Review
Oncology
Sarah Killcoyne, Rebecca C. Fitzgerald
Summary: Cancer cells evolve through DNA mutation, cell selection, and population expansion, driven by mutated driver genes and structural alterations to the genome. Early genomic instability in Barrett's esophagus (BE) may lead to esophageal adenocarcinoma (EAC). Understanding these patterns and genomic changes can improve early detection of EAC and provide insights into cancer evolution.
NATURE REVIEWS CANCER
(2021)
Review
Gastroenterology & Hepatology
Nour Hamade, Amrit K. Kamboj, Rajesh Krishnamoorthi, Siddharth Singh, Leslie C. Hassett, David A. Katzka, Charles J. Kahi, Hala Fatima, Prasad G. Iyer
Summary: Through analysis of multiple studies, a statistically significant inverse correlation was found between neoplasia detection rate and post-endoscopy Barrett's neoplasia, indicating that with an increase in neoplasia detection rate, post-endoscopy Barrett's neoplasia decreases. Further studies are needed to validate this correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Emily L. Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Rebecca C. Fitzgerald
Summary: The controversy of whether gastric metaplasia should be considered as Barrett's esophagus is explored in this study. Through clinical and genomic analysis, the researchers found that the malignant potential of gastric metaplasia is lower than intestinal metaplasia. Therefore, the inclusion of gastric metaplasia in the surveillance of Barrett's esophagus is questionable.
Article
Oncology
Jouke J. H. van der Laan, Joost A. van der Putten, Xiaojuan Zhao, Arend Karrenbeld, Frans T. M. Peters, Jessie Westerhof, Peter H. N. de With, Fons van der Sommen, Wouter B. Nagengast
Summary: This study investigated whether artificial intelligence (AI) as a second assessor can assist doctors in assessing complex, microscopic endoscopy images for the presence of oesophageal cancer. The findings showed that the best diagnostic scores for cancer recognition emerged through the collaboration between doctors and AI as the second assessor.
Review
Oncology
Darragh O'Dowd, Jacintha O'Sullivan, Simone Marcone
Summary: Oesophageal adenocarcinoma (OAC) is a type of cancer with poor patient outcomes. Surveillance programs for its precursor lesion, Barrett's oesophagus (BO), are expensive and unpleasant. Prognostic and diagnostic biomarkers can improve surveillance and early detection, while predictive biomarkers can enhance individualized therapy.
Review
Oncology
Ksenia S. Maslyonkina, Alexandra K. Konyukova, Darya Y. Alexeeva, Mikhail Y. Sinelnikov, Liudmila M. Mikhaleva
Summary: Barrett's esophagus is a chronic and widespread disease that can progress to neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis. Research suggests that molecular, genetic, and epigenetic alterations in the esophagus occur earlier than cancerous transformation, providing insight into potential preventative strategies.
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Carlijn A. M. Roumans, Pauline A. Zellenrath, Ewout W. Steyerberg, Iris Lansdorp-Vogelaar, Michael Doukas, Katharina Biermann, Joyce Alderliesten, Gert van Ingen, Wouter B. Nagengast, Arend Karrenbeld, Frank ter Borg, Mariska Hage, Pieter C. J. ter Borg, Michael A. den Bakker, Alaa Alkhalaf, Frank C. P. Moll, Lieke Brouwer-Hol, Joop van Baarlen, Rutger Quispel, Arjan van Tilburg, Jordy P. W. Burger, Antonie J. P. van Tilburg, Ariadne H. A. G. Ooms, Thjon J. Tang, Marielle J. L. Romberg-Camps, Danny Goudkade, Marco J. Bruno, Dimitris Rizopoulos, Manon C. W. Spaander
Summary: Barrett's esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC). The cost-effectiveness of current surveillance strategies for BE is debatable. This multicenter prospective cohort study aimed to evaluate sex differences in 868 BE patients. The results showed that males had higher risk and shorter time to neoplastic progression, while females were more likely to be diagnosed with (advanced) EAC. These findings can guide the development of sex-specific guidelines and improve neoplastic risk stratification in BE surveillance.
Article
Cell Biology
Wladyslaw Januszewicz, Nastazja D. Pilonis, Tarek Sawas, Richard Phillips, Maria O'Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Adrienn Blasko, David A. Katzka, Rebecca C. Fitzgerald, Massimiliano di Pietro
Summary: This study assessed the utility of p53 immunohistochemistry in evaluating BE-IND specimens. The results showed that p53-IHC reduced the rate of BE-IND diagnoses and improved the interobserver agreement among pathologists.
Article
Gastroenterology & Hepatology
Noam Peleg, Hemda Schmilovitz-Weiss, Steven Shamah, Ariel Schwartz, Iris Dotan, Boris Sapoznikov
Summary: NLR can serve as a predictor for histologic progression in patients with BE, with a high discriminatory capacity for progression to HGD and EAC, especially effective in patients with NDBE.
Article
Pathology
Olli Helminen, Jukka Melkko, Juha Saarnio, Eero Sihvo, Teijo Kuopio, Pasi Ohtonen, Joonas H. Kauppila, Tuomo J. Karttunen, Heikki Huhta
Summary: The aim of this study was to evaluate the value of p53, Ki67, and toll-like receptor 5 (TLR5) in predicting the malignant progression of Barrett's esophagus. It was found that aberrant p53 expression is associated with a high risk of malignant progression in Barrett's low-grade dysplasia. Routine staining of p53 is recommended in expert confirmed low-grade dysplasia cases.
Article
Gastroenterology & Hepatology
Prashanthi N. Thota, Jalil Nasibli, Prabhat Kumar, Madhusudhan R. Sanaka, Amitabh Chak, Xuefeng Zhang, Xiuli Liu, Shikhar Uttam, Yang Liu
Summary: Nanoscale nuclear architecture mapping (nanoNAM) is a method for detecting structural alterations in the chromatin of epithelial cell nuclei. This study demonstrates that nanoNAM can be used to identify patients with Barrett's esophagus (BE) at risk for developing high-grade dysplasia or esophageal adenocarcinoma (EAC), and a prediction model based on nanoNAM features was developed.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Vidhi Patel, Madhusudhan R. Sanaka, Yi Qin, John McMichael, James Bena, Claire Beveridge, John Barron, Siva Raja, Jamak Modaresi Esfeh, Prashanthi N. Thota
Summary: This retrospective cohort study demonstrates that immunosuppressant use is associated with neoplastic progression in Barrett's esophagus (BE) patients, while solid organ transplantation (SOT) is not. Therefore, close surveillance of BE patients on chronic immunosuppressants needs to be considered.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Esther Klaver, Angela Bureo Gonzalez, Nahid Mostafavi, Rosalie Mallant-Hent, Lucas C. Duits, Bert Baak, Clarisse J. M. Bohmer, Arnoud H. A. M. van Oijen, Ton Naber, Pieter Scholten, Sybren L. Meijer, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: This study utilized a large, prospective community-based Barrett's cohort and found that Barrett's length, low-grade dysplasia, and age were important risk factors for progression to HGD/EAC.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Cell Biology
Xiuxu Chen, Bella Lingjia Liu, Noam Harpaz, Hongfa Zhu, Alexandros D. Polydorides, Qingqing Liu
Summary: The study aimed to investigate the role of p53 immunohistochemical expression and other clinical parameters as prognostic markers for predicting neoplastic progression in Barrett esophagus patients with indefinite dysplasia. The results showed that the number of indefinite dysplasia diagnoses and p53 expression status were associated with the risk of neoplastic progression.
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker
Summary: This study assessed the detection rate and positive predictive value (PPV) of advanced serrated polyps (ASPs) in a FIT-based screening program. The results showed that 5.9% of FIT-positive screenees had ASPs, and including ASPs slightly increased the yield of the screening.
Article
Oncology
Emilie C. H. Breekveldt, Esther Toes-Zoutendijk, Manon C. W. Spaander, Hilliene J. van de Schootbrugge-Vandermeer, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian R. B. Ramakers, Evelien Dekker, Iris D. Nagtegaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The Dutch colorectal cancer (CRC) screening programme based on faecal immunochemical testing has shown a decrease in advanced-stage CRC incidence after its introduction in 2014. The incidence initially increased before screening but later decreased and remained below expected levels. These findings provide evidence for the effectiveness of the Dutch screening programme in reducing advanced-stage CRC incidence.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Emilie C. H. Breekveldt, Esther Toes-Zoutendijk, Hilliene J. van de Schootbrugge-Vandermeer, Lucie de Jonge, Arthur I. Kooyker, Manon C. W. Spaander, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Evelien Dekker, Iris D. Nagtegaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The interval colorectal cancer (CRC) rate after negative fecal immunochemical testing (FIT) is an important quality indicator of CRC screening programs. Our study analyzed the outcomes of a FIT-based CRC screening program in the Netherlands, showing low incidence of interval CRC and high FIT-sensitivity. Risk-stratified CRC screening based on prior fecal hemoglobin concentration (f-Hb) may further optimize the screening program.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Sabine E. Hannema, Katja P. Wolffenbuttel, Yolande van Bever, Hennie T. Bruggenwirth, Sjoerd A. A. van den Berg, Remko Hersmus, J. Wolter Oosterhuis, Leendert H. J. Looijenga
Summary: Individuals with 45,X/46,XY or 46,XY gonadal dysgenesis have an increased risk of germ cell malignancies. This study aimed to determine if undetectable preoperative serum anti-Mullerian hormone (AMH) and inhibin B can predict the absence of germ cells or (pre)malignant conditions. The results suggest that undetectable AMH and inhibin B cannot reliably predict the absence of germ cells in individuals with gonadal dysgenesis. Rating: 8/10.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laurelle van Tilburg, Steffi E. M. van de Ven, Pieter Jan F. de Jonge, Wilmar de Graaf, Manon C. W. Spaander, Suzan Nikkessen, Jose A. Hardillo, Aniel Sewnaik, Dominiek A. Monserez, Hetty Mast, Stijn Keereweer, Marco J. Bruno, Robert Baatenburg J. de Jong, Arjun D. Koch
Summary: This study conducted endoscopic screening in patients with locally advanced or advanced head and neck squamous cell carcinoma (HNSCC), and found that 5% of patients had esophageal high-grade dysplasia and squamous cell carcinoma detected during screening. This suggests that endoscopic screening can help identify second primary tumors in patients at an early stage and improve survival.
Article
Oncology
Hilliene J. van de Schootbrugge-Vandermeer, Iris Lansdorp-Vogelaar, Lucie de Jonge, Anneke J. van Vuuren, Evelien Dekker, Manon C. W. Spaander, Christian R. B. Ramakers, Iris D. Nagtegaal, Folkert J. van Kemenade, Monique E. van Leerdam, Esther Toes-Zoutendijk
Summary: In the Dutch CRC screening programme, individuals who are single, have an immigrant background, and have low income are less likely to participate. Targeted interventions are needed to reduce inequalities.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Esther Toes-Zoutendijk, Lucie de Jonge, Carola Adriana van Iersel, Manon C. W. Spaander, Anneke J. van Vuuren, Folkert van Kemenade, Christian R. Ramakers, Evelien Dekker, Iris D. Nagetaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The study assessed the impact of delayed invitation on screen-detected and interval colorectal cancers (CRC) in a FIT-based CRC screening program. Individual-level data from individuals who participated in 2017 and 2018 with a negative FIT and were eligible for screening in 2019 and 2020 were analyzed. The results showed that the first COVID-19 wave had a modest impact on screening yield, and a small proportion of FIT negatives had interval CRC, possibly due to an extended invitation interval.
Review
Biochemistry & Molecular Biology
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. E. Wever, Christine L. L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Summary: Pluripotency is crucial for assessing stem cells, but there is a lack of standardization in the teratoma assay and ethical concerns about animal use. In vitro alternatives have been developed, but their use and malignancy testing remain limited. The teratoma assay is still preferred for safety assessment, highlighting the need for an in vitro assay for testing stem cell malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Summary: This study provides multi-omics profiling of malignant germ cell tumors (GCTs) across different age groups, showing that the WNT signaling pathway is activated in GCTs and is associated with poor clinical outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Manon C. W. Spaander, Ann G. Zauber, Sapna Syngal, Martin J. Blaser, Joseph J. Sung, Y. Nancy You, Ernst J. Kuipers
Summary: In the past decades, the incidence of early-onset colorectal cancer (CRC) or young-onset CRC (YO-CRC) has increased globally in both men and women. About 20% of YO-CRC patients have a hereditary cancer syndrome, while most cases have no genetic predisposition. Lifestyle changes such as antibiotic use, low physical activity, and obesity since the 1950s have been suggested as important factors in YO-CRC development by affecting the gut microbiome. Long-term prospective studies with childhood lifestyle data are needed to better understand the underlying mechanisms and relationships between environmental factors and YO-CRC.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Gastroenterology & Hepatology
Laurelle van Tilburg, Manon C. W. Spaander, Marco J. Bruno, Lindsey Oudijk, Lara R. Heij, Michail Doukas, Arjun D. Koch
Summary: This study investigated the risk of esophageal squamous cell carcinoma (ESCC) in patients with squamous dysplasia in a Western country and found that all patients with squamous dysplasia have a substantial risk of developing ESCC. Therefore, endoscopic surveillance or treatment should be considered for patients with mild-to-moderate dysplasia in Western countries.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Gastroenterology & Hepatology
Bas L. A. M. Weusten, Raf Bisschops, Mario Dinis-Ribeiro, Massimiliano di Pietro, Oliver Pech, Manon C. W. Spaander, Francisco Baldaque-Silva, Maximilien Barret, Emmanuel Coron, Gloria Fernandez-Esparrach, Rebecca C. Fitzgerald, Marnix Jansen, Manol Jovani, Ines Marques-de-Sa, Arti Rattan, W. Keith Tan, Eva P. D. Verheij, Pauline A. Zellenrath, Konstantinos Triantafyllou, Roos E. Pouw
Summary: This recommendation provides standards and guidelines for the surveillance, endoscopic eradication therapy, and follow-up of Barrett's esophagus (BE), including surveillance intervals, indications, precautions, and recommendations for different scenarios. The recommendation also indicates the level of recommendation and quality of evidence for each recommendation.
Article
Gastroenterology & Hepatology
Michiel C. Mommersteeg, Stella A. V. Nieuwenburg, Leonieke M. M. Wolters, Buddy H. C. M. Roovers, Hanneke A. J. van Vuuren, Auke P. Verhaar, Marco J. Bruno, Ernst J. Kuipers, Maikel P. Peppelenbosch, Manon C. W. Spaander, Gwenny M. Fuhler
Summary: This study investigates the feasibility of using non-invasive stool tests to verify successful Helicobacter pylori (H. pylori) eradication and determine clarithromycin resistance. The results indicate that H. pylori antigen testing on fecal immunochemical test (FIT) stool samples has similar accuracy as testing on dry stool samples.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Oncology
Francis S. P. L. Wens, Caroline C. C. Hulsker, Marta Fiocco, Jozsef Zsiros, Stephanie E. Smetsers, Ronald R. de Krijger, Alida F. W. van der Steeg, Ronald P. Zweemer, Inge O. Baas, Eva Maria Roes, Leendert H. J. Looijenga, Cornelis G. Gerestein, Annelies M. C. Mavinkurve-Groothuis
Summary: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive ovarian cancer with a poor prognosis. More research and international collaboration are needed to improve the treatment and outcome for SCCOHT patients. Mutations in the SMARCA4 gene play a crucial role in accurate diagnosis and may lead to new treatment options.
