Article
Neurosciences
Kathryn L. Mills, Kimberly D. Siegmund, Christian K. Tamnes, Lia Ferschmann, Lara M. Wierenga, Marieke G. N. Bos, Beatriz Luna, Chun Li, Megan M. Herting
Summary: This study examined individual variability and sex differences in changes in brain structure across ages 8.0-26.0 years. Results showed considerable inter-individual variability in brain measures, with most individuals demonstrating decreases in certain areas during mid-adolescence. There were also sex differences in these patterns and an association between brain structure size and rate of change.
Article
Psychology, Clinical
Divyangana Rakesh, Reham Elzeiny, Nandita Vijayakumar, Sarah Whittle
Summary: This study investigated the associations between childhood maltreatment, adolescent brain development and mental health trajectories. The findings showed significant differences in the associations between childhood maltreatment and the volume development of amygdala and hippocampus, as well as the coupling between subcortical regions and prefrontal cortex. Additionally, the study found that brain development played a mediating role in the association between maltreatment and depressive and anxiety symptom trajectories.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Sammy F. Ahmed, Alexa Ellis, Kaitlin P. Ward, Natasha Chaku, Pamela E. Davis-Kean
Summary: This study used nationally representative data to examine the development of working memory from ages 3 to 19. The results showed that working memory experienced the most rapid growth during childhood, followed by a brief accelerated period of growth during early adolescence. Similar developmental trajectories were found for males and females in the U.S. population.
DEVELOPMENTAL PSYCHOLOGY
(2022)
Review
Psychology, Social
Helena R. Slobodskaya
Summary: Research on personality development has been on the rise in recent years, primarily utilizing self-report questionnaires and parent/teacher ratings; The Big Five traits show the most evidence of age changes in personality, with less known about age differences in lower-order traits and lacking evidence on higher-order traits development.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Neurosciences
Zoey Y. Zhang, Ian G. Campbell, Pari Dhayagude, Harrison C. Espino, Irwin Feinberg
Summary: The study revealed age-related changes in sleep spindle characteristics, with spindle wave frequency increasing linearly with age, central spindle density peaking at 15.1 years, and spindle wave amplitude and duration showing different patterns of change. Sex differences were observed in spindle amplitude dynamics, with females experiencing the most rapid decline 1.4 years earlier than males. These findings suggest maturation of thalamocortical circuits and changes in sleep depth over the course of development.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Psychology, Multidisciplinary
Cynthia J. J. Willner, Jessica D. D. Hoffmann, Craig S. S. Bailey, Alexandra P. P. Harrison, Beatris Garcia, Zi Jia Ng, Christina Cipriano, Marc A. A. Brackett
Summary: This paper presents a systematic review on the development of cognitive reappraisal from early childhood to adolescence. It shows that cognitive reappraisal undergoes significant developmental changes in its use and effectiveness. The findings indicate that children's ability to regulate emotions through cognitive reappraisal improves with age. However, there are methodological differences in current studies, highlighting the need for consistency in future research.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Anatomy & Morphology
Marissa DiPiero, Patrik Goncalves Rodrigues, Alyssa Gromala, Douglas C. Dean III
Summary: Brain development during early life is a complex process that continues from the third trimester of gestation into the first decade of life. Understanding the structural changes that occur during this developmental period is crucial for detecting potential neurodevelopmental and psychiatric disorders later in life. This review examines the application, findings, and limitations of advanced diffusion magnetic resonance imaging (dMRI) methods in quantifying the microstructural changes that support brain development in early life.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Cardiac & Cardiovascular Systems
Georgios Georgiopoulos, Dimitrios Oikonomou, Konstantinos Pateras, Stefano Masi, Nikolaos Magkas, Dimitrios Delialis, Erold Ajdini, Victoria Vlachou, Kimon Stamatelopoulos, Marietta Charakida
Summary: This study found that smoking exposure is associated with early vascular damage in children and adolescents, affecting indices such as flow-mediated dilatation, pulse wave velocity, and carotid intima-media thickness. Both active and passive smoking were shown to have a negative impact on arterial health, emphasizing the importance of preventing smoking exposure in young age groups.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Psychology, Developmental
Eun Jung Choi, Marlee M. Vandewouw, Kathrina de Villa, Takeshi Inoue, Margot J. Taylor
Summary: This study investigated the developmental changes in the dorsal striatal network from childhood to adulthood. The results showed that connectivity within the striatum and to sensorimotor regions was established early in life and remained strong during adolescence. However, this connectivity diminished with age as behaviors became more efficient and automated. Adolescence was characterized by a transition phase where connectivity to the dorsolateral prefrontal cortex emerged, but connectivity to other brain regions only appeared in adults. This prolonged maturation in between-network integration may explain the cognitive and risk-taking behaviors observed in adolescence.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Serena Verdi, Seyed Mostafa Kia, Keir X. X. Yong, Duygu Tosun, Jonathan M. Schott, Andre F. Marquand, James H. Cole
Summary: Using neuroanatomical normative modeling, we found significant individual differences and outliers in cortical thickness in AD patients, MCI patients, and controls. These differences were associated with cognitive function, β-amyloid, phosphorylated-tau, and ApoE genotype. Cortical thickness heterogeneity was also predictive of conversion from MCI to AD.
Article
Pediatrics
Shinya Fujikawa, Lisa K. Mundy, Louise Canterford, Margarita Moreno-Betancur, George C. Patton
Summary: The study found high rates of bullying in both sexes during late childhood and early adolescence, with more persistent bullying observed in girls. Declines in bullying rates with the transition to secondary school and increasing age suggest the potential for interventions to further reduce the prevalence of bullying.
ACADEMIC PEDIATRICS
(2021)
Article
Neurosciences
Stefanie Dimov, Lisa K. Mundy, Jordana K. Bayer, Felice N. Jacka, Louise Canterford, George C. Patton
Summary: This study investigated the relationship between overall diet quality and mental health problems in pre-adolescent children, finding a negative association between overall diet quality and children's mental health. The use of a brief parent-report questionnaire with six items was shown to be effective as an indicator of overall diet quality.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Neuroimaging
Marissa A. DiPiero, Olivia J. Surgent, Brittany G. Travers, Andrew L. Alexander, Janet E. Lainhart, Douglas C. Dean III
Summary: In this study, Gray-Matter Based Spatial Statistics (GBSS) was used to analyze the cortical microstructure differences between autistic and typically developing males. The results showed increased neurite density in the right frontal, temporal, and occipital regions of autistic males. Negative correlations between neurite dispersion and autistic symptoms were also observed. These findings provide important insights into the neural basis of autism and may contribute to the development of personalized interventions.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychology, Developmental
Katerina Koutra, Katerina Margetaki, Mariza Kampouri, Andriani Kyriklaki, Theano Roumeliotaki, Marina Vafeiadi, Panos Bitsios, Manolis Kogevinas, Leda Chatzi
Summary: This study found that maternal sleep disturbances during late pregnancy could potentially affect the neuropsychological and behavioral development of children in preschool years, such as reducing cognitive abilities, memory functions, and increasing hyperactivity.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Mariah T. Hawes, McKenna R. Farrell, Jessica L. Cannone, Megan C. Finsaas, Thomas M. Olino, Daniel N. Klein
Summary: This study found relationships between child temperament at age 3 and IU in early adolescence, with higher levels of negative emotionality/neuroticism and lower levels of positive emotionality/extraversion predicting higher levels of IU. Unique relationships were found at the trait facet level, and differences were observed between informants.
JOURNAL OF ANXIETY DISORDERS
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Neurosciences
Catherine Lebel, Xiangyu Long
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Claire Donnici, Xiangyu Long, Jess Reynolds, Gerald F. Giesbrecht, Deborah Dewey, Nicole Letourneau, Yuankai Huo, Bennett Landman, Catherine Lebel
Summary: Prenatal depressive symptoms are associated with negative outcomes in children and predict later psychopathology. This study investigates the relationship between symptoms and brain structure development over time. Results show that moderate symptoms of prenatal depression are linked to changes in brain regions and networks involved in emotion processing, even in low socioeconomic risk samples.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Brandon T. Craig, Bryce Geeraert, Eli Kinney-Lang, Alicia J. Hilderley, Keith O. Yeates, Adam Kirton, Melanie Noel, Frank P. MacMaster, Signe Bray, Karen M. Barlow, Brian L. Brooks, Catherine Lebel, Helen L. Carlson
Summary: Developmental lateralization of brain function is crucial for behavioral specialization. This study compares the lateralization of structural connectivity patterns across different age groups and demonstrates that topological lateralization remains consistent throughout development. These findings highlight potential nonlinear mechanisms underlying developmental specialization.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Ashley L. Ware, Catherine Lebel, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates
Summary: This prospective cohort study investigated the trajectories of brain gray matter macrostructure after pediatric mild traumatic brain injury (mTBI). The study found that mTBI can alter the typical course of cortical gray matter thinning up to 6 months postinjury, even after symptoms typically abate in most children. Therefore, it is important to examine neurobiology in relation to clinical outcomes and within a neurodevelopmental framework.
Article
Neurosciences
Curtis Ostertag, Jess E. Reynolds, Preeti Kar, Deborah Dewey, W. Ben Gibbard, Christina Tortorelli, Catherine Lebel
Summary: This study aimed to investigate the impact of prenatal alcohol exposure (PAE) on the development of the arcuate fasciculus (AF) and pre-reading language skills in young children. The results showed that children with PAE had altered developmental trajectories in AF and exhibited similar brain-language relationships to younger typically developing children, regardless of age.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Sarah J. MacEachern, Preeti Kar, Daphne Nakhid, Elena Mitevska, Christina Tortorelli, Nils D. Forkert, Catherine Lebel, Carly A. McMorris, W. Ben Gibbard
Summary: Prenatal alcohol exposure (PAE) has negative effects on children's health, often accompanied by other adverse exposures. The association between multiple adverse exposures and health concerns and atypical behaviors in children with PAE is unclear.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biology
Ford Burles, Rebecca Williams, Lila Berger, G. Bruce Pike, Catherine Lebel, Giuseppe Iaria
Summary: After spaceflight, astronauts experience upward shifting of the brain and redistribution of cerebrospinal fluid. Brain volume changes observed in astronauts are contaminated by preprocessing errors and may not be direct evidence of neuroplastic adaptation. New preprocessing methods or experimental paradigms are needed to resolve this issue in space health research.
Article
Medicine, Research & Experimental
E. Bailin Xie, Makayla Freeman, Lara Penner-Goeke, Kristin Reynolds, Catherine Lebel, Gerald F. Giesbrecht, Charlie Rioux, Anna MacKinnon, Shannon Sauer-Zavala, Leslie E. Roos, Lianne Tomfohr-Madsen
Summary: This study investigates the feasibility, acceptability, and efficacy of an online group therapy and app-based program for mothers of infants. The results show moderate levels of feasibility and strong preliminary efficacy of the program.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Neurosciences
Meaghan V. Perdue, Marilena M. DeMayo, Tiffany K. Bell, Elodie Boudes, Mercedes Bagshawe, Ashley D. Harris, Catherine Lebel
Summary: Metabolites in the brain have important roles in development, with rapid changes during prenatal and infancy stages. However, there is limited research on neurochemistry changes in early-middle childhood. In this study, we analyzed the levels of key metabolites in two brain regions using magnetic resonance spectroscopy in children aged 2-11 years. We found significant age-related changes in metabolite levels, suggesting their involvement in structural and functional brain development.
Article
Multidisciplinary Sciences
Catherine Lebel, Lianne Tomfohr-Madsen, Gerald Giesbrecht, Beatrice Pui Yee Lai, Mercedes Bagshawe, Makayla Freeman, Mary Kate Hapin, Anna MacKinnon, Palak Patel, Melinda van Sloten, Marcel van de Wouw
Summary: This study aimed to understand the impact of COVID-19-related stresses on pregnant individuals and their infants in Canada. The dataset collected includes baseline prenatal data and basic birth outcomes, providing valuable information for researching stress during pregnancy or birth outcomes during the COVID-19 pandemic.
Article
Pediatrics
Fanny Degeilh, Jessica Lacombe-Barrios, Carola Tuerk, Catherine Lebel, Veronique Daneault, Ramy El-Jalbout, Jocelyn Gravel, Sylvain Deschenes, Josee Dubois, Chantale Lapierre, Isabelle Gagnon, Mathieu Dehaes, Thuy Mai Luu, Miriam H. Beauchamp
Summary: This study aimed to compare the effectiveness of a brief behavioral-play familiarization for acquiring non-sedated MRI in young children with and without mTBI and identify factors associated with successful MRI acquisition. The results showed that the success rate of acquiring MRI using behavioral-play familiarization was comparable between the mTBI group and the control group. Factors associated with success included older child age and fewer parental concerns about the MRI procedure.
PEDIATRIC RADIOLOGY
(2023)
Article
Clinical Neurology
Ashley L. Ware, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Sylvain Deschenes, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates, Catherine Lebel
Summary: Advanced diffusion-weighted imaging techniques have enhanced understanding of the neuropathology of paediatric mild traumatic brain injury. This study compared the structural connectome of children with concussion to those with mild orthopaedic injury and found that regional network metrics in the post-acute phase can distinguish concussion from mild orthopaedic injury and predict symptom recovery at 1-month post-injury.
BRAIN COMMUNICATIONS
(2023)
Article
Pediatrics
Sarah Fletcher, David Lardner, Mercedes Bagshawe, Lisa Carsolio, Martin Sherriff, Cathy Smith, Catherine Lebel
Summary: Mock scanner training, play-based training, and home book and video preparation were all effective in allowing non-sedated clinical MRI scanning in children aged 3-7 years. Most young children can tolerate awake MRI scans and do not need to be routinely anesthetized.
PEDIATRIC RADIOLOGY
(2023)
Article
Substance Abuse
Daphne Nakhid, Darpal Patel, Carly A. Mcmorris, W. Ben Gibbard, Christina Tortorelli, Jacqueline Pei, Catherine Lebel
Summary: This study investigates the impact of prenatal alcohol exposure on brain structures in youth and its association with depression and anxiety symptoms. The findings show that youth with prenatal alcohol exposure have smaller volumes in the hippocampus and thalamus, and there is a negative association between depression and anxiety symptoms and limbic subregion volumes.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)