Article
Immunology
Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Andre Herbelin, Jean-Marc Gombert, Alice Barbarin
Summary: Immunosenescence is a physiological process associated with changes in the immune system, particularly involving CD8 T cells. The newly described innate E(+) CD8 T cells may exhibit an exacerbated senescent phenotype in a chronic inflammatory environment, especially in kidney transplant and cytomegalovirus-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
David O. 'Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, Erika L. Pearce
Summary: Fever can enhance metabolic activity and effector functions of activated CD8* T cells, with limited effects on proliferation or activation marker expression. Exposure to 39 degrees Celsius increases mass and metabolism in T cells, with mitochondrial translation playing a crucial role in the enhanced metabolic activity and function observed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Fisheries
Matthieu Paiola, Dionysia Dimitrakopoulou, Martin S. Pavelka Jr, Jacques Robert
Summary: Mycobacterial infections are a major concern for both humans and vertebrates in aquatic and terrestrial environments. There are common features in the interactions between non-tuberculous mycobacteria and endo-and ectothermic animals, similar to those observed in Mycobacterium tuberculosis infections. The detection of non-tuberculous mycobacteria in amphibians is not only economically damaging but also poses a growing threat to human health.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Emma C. Reilly, Mike Sportiello, Kris Lambert Emo, Andrea M. Amitrano, Rakshanda Jha, Ashwin B. R. Kumar, Nathan G. Laniewski, Hongmei Yang, Minsoo Kim, David J. Topham
Summary: CD8 T cell memory within lung tissue is highly heterogeneous, with various subsets such as T-CM, T-EM, T-RM, and populations not fitting neatly into these classifications. CD49a-expressing T-RM cells exhibit increased and diverse effector potential, functioning as a versatile group with antiviral activity, chemokine production, release of GM-CSF, and the ability to kill specific targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ignacio Juarez, Shi Su, Zachary T. Herbert, John R. Teijaro, Vaishali R. Moulton
Summary: SRSF1 plays an essential role in the homeostasis and function of CD8 T cells, controlling their numbers, proliferative capacity, and cytotoxic function. It is also involved in the immune response to viral infection, regulating multiple signaling pathways in the transcriptome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Isabella Pirozzolo, Martin Sepulveda, Luqiu Chen, Ying Wang, Yuk Man Lei, Zhipeng Li, Rena Li, Husain Sattar, Betty Theriault, Yasmine Belkaid, Anita S. Chong, Maria-Luisa Alegre
Summary: The presence of commensal microbes in transplanted organs can induce immune responses and damage the grafts, leading to poorer outcomes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Simon Hirschberger, Luca Gellert, David Effinger, Maximilian Muenchhoff, Markus Herrmann, Josef-Maria Briegel, Bernhard Zwissler, Simone Kreth
Summary: This study investigates the potential of metabolic reprogramming of CD8(+) T cells using ketone bodies in COVID-19 patients. The results show that ketone treatment can enhance cytokine expression and cell lysis capacity of CD8(+) T cells, as well as increase mitochondrial activity.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Article
Immunology
Yanhua Gao, Ira Bergman
Summary: Simple and reliable methods are needed to detect anti-tumor memory T-cells for clinical tumor vaccination. A mouse model of curative viral onco-immunotherapy showed that peritoneal tumor challenge can identify an oligoclonal anti-tumor memory CD4 and CD8 T-cell response. Different clonotypes were found among challenged animals, but were consistent in blood, spleen, and peritoneal cells of the same animal. These findings suggest that this methodology can be used to assess the effectiveness of tumor vaccines or therapeutic T-cell vaccines using blood and tissue sampling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Alexandra Vujkovic, My Ha, Tessa de Block, Lida van Petersen, Isabel Brosius, Caroline Theunissen, Sabrina H. van Ierssel, Esther Bartholomeus, Wim Adriaensen, Guido Vanham, George Elias, Pierre Van Damme, Viggo Van Tendeloo, Philippe Beutels, Maartje van Frankenhuijsen, Erika Vlieghe, Benson Ogunjimi, Kris Laukens, Pieter Meysman, Koen Vercauteren
Summary: This study demonstrates that annotating TCR sequences of activated CD8+ T cells can be used to diagnose acute viral infections and differentiate them from historical exposures.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Marion Griessl, Angelique Renzaho, Kirsten Freitag, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: This study investigated the transcription of viral genes during latent infection of murine cytomegalovirus, revealing that the transcription of antigenic peptides driving memory inflation rarely coincides with the transcription of immune evasion proteins. The stochastic transcription hypothesis explains why immune evasion does not interfere with memory inflation in latently infected cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Entomology
Qinjian Pan, Ikkei Shikano, Gary W. Felton, Tong-Xian Liu, Kelli Hoover
Summary: Insects exhibit diverse immune responses and developmental costs when combating different baculoviruses, highlighting the complexity of host-pathogen interactions.
Article
Multidisciplinary Sciences
David M. Schauder, Jian Shen, Yao Chen, Moujtaba Y. Kasmani, Matthew R. Kudek, Robert Burns, Weiguo Cui
Summary: During acute viral infections, CD8 T cells encounter various antigenic and inflammatory signals, leading to differentiation into memory cells or death. Research has shown that memory precursor effector cells maintain open enhancers for key memory genes, with a high enrichment of E2A binding sites. E2A directly regulates the accessibility of enhancers for memory-related genes, increasing the frequency of memory precursor effector cells and accelerating memory cell formation while reducing short-lived effector cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xiaochen Wang, Jianchu Wang, Haiyuan Shen, Zongjiang Luo, Xiaojie Lu
Summary: This study found that TPX2 regulates the antitumor effect of CD8 + T cells in hepatocellular carcinoma (HCC) by modulating CXCR5. Overexpression of TPX2 enhances the anticancer function of CD8 + T cells and shows synergistic effects with anti-PD-1 therapy.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Ee W. Su, Caitlin J. Moore, Samantha Suriano, Christopher Bryce Johnson, Neizel Songalia, Alicia Patterson, Daniel J. Neitzke, Kristina Andrijauskaite, Elizabeth Garrett-Mayer, Shikhar Mehrotra, Chrystal M. Paulos, Andrew L. Doedens, Ananda W. Goldrath, Zihai Li, David J. Cole, Mark P. Rubinstein
SCIENCE TRANSLATIONAL MEDICINE
(2015)
Article
Immunology
Anthony T. Phan, Andrew L. Doedens, Asis Palazon, Petros A. Tyrakis, Kitty P. Cheung, Randall S. Johnson, Ananda W. Goldrath
Article
Multidisciplinary Sciences
Petros A. Tyrakis, Asis Palazon, David Macias, Kian L. Lee, Anthony T. Phan, Pedro Velica, Jia You, Grace S. Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E. Evans, John R. Griffiths, Lorenz Poellinger, Ananda W. Goldrath, Randall S. Johnson
Article
Oncology
Andrew L. Doedens, Mark P. Rubinstein, Emilie T. Gross, J. Adam Best, David H. Craig, Megan K. Baker, David J. Cole, Jack D. Bui, Ananda W. Goldrath
CANCER IMMUNOLOGY RESEARCH
(2016)
Article
Oncology
Andrew L. Doedens, Christian Stockmann, Mark P. Rubinstein, Debbie Liao, Na Zhang, David G. DeNardo, Lisa M. Coussens, Michael Karin, Ananda W. Goldrath, Randall S. Johnson
Article
Immunology
Rodrigo Hess Michelini, Andrew L. Doedens, Ananda W. Goldrath, Stephen M. Hedrick
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Oncology
Mark P. Rubinstein, Mohamed L. Salem, Andrew L. Doedens, Caitlin J. Moore, Cody Chiuzan, Guillermo L. Rivell, David J. Cole, Ananda W. Goldrath
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2013)
Letter
Dermatology
Christian Stockmann, Santina Kirmse, Iris Helfrich, Alexander Weidemann, Norihiko Takeda, Andrew Doedens, Randall S. Johnson
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2011)
Article
Immunology
Andrew L. Doedens, Anthony T. Phan, Martin H. Stradner, Jessica K. Fujimoto, Jessica V. Nguyen, Edward Yang, Randall S. Johnson, Ananda W. Goldrath
Article
Immunology
J. Adam Best, David A. Blair, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L. Dustin, Ananda W. Goldrath
Article
Multidisciplinary Sciences
Christian Stockmann, Yann Kerdiles, Marc Nomaksteinsky, Alexander Weidemann, Norihiko Takeda, Andrew Doedens, Antonio X. Torres-Collado, Luisa Iruela-Arispe, Victor Nizet, Randall S. Johnson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Cell Biology
Arnaud Delpoux, Nimi Marcel, Rodrigo Hess Michelini, Carol D. Katayama, Karmel A. Allison, Christopher K. Glass, Sergio M. Quinones-Parra, Cornelis Murre, Liyen Loh, Katherine Kedzierska, Martha Lappas, Stephen M. Hedrick, Andrew L. Doedens
Summary: This study demonstrates the crucial role of FOXO1 in maintaining cellular vitality and response to antigenic stress in T cells. Different cellular age states may lead to alterations in levels of FOXO1, TCF7, and AP-1 factors. These characteristics are also associated with the formation of T cells with features of cellular senescence.
Article
Immunology
Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis
NATURE REVIEWS IMMUNOLOGY
(2012)
Review
Immunology
Stephen M. Hedrick, Rodrigo Hess Michelini, Andrew L. Doedens, Ananda W. Goldrath, Erica L. Stone
NATURE REVIEWS IMMUNOLOGY
(2012)