics of cell spreading on elastic substrates

(2014) Noam Nisenholz et al.   Soft Matter

Necking and failure of constrained 3D microtissues induced by cellular tension

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain history dependence of the nonlinear stress response of fibrin and collagen networks

(2013) S. Munster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly sensitive single-fibril erosion assay demonstrates mechanochemical switch in native collagen fibrils

(2012) Brendan P. Flynn et al.   Biomechanics and Modeling in Mechanobiology

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Complex Interactions between Human Myoblasts and the Surrounding 3D Fibrin-Based Matrix

(2012) Stéphane Chiron et al.   PLoS One

Spatiotemporal Constraints on the Force-Dependent Growth of Focal Adhesions

(2011) Jonathan Stricker et al.   BIOPHYSICAL JOURNAL

Regulation of Cell Adhesion Strength by Peripheral Focal Adhesion Distribution

(2011) Kranthi Kumar Elineni et al.   BIOPHYSICAL JOURNAL

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Probing mechanical principles of focal contacts in cell-matrix adhesion with a coupled stochastic-elastic modelling framework

(2011) H. Gao et al.   Journal of the Royal Society Interface

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Single-cell response to stiffness exhibits muscle-like behavior

(2009) D. Mitrossilis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter