Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing

(2016) Daniel J. O’Connell et al.   Cell Systems

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

(2015) Nidhi Sahni et al.   CELL

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARD9 Deficiency and Spontaneous Central Nervous System Candidiasis: Complete Clinical Remission With GM-CSF Therapy

(2014) C. Gavino et al.   CLINICAL INFECTIOUS DISEASES

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization

(2013) Fang Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice

(2013) Harry Sokol et al.   GASTROENTEROLOGY

CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies

(2013) Xiaowen Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tripartite Motif Ligases Catalyze Polyubiquitin Chain Formation through a Cooperative Allosteric Mechanism

(2013) Frederick C. Streich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Deep Dermatophytosis and Inherited CARD9 Deficiency

(2013) Fanny Lanternier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

(2013) Mélissa Beaudoin et al.   PLoS Genetics

Expanding the Number of ‘Druggable’ Targets: Non-Enzymes and Protein-Protein Interactions

(2012) Leah N. Makley et al.   Chemical Biology & Drug Design

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Clinical use of CCR5 inhibitors in HIV and beyond

(2011) Bruce L Gilliam et al.   Journal of Translational Medicine

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

(2010) Rebecca A. Drummond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE