Article
Neurosciences
Shinya Nakamura, Yodai Kishimoto, Masaki Sekino, Motoaki Nakamura, Ken-Ichiro Tsutsui
Summary: Using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) to inhibit neural activity in the ventral region of the medial frontal cortex (vMFC), this study found that the vMFC plays a causal role in regulating mood and the LF-rTMS-induced dysfunction of the vMFC serves as a valid nonhuman primate model of depression. The study also demonstrated that LF-rTMS targeting the vMFC induced depression-like symptoms in monkeys, including reduced movement activity, impaired sociability, decreased motivation, and increased plasma cortisol level.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Eisa Jafari, Jaber Alizadehgoradel, Fereshteh Pourmohseni Koluri, Ezzatollah Nikoozadehkordmirza, Meysam Refahi, Mina Taherifard, Vahid Nejati, Amir-Homayun Hallajian, Elham Ghanavati, M. Carmelo Vicario, A. Michael Nitsche, Mohammad Ali Salehinejad
Summary: Modulation of dorsolateral and medial PFC activity with intensified stimulation can improve core symptoms of SAD, treatment-related variables, and reduce attention bias to threatening stimuli. This effect is more significant with 2-mA intensity compared to 1-mA, highlighting the potential therapeutic benefits of higher stimulation intensity in SAD treatment.
Article
Behavioral Sciences
Haixia Wang, Hanqi Zhang
Summary: The study found that using high-definition transcranial direct current stimulation (HD-tDCS) over the right dorsolateral prefrontal cortex (DLPFC) can enhance individuals' tendencies for maximization. This enhancement was driven by motivational changes rather than working memory improvement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychiatry
Jonas Rauh, Anne S. M. Mueller, Guido Nolte, Moritz Haaf, Marius Mussmann, Saskia Steinmann, Christoph Mulert, Gregor Leicht
Summary: This study investigated the effects of non-invasive brain stimulation on working memory performance. The results show that under specific conditions, using transcranial alternating current stimulation at a frequency of 5 Hz on the left dorsolateral prefrontal cortex can significantly improve working memory performance.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Clinical Neurology
Qingqing Zhang, Tingting Chen, Shanshan Liu, Xinying Liu, Yifan Zhang, Fengqiong Yu, Gong-Jun Ji, Xiaoming Li, Chunyan Zhu
Summary: This study investigated the effects of anodal high-definition transcranial direct current stimulation (HD-tDCS) on the right ventrolateral prefrontal cortex (rVLPFC) and the right dorsolateral prefrontal cortex (rDLPFC) on implicit emotion regulation (ER). The results showed that stimulation of both the rVLPFC and the rDLPFC could significantly reduce the affective responses caused by social exclusion, and rDLPFC activation may contribute to the involvement of early cognitive resources in the implicit ER process of social pain, thus helping to reduce the subjective negative experience of individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Shuang Liu, Yuchen He, Dongyue Guo, Xiaoya Liu, Xinyu Hao, Pengchong Hu, Dong Ming
Summary: Recent studies have found that transcranial alternating current stimulation (tACS) has significant effects on emotional attention. In this study, active-tACS at individual alpha frequency (IAF) was delivered to the bilateral dorsolateral prefrontal cortex (dlPFC), resulting in increased alpha entrainment at rest and improved attention in facial emotion processing.
COGNITIVE NEURODYNAMICS
(2023)
Review
Behavioral Sciences
Miles Wischnewski, Ivan Alekseichuk, Alexander Opitz
Summary: Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior, making it a potential tool for cognitive research and brain disorder therapies. It generates oscillating electric fields in the brain that can influence neural spike timing, local neural oscillatory power, and cross-frequency and cross-area coherence. tACS affects cognitive performance by modulating brain rhythms, synchronization, and metabolic activity. It also shows promising results in alleviating psychiatric and neurological symptoms by targeting abnormal neural oscillations. We summarize the mechanisms of tACS, its cognitive applications, and novel developments for personalized stimulation.
TRENDS IN COGNITIVE SCIENCES
(2023)
Article
Neurosciences
Tingni Li, Yichen Chang, Shuzhi Zhao, Jeffery A. Jones, Xi Chen, Chu Gan, Xiuqin Wu, Guangyan Dai, Jingting Li, Ying Shen, Peng Liu, Hanjun Liu
Summary: Current models of speech motor control propose a role for the left inferior frontal gyrus (IFG) in feedforward control of speech production. However, there is evidence suggesting the functional relevance of the left IFG in the neuromotor processing of vocal feedback errors. This study provides causal evidence linking the left IFG to vocal pitch regulation using high-definition transcranial alternating current stimulation (HD-tACS).
Article
Clinical Neurology
Yuefeng Huang, Anusha Mohan, S. Lauren McLeod, Alison M. Luckey, John Hart Jr, Sven Vanneste
Summary: The study demonstrates that modulating activity in the aDMN and pDMN causally affect memory retrieval performance. Anodal stimulation of the pDMN and cathodal stimulation of the aDMN equally improve the percentage of word-associations recalled 7 days after learning, suggesting a possible functional dissociation between the aDMN and pDMN in episodic memory retrieval.
Article
Mathematical & Computational Biology
William H. Alexander, Thilo Womelsdorf
Summary: The interaction between medial and lateral prefrontal cortex plays a crucial role in cognitive control and decision-making, with proposals suggesting complementary roles in different aspects of behavior. The Hierarchical Error Representation model places these regions within the framework of predictive coding, demonstrating how they interact during behavioral periods. This model is able to capture neurophysiological, behavioral, and network effects, providing evidence for predictive coding as a unifying framework for understanding PFC function.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Xixi Chen, Yuwei Wu, Xiaolong Shi, Zhiqing Zhou, Tingyi Feng, Meng Ren, Yuanli Li, Chunlei Shan
Summary: This study investigates the immediate effects of high-definition theta transcranial alternating current stimulation (HD theta-tACS) on the human left parietal cortex using short-latency afferent inhibition (SAI) and electroencephalography (EEG). It found that HD theta-tACS leads to a decrease in SAI and strengthens the left frontoparietal network, potentially facilitating memory formation, encoding, and consolidation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Renata Kabiljo, Alfredo Iacoangeli, Ammar Al-Chalabi, Ivana Rosenzweig
Summary: ALS is a devastating neurodegenerative disease with unclear association with the cerebellar role, recent findings suggest certain gene variants are significantly linked to ALS risk. Gene-based and tissue enrichment analysis show a specific relationship between cerebellar tissue and ALS, calling for a re-evaluation of cerebellar involvement in ALS pathology.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Javier Pena, Agurne Sampedro, Yolanda Balboa-Bandeira, Naroa Ibarretxe-Bilbao, Leire Zubiaurre-Elorza, M. Acebo Garcia-Guerrero, Natalia Ojeda
Summary: This study examines the neural basis of creativity and finds that the left DLPFC and left IFG are associated with divergent thinking and convergent thinking. The results show that tRNS may have advantages over tDCS in divergent thinking.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Ophthalmology
Daniel P. Bliss, Dobromir Rahnev, Wayne E. Mackey, Clayton E. Curtis, Mark D'Esposito
Summary: Through two experiments, we tested the importance of the frontal lobe in serial dependence. In the first experiment, stimulation of the lateral prefrontal cortex (LPFC) decreased serial dependence in the first saccade to the target, while stimulation posterior to the LPFC decreased serial dependence in adjustments to eye position after the first saccade. In the second experiment, stimulation anterior to, in, and posterior to the LPFC all caused equivalent decreases in serial dependence.