Article
Oncology
Alexandra R. R. Esimbekova, Nadezhda V. V. Palkina, Ivan S. S. Zinchenko, Vasiliy D. D. Belenyuk, Andrey A. A. Savchenko, Ekaterina Yu Sergeeva, Tatiana G. Ruksha
Summary: It has been found that the anticancer drug dacarbazine can induce melanoma cells to enter the G(0) phase of the cell cycle, leading to drug resistance. The transition to the G(0) phase is associated with the VEGFA-VEGFR2 signaling pathway and cell cycle signaling. Treatment of melanoma cells with dacarbazine resulted in an increase in G(0)-positive cells. These findings may contribute to a better understanding of the mechanisms of drug resistance in melanoma.
Article
Oncology
Meiyun Sun, Jinjing Xie, Dongze Zhang, Chunyang Chen, Simin Lin, Yan Chen, Guangbo Zhang
Summary: In this study, it was found that B7-H3 inhibits the apoptosis of gastric cancer cells through the regulation of the FN-mediated PI3K/AKT signaling pathway.
Article
Multidisciplinary Sciences
Kaustav Bera, Alexander Kiepas, Ines Godet, Yizeng Li, Pranav Mehta, Brent Ifemembi, Colin D. Paul, Anindya Sen, Selma A. Serra, Konstantin Stoletov, Jiaxiang Tao, Gabriel Shatkin, Se Jong Lee, Yuqi Zhang, Adrianna Boen, Panagiotis Mistriotis, Daniele M. Gilkes, John D. Lewis, Chen-Ming Fan, Andrew P. Feinberg, Miguel A. Valverde, Sean X. Sun, Konstantinos Konstantopoulos
Summary: Cells can respond to changes in extracellular fluid viscosity, and higher viscosity can increase cell motility and dissemination. This is achieved through the formation of a dense actin network and the activation of specific signaling pathways. Additionally, cancer cells exposed to high viscosity can acquire mechanical memory and enhance migration and metastasis through transcriptional control.
Article
Oncology
Yumeng Zhang, Shu Liu, Shu Zhou, Dandan Yu, Junjie Gu, Qin Qin, Yu Cheng, Xinchen Sun
Summary: Oesophageal cancer is highly invasive and prone to recurrence and metastasis, with a low five-year survival rate, making the development of new therapeutic interventions crucial. Focal adhesion kinase (FAK) plays a key role in survival, proliferation, and migration of cancer cells, making it a potential therapeutic target for oesophageal cancer. The combination of FAK inhibitors with other treatments is expected to improve patient survival.
Article
Biochemistry & Molecular Biology
Peiling Zhang, Xiaofei Cao, Mingmei Guan, Dailing Li, Hong Xiang, Qian Peng, Yun Zhou, Chengyin Weng, Xisheng Fang, Xia Liu, Haibo Mao, Qiao Li, Guolong Liu, Lin Lu
Summary: This study elucidated the oncogenic role and biological function of copine VIII (CPNE8) in gastric cancer (GC). Increased expression of CPNE8 was positively correlated with metastasis and served as an independent prognostic risk factor for poor survival. CPNE8 promoted cell proliferation, migration, and invasiveness in GC. Additionally, CPNE8 was significantly associated with the tumor microenvironment and predicted poor efficacy of immune checkpoint therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kumiko Nakai, Hideki Tanaka, Kyoko Fukuzawa, Jyunya Nakajima, Manami Ozaki, Nobue Kato, Takayuki Kawato
Summary: Electric-toothbrush vibrations increase the expression of collagen, elastin, and fibronectin through the FAK-signaling pathway in human gingival fibroblasts.
Article
Cell Biology
Wenjun Shao, Jiawei Li, Qianling Piao, Xinlei Yao, Mingyue Li, Shuyue Wang, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Chunlei Yu, Yanxin Huang, Yongli Bao, Luguo Sun
Summary: In this study, the researchers identified FRMD3 as a novel tumor suppressor in breast cancer. They found that low FRMD3 expression is associated with advanced breast cancer and decreased survival time. Further analysis revealed that FRMD3 interacts with vimentin and the protein ligase UBE3A to promote the degradation of vimentin, resulting in inhibition of cell proliferation and metastasis.
CELL DEATH & DISEASE
(2023)
Article
Genetics & Heredity
Guanghui Zhao, Tianqi Luo, Zexian Liu, Jianjun Li
Summary: This study built a prognostic model based on focal adhesion-related genes to accurately predict gastric cancer prognosis and identify key prognostic genes. Through gene expression and clinical data, gastric cancer patients were divided into high-risk and low-risk groups, with low-risk patients showing higher overall survival. The study also found a correlation between high-risk gastric cancer and extracellular matrix receptor interaction, high infiltration of macrophages, CD44, and HLA-DOA.
FRONTIERS IN GENETICS
(2023)
Review
Cell Biology
Yasaswi Gayatri Mishra, Bramanandam Manavathi
Summary: Cell-ECM adhesions, with integrins at their core, serve as a crucial link between the cell cytoskeleton and the extracellular matrix, playing a major role in cell signalling for mechanotransduction, migration, proliferation, and other cellular processes. The diverse integrin adhesion complexes, such as focal adhesions and invadosomes, are not only essential for normal cell survival and development, but also play significant roles in various pathological processes.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Lang Xie, Hongyun Huang, Zheng Zheng, Qian Yang, Shubo Wang, Yaoxu Chen, Jinlong Yu, Chunhui Cui
Summary: CRC patients with high expression of MYO1B are at greater risk of tumor metastasis and poor prognosis. MYO1B plays a vital role in CRC metastasis by promoting the activation of RhoA. It may serve as a potential therapeutic target for patients at high risk of tumor metastasis.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu
Summary: CD248 expression in melanoma cells promotes malignant transformation by increasing the activity of cell adhesion, migration, and vascular mimicry, whereas rCD248 protein functions as a molecular decoy interfering with tumor-promoting effects of CD248 in melanoma cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Xiao-Jing Pang, Xiu-Juan Liu, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Jian Song, Cheng-Yun Jin, Sai-Yang Zhang
Summary: FAK, a nonreceptor intracellular tyrosine kinase, is overexpressed in many human cancer cell lines, promoting tumor growth by controlling various cellular functions. Targeting FAK with small molecule inhibitors is considered a promising cancer therapy, with several FAK inhibitors undergoing clinical trials in different phases. Additionally, the development of novel FAK inhibitors, including FAK degraders through PROTAC technology, provides potential for new anticancer agents.
Article
Polymer Science
Jun Guo, Ruoyang Zhao, Feng Gao, Xiaofang Li, Liping Wang, Feng Zhang
Summary: This study demonstrates that the amino acid sequence can encode the properties of tripeptide nanoassemblies and guide the pathways towards fluorescent or melanin-like nanoassemblies through modulating the enzymatic oxidation of tyrosinase accompanied by self-assembly. The findings provide inspiration for designing complex bioactive peptide nanomaterials for biomedical applications.
Article
Polymer Science
Jun Guo, Ruoyang Zhao, Feng Gao, Xiaofang Li, Liping Wang, Feng Zhang
Summary: In this study, we demonstrate how amino acid sequence encodes the property of tripeptide nanoassemblies by modulating the enzymatic oxidation of tyrosinase with the accompanied self-assembly. We select the pathways toward fluorescent or melanin-like nanoassemblies. Our findings provide inspiration for designing complex bioactive peptide nanomaterials for biomedical applications.
Article
Engineering, Biomedical
Miusi Shi, Wenting Mo, Haoning Qi, Yueqi Ni, Rui Wang, Kailun Shen, Fanyu Zhang, Shuting Jiang, Xuehui Zhang, Lili Chen, Yufeng Zhang, Xuliang Deng
Summary: This study reveals the vital role of the Pro-His-Ser-Arg-Asn peptide in fibronectin-mediated cell adhesion on implant surfaces. Molecular dynamics simulation shows that the peptide has a higher affinity and greater adsorption energy with the titanium oxide surface due to the formation of stronger hydrogen bonds. Increasing the oxygen content in the titanium oxide surface through ion-beam implantation improves cell adhesion, cell differentiation, and subsequent biomineralization on titanium implants.
ADVANCED HEALTHCARE MATERIALS
(2022)
Letter
Dermatology
Mattias A. S. Henning, Pernille L. Andersen, Kristina S. Ibler, Henrik Ullum, Christian Erikstrup, Kaspar R. Nielsen, Mie T. Bruun, Andreas S. Rigas, Khoa M. Dinh, Klaus Rostgaard, Ditte M. L. Saunte, Ole B. Pedersen, Gregor B. Jemec
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
H. C. Ring, J. Thorsen, K. Fuursted, T. Bjarnsholt, L. Bay, D. M. Saunte, S. F. Thomsen, G. B. Jemec
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Dermatology
Julia J. Shen, Maiken C. Arendrup, Shyam Verma, Ditte Marie L. Saunte
Summary: Dermatophytosis is commonly encountered in dermatological clinics, with Trichophyton rubrum, T. mentagrophytes, and T. interdigitale as the main causative agents. Terbinafine therapy is effective but increasing resistance and mutations in the SQLE gene have been documented. Antifungal susceptibility testing is not routinely performed for dermatophytes, leading to difficulties in interpreting MICs.
Article
Dermatology
R. Kjaersgaard Andersen, I. C. Loft, T. Hansen, H. Hjalgrim, K. Rostgaard, K. Banasik, M. Bruun, K. Nielsen, K. M. Dinh, E. Sorensen, K. Burgdorff, C. Erikstrup, H. Ullum, D. M. Saunte, O. B. Pedersen, G. B. E. Jemec
Summary: The incidence and remission rates of self-reported HS are high, with factors such as gender, smoking, and BMI affecting both the development and recovery of HS. Females with BMI above 25, active smokers, and individuals with symptoms in multiple areas are more likely to develop self-reported HS, while weight loss and smoking cessation can significantly impact the remission rate.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Microbiology
Karen Marie Thyssen Astvad, Rasmus Kroger Hare, Karin Meinike Jorgensen, Ditte Marie Lindhardt Saunte, Philip Kjettinge Thomsen, Maiken Cavling Arendrup
Summary: Terbinafine resistance in Trichophyton species is increasing in Denmark, with a high prevalence of non-wildtype isolates and known/novel SQLE mutations. T. rubrum is the most common species, but T. mentagrophytes/interdigitale SC isolates also contribute to resistance. Population-based studies and susceptibility testing are important for understanding and addressing this emerging problem.
Letter
Dermatology
H. C. Ring, J. Thorsen, K. Fuursted, T. Bjarnsholt, L. Bay, A. Egeberg, A. C. Ingham, H. Vedel Nielsen, W. J. Frew, D. M. L. Saunte, S. F. Thomsen, G. B. Jemec
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Editorial Material
Dermatology
Sofia H. C. Botvid, Lone Storgaard Hove, Dorra Bouazzi, Rune Kjaersgaard Andersen, Simon Francis Thomsen, Ditte Marie Saunte, Gregor B. E. Jemec
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
K. R. van Straalen, T. Tzellos, A. Alavi, F. Benhadou, C. Cuenca-Barrales, M. Daxhelet, M. Daoud, O. Efthymiou, E. J. Giamarellos-Bourboulis, P. Guillem, W. Gulliver, G. B. E. Jemec, A. C. Katoulis, A. Koenig, E. Lazaridou, M. A. Lowes, A. Marzano, L. Matusiak, A. Molina-Leyva, C. Moltrasio, A. Pinter, C. Potenza, E. P. Prens, J. Romani, D. M. Saunte, C. J. Sayed, N. Skroza, D. Stergianou, J. C. Szepietowski, A. Trigoni, E. Vilarrasa, A. Kyrgidis, C. C. Zouboulis, H. H. van der Zee
Summary: This study validates the novel IHS4-55 outcome measure by showing its significant association with reduction in inflammatory lesion counts and achievement of MCIDs for DLQI, NRS Pain, and NRS Pruritus in an antibiotic-treated cohort. These findings support the use of IHS4-55 as a novel primary outcome measure in clinical trials.
Review
Immunology
Christoffer Kursawe Larsen, Rune Kjaersgaard Andersen, Ditte Marie Lindhardt Saunte, Gregor Borut Ernst Jemec
Summary: An abscess is a pus-filled cavity in the tissue, commonly perceived as an infection. However, this diagnosis does not always require an infection. This study aims to review the microbiome of bacteria-positive primary skin abscesses to explore the reported microbiota.
Letter
Immunology
Dorra Bouazzi, Pernille Lindso Andersen, Ester Weihe Jacobsen, Maiken Cavling Arendrup, Gregor B. E. Jemec, Ditte M. L. Saunte
Article
Dermatology
M. A. S. Henning, R. Hay, C. Rodriguez-Cerdeira, J. C. Szepietowski, B. M. Piraccini, M. P. Ferreiros, M. Arabatzis, A. Sergeev, P. Nenoff, L. Kotrekhova, R. J. Nowicki, J. Faergemann, V. Padovese, A. Prohic, M. Skerlev, P. Schmid-Grendelmeier, B. Sigurgeirsson, G. Gaitanis, P. Lecerf, D. M. L. Saunte
Summary: Malassezia folliculitis occurs when the benign colonization of hair follicles by the yeast Malassezia becomes symptomatic, leading to itchy papules and pustules. However, diagnosing and treating this condition varies among dermatologists and countries. The European Academy of Dermatology and Venereology Mycology Task Force has developed recommendations to guide the diagnosis and management of Malassezia folliculitis, including diagnostic methods, required positive findings before treatment, and specific treatment algorithms for different patient groups. Overall, this study provides a clinical strategy for diagnosing and managing Malassezia folliculitis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Hans Christian Ring, Jonathan Thorsen, Berit Lilje, Lene Bay, Thomas Bjarnsholt, Kurt Fuursted, Ditte Marie Saunte, Gregor Borut Jemec, Simon Francis Thomsen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Pernille Lindso Andersen, Bente Villumsen, Ditte Marie Lindhardt Saunte, Kristoffer Solvsten Burgdorf, Maria Didriksen, Sisse Rye Ostrowski, Lise Wegner Thorner, Christian Erikstrup, Khoa Manh Dinh, Kaspar Rene Nielsen, Thorsten Brodersen, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Ole Birger Pedersen, Gregor Borut Jemec
Summary: This study explores the possible association between HS and ADHD, and finds a positive correlation between ADHD and HS. This result has significant implications for the research on psychiatric comorbidity of HS.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Pernille Lindso Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjorup Saekmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
Summary: This study found two protective HLA alleles, DQB1*06:04 and DRB1*13:02, that can reduce the risk of onychomycosis.
SKIN APPENDAGE DISORDERS
(2023)
Article
Dermatology
P. Lindso Andersen, G. B. Jemec, C. Erikstrup, M. Didriksen, K. M. Dinh, S. Mikkelsen, E. Sorensen, K. R. Nielsen, M. T. Bruun, H. Hjalgrim, T. F. Hansen, S. G. Saekmose, S. R. Ostrowski, D. M. L. Saunte, O. B. Pedersen
Summary: This study investigated the association between HLA alleles and MRSD, identifying five novel associations and confirming one previous association.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)