Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Review
Pharmacology & Pharmacy
Xiaohong Li, Weichen Yuan, Jibiao Wu, Jianhua Zhen, Qihui Sun, Minmin Yu
Summary: Andrographolide, a natural active ingredient derived from Andrographis paniculata, has anti-inflammatory effects and can be used to treat various inflammatory diseases. It acts on multiple inflammation-related signaling pathways and has potential clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jingxuan Liu, Yueying Yang, Xiao Liu, Andy Samuel Widjaya, Baohong Jiang, Yanyan Jiang
Summary: The study suggests that utilizing nanotherapy, such as PM/TN-CCLP, can significantly prevent and treat aortic dissection by reducing the rupture rate, preventing loss of elastic fibers, and decreasing inflammation at the lesion site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Kariagina, Andrea I. Doseff
Summary: Flavones, natural phytochemicals found in our diet, possess anti-inflammatory properties that can effectively control the innate immune system and inflammation. They play a significant role in chronic inflammation, particularly in obesity and cancer, by influencing molecular mechanisms. Flavones restore immune landscape by impacting innate immune cell repertoire and reestablish immune homeostasis through NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways. With no adverse side effects, flavones could be alternative opportunities for treating and preventing chronic inflammation associated with obesity and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Biochemistry & Molecular Biology
Valerio Chiurchiu, Lucia Scipioni, Beatrice Arosio, Daniela Mari, Sergio Oddi, Mauro Maccarrone
Summary: Growing evidence suggests that the immune system plays a critical role in the pathogenesis and progression of Alzheimer's disease, with targeting peripheral immune mechanisms showing promise as therapeutic strategies. Research has found that in AD patients, there is significantly reduced expression of CB1 and CB2 in B-lymphocytes, and decreased CB2 and increased FAAH in monocytes. Pharmacological inactivation of FAAH in monocytes from AD patients can modulate immune responses by altering cytokine production.
Article
Neurosciences
Katrin Richter, Roger L. Papke, Clare Stokes, Danika C. Roy, Eduardo S. Espinosa, Philipp M. K. Wolf, Andreas Hecker, Juliane Liese, Vijay K. Singh, Winfried Padberg, Klaus-Dieter Schluter, Marius Rohde, J. Michael McIntosh, Barbara J. Morley, Nicole A. Horenstein, Veronika Grau, Alain R. Simard
Summary: Activation of nicotinic acetylcholine receptors can attenuate pro-inflammatory responses, and silent nAChR agonists are expected to be effective in preventing and treating various inflammatory diseases by down-modulating inflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Iason Thomas, Ioannis Panagoulias, Ioanna Aggeletopoulou, Anastasia Varvarigou, Bessie E. Spiliotis, Athanasia Mouzaki
Summary: In children with acute ITP, leptin levels were significantly increased and inversely correlated with platelet count. IVIg treatment maintained high leptin levels, while steroid treatment lowered leptin below control levels. Leptin acts as an active anti-inflammatory agent in childhood ITP by promoting IL-10 secretion by monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Hashim Islam, Helena Neudorf, Alice L. Mui, Jonathan P. Little
Summary: Interpreting changes in circulating cytokine concentrations as evidence for altered inflammation may overlook important functional changes in cytokine action at the tissue/cellular level, due to factors influencing cytokine function. Therefore, relying solely on changes in cytokine concentrations may miss significant alterations in inflammatory processes.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Endocrinology & Metabolism
Robin Kristofi, Jan W. Eriksson
Summary: Metformin, a widely used drug for type 2 diabetes, primarily lowers blood glucose by suppressing hepatic gluconeogenesis and has anti-inflammatory effects, possibly through AMP kinase activation and inhibition of mTOR and NF-κB pro-inflammatory signaling pathways.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Melanie A. Kimm, Christopher Klenk, Marianna Alunni-Fabbroni, Sophia Kaestle, Matthias Stechele, Jens Ricke, Michel Eisenblaetter, Moritz Wildgruber
Summary: This review provides an overview of the origin of tumor-associated macrophages, their polarization into different subtypes, and how characteristic markers of the subtypes can be used as targets for molecular imaging and theranostic approaches.
Article
Biochemistry & Molecular Biology
Malgorzata Koltun-Jasion, Paulina Sawulska, Andrzej Patyra, Marta Wozniak, Marta Katarzyna Dudek, Agnieszka Filipek, Anna Karolina Kiss
Summary: Inflammation is the body's defense mechanism against external and internal stimuli. However, an inappropriate immune response can lead to chronic diseases. Phytotherapy, especially raw materials with a long tradition of use, may play a role in alleviating inflammatory processes. This study aims to analyze the phytochemicals in ash leaves and evaluate their effects on anti-inflammatory cytokines in monocyte/macrophage cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Karen Alvarez, Mauricio Rojas
Summary: Autoimmune diseases are challenging to diagnose and treat. Nanoparticles offer promising strategies for targeting monocyte populations and delivering drugs for the diagnosis and treatment of autoimmune diseases. This field of research is of great importance.
Review
Immunology
Maedeh Arabpour, Amene Saghazadeh, Nima Rezaei
Summary: MSC-derived exosomes have the potential to polarize M2 macrophages and modulate inflammation in various diseases and conditions like CNS diseases, autoimmune diseases, inflammatory bowel disease, and cardiomyopathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhoefer, Georgiana Crainiciuc, Jonas Hahn, Anika Grueneboom, Falk Nimmerjahn, Stefan Uderhardt, Andres Hidalgo, Georg H. Schett, Markus Hoffmann, Gerhard Kroenke
Summary: The authors have found that the anti-inflammatory effects of clodronate liposomes are not due to the depletion of mononuclear phagocytes, but rather a functional inhibition of polymorphonuclear neutrophils. This finding calls for a critical revision of the current literature on the role of monocytes and macrophages in inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ana P. Silva, Carla S. B. Viegas, Patricia Guilherme, Nelson Tavares, Carolina Dias, Fatima Rato, Nelio Santos, Marilia Faisca, Edgar de Almeida, Pedro L. Neves, Dina C. Simes
Summary: Accelerated and premature cardiovascular calcification is common in chronic kidney disease patients, with valvular calcification being a critical indicator of cardiovascular disease. Low levels of Gla-rich protein (GRP) and magnesium, along with high levels of phosphate, are associated with mitral and aortic valves calcification. The diagnostic value of GRP may be potentially useful in assessing cardiovascular risk in this population.
Article
Biochemistry & Molecular Biology
Carla S. B. Viegas, Nuna Araujo, Joana Carreira, Jorge F. Pontes, Anjos L. Macedo, Mauricia Vinhas, Ana S. Moreira, Tiago Q. Faria, Ana Grenha, Antonio A. de Matos, Leon Schurgers, Cees Vermeer, Dina C. Simes
Summary: In this study, nanoparticles were produced to enhance the bioavailability, stability, and anti-inflammatory potential of Gla-rich protein. The results showed that the nanoparticles had suitable characteristics for biomedical applications and exhibited anti-inflammatory activity in vitro, indicating their potential therapeutic application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Melanie Silva, Farah Kamberovic, Sisay Tesema Uota, Ismael-Mohammed Kovan, Carla S. B. Viegas, Dina C. Simes, Katkam N. Gangadhar, Joao Varela, Luisa Barreira
Summary: Microalgae are a promising source of bioactive compounds with potential applications in antioxidant, anti-tumoral, and metal chelation activities. Different species of microalgae extracts showed various bioactivities, suggesting their potential use in functional food and pharmaceutical industries.
APPLIED SCIENCES-BASEL
(2022)
Editorial Material
Oncology
Paula Alexandra Videira, Marco Borghesi, Eric A. A. Singer
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Sobral, Rita Francisco, Laura Duro, Paula Alexandra Videira, Ana Rita Grosso
Summary: This study provides insight into the complex role of glycosylation in humans by combining genome and transcriptome profiles. It reveals that glycosylation factors are tightly regulated in healthy tissues, but impaired in aging and tumorigenesis. They may serve as potential prognostic biomarkers or therapeutic targets.
Article
Biochemistry & Molecular Biology
Mariarita Brancaccio, Alfonsina Milito, Carla Alexandra Viegas, Anna Palumbo, Dina Costa Simes, Immacolata Castellano
Summary: The use of ovothiol (ovo) and 5-thiohistidine (5-thio) in skin cells and tissues can reduce inflammation, providing skin protection and preventing inflammatory conditions caused by environmental stress and aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Genetics & Heredity
C. Pascoal, I Ferreira, C. Teixeira, E. Almeida, A. Slade, S. Brasil, R. Francisco, A. N. Ligezka, E. Morava, H. Plotkin, J. Jaeken, P. A. Videira, L. Barros, V. dos Reis Ferreira
Summary: This study aimed to identify the most impactful clinical signs and symptoms of PMM2-CDG, as well as patient and observer reported outcome measures (PROMs and ObsROMs) that can adequately assess the impact on patients' quality of life (QoL). The identified signs and symptoms were verified and refined, and PROMs/ObsROMs from other diseases were analyzed for potential use in PMM2-CDG. These findings are crucial for the development of a specific QoL questionnaire and can be applied to other CDG and rare diseases.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Environmental Sciences
Rita Francisco, Susana Alves, Catarina Gomes, Pedro Granjo, Carlota Pascoal, Sandra Brasil, Alice Neves, Ines Santos, Andrea Miller, Donna Krasnewich, Eva Morava, Christina Lam, Jaak Jaeken, Paula A. Videira, Vanessa dos Reis Ferreira
Summary: This study developed a methodology for clinical management guidelines (CMGs) that addresses the needs and preferences of family and professional stakeholders. Using the CDG community as a pilot, the researchers surveyed families and professionals to understand their needs and preferences related to CMGs. Based on the results, a participatory framework was created to improve CMG comprehension and accessibility. The study highlights the importance of involving stakeholders and adapting CMGs to their preferences and language.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Carlota Pascoal, Mylene A. Carrascal, Daniela F. Barreira, Rita A. Lourenco, Pedro Granjo, Ana R. R. Grosso, Paula Borralho, Sofia Braga, Paula A. A. Videira
Summary: This study investigated the relevance of sLe(X/A) in TNBC by analyzing patient tissues, cell lines, and datasets. The results showed that sLe(X/A) is associated with lower disease-free survival in TNBC patients and negatively correlated with cytokeratins. Inhibition of sLe(X/A) increased the expression of cytokeratins and reduced proliferation and invasion capacity in vitro. This study highlights sLe(X/A) as a critical biomarker and potential therapeutic target for TNBC.
Review
Biochemistry & Molecular Biology
Patricia S. Sobral, Vanessa C. C. Luz, Joao M. G. C. F. Almeida, Paula A. Videira, Florbela Pereira
Summary: Computational approaches are being used to identify potential immune targets and develop novel drugs in immune-oncology therapies, with a particular focus on PD-1/PD-L1 immune checkpoint inhibitors. These approaches involve analyzing large datasets of molecules, gene expression, and protein-protein interactions using cheminformatics and bioinformatics tools. The computational methodologies used in the discovery and development of PD-1/PD-L1 inhibitors, such as computer-aided drug design and virtual screening, are discussed. Recent databases and web tools related to cancer and immunotherapy are also compiled to aid in this research. In summary, computational approaches have become valuable tools for discovering and developing immune checkpoint inhibitors, but there is still a need for improved drugs and biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Catia Goncalves, Antonio P. Alves de Matos, Pedro M. Costa
Summary: Polychaeta are highly diversified invertebrates that possess unique jaw apparatus, revealing defense and predation mechanisms as well as their relation to environmental chemistry. This study compared the structure and chemical profile of the jaws from different estuarine Polychaeta species, revealing differences in structure and chemistry that are related to their feeding habits and environmental adaptations.
JOURNAL OF ANATOMY
(2023)
Review
Chemistry, Analytical
Hugo M. Santos, Luis B. Carvalho, Carlos Lodeiro, Goncalo Martins, Ines L. Gomes, Wilson D. T. Antunes, Vanessa Correia, Maria M. Almeida-Santos, Helena Rebelo-de-Andrade, Antonio P. A. Matos, J. L. Capelo
Summary: This work presents a tutorial on the capabilities of bioanalytical mass spectrometry in detecting and differentiating viruses at the peptide level, as well as providing diagnosis and prognosis for infected patients. It offers insights into the possibilities of current high-resolution mass spectrometry technology and bioinformatics.
MICROCHEMICAL JOURNAL
(2023)