期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 114, 期 8, 页码 1988-1993出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1610630114
关键词
plasmacytoid dendritic cells; CD2; CD81; CD5; type I IFN
资金
- National Institutes of Health [5RO1AI118884]
Plasmacytoid dendritic cells (pDCs) are known mainly for their secretion of type I IFN upon viral encounter. We describe a CD2(hi)CD5(+) CD81(+) pDC subset, distinguished by prominent dendrites and a mature phenotype, in human blood, bone marrow, and tonsil, which can be generated from CD34(+) progenitors. These CD2(hi)CD5(+) CD81(+) cells express classical pDC markers, as well as the toll-like receptors that enable conventional pDCs to respond to viral infection. However, their gene expression profile is distinct, and they produce little or no type I IFN upon stimulation with CpG oligonucleotides, likely due to their diminished expression of IFN regulatory factor 7. A similar population of CD5(+) CD81(+) pDCs is present in mice and also does not produce type I IFN after CpG stimulation. In contrast to conventional CD5(-)CD81(-) pDCs, human CD5(+) CD81(+) pDCs are potent stimulators of B-cell activation and antibody production and strong inducers of T-cell proliferation and Treg formation. These findings reveal the presence of a discrete pDC population that does not produce type I IFN and yet mediates important immune functions previously attributed to all pDCs.
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