Article
Biophysics
Jishizhan Chen
Summary: Bone defects pose challenges to healthcare systems, especially with the aging population. While biomaterials for bone fillers and scaffolds have been developed, the need for bone-mimetic materials still remains. Incorporating anisotropic structures in bone-facilitated scaffolds is crucial for better outcomes. Although various approaches have been used to create anisotropic micro/nanostructures, biomimetic bone anisotropic structures are still in the early stages of development.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Engineering, Biomedical
Peng Wang, Yonghui Yuan, Ke Xu, Hongshan Zhong, Yinghui Yang, Shiyu Jin, Ke Yang, Xun Qi
Summary: Copper is an essential trace element in the human body, impacting health through enzyme and protein functions. Researchers are increasingly focusing on developing novel copper-containing biomaterials with unique properties for cardiovascular protection, bone healing, and antibacterial effects. These materials also show potential in wound healing, cancer treatment, PET imaging, and radiotherapy applications.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Xiaohui Sun, Xiaoning Xu, Renhao Xue, Ligang Zhang, Libin Liu
Summary: Bio-piezoelectric materials can improve the osseointegration properties of implants by converting mechanical forces into electrical signals. In this study, perovskite piezoelectric materials were deposited on the surface of a zirconium alloy, giving the metallic biomaterial a favorable piezoelectric property. Biological experiments confirmed the promotion effect of the piezoelectric coated film on osteogenesis.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Article
Materials Science, Biomaterials
Hui-Jie Zhang, Fu-Shu Li, Feng Wang, Han Wang, Tong-Chuan He, Russell R. Reid, Bai-Cheng He, Qingyou Xia
Summary: Silk sericin-based hydrogel, derived from transgenic platelet-derived growth factor (PDGF)-BB, effectively enhances osteogenesis and inhibits adipogenic differentiation. The cross-talk between Smad and Stat3 pathways is involved in the synergistic induction of osteogenic differentiation by BMP9 and PDGF-BB in mesenchymal stem cells (MSCs).
REGENERATIVE BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Lijie Mao, Yanrong Yin, Lixin Zhang, Xiaolei Chen, Xinqing Wang, Fangping Chen, Changsheng Liu
Summary: Neutralizing acidity to improve cell proliferation and bone repair is a promising strategy. In this study, a polymer containing an alkaline fragment was synthesized and used to fabricate porous scaffolds, effectively neutralizing acidity and improving biocompatibility and cell adhesion and proliferation. The scaffolds also reduced inflammatory response and promoted bone cell regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Fanglin Wang, Qiao Wang, Yu Zhao, Zhiyu Tian, Shijie Chang, Hao Tong, Ningwei Liu, Shuling Bai, Xiang Li, Jun Fan
Summary: This study investigated the role of miR-150-5p and its related mechanisms in the osteogenesis of adipose-derived mesenchymal stem cells (ADSCs). The results showed that miR-150-5p regulates Notch3 during ADSCs osteogenesis. It was found that inhibition of miR-150-5p enhanced the osteogenic capacity of ADSCs, and partially reversed the inhibition effect of Notch3 knockdown on osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Sayan Deb Dutta, Dinesh K. Patel, Keya Ganguly, Ki-Taek Lim
Summary: Cellulose nanocrystals (CNCs) extracted from coffee grounds showed excellent physicochemical properties and biocompatibility, with enhanced mineralization and osteogenesis observed in a CNC-treated group compared with an untreated control group. The extracted CNCs have promising applications in tissue engineering, especially for bone tissues.
Article
Computer Science, Information Systems
Shuai Jin, Dan Qin, Bao-Sheng Liang, Li-Chuan Zhang, Xiao-Xia Wei, Yu-Jie Wang, Bing Zhuang, Tong Zhang, Zhen-Peng Yang, Yi-Wei Cao, San-Li Jin, Ping Yang, Bo Jiang, Ben-Qiang Rao, Han-Ping Shi, Qian Lu
Summary: This study developed and validated machine learning models for predicting cancer-associated deep vein thrombosis (DVT) using five algorithms. The best recommended model was visualized through a nomogram and web calculator. It provides assistance in evaluating individualized DVT risk and making decisions.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2022)
Article
Engineering, Biomedical
Angela R. Armiento, Karen Mys, Keith Thompson, Maria Hildebrand, Dirk Nehrbass, Stephan Zeiter, David Eglin, Martin J. Stoddart, Luan P. Hatt, Werner E. G. Mueller
Summary: Understanding the optimal conditions for bone healing is crucial for addressing non-unions and large bone defects. In this study, a tissue engineered complex combining bioactive factors, regenerative progenitor cells, and biomaterials was tested in vitro and in vivo. The results showed enhanced gene expression and mineral deposition in the biomaterials in vitro, but limited ectopic bone formation and no enhanced bone healing in vivo. The study highlights the discrepancy between in vitro and in vivo outcomes and calls for more complex in vitro models for translational studies.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Jie Wang, Yuan Chi, Baohui Yang, Qiongchi Zhang, Dong Wang, Xijing He, Haopeng Li
Summary: This study comprehensively analyzed the hotspots and future trends in biomaterials research for osteogenesis. It found that China has a leading position in global biomaterials research, and the mechanisms of osteogenesis, bone tissue engineering, and regenerative medicine will remain important areas of focus in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Long Zhu, Antian Huo, Yangqian Sun, Yanzhao Chen, Chongjiang Cao, Yueqin Zheng, Weiwei Guo
Summary: Inspired by artificial photosynthesis, a hydrogel formulation of a photocatalytic metal-organic cluster is designed for efficient generation of reactive oxygen species thus for bacteria killing and wound healing. It is approximately 99% efficient against S. aureus and E. coli at a low dosage (40 mu g mL-1), and its hydrogel formulation shows excellent therapeutic efficiency for healing wounds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Feng Peng, Longhai Qiu, Mengyu Yao, Lidan Liu, Yufeng Zheng, Shuilin Wu, Qingdong Ruan, Xuanyong Liu, Yu Zhang, Mei Li, Paul K. Chu
Summary: In this study, it was found that incorporating lithium into titanium implants can enhance immune-modulated osteogenesis and osseointegration, improving the osteogenic properties of bone implants. The beneficial effects of lithium doping on bone implants are achieved by regulating cascade molecules in the PI3K/AKT signaling pathway.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Danai Papadogianni, Maria Chatzinikolaidou
Summary: This study fabricated 3D scaffolds comprising kappa-carrageenan, chitosan, and gelatin, and evaluated their mechanical and biological properties for bone tissue engineering. The scaffolds showed appropriate degradation rate, pore size distribution, porosity, and exhibited the ability to support osteoblast proliferation and differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Hee Jeong Jang, Moon Sung Kang, Won-Hyeon Kim, Hyo Jung Jo, Sung-Ho Lee, Eun Jeong Hahm, Jung Hyun Oh, Suck Won Hong, Bongju Kim, Dong-Wook Han
Summary: We used 3D printing to fabricate graphene oxide (GO)-incorporated polylactic acid (PLA) films and explored their benefits as barrier membranes in guided bone regeneration (GBR). Our results showed that the 3D printed GO-PLA films provided a favorable environment for preosteoblasts and promoted new bone formation in rat calvarial bone defect models.
NANOSCALE ADVANCES
(2023)
Review
Chemistry, Physical
Francesco Baino, Maziar Montazerian, Enrica Verne
Summary: Improving angiogenesis is crucial for successful regenerative medicine approaches, and cobalt-doped bioactive glasses offer potential by combining traditional bioactivity with pro-angiogenic effects. Concerns about possible toxic effects on cells and tissues have been raised, but important biological improvements have been observed in vitro and in vivo. This review provides an overview of biomedical applications of Co-releasing glasses, including various products and their therapeutic applications in bone repair, wound healing, and cancer treatment, along with existing evidence and future challenges.
Article
Oncology
Hisaki Aiba, Kunihiro Ikuta, Kunihiro Asanuma, Katsuhisa Kawanami, Satoshi Tsukushi, Akihiko Matsumine, Daisuke Ishimura, Akihito Nagano, Yoji Shido, Eiji Kozawa, Kenji Yamada, Junji Wasa, Hiroaki Kimura, Takao Sakai, Hideki Murakami, Tomohisa Sakai, Tomoki Nakamura, Yoshihiro Nishida
Summary: This study investigated the effect of neoadjuvant therapy on highly malignant soft tissue tumors with tail-like lesions. The regression of lesions was related to the necrosis rate of the main part of the tumor but did not directly impact achieving surgery with a negative margin or improvements in oncological outcomes. A more comprehensive evaluation is necessary to elaborate on surgical strategy.
Article
Oncology
Tomoki Nakamura, Kunihiro Asanuma, Motoshi Takao, Takashi Yamanaka, Hiroshi Koike, Toyofumi F. Chen-Yoshikawa, Satoshi Tsukushi, Hiroaki Kuroda, Eiji Kozawa, Masaaki Sano, Hisaki Aiba, Ryoichi Nakanishi, Akihito Nagano, Kenji Yamada, Yoji Shido, Katsuhisa Kawanami, Yuya Izubuchi, Akihiro Sudo, Yoshihiro Nishida
Summary: The study investigated the oncological outcomes of lung metastasectomy and/or radiofrequency ablation in patients with soft tissue sarcoma. Results showed that complete treatment for the initial metastasis improved post-metastatic survival rates, with tumor size and number being important variables for clinical decision-making. Patients with a smaller single metastasis had better post-metastasis survival rates compared to those with larger and multiple metastases. The 5-year post-metastatic survival rates were higher for patients with a smaller single metastasis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Eiji Kozawa, Yoshihiro Nishida, Akira Kawai, Keiko Hayakawa, Nokitaka Setsu, Hiroyuki Kawashima, Shintaro Iwata, Hiroyuki Tsuchiya, Satoshi Tsukushi, Satoshi Takenaka, Jungo Imanishi, Ichiro Baba, Akihito Nagano, Takeshi Morii, Toshiharu Shirai, Koki Shimizu, Hirotaka Kawano
Summary: This study evaluated the survival rates and prognostic factors in patients with dedifferentiated chondrosarcoma or grade 3 chondrosarcoma in Japan. The prognosis of dedifferentiated chondrosarcoma remains poor, and more effective and/or intensive chemotherapeutic regimens or agents should be considered or developed.
Article
Orthopedics
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Kan Ito, Lisheng Zhuo, Kazuki Nishida, Koji Kimata, Kunihiro Ikuta, Tomohisa Sakai, Hiroshi Urakawa, Taisuke Seki, Shiro Imagama
Summary: This study investigated the metabolism of HA in OA and ONFH, finding that KIAA1199 is overexpressed in OA cartilage but less expressed in ONFH cartilage. Additionally, the molecular weight of HA increased in OA cartilage but decreased in ONFH cartilage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Oncology
Takeshi Morii, Ukei Anazawa, Chiaki Sato, Shintaro Iwata, Makoto Nakagawa, Makoto Endo, Tomoki Nakamura, Kunihiro Ikuta, Yoshihiro Nishida, Robert Nakayama, Toru Udaka, Teruya Kawamoto, Munehisa Kito, Kenji Sato, Jungo Imanishi, Toru Akiyama, Hiroshi Kobayashi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Toshihiko Nishisho, Keita Sasa, Yoshiyuki Suehara, Hirotaka Kawano, Takafumi Ueda, Hideo Morioka
Summary: Retrospective multicentric study analyzed the clinical characteristics, treatment outcomes, and risk factors for poor oncological outcomes in cases of dedifferentiated liposarcoma in the extremity or trunk wall. The study confirmed the typical clinical characteristics of dedifferentiated liposarcoma and identified independent risk factors for local recurrence, metastasis, and disease-specific mortality. Adequate evaluation and management of the dedifferentiated area, including grade, extension, and pathological margin, were crucial in the treatment of this entity.
Article
Multidisciplinary Sciences
Kunihiro Ikuta, Yoshihiro Nishida, Takehiro Ota, Satoshi Tsukushi, Eiji Kozawa, Hiroatsu Nakashima, Kenji Yamada, Satoshi Yamashita, Shiro Imagama
Summary: This study investigated the efficacy of Affinos on the healing process after filling bone defects. The results showed that radiographic evaluation and bone metabolic markers could predict the healing status at 12 months postoperatively in the defects followed by Affinos filling.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Tomohisa Sakai, Yoshihiro Nishida, Kan Ito, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Shiro Imagama
Summary: Active surveillance (AS) has been shown to be an effective treatment modality for desmoid-type fibromatosis (DF). Neck location and CTNNB1 S45F mutation are significant factors associated with the transition to active treatment.
Article
Oncology
Mikiya Ishihara, Yoshihiro Nishida, Shigehisa Kitano, Akira Kawai, Daisuke Muraoka, Fumiyasu Momose, Naozumi Harada, Yoshihiro Miyahara, Naohiro Seo, Hiroyoshi Hattori, Kohichi Takada, Makoto Emori, Shigeki Kakunaga, Makoto Endo, Yoshihiro Matsumoto, Tetsuro Sasada, Eiichi Sato, Tomomi Yamada, Akihiko Matsumine, Yasuhiro Nagata, Takashi Watanabe, Shinichi Kageyama, Hiroshi Shiku
Summary: The efficacy of immune checkpoint inhibitors is limited in refractory solid tumors. TCR-T-cell therapy combined with pullulan nanogel: LPA vaccine has shown promising results in a mouse sarcoma model resistant to immune checkpoint inhibition. In a phase 1 trial, NY-ESO-1-specific TCR-T-cell therapy plus vaccination with the pullulan nanogel carrying an LPA containing the NY-ESO-1 epitope without lymphodepletion was found to be feasible and induced long-lasting therapeutic effects in refractory synovial sarcoma patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Otorhinolaryngology
Takashi Okada, Hidetoshi Yamaguchi, Shinya Tanaka, Kyohei Koyama, Aika Hishida, Suzuna Konno, Masataka Nakamura, Hideshi Sugiura, Yoshihiro Nishida
Summary: The purpose of this study is to investigate whether grip strength can be used as an indicator of swallowing function. The results showed that grip strength assessment based on the criteria for sarcopenia can be a useful tool for estimating swallowing function.
Review
Oncology
Kunihiro Ikuta, Yoshihiro Nishida, Shiro Imagama, Kazuhiro Tanaka, Toshifumi Ozaki
Summary: Clear cell sarcoma (CCS) is a rare melanocytic soft tissue sarcoma with high lymphatic metastasis and poor prognosis. The management of CCS remains challenging due to its rarity, unique biology, and limited understanding of its molecular pathogenesis. Surgical excision is the standard treatment, but the role of adjuvant therapy is uncertain. Targeted therapies and immunotherapy show promise but further research is needed.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Souichi Suenobu, Keita Terashima, Masaharu Akiyama, Tomoyo Oguri, Asako Watanabe, Masatoshi Sugeno, Mitsuo Higashimori, Karen So, Yoshihiro Nishida
Summary: This study evaluated the use of Selumetinib in Japanese children with neurofibromatosis. The results showed that the medication had a certain improvement in the patients' condition and the side effects were manageable.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Oncology
Hiroshi Urakawa, Akihito Nagano, Ryunosuke Machida, Kazuhiro Tanaka, Tomoko Kataoka, Yuta Sekino, Yoshihiro Nishida, Mitsuru Takahashi, Toshiyuki Kunisada, Masanori Kawano, Yukihiro Yoshida, Tatsuya Takagi, Kenji Sato, Toru Hiruma, Hiroshi Hatano, Satoshi Tsukushi, Akio Sakamoto, Toshihiro Akisue, Koji Hiraoka, Toshifumi Ozaki
Summary: The superiority of preoperative denosumab was not observed in terms of relapse-free survival in patients with giant cell tumor of bone without possible post-operative large bone defect.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Yoshihiro Nishida, Akira Kawai
Summary: A survey conducted in Japan on extremity rhabdomyosarcoma treatment revealed the necessity of continuing and devising more efficient enlightenment activities. The study found that a low percentage of facilities performed both excision and lymph node dissection, indicating the need for improved educational activities on appropriate treatment modalities for this type of cancer.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Tomohito Hagi, Tomoki Nakamura, Akihito Nagano, Hiroshi Koike, Kenji Yamada, Hisaki Aiba, Nasa Fujihara, Junji Wasa, Kunihiro Asanuma, Eiji Kozawa, Daisuke Ishimura, Katsuhisa Kawanami, Yuya Izubuchi, Yoji Shido, Akihiro Sudo, Yoshihiro Nishida
Summary: This study investigated 55 patients with extremity soft tissue sarcoma who required amputation. The results showed that amputation is a useful treatment option for achieving local control, especially for patients with large tumors. Patients who underwent below the knee amputation had better survival prognosis and walking capabilities.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)