Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2

Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation

(2017) Lanfranco Leo et al.   HUMAN MOLECULAR GENETICS

Mechanisms of prion-induced neurodegeneration

(2016) Paula Saá et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme

(2016) Szu-Ting Chou et al.   JOURNAL OF CONTROLLED RELEASE

Tau pathology-mediated presynaptic dysfunction

(2016) H. Moreno et al.   NEUROSCIENCE

Transgenic mice recapitulate the phenotypic heterogeneity of genetic prion diseases without developing prion infectivity: Role of intracellular PrP retention in neurotoxicity

(2016) Roberto Chiesa et al.   Prion

Regulation of Axonal Transport by Protein Kinases

(2015) Katherine L. Gibbs et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Elusive Role of the Prion Protein and the Mechanism of Toxicity in Prion Disease

(2015) Roberto Chiesa   PLoS Pathogens

Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84

(2014) Kiev R. Blasier et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking

(2013) Jonatan Sanchez-Garcia et al.   HUMAN MOLECULAR GENETICS

The identification and management of pain, suffering and distress in cephalopods, including anaesthesia, analgesia and humane killing

(2013) Paul L.R. Andrews et al.   JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY

Dysfunction of the PI3K-Akt-GSK-3 pathway is a common featurein cell cultureandin vivomodels of prion disease

(2013) D. Simon et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy

(2013) Simon Mead et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

(2013) Gerardo A. Morfini et al.   PLoS One

Prions disturb post-Golgi trafficking of membrane proteins

(2013) Keiji Uchiyama et al.   Nature Communications

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Trk Activation of the ERK1/2 Kinase Pathway Stimulates Intermediate Chain Phosphorylation and Recruits Cytoplasmic Dynein to Signaling Endosomes for Retrograde Axonal Transport

(2012) D. J. Mitchell et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit

(2012) Assunta Senatore et al.   NEURON

Highly neurotoxic monomeric  -helical prion protein

(2012) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers

(2012) Yong Tang et al.   TRAFFIC

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

An N-terminal Polybasic Domain and Cell Surface Localization Are Required for Mutant Prion Protein Toxicity

(2011) Isaac H. Solomon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

(2011) N. M. Kanaan et al.   JOURNAL OF NEUROSCIENCE

The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons

(2011) J. S. Kim-Han et al.   JOURNAL OF NEUROSCIENCE

A Nine Amino Acid Domain Is Essential for Mutant Prion Protein Toxicity

(2011) L. Westergard et al.   JOURNAL OF NEUROSCIENCE

The N-Terminal, Polybasic Region Is Critical for Prion Protein Neuroprotective Activity

(2011) Jessie A. Turnbaugh et al.   PLoS One

Prions

(2011) D. W. Colby et al.   Cold Spring Harbor Perspectives in Biology

Role of the Highly Conserved Middle Region of Prion Protein (PrP) in PrP−Lipid Interaction

(2010) Fei Wang et al.   BIOCHEMISTRY

A Perspective on Neuronal Cell Death Signaling and Neurodegeneration

(2010) Scott Brady et al.   MOLECULAR NEUROBIOLOGY

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Internalization and signal transduction of PrP106−126 in neuronal cells

(2009) Lars-Ove Brandenburg et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Cytoplasmic prion protein induces forebrain neurotoxicity

(2009) Xinhe Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ultramicroscopy Reveals Axonal Transport Impairments in Cortical Motor Neurons at Prion Disease

(2009) Vladimir Ermolayev et al.   BIOPHYSICAL JOURNAL

Prion Topology and Toxicity

(2009) Adriano Aguzzi et al.   CELL

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein

(2009) Henryk Faas et al.   NEUROIMAGE

Functionally Relevant Domains of the Prion Protein Identified In Vivo

(2009) Frank Baumann et al.   PLoS One

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

(2009) H. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Axonal Transport in Motor Neurons Correlates with Clinical Prion Disease

(2009) Vladimir Ermolayev et al.   PLoS Pathogens

Casein kinase II interacts with prion proteinin vitroand forms complex with native prion proteinin vivo

(2008) Jianming Chen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

The kinesin I family member KIF5C is a novel substrate for protein kinase CK2

(2008) Barbara Schäfer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to Neurodegeneration

(2008) Neena S. Rane et al.   DEVELOPMENTAL CELL

Aggregated, Wild-Type Prion Protein Causes Neurological Dysfunction and Synaptic Abnormalities

(2008) R. Chiesa et al.   JOURNAL OF NEUROSCIENCE

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice

(2008) Andrea Z. Medrano et al.   NEUROBIOLOGY OF DISEASE