Article
Chemistry, Inorganic & Nuclear
Yan Cai, Xin Yan, Siyuan Wang, Zhiwen Zhu, Moupan Cen, Changjin Ou, Qin Zhao, Qian Yan, Jin Wang, Yong Yao
Summary: Researchers successfully designed and prepared a hybrid polymeric material incorporating Pd nanoparticles, which exhibited desirable catalytic activity for reductions of toxic nitroaromatics and C-C bond-forming reactions in aqueous solution.
INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Li Wang, Guang Li, Lei Yang, Haonan Qu, Jing Cheng, Mohammed Abdallah, Dalia A. Barakat, Haibing Li
Summary: This study successfully prepared MIMs using S-triadimefon as the template molecule and improved the chiral selectivity by adding macrocyclic molecular 1,4-bis(allyloxy)pillar[5]arene. The results showed that the addition of pillar[5]arene significantly improved the separation effect of MIM on triadimefon enantiomers.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The application of heterogeneous catalysts in continuous-flow enantioselective hydroacylation reactions was studied. Catalysts were prepared by mixing supports and rhodium complexes, and showed excellent activity and enantioselectivity. Under optimized conditions, the catalysts exhibited high turnover numbers and could be applied to various substrates. Furthermore, sequential-flow reactions with other heterogeneous catalysts were demonstrated for the synthesis of biologically active molecules and functional materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Polymer Science
Xiao-Ni Qi, Qi Lin, Tai-Bao Wei, Wei Tian, Zhen-Liang Li
Summary: Among advanced materials, supramolecular gel (SG) materials based on pillar[5]arene have attracted significant attention due to their fine processability, recyclability, stimulus-responsiveness, and self-repair capabilities. This review thoroughly discusses the dependency relationship between multiapplication performance and design strategy of SGs based on pillar[5]arene. Various specific application examples are summarized, including fluorescence sensing, pollutant separation, stimulus conversion, self-healing, and dye removal. The opportunities, challenges, and prospects of pillar[5]arene-based SGs in this field are also discussed.
Article
Chemistry, Multidisciplinary
Sheng Yu, Yaqi Wang, Sobhan Chatterjee, Feng Liang, Fei Zhu, Haibing Li
Summary: The research demonstrated the enantioselective recognition of the chiral drug propranolol through an electrochemical method in a nanochannel platform, showcasing its potential applications in the recognition of chiral molecules.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Shixin Fa, Masayuki Mizobata, Shusaku Nagano, Kota Suetsugu, Takahiro Kakuta, Tada-aki Yamagishi, Tomoki Ogoshi
Summary: The study presents chiral assemblies with dual-stimuli responsiveness, consisting of planar-chiral pillar[5]arenes with azobenzene groups that undergo chiral amplification and collapse under thermo- and photostimuli control. The alignment of azobenzenes in the assemblies leads to chiral propagation and amplification, which can be switched on and off through trans to cis photoisomerization and cis to trans thermo-isomerization of the azobenzene groups.
Article
Chemistry, Applied
Liang Xu, Jia Cui, Shan Gao, Jianjun Wang, Jiao Liu, Hongge Jia, Zhuanfang Zhang, Fengjuan Miao, Yu Zang
Summary: Chiral conjugated microporous polymers (CCMPs) containing amide groups were designed and synthesized for the first time as heterogeneous asymmetric catalyst platforms for the stabilization of Pd in asymmetric catalytic synthesis. Four Pd/CCMPs heterogeneous catalysts exhibited efficient catalytic activity and excellent enantioselectivity in the asymmetric Henry reaction, with a wide range of substrates and easy recovery. The Pd/CCMPs composites could be easily recycled and maintained catalytic activity after 3 cycles of reactions.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Shang Lan, Li Ling, Shuyi Wang, Da Ma
Summary: Size-selective catalysis is crucial for the conversion of crude oil or biomass. In this study, we fabricated a new type of porous organic polymer with a high surface-to-mass ratio using 3D cross-linkers. These polymers exhibited exceptional size-selective catalysis in Knoevenagel condensation reactions. Mechanistic studies revealed that the size-selective catalysis is attributed to the host-guest interaction between the polymer and substrates. Therefore, these macrocycle-containing polymers could be promising candidates for size-selective catalysis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Haiying Wang, Weiwei Yang, Kim K. Baldridge, Cai-Hong Zhan, Tushar Ulhas Thikekar, Andrew C. -H. Sue
Summary: Stereolabile pillar[5]arene (P[5]) derivatives were used as platforms to study chiral symmetry breaking during crystallisation due to their dynamic racemic mixtures in solution. Crystal enantiomeric excess of a conglomerate-forming P[5] derivative can be obtained without external chiral entities through handpicking and Viedma ripening, while the handedness of P[5] derivative crystals can be directed and subsequently inverted in a highly controllable manner in the presence of optically-active solvents and chiral guests like ethyl d/l-lactate.
Article
Chemistry, Organic
Chunhong Liu, Jiabin Yao, Chao Xiao, Ting Zhao, Narayanan Selvapalam, Cuisong Zhou, Wanhua Wu, Cheng Yang
Summary: A bicyclic pillar[5]arene derivative fused with a bipyridine side ring, named a molecular universal joint (MUJ), was synthesized and the pair of enantiomers was resolved using high-performance liquid chromatography. The electrochemiluminescent detection based on the ruthenium complex of enantiopure MUJ demonstrated excellent chiral discrimination towards certain amino acids.
Article
Chemistry, Multidisciplinary
Kenichi Kato, Shunsuke Ohtani, Masayuki Gon, Kazuo Tanaka, Tomoki Ogoshi
Summary: The spatial arrangement of multiple planar chromophores is an emerging strategy for molecule-based chiroptical materials, and in this study, five pyrene planes were attached to a chiral macrocycle pillar[5]arene to produce a set of chiroptical molecules. The chiroptical response was found to depend on linker structures and substituted patterns due to variable interactions between pyrene units, leading to enhanced dissymmetry factors and response wavelengths.
Article
Chemistry, Inorganic & Nuclear
Yang Wang, Ruowen Tang, Yue Zhang, Yu Dai, Qixiang Zhou, Youjun Zhou, Chao-Guo Yan, Bing Lu, Jin Wang, Yong Yao
Summary: Metal nanoparticle catalysts have high surface-to-volume ratios and a large number of active sites, but they often aggregate during catalytic reactions, leading to a decrease in catalytic activity. In this study, a monoterpyridine-unit-functionalized pillar[5]arene was synthesized and used as anchoring sites for the preparation of well-dispersed palladium nanoparticles. The as-prepared nanoparticles were characterized and found to be excellent and reusable catalysts for the reduction of nitrophenols in aqueous solution.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chengxiang Shi, Hui Li, Xiaofeng Shi, Liang Zhao, Hongdeng Qiu
Summary: Chiral pillar[5]arene-functionalized silica microspheres were successfully prepared and characterized for the first time as a new type of chiral stationary phase. They demonstrated effective enantioseparation under reversed-phase and normal phase modes with good reproducibility and stability.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Polina Skvortsova, Dmitriy Shurpik, Ivan Stoikov, Bulat Khairutdinov
Summary: The spatial separation and organization of chemical reactions are important for cell functioning. This is achieved through cellular compartments and membraneless organelles. These compartments contain complex molecules such as proteins, DNA, and RNA.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Junwen Wang, Jun Li, Yan Wang, Sisi He, Hengzhi You, Fen -Er Chen
Summary: In this study, a polymer-supported chiral heterogeneous copper catalyst was reported, which demonstrated high reactivity and enantioselectivity in asymmetric conjugate addition reactions.
Article
Chemistry, Multidisciplinary
Zheng-Hua Zhang, You-Ming Zhang, Wen-Juan Qu, Bingbing Shi, Hong Yao, Tai-Bao Wei
Summary: In this paper, a series of tripodal nitrogen mustard derivatives (TMs) were developed, and the host-guest binding model was successfully tuned by rationally designing the intramolecular alkyl chain lengths of the host. This transformation from pi-pi to multiple hydrogen bonds enhanced the host-guest binding force and recognition efficiency.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhiguo Zhang, Xiyang Cao, Xiaoqing Song, Gang Wang, Bingbing Shi, Xiang Li, Nana Ma, Lantao Liu, Guisheng Zhang
Summary: Atom- and step-economy in IBX-assisted diversity-oriented synthesis is achieved with a versatile AQ auxiliary alpha-amino acid analogs, offering rapid access to polycyclic spiro-quinolines featuring a quaternary stereocenter in 20%-91% yields under mild conditions via 7,8-dearomatization of quinolines. The highlight of this intramolecular oxidation spiroannulation tandem reaction is the absence of a preinstalled activation group. These traditionally difficult-to-access N-heterospirocycles may provide a potentially interesting scaffold for synthetic and medicinal chemistry.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Mei Sun, Juan Liu, Zhao-Hui Li, Yong-Peng Fu, Ting-Ting Huang, Zhong-Di Tang, Bingbing Shi, Hong Yao, Tai-Bao Wei, Qi Lin
Summary: In the past twenty years, aggregation-induced emission (AIE) has gained widespread interest due to its promising applications. The development of novel and easily synthesized AIE luminogens (AIEgens) is a fascinating research topic. This study aims to investigate the structure-property relationship of AIEgens by using a series of azine derivatives (ADs) as models.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yu Yao, Jiyong Liu, Peiling Zhang, Kechang Sun, Leqiong Jin, Shijun Li, Feihe Huang, Zhigang Ni, Zibin Zhang
Summary: Self-assembly is a fundamental tool for constructing materials. Copillar[5]arenes, driven by CH center dot center dot center dot 7r interactions, are optimal models for building heteroditopic monomers. The self-assembly manner of copillar[5]arenes in the solid state depends on the competition between the pillar[5]arene cavity and the threading guest moiety or solvent molecules.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Ming Li, Yang Liu, Li Shao, Bin Hua, Mengbin Wang, Haozhong Liang, Niveen M. Khashab, Jonathan L. Sessler, Feihe Huang
Summary: Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as they allow for the study of structure-property relationships and the synthesis of new scaffolds. In this work, the concept of variable stoichiometry co-crystals is extended to pillararene chemistry, resulting in the construction of a diverse set of supramolecular structures. These co-crystals display different physicochemical properties and can be used for vapochromic-based detection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Xiaodan Xu, Rui Wang, Dongdong Li, Jiajia Xiang, Wei Zhang, Xueying Shi, Hongxia Xu, Shasha Yao, Jiwei Liu, Shiqun Shao, Zhuxian Zhou, Feihe Huang, Youqing Shen, Jianbin Tang
Summary: In this study, a pH-responsive polymer nanocarrier modified with aminoguanidine was developed for efficient delivery of bortezomib. The nanoparticles exhibited pH-responsive release in the acidic tumor microenvironment and induced immune activation and antigen uptake by dendritic cells. Consequently, they stimulated cytotoxic T lymphocyte infiltration and triggered robust antitumor immune responses, showing potent antitumor efficacy when combined with an immune checkpoint-blocking antibody.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Haoke Zhang, Li Xin Hou, Min Zuo, Miao Du, Feihe Huang, Qiang Zheng, Zi Liang Wu
Summary: We propose a facile strategy to achieve room-temperature phosphorescence in conventional hydrogels by polymerization-induced crystallization of dopant molecules, leading to clusterization-induced phosphorescence. Crown ethers dissolved in a concentrated acrylamide aqueous solution crystallize during polymerization to form large spherulites in the hydrogel, resulting in carbonyl clusters and phosphorescence emission. This strategy is universally applicable to hydrogels with different polymeric matrices and dopant molecules. The development of hydrogels with mechanical and phosphorescent properties holds great potential in the biomedical and engineering fields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao, Yuan Ding, Weilin Wang
Summary: With the increasing demand for personalized medical care, supramolecular theranostic systems based on cyclodextrins (CDs) have become popular due to their reversible switchable structures, sensitive response to biological stimuli, and ability to integrate multiple capabilities in a programmable manner. This review focuses on the design of various functional modules and interactions in CD-based supramolecular systems for cancer diagnostics and therapeutics. By providing state-of-the-art examples, the review aims to enhance the understanding of the important role of cyclodextrin-based nanoplatforms in advancing supramolecular cancer theranostics.
Review
Polymer Science
Ruoqian Zhang, Rongrong Li, Feihe Huang, Mingming Zhang
Summary: This review summarizes the progress of metallacycle/metallacage-cored supramolecular networks, focusing on the structures connected by covalent or non-covalent interactions. The detailed descriptions of the structures, properties, functions, and applications of such networks are provided to showcase the exciting achievements in this emerging field. The review also highlights the remaining challenges and perspectives to attract more scientists to contribute to this promising area.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Summary: Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics due to their advantages over traditional conjugated dyes in biological applications. However, their weak visible emissions in the aggregate state have hindered their development. This study proposes a strategy to construct a higher-level intramolecular through-space interaction (TSI) in multi-aryl-substituted alkanes, resulting in efficient clusteroluminescence (CL) with high luminescence quantum yield and long emission wavelength.
Article
Chemistry, Multidisciplinary
Yunxuan Feng, Shaolong Qi, Xinyang Yu, Xueyan Zhang, Huangtianzhi Zhu, Guocan Yu
Summary: Despite the breakthrough of immunotherapy, immune checkpoint inhibitors often have low response rate and resistance towards solid tumors. A hypoxic tumor microenvironment provides tumor cells with high concentrations of HIF-1 and polyamines to evade immune cell destruction. Reprogramming the immunogenic microenvironment has shown promising results in boosting immunotherapeutic performances.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Qiong Chen, Zhaoyong Li, Ye Lei, Yixin Chen, Hua Tang, Guangcheng Wu, Bin Sun, Yuxi Wei, Tianyu Jiao, Songna Zhang, Feihe Huang, Linjun Wang, Hao Li
Summary: Controlling the self-assembly on noncovalent components is possible by suppressing entropy loss with templates but this is challenging for covalent components. Here the authors employed directing groups to endow purely covalent molecular building blocks with different conformations which favor the formation of specific self-assembled products.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Liya Chen, Bin Sun, Mengbin Wang, Hao Li, J. Fraser Stoddart, Feihe Huang
Summary: Macrocyclic molecules have broad applications due to their guest binding properties. Extending host-guest chemistry from solution to the solid state enables the formation of more stable and processable complexes. Solid-state host-guest chemistry can encapsulate guests with higher affinities, which is crucial for applications in separation science and devices.
NATURE REVIEWS CHEMISTRY
(2023)
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.
