Three tRNAs on the ribosome slow translation elongation

Ribosome pausing, arrest and rescue in bacteria and eukaryotes

(2017) Allen R. Buskirk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

(2016) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elongation factor G initiates translocation through a power stroke

(2016) Chunlai Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular choreography of protein synthesis: translational control, regulation, and pathways

(2016) Jin Chen et al.   QUARTERLY REVIEWS OF BIOPHYSICS

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

(2016) Stefan Arenz et al.   Nature Communications

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

(2016) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association

(2016) T. Sprink et al.   Science Advances

Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis

(2015) Anneli Borg et al.   JOURNAL OF MOLECULAR BIOLOGY

Initiation factor 2 stabilizes the ribosome in a semirotated conformation

(2015) Clarence Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli

(2014) Rohan Balakrishnan et al.   NUCLEIC ACIDS RESEARCH

The ribosome uses cooperative conformational changes to maximize and regulate the efficiency of translation

(2014) W. Ning et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of the Translational Elongation Cycle

(2013) Rebecca M. Voorhees et al.   Annual Review of Biochemistry

Coordinated conformational and compositional dynamics drive ribosome translocation

(2013) Jin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-throughput platform for real-time monitoring of biological processes by multicolor single-molecule fluorescence

(2013) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual Basepair Stability of DNA and RNA Studied by NMR-Detected Solvent Exchange

(2012) Hannah S. Steinert et al.   BIOPHYSICAL JOURNAL

Characterization of Dark Quencher Chromophores as Nonfluorescent Acceptors for Single-Molecule FRET

(2012) Ludovic Le Reste et al.   BIOPHYSICAL JOURNAL

Furtherin VitroExploration Fails to Support the Allosteric Three-site Model

(2012) Alexandros D. Petropoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonfluorescent Quenchers To Correlate Single-Molecule Conformational and Compositional Dynamics

(2012) Jin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis

(2011) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations

(2011) M. Pech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

Single-Molecule Four-Color FRET

(2010) Jinwoo Lee  et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome

(2010) Joachim Frank et al.   Annual Review of Biochemistry

Four-color single-molecule fluorescence with noncovalent dye labeling to monitor dynamic multimolecular complexes

(2010) Vanessa C. DeRocco et al.   BIOTECHNIQUES

Real-time tRNA transit on single translating ribosomes at codon resolution

(2010) Sotaro Uemura et al.   NATURE

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

(2010) Niels Fischer et al.   NATURE

Following the intersubunit conformation of the ribosome during translation in real time

(2010) Colin Echeverría Aitken et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correlated conformational events in EF-G and the ribosome regulate translocation

(2010) James B Munro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution

(2010) Jörg Rinnenthal et al.   NUCLEIC ACIDS RESEARCH

Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation

(2009) J. Fei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single molecule measurement of the "speed limit" of DNA polymerase

(2009) J. J. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural dynamics of the ribosome

(2008) Andrei Korostelev et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome

(2008) Xabier Agirrezabala et al.   MOLECULAR CELL

Coupling of Ribosomal L1 Stalk and tRNA Dynamics during Translation Elongation

(2008) Jingyi Fei et al.   MOLECULAR CELL

Irreversible chemical steps control intersubunit dynamics during translation

(2008) R. A. Marshall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA