Article
Biochemistry & Molecular Biology
Qiang Zhang, Yuanyuan Liu, Yucheng Fei, Jiguo Xie, Xiaofei Zhao, Zhiyuan Zhong, Chao Deng
Summary: The study presents a novel synthesis method for phenylboronic acid-functionalized copolypeptides based on an L-boronophenylalanine N-carboxyanhydride (BPA-NCA) monomer, and demonstrates their potential for co-encapsulation and responsive release of dual anticancer drugs. The synthesized copolypeptides show controlled compositions and can self-assemble into uniform micellar nanoparticles for drug delivery. The resulting nanoparticles exhibit enhanced anticancer effects and have potential applications in smart cancer nanomedicines.
Article
Nanoscience & Nanotechnology
Yanchi Liu, Shanfeng Zhu, Jinchen Fan, Wenyao Guo, Yulin Min, Xuesong Jiang, Jin Li
Summary: Efficient dispersion of nanoparticles (NPs) in coatings, inks, and related materials is a crucial challenge. Physical adsorption and chemical modification are common methods, but suffer from desorption and limited versatility. To address these issues, we developed a novel photo-cross-linked polymeric dispersant, bPEA, which forms a dense and stable shell on the surface of pigment NPs through physical adsorption and subsequent chemical photo-cross-linking. These dispersants show high stability and compatibility with various printing methods, providing uniformity, color fastness, and less color shading in ornamental products.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Mansha, Rajendra A. Kalgaonkar, Nour Baqader, Nisar Ullah
Summary: This research successfully synthesized two new zwitterionic gemini surfactants and found that they can significantly increase viscosity when mixed with a known amidosulfobutaine. This makes them suitable for hydraulic fracturing applications.
Article
Chemistry, Physical
Ajaya Bhattarai, Malik Abdul Rub, Mihalj Posa, Bidyut Saha, Abdullah M. Asiri, Dileep Kumar
Summary: This study investigates the behavior of ninhydrin (N) and phenylalanine (Phe) in a cationic gemini micellar system using a spectrophotometer. The results show that the reaction of N follows fractional-order kinetics, while the reaction of Phe follows first-order kinetics. The gemini surfactant system significantly catalyzes the reactions, even at concentrations lower than the critical micelle concentration (cmc).
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Lixin Zhang, Daowen Zhang, Yongfang Yang, Yue Zhang
Summary: A new method of stimuli-responsive proteinosome fabrication using shell cross-linked micelle as a template was reported in this research. The proteinosomes had a size of about 50 nm and capsule-like structures, were thermoresponsive with a phase transition temperature at 35 degrees C. The proteinosome showed low toxicity to cells and could be internalized. The fabrication had no significant influence on the structure and activity of the protein.
Article
Chemistry, Multidisciplinary
Zohaib Hussain, Seoungkyun Kim, Jinhwan Cho, Gyudae Sim, Youngjune Park, Inchan Kwon
Summary: This study introduces a novel method for the selective extraction and recovery of total rare earth elements (REEs) using elastin-like polypeptide (ELP) and the REE-binding domain (lanmodulin). By controlling solution temperature and pH, RELP shows high REE specificity and allows for easy recovery of bound REEs during repeated cycles.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Wenqian Yang, Pengwen Chen, Eger Boonstra, Taehun Hong, Horacio Cabral
Summary: Messenger RNA (mRNA) is a promising therapeutic modality, but its fragility and limited intracellular access pose challenges. This study developed pH-responsive cross-linked micelles for stable mRNA delivery and complete release in endosomal pH. The cross-linked micelles increased mRNA delivery efficiency and promoted protein expression.
Article
Polymer Science
Yihenew Simegniew Birhan, Endris Yibru Hanurry, Tefera Worku Mekonnen, Haile Fentahun Darge, Yu-Hsuan Lin, Ming-Chien Yang, Hsieh-Chih Tsai
Summary: Polymeric micelles assembled from star-shaped amphiphilic copolymers have potential as a delivery tool for cancer treatment due to their long half-life, cancer-specific internalization, and controlled release of drugs. In this study, a biotin-decorated and diselenide-linked star-shaped amphiphilic copolymer was used to form stable micelles with high drug loading content and encapsulation efficiency. The micelles showed selective cytotoxicity against cancer cells and desirable drug release in a simulated cancer environment.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Engineering, Chemical
Juanjuan Han, Shengqi Gong, Zhongshi Peng, Xueqi Cheng, Yuhan Li, Hanqing Peng, Yuchan Zhu, Zhandong Ren, Li Xiao, Lin Zhuang
Summary: The study found that the topology of comb-shaped anion exchange membranes has a significant impact on membrane properties, with membranes where side chains are grafted onto backbones showing better ion conduction and chemical stability compared to those with side chains tethered to cations. Increasing side chain length enhances the chemical stability of the membranes.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Materials Science, Paper & Wood
Xiaohong Liu, Ming Li, Haichuan Zhang, Liheng Chen, Shiyu Fu
Summary: A cellulose-grafted-poly(N-isopropylacrylamide) copolymer with thermo-responsivity was synthesized and used to form an injectable thermoresponsive hydrogel for the sustained release of the anticancer drug doxorubicin. Cytotoxicity tests showed that the hydrogel was biocompatible, indicating its potential for application in smart drug delivery systems.
Article
Chemistry, Physical
Chuan Yan, Liqin Yang, Xiangquan Mo, Keying Chen, Weiya Niu, Zhiju Zhao, Guanghua Li
Summary: PMAAAB-ran-PHEA micelles exhibit porous or bowl-shaped structure with a size of 135-150 nm. They possess reversible hydrophobicity, temperature-dependent size, and solubilization capacity.
Article
Biochemistry & Molecular Biology
Hong Yu Yang, Jia Meng Du, Moon-Sun Jang, Xin Wang Mo, Xin Shun Sun, Doo Sung Lee, Jung Hee Lee, Yan Fu
Summary: EPNGs were successfully fabricated for CD44-targeted transport of cytochrome c through UV-triggered chemical cross-linking, showing stable and high protein encapsulation efficiency in blood circulation and rapid release in targeted tumor cells.
Article
Polymer Science
Siyu Li, Peng Liu, Zhigang Wang, Lu Lian, Youliang Zhao
Summary: The combination of cyclic and linear segments offers a promising opportunity to create polymeric materials with intriguing physical properties. This study focuses on the design of comb-like-linear diblock copolymers to achieve thermoresponsive and aggregation properties. Toothbrush-like and jellyfish-like copolymers with grafts of poly(2-(dimethylamino)ethyl methacrylate) tethered to a linear or cyclic polyacrylate-block-poly(N-isopropylacrylamide) backbone were synthesized. The self-assembly of these copolymers resulted in various nanostructures through thermo/pH-induced changes, and the cyclic architecture played a significant role in the self-assembly process.
Article
Pharmacology & Pharmacy
Yanhua Liu, Jingjing Sun, Yixian Huang, Yichao Chen, Jiang Li, Lei Liang, Jieni Xu, Zhuoya Wan, Bei Zhang, Zuojun Li, Song Li
Summary: The novel PMet-P(cdmPEG2K) polymeric micellar carrier shows potential in cancer therapy by co-delivering DOX and nucleic acids, enhancing cytotoxicity and transfection efficiency in acidic tumor microenvironments. This carrier system also demonstrates effectiveness in combined chemotherapy and gene therapy, inhibiting tumor growth more effectively than individual treatments.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Soheila Ghasemi, Leila Ahmadi, Fatemeh Farjadian
Summary: In this study, a thermo-responsive smart amphiphilic block copolymer was synthesized through controlled polymerization method and self-assembled into stable nanomicelles for efficient loading and sustained release of an anti-cancer drug DTX. Results showed that the DTX-loaded polymeric micelles exhibited comparable toxicity to free drugs and could potentially serve as an effective intracellular drug delivery system in chemotherapy.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Jialiang Zhang, Ling'e Zhang, Shun Li, Changfeng Yin, Cheng Li, Wei Wu, Xiqun Jiang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Multidisciplinary Sciences
Zhengkui Zhang, Changren Liu, Cheng Li, Wei Wu, Xiqun Jiang
Article
Multidisciplinary Sciences
Huang Tang, Zhewei Gu, Haifeng Ding, Zhibo Li, Shiyan Xiao, Wei Wu, Xiqun Jiang
Article
Nanoscience & Nanotechnology
Peng Zhang, Xiaoke Zhang, Cheng Li, Sensen Zhou, Wei Wu, Xiqun Jiang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Ling'e Zhang, Zhengkui Zhang, Changren Liu, Xiaoke Zhang, Quli Fan, Wei Wu, Xiqun Jiangsu
Article
Engineering, Biomedical
Ling'e Zhang, Changren Liu, Sensen Zhou, Ruonan Wang, Quli Fan, Dongfang Liu, Wei Wu, Xiqun Jiang
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Shun Li, Changfeng Yin, Ruonan Wang, Quli Fan, Wei Wu, Xiqun Jiang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Chemistry, Multidisciplinary
Weizhi Chen, Xu Zhen, Wei Wu, Xiqun Jiang
SCIENCE CHINA-CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Shun Li, Tianyuan Cheng, Changfeng Yin, Sensen Zhou, Quli Fan, Wei Wu, Xiqun Jiang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Changren Liu, Ling'e Zhang, Sensen Zhou, Xiaoke Zhang, Wei Wu, Xiqun Jiang
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Changfeng Yin, Ruonan Wang, Ying Sun, Shun Li, Xiaoke Zhang, Jie Gu, Wei Wu, Xiqun Jiang
Summary: This study investigated the properties of cyclic cylindrical polymer brushes (CPBs) with a ringlike morphology for the first time and found that they are more prone to non-specific protein adsorption compared to their linear counterparts. Despite lower cellular uptake and tumor permeability, cyclic CPBs exhibited excellent passive tumor targeting ability and achieved a tumor uptake of about 8.2% of the injected dose per gram of tissue after a single intravenous administration.
Review
Materials Science, Biomaterials
Xu Zhen, Rui Qu, Weizhi Chen, Wei Wu, Xiqun Jiang
Summary: Phosphorescence is a promising technique for in vitro and in vivo bioimaging, and the modification of phosphorescent materials with improved solubility for biocompatibility is essential for advancing their applications.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Zhengkui Zhang, Ling'e Zhang, Jiaojiao Zhao, Cheng Li, Wei Wu, Xiqun Jiang
BIOMATERIALS SCIENCE
(2019)
Article
Materials Science, Biomaterials
Huang Tang, Zhewei Gu, Cheng Li, Zhibo Li, Wei Wu, Xiqun Jiang
BIOMATERIALS SCIENCE
(2019)
Article
Polymer Science
Dan Zhang, Wei Wu, Xi-qun Jiang
ACTA POLYMERICA SINICA
(2019)
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.
