Article
Biochemistry & Molecular Biology
Sophida Phuthong, Cynthia Guadalupe Reyes-Hernandez, Pilar Rodriguez-Rodriguez, David Ramiro-Cortijo, Marta Gil-Ortega, Raquel Gonzalez-Blazquez, M. Carmen Gonzalez, Angel Luis Lopez de Pablo, Silvia M. Arribas
Summary: Fetal undernutrition has a significant impact on cardiometabolic diseases, with males showing higher susceptibility. The study revealed that male fetuses demonstrate poorer adaptation to undernutrition, associated with oxidative imbalance, reduced vascularization, and glucocorticoid barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Yubo Ma, Juan Chen, Hecheng Li, Fangshi Xu, Tie Chong, Ziming Wang, Liandong Zhand
Summary: This study combines testicular culture and xenotransplantation to create an integrative model for the study of testicular development. The results show that immature testicular tissue can survive and continue to develop in this model. However, some changes in testicular gene expression and signs of oxidative damage were observed, indicating the need for further study to optimize the model.
BIOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mohamed A. El-Mahdy, Elsayed M. Mahgoup, Mohamed G. Ewees, Mahmoud S. Eid, Tamer M. Abdelghany, Jay L. Zweier
Summary: A chronic mouse exposure model that mimics human e-cigarette vaping was developed and utilized for longitudinal studies of alterations in cardiovascular function. The study found that long-term vaping can induce cardiovascular diseases similar to smoking, with severity increasing with exposure duration and nicotine content.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Manuela Zinni, Julien Pansiot, Marina Colella, Valerie Faivre, Andree Delahaye-Duriez, Francois Guillonneau, Johanna Bruce, Virginie Salnot, Jerome Mairesse, Marit Knoop, Marie-Laure Possovre, Daniel Vaiman, Olivier Baud
Summary: The study found that IUGR induced by LPD significantly affects the development and proteome of microglial cells. Proteins associated with fetal growth, inflammation, immune response, and oxidative stress were significantly enriched or upregulated in LPD microglia at P1 and P4. Additionally, differences in protein expression were observed between control and LPD microglia during postnatal development.
Article
Biochemistry & Molecular Biology
Jian Yang, Van Anthony M. Villar, Pedro A. Jose, Chunyu Zeng
Summary: The kidney plays a crucial role in blood pressure control, with dopamine regulating oxidative stress. Understanding the antioxidative effects of renal dopamine receptors is important in hypertension pathogenesis.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Pauline Robert, Phuc Minh Chau Nguyen, Alexis Richard, Celine Grenier, Arnaud Chevrollier, Mathilde Munier, Linda Grimaud, Coralyne Proux, Tristan Champin, Eric Lelievre, Emmanuelle Sarzi, Emilie Vessieres, Samir Henni, Delphine Prunier, Pascal Reynier, Guys Lenaers, Celine Fassot, Daniel Henrion, Laurent Loufrani
Summary: The study found that mitochondrial fusion plays a protective role in hypertension by reducing oxidative stress. Defects in mitochondrial fusion worsen hypertension. Additionally, increased mitochondrial ROS production leads to apoptosis in vascular cells and decreased proliferation of VSMCs.
Article
Pharmacology & Pharmacy
Lukas Roubenne, Margaux Laisne, David Benoist, Marilyne Campagnac, Benedicte Prunet, Philippe Pasdois, Guillaume Cardouat, Thomas Ducret, Jean-Francois Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Bruno Le Grand, Veronique Freund-Michel, Christelle Guibert
Summary: The drug OP2113 has a selective protective effect on PA and RV alterations in rats with CH-PH, without side effects in control rats. It improves PA remodeling and hyperreactivity and increases mitochondrial mass in the RV. However, it has no effect on oxidative stress.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ilhem Shili, Yosra Hamdi, Ammar Marouani, Zakaria Ben Lasfar, Taoufik Ghrairi, Benjamin Lefranc, Jerome Leprince, David Vaudry, Masmoudi-Kouki Olfa
Summary: The study demonstrates that PACAP has potent neuroprotective effects against alcohol toxicity during brain development. It can alleviate behavioral abnormalities caused by prenatal ethanol exposure, suggesting that PACAP or its analogs may be a useful tool for treating alcohol intoxication during pregnancy.
Review
Biochemistry & Molecular Biology
Marion Mueller, Elfi Donhauser, Tibor Maske, Cornelius Bischof, Daniel Dumitrescu, Volker Rudolph, Anna Klinke
Summary: In order to develop targeted therapies for the growing patient population with right ventricular dysfunction (RVD) and right heart failure (RHF), molecular processes underlying these conditions need to be understood. Mitochondrial dysfunction has been identified as a potential key player in the development of RHF, affecting mitochondrial biogenesis, substrate utilization, redox balance, and oxidative phosphorylation. This review aims to comprehensively analyze the current knowledge on mitochondrial dysregulation in RVD and RHF and its relationship with the functional aspects of the right ventricle (RV).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sukhchain Kaur, Rubal, Satveer Kaur, Amandeep Kaur, Sandeep Kaur, Sushil Gupta, Sunil Mittal, Monisha Dhiman
Summary: The present study aims to understand the complex interaction between oxidative stress, inflammation and antioxidant system in hypertension. It is observed that metabolic markers are altered in hypertensive subjects, showing increased oxidative and inflammatory profiles and compromised antioxidant status compared to normotensive subjects. Correlation analysis validates the involvement of inflammation and oxidative stress in impaired endothelial function and vital organ damage.
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Javier Bermejo, Ana Gonzalez-Mansilla, Teresa Mombiela, Ana I. Fernandez, Pablo Martinez-Legazpi, Raquel Yotti, Rocio Garcia-Orta, Pedro L. Sanchez-Fernandez, Mario Castano, Javier Segovia-Cubero, Pilar Escribano-Subias, J. Alberto San Roman, Xavier Borras, Angel Alonso-Gomez, Javier Botas, Maria G. Crespo-Leiro, Sonia Velasco, Antoni Bayes-Genis, Amador Lopez, Roberto Munoz-Aguilera, Manuel Jimenez-Navarro, Jose R. Gonzalez-Juanatey, Arturo Evangelista, Jaime Elizaga, Javier Martin-Moreiras, Jose M. Gonzalez-Santos, Eduardo Moreno-Escobar, Francisco Fernandez-Aviles
Summary: The study reveals that the presence of pulmonary hypertension following successful correction of valvular heart disease is associated with a higher mortality rate, which is related to factors such as pulmonary vascular resistance, diabetes mellitus, and residual effective valve area. These findings have significant implications for individualizing valve correction procedures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Shiori Minabe, Kinuyo Iwata, Youki Watanabe, Hirotaka Ishii, Hitoshi Ozawa
Summary: This study found that intrauterine malnutrition has long-term adverse effects on the reproductive center kisspeptin-neurokinin B-dynorphin A (KNDy) neurons in the hypothalamic arcuate nucleus (ARC) of female offspring. Female offspring of undernourished dams showed low birth weight and signs of precocious puberty. Furthermore, the number of KNDy gene-expressing cells significantly decreased in the offspring after 29 weeks of age.
ENDOCRINE CONNECTIONS
(2023)
Article
Public, Environmental & Occupational Health
Robbie M. Parks, Yanelli Nunez, Arin A. Balalian, Elizabeth A. Gibson, Johnni Hansen, Ole Raaschou-Nielsen, Matthias Ketzel, Jibran Khan, Jorgen Brandt, Roel Vermeulen, Susan Peters, Jeff Goldsmith, Diane B. Re, Marc G. Weisskopf, Marianthi-Anna Kioumourtzoglou
Summary: This study found a high probability of a positive association between ALS diagnosis and elemental carbon concentration. There were negative associations for nitrogen oxides, carbon monoxide, and no association for non-elemental carbon fine particles. Further research is needed to understand the role of traffic-related air pollution in ALS pathogenesis.
Article
Environmental Sciences
Sibel Silici, Leylagul Kaynar, Asli Okan, Zueleyha Doganyigit
Summary: This study investigated the effect of olive oil extract of propolis (OEP) on rats receiving tamoxifen (TAM) treatment. The results showed that the combined application of OEP and TAM improved hematological and antioxidant parameters and reduced tissue damage.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Neurosciences
Jesus Fernandez-Felipe, Maria Valencia-Avezuela, Beatriz Merino, Beatriz Somoza, Victoria Cano, Ana B. Sanz-Martos, Laura M. Frago, Maria S. Fernandez-Alfonso, Mariano Ruiz-Gayo, Julie A. Chowen
Summary: This study found that diets rich in fatty acids can increase body weight and adiposity, even without increased energy intake. Different intake of saturated and unsaturated fatty acids can differentially modify metabolic parameters. Further research is needed to understand how specific nutrients affect metabolism and obesity-associated complications.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pilar Rodriguez-Rodriguez, Kendal Ragusky, Sophida Phuthong, Santiago Ruvira, David Ramiro-Cortijo, Silvia Canas, Miguel Rebollo-Hernanz, Maria Dolores Morales, Angel L. Lopez de Pablo, Maria A. Martin-Cabrejas, Silvia M. Arribas
Summary: This study investigates the vasodilatory effects of cocoa shell extract and its potential to improve age-induced endothelial dysfunction. The findings suggest that cocoa shell extract has vasodilatory properties associated with increased nitric oxide bioavailability, mainly due to its antioxidant components, particularly protocatechuic acid. Therefore, cocoa shell extract has the potential to be used as a food ingredient for diseases related to endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Maria Sofia Vieira-Rocha, Joana Beatriz Sousa, Pilar Rodriguez-Rodriguez, Silvia Madaglena Arribas, Carmen Diniz
Summary: Sympathetic hyperinnervation may be one of the contributors to vascular remodelling and hypertension in rats exposed to undernutrition during intrauterine life.
Article
Environmental Sciences
Gema Cabrera-Dominguez, Maria de la Calle, Gloria Herranz Carrillo, Santiago Ruvira, Pilar Rodriguez-Rodriguez, Silvia M. Arribas, David Ramiro-Cortijo
Summary: Sleep, mental health, and physical activity are crucial for women's wellbeing. During the lactation period, poor sleep quality, decreased physical activity, and lower social support may lead to inadequate mental health adjustment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
David Ramiro-Cortijo, Sonia Del Pozo Arribas, Lidia Inisterra Viu, Natalia Garcia Vazquez, Miguel Saenz de Pipaon
Summary: Resolution of cholestasis was observed in 73.7% of infants after receiving Omegaven (TM) as a replacement for the previous partially fish oil-based emulsion. The use of a 100% fish oil-based emulsion was associated with a decrease in bilirubin levels.
Article
Endocrinology & Metabolism
David Ramiro-Cortijo, Pratibha Singh, Gloria Herranz Carrillo, Andrea Gila-Diaz, Maria A. Martin-Cabrejas, Camilia R. Martin, Silvia M. Arribas
Summary: Preterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, but breast milk can counteract these effects. Preterm infants have abnormal levels of adipokines and gut hormones, which are also present in breast milk and may improve infant growth. The study found that breast milk from women with preterm labor had lower ghrelin levels and higher levels of other hormones. In premature infants, growth was positively associated with breast milk ghrelin, while in term infants, it was positively associated with insulin and negatively with peptide YY.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Santiago Ruvira, Pilar Rodriguez-Rodriguez, Silvia Canas, David Ramiro-Cortijo, Yolanda Aguilera, David Munoz-Valverde, Silvia M. Arribas
Summary: A protocol using small gelatin cubes to train rats was developed, and most animals were easily trained to accept the gelatin cube in 2-3 days. Sex and fasting influenced the acceptance rate, while flavoring and sweeteners did not. Rats trained with the gelatin-based supplement during lactation showed no problems with their pups.
Article
Biochemistry & Molecular Biology
Silvia Canas, Miguel Rebollo-Hernanz, Patricia Bermudez-Gomez, Pilar Rodriguez-Rodriguez, Cheyenne Braojos, Alicia Gil-Ramirez, Vanesa Benitez, Yolanda Aguilera, Maria A. Martin-Cabrejas
Summary: The digestion process can modify the bioaccessibility, bioavailability, and bioactivity of phenolic compounds found in cocoa shell, a by-product of the cocoa industry. This study assessed the influence of simulated gastrointestinal digestion on the concentration of phenolic compounds in cocoa shell flour and extract, as well as their antioxidant activity in intestinal epithelial and hepatic cells. The results showed that gastrointestinal digestion increased the antioxidant capacity of cocoa shell and exhibited free radical scavenging capacity. The cocoa shell did not show cytotoxicity and effectively countered oxidative stress in both cell lines, suggesting its potential as a functional food ingredient.
Article
Biochemistry & Molecular Biology
David Ramiro-Cortijo, Gloria Herranz Carrillo, Pratibha Singh, Miguel Rebollo-Hernanz, Pilar Rodriguez-Rodriguez, Santiago Ruvira, Maria Martin-Trueba, Camilia R. Martin, Silvia M. Arribas
Summary: This study aimed to examine the changes in breast milk cytokines during the first month of lactation in Spanish breastfeeding women and their modulation by neonatal and maternal factors. The study found that breast milk cytokines shifted towards an anti-inflammatory profile during lactation, mainly influenced by prematurity. MCP-1 in breast milk was associated with maternal and neonatal inflammatory processes.
Article
Biochemistry & Molecular Biology
Alicia Hernandez, Angela Sanz, Emanuela Spagnolo, Ana Lopez, Paloma Martinez Jorge, Silvia Iniesta, Elena Rodriguez, Sara Fernandez Prada, David Ramiro-Cortijo
Summary: Anti-Mullerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF), and these parameters drop even further after OMA surgery. The study compares reproductive variables in IVF-treated women with and without endometriosis, and investigates the potential impact of endometrioma surgery on these variables. The findings suggest that OMA surgery can improve pregnancy outcomes, but it is crucial to inform patients about the potential effects of endometrioma on oocyte quality before undergoing surgery.
Article
Biochemistry & Molecular Biology
Santiago Ruvira, Pilar Rodriguez-Rodriguez, David Ramiro-Cortijo, Maria Martin-Trueba, Maria A. Martin-Cabrejas, Silvia M. Arribas
Summary: Supplementation with cocoa shell extract (CSE) has antihypertensive effects, possibly achieved through upregulation of e-NOS and Nrf2 expression, elevation of GSH levels, and antioxidant effects of CSE bioactive components.
Article
Food Science & Technology
Cheyenne Braojos, Andrea Gila-Diaz, Pilar Rodriguez-Rodriguez, Ignacio Monedero-Cobeta, Maria Dolores Morales, Santiago Ruvira, David Ramiro-Cortijo, Vanesa Benitez, Maria A. Martin-Cabrejas, Silvia M. Arribas
Summary: Coffee and cocoa manufacturing generate a substantial amount of waste, which contains bioactive compounds with antioxidant and anti-inflammatory properties. This study compared the efficacy of aqueous extracts and flours from coffee pulp and cocoa shell to ameliorate MetS induced by a high-fat diet. The results showed that coffee pulp ingredients had a better efficacy in reducing MetS parameters, likely due to the synergic effect of caffeine, protocatechuic, and chlorogenic acids. This by-product could be potentially used as a treatment for obesity-related MetS alterations in humans.