Article
Engineering, Biomedical
Terufumi Kokabu, Yuichiro Abe, Katsuhisa Yamada, Norimasa Iwasaki, Hideki Sudo
Summary: The study showed that multilevel facetectomy significantly increased segmental spinal flexibility in patients with thoracic adolescent idiopathic scoliosis, with a greater effect observed on the concave side compared to the convex side.
CLINICAL BIOMECHANICS
(2021)
Article
Clinical Neurology
Yohei Yamada, Satoru Demura, Satoshi Kato, Kazuya Shinmura, Noriaki Yokogawa, Makoto Handa, Ryohei Annen, Motoya Kobayashi, Satoshi Nagatani, Hiroyuki Tsuchiya
Summary: This observational study retrospectively analyzed patients who underwent CT angiography of the thoracic spine to investigate the anatomical characteristics and variations of the thoracic segmental arteries. The distribution of segmental arteries was found to be asymmetrical and varied depending on the vertebral level. The results provide critical information for avoiding vascular injuries in thoracic spine surgery.
Article
Medicine, General & Internal
Jesus Burgos, Carlos Barrios, Gonzalo Mariscal, Alejandro Lorente, Rafael Lorente
Summary: The study analyzed the range of motion of the thoracic spine by measuring changes in the sagittal profile of different thoracic segments during maximal inspiration and exhalation. Results showed that the flexibility of the thoracic spine during deep breathing was wider in the caudal hemicurve than in the cranial hemicurve, with angular movements of the T7-T10 segment playing a significant role in maximal inspiration.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kuankuan Liu, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, Chi Zhang
Summary: This study identified the increased expression of PTGR1 in thoracic ossification of the ligamentum flavum (TOLF) and demonstrated its involvement in cell proliferation, possibly through activating the expression of c-Myc and CyclinD1 via the JNK pathway.
Article
Biotechnology & Applied Microbiology
Paul Mcmullin, Darian Emmett, Andrew Gibbons, Kelly Clingo, Preston Higbee, Andrew Sykes, David T. Fullwood, Ulrike H. Mitchell, Anton E. Bowden
Summary: This study utilized an optical motion capture system and a new marker set to non-invasively measure the dynamic, 3D in vivo segmental kinematics of the lower spine in a laboratory setting. The results were consistent with previous studies and identified motion coupling paradigms in the lumbar spinal segments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Anatomy & Morphology
Hans-Joachim Wilke, Volker Michael Betz, Annette Kienle
Summary: Based on the kangaroo's bipedal locomotion and upright position, it is suggested that the kangaroo could be an interesting model for spine research and a reasonable surrogate for biomechanical in vitro tests. This in vitro study aimed to provide biomechanical properties of the kangaroo spine and compare them with human spinal data. The flexibility of the kangaroo spine was found to be greater overall, with similarities only found in the cervical, lower thoracic, and lumbar regions.
JOURNAL OF ANATOMY
(2023)
Article
Orthopedics
Shun Yamamoto, Luis Dias, John Street, Peter A. Cripton, Thomas R. Oxland
Summary: Biomechanical properties of the upper thoracic spine were evaluated with anterior-posterior shear loading at various displacement rates. The stiffness of the specimens was significantly higher in the anterior direction compared to the posterior direction, with the shear displacement rate having a minor effect on the load response. The shear stiffness in the upper thoracic spine is greatest in the anterior loading direction due to facet interactions.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Mattan R. Orbach, Jonathan Mahoney, Brandon S. Bucklen, Sriram Balasubramanian
Summary: This study investigates the coupled motions of the thoracic spine and lumbar spine with rib cage in vitro to provide quantitative data on motion patterns and magnitudes. The findings contribute to the understanding of complex spinal deformities and the validation of computational models.
Article
Surgery
Peyton Tharp, Ryan W. King, Bruce M. Frankel, Mathew D. Wooster
Summary: This study reported a successful combination surgery of TEVAR and spinal screw removal in a 36-year-old female patient with iatrogenic aortic injury due to pedicle screws. The patient recovered well postoperatively with no complications.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Construction & Building Technology
Kun Feng, Li Zhang, Wenqi Guo, Renjie Yang, Chuan He, Jingxuan Zhang
Summary: This study established a finite element model and iterative algorithm to analyze the structural behavior of segmental linings, finding that the convergence of the iterative algorithm in staggered-jointed assembly structures is better than straight-jointed assembly structures, and that the assembly angles have significant influence on the structural internal forces and deformation.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2021)
Article
Clinical Neurology
Christian Herren, Jan-Sven K. Jarvers, Matthias Jung, Christian Blume, Holger Meinig, Michael Ruf, Thomas Weiss, Hauke Ruether, Thomas Welk, Andreas Badke, Oliver E. Gonschorek, Christoph Heyde, Frank Kandziora, Christian Knop, Philipp Kobbe, Matti Scholz, Holger Siekmann, Ulrich Spiegl, Peter Strohm, Christoph Struewind, Stefan C. Matschke, Alexander Disch, Michael Kreinest
Summary: This study aimed to provide epidemiological data on paediatric patients with thoracolumbar spinal trauma in Germany, in order to improve decision-making regarding diagnostics and treatment. The study found that falls and traffic accidents were the main causes of thoracolumbar spine injuries, with the majority of patients receiving conservative treatment and a small percentage requiring surgery, with an acceptable complication rate.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Peiyu Du, Lei Ma, Wenyuan Ding
Summary: This study investigated the correlation between the type of ossification and radiological parameters, modified thoracic JOA scores, and complications in patients with thoracic ossification of ligamentum flavum. The results showed that sagittal morphology had a significant adverse effect on postop JOA score and surgical outcome, while axial morphology had no effect on surgical outcome, and there was no interaction between sagittal morphology and axial morphology.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Orthopedics
Alena Kobesova, Ross Andel, Karolina Cizkova, Pavel Kolar, Jiri Kriz
Summary: This study assessed the effects of exercise targeting proper trunk stabilization and segmental spinal movement on back pain and sensory perception in cross-country skiers. The results showed significant improvements in pain intensity and frequency, graphesthesia, vibration perception, and 2-point discrimination in the experimental group compared to the control group. The conclusion suggests that exercise targeting the mid-thoracic spine can reduce back pain and enhance sensory perception in this population.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Alessandro Mariotti, Emanuele Vignali, Emanuele Gasparotti, Mario Morello, Jaskaran Singh, Maria Vittoria Salvetti, Simona Celi
Summary: This study performs a stochastic sensitivity analysis on the experimental setup of a mock circulatory loop for in vitro hemodynamics analysis in the ascending thoracic aorta at a patient-specific level. The main findings are that the flow rate and pressure waveforms are primarily influenced by the cardiac cycle period and the stroke volume, while the impact of the spatial distribution of the inlet velocity profile is negligible. Additionally, the study emphasizes the importance of replicating the patient-specific inflow waveform in experiments.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Kwong Hang Yeung, Gene Chi Wai Man, Wafa Skalli, Zongshan Hu, Vivian Wing Yin Hung, Alec Lik Hang Hung, Tsz Ping Lam, Bobby Kin Wah Ng, Jack Chun Yiu Cheng, Claudio Vergari, Winnie Chiu Wing Chu
Summary: This study aimed to characterize global sagittal alignment in adolescent idiopathic scoliosis (AIS) patients with normal kyphosis (NTK) and thoracic hypokyphosis (THK) before and after posterior spinal fusion. The results showed differences in global sagittal alignment between NTK and THK, as well as compared to asymptomatic controls. THK patients had initially compensated balance with unusual forward leaning posture, but gradually achieved balance after surgery.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Marco Palanca, Christian Liebsch, Shamila Hubner, Daniele Marras, Maria Luisa Ruspi, Francesco Marconi, Luca Cristofolini, Hans-Joachim Wilke
Summary: Experimental characterization of human ribs revealed two main mechanisms of failure: brittle and buckling. Ribs undergoing brittle fracture had thicker cortical bone than those undergoing buckling, and larger tensile strains were observed in specimens with brittle fractures. This supports the focus on cortical thickness modeling to enhance computational models for forensic investigations and device design.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Raquel M. Goncalves, Taryn Saggese, Zhiyao Yong, Joana R. Ferreira, Anita Ignatius, Hans-Joachim Wilke, Cornelia Neidlinger-Wilke, Graciosa Q. Teixeira
Summary: This study investigated the impact of the MSC secretome on human annulus fibrosus cells exposed to mechanical loading and a pro-inflammatory environment. The results showed that the inflammatory milieu had a stronger impact on the cells than physiological mechanical stress. The MSC secretome decreased the production of certain proteases in the cells and increased the production of TIMP-1.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Alexander L. Hornung, Christopher M. Hornung, G. Michael Mallow, J. Nicolas Barajas, Augustus Rush, Arash J. Sayari, Fabio Galbusera, Hans-Joachim Wilke, Matthew Colman, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: This article reviews the history, applications, and future developments of artificial intelligence and machine learning in spine research. Artificial intelligence and machine learning have been extensively used in various aspects of spine care, including imaging techniques, predictive modeling, and pathology algorithms. The article emphasizes the importance for spine specialists to understand and assess the utility of novel AI research.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Samuel S. Rudisill, Alexander L. Hornung, J. Nicolas Barajas, Jack J. Bridge, G. Michael Mallow, Wylie Lopez, Arash J. Sayari, Philip K. Louie, Garrett K. Harada, Youping Tao, Hans-Joachim Wilke, Matthew W. Colman, Frank M. Phillips, Howard S. An, Dino Samartzis
Summary: This study developed and validated a machine learning model to predict the risk of early-onset adjacent segment degeneration (EO-ASD) following anterior cervical discectomy and fusion (ACDF). The model demonstrated good performance in predicting EO-ASD based on preoperative demographic, clinical, and radiographic parameters. This ML approach addresses the limitations of traditional statistics and has the potential to support discovery and clinical decision-making in spine care.
EUROPEAN SPINE JOURNAL
(2022)
Article
Orthopedics
James D. Baker, Arash J. Sayari, Youping Tao, Philip K. Louie, Bryce A. Basques, Fabio Galbusera, Frank Niemeyer, Hans-Joachim Wilke, Howard S. An, Dino Samartzis
Summary: Modic changes (MC) and endplate abnormalities (EA) may have a negative impact on cervical alignment. This study found that patients with MC and endplate pathologies such as the Modic-Endplate-Complex (MEC) had worse cervical alignment compared to those without these phenotypes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Daniel L. Belavy, Gabriele Armbrecht, Kirsten Albracht, Helena Brisby, Deborah Falla, Richard Scheuring, Roope Sovelius, Hans-Joachim Wilke, Kajsa Rennerfelt, Eduardo Martinez-Valdes, Michail Arvanitidis, Fabian Goell, Bjoern Braunstein, Svenja Kaczorowski, Vera Karner, Nitin Kumar Arora
Summary: This study aims to investigate the impact of spaceflight on the risk of cervical intervertebral disc herniation and explore the adaptations in astronauts' cervical spine. Data collection will involve MRI, cervical 3D kinematics, muscle testing, and questionnaires. The results will inform preventive measures for astronauts and contribute to the understanding of disc herniation risk in the cervical spine for people on Earth, as well as provide insights into the etiology of neck pain.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Frank Niemeyer, Annika Zanker, Rene Jonas, Youping Tao, Fabio Galbusera, Hans-Joachim Wilke
Summary: This study developed a deep learning-based tool that can automatically and accurately segment lumbar muscles and validated the tool on an external dataset. The tool can be used for large-scale studies on spinal disorders and sarcopenia, overcoming the limitations of manual segmentation.
EUROPEAN SPINE JOURNAL
(2022)
Editorial Material
Clinical Neurology
Dino Samartzis, Fabio Galbusera, Hans-Joachim Wilke
EUROPEAN SPINE JOURNAL
(2022)
Review
Anatomy & Morphology
Hans-Joachim Wilke, Volker Michael Betz, Annette Kienle
Summary: Based on the kangaroo's bipedal locomotion and upright position, it is suggested that the kangaroo could be an interesting model for spine research and a reasonable surrogate for biomechanical in vitro tests. This in vitro study aimed to provide biomechanical properties of the kangaroo spine and compare them with human spinal data. The flexibility of the kangaroo spine was found to be greater overall, with similarities only found in the cervical, lower thoracic, and lumbar regions.
JOURNAL OF ANATOMY
(2023)
Article
Clinical Neurology
Hiroyuki Nakarai, Andrea Cina, Catherine Jutzeler, Alexandra Grob, Daniel Haschtmann, Markus Loibl, Tamas F. Fekete, Frank Kleinstuck, Hans-Joachim Wilke, Youping Tao, Fabio Galbusera
Summary: This study aims to develop a deep learning model for the automatic calculation of important spine parameters from lateral cervical radiographs. Two datasets were used for training and validation, and the results demonstrate the accuracy of the model in predicting cervical spine parameters.
GLOBAL SPINE JOURNAL
(2023)
Article
Cell & Tissue Engineering
E. Salzer, T. C. Schmitz, V. H. M. Mouser, A. Vernengo, B. Gantenbein, J. U. Jansen, C. Neidlinger-Wilke, H-j. Wilke, S. Grad, C. L. Le Maitre, M. A. Tryfonidou, K. Ito
Summary: Strategies to regenerate or repair intervertebral discs are being explored, and ex vivo disc cultures are frequently used for studying human intervertebral disc degeneration (IVDD). A systematic search of induction methods for degenerative changes revealed five categories and 129 studies. Currently, spontaneously degenerated disc cultures from large animals provide the closest resemblance to human IVDD. Future advancements in disc culture setups may better mimic human IVDD.
EUROPEAN CELLS & MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Guangsheng Song, Zhihui Qian, Kunyang Wang, Jing Liu, Yuyang Wei, Fabio Galbusera, Zhenmin Zou, Hans-Joachim Wilke, Luquan Ren, Lei Ren
Summary: The intervertebral disc is an important component of the human spine, and its degeneration can cause pain and disability. Total disc replacement is an effective treatment approach, but the complex environment and conditions present challenges in device design, materials, and processes. This review discusses the advantages and challenges of current total disc replacement devices and proposes a novel fabrication strategy to restore biofunction and improve performance.
PROGRESS IN MATERIALS SCIENCE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Graciosa Q. Teixeira, Andreas Ekkerlein, Raquel M. Goncalves, Joana R. Ferreira, Yana Hoepfner, Julia Nothelfer, Anita Ignatius, Hans-Joachim Wilke, Cornelia Neidlinger-Wilke
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Andrea Vernengo, Nadine Kluser, Astrid Soubrier, Jan Gewiess, Jan Ulrich Jansen, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke, Zhen Li, Mauro Alini, Sibylle Grad
TISSUE ENGINEERING PART A
(2022)
Article
Medicine, General & Internal
Markus Windolf, Maximilian Heumann, Viktor Varjas, Caroline Constant, Manuela Ernst, Robert Geoff Richards, Hans-Joachim Wilke, Lorin Michael Benneker
Summary: Spinal fusion is a widely used intervention with complications. Current diagnostic methods are limited, but a new implantable sensor system has the potential to overcome these limitations. However, its application in spinal fusion has not been demonstrated yet.
MEDICINA-LITHUANIA
(2022)