Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Article
Biochemistry & Molecular Biology
Luciane de L. Teixeira, Genevieve Pilon, Camille Perella Coutinho, Stephanie Dudonne, Pascal Dube, Vanessa Houde, Yves Desjardins, Franco M. Lajolo, Andre Marette, Neuza M. A. Hassimotto
Summary: The study found that the polyphenolic extract from purple grumixama has significant effects on reducing obesity and improving insulin resistance, leading to decreased body weight gain, improved insulin sensitivity, and reduced hepatic fat accumulation.
Article
Biology
Valentina Murtaj, Silvia Penati, Sara Belloli, Maria Foti, Angela Coliva, Angela Papagna, Cecilia Gotti, Elisa Toninelli, Remy Chiaffarelli, Stefano Mantero, Susanna Pucci, Michela Matteoli, Maria Luisa Malosio, Rosa Maria Moresco
Summary: The study found that male mice exposed to a high fat diet are more susceptible to metabolic changes compared to female mice, showing faster and higher weight gain, elevated cholesterol and liver enzyme levels, and more prominent brain inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiang Gao, Lei Du, Edward Randell, Huijun Zhang, Kelei Li, Duo Li
Summary: The study showed that EPA/DHA-PC derived from Sthenototeuthis oualaniensis effectively reversed obesity, insulin resistance, and hyperglycemia induced by a high-fat diet in mice. The mechanism of action included modulating insulin signaling pathways, improving inflammatory pathways in adipose tissue, and altering gut microbiota composition.
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Endocrinology & Metabolism
Xiao-Bing Cui, Jia Fei, Sisi Chen, Gaylen L. Edwards, Shi-You Chen
Summary: This study identifies adenosine deaminase acting on RNA 1 as a novel factor promoting high-fat diet induced obesity, at least partially, through modulating appetite-related genes ghrelin and PYY.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Siqi Li, Mengqian Wang, Chang Li, Qingjia Meng, Yantong Meng, Jian Ying, Shuqun Bai, Qun Shen, Yong Xue
Summary: This study found that partly milled highland barley (PHB) can regulate the serum glucose and lipid disorders of mice fed a high-fat diet (HFD) and has the potential to modulate gut microbiota. PHB supplementation reduced fasting blood glucose and improved oral glucose tolerance. PHB also prevented HFD-induced gut microbiota dysbiosis, enriching beneficial bacteria and reducing HFD-dependent taxa.
Article
Nutrition & Dietetics
Taesang Son, Inae Jeong, Jeongjin Park, Woojin Jun, Andre Kim, Ok-Kyung Kim
Summary: The study aimed to investigate the effects of a high-fat diet on hepatic endoplasmic reticulum stress, inflammation, insulin signaling, and lipid metabolism in mice, in order to identify the correlations between obesity and metabolic diseases in the liver. Different durations of high-fat diet were used, and exosomes were isolated from adipose tissue to confirm their effects on metabolic disorders in obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Patricia Perez-Matute, Iciar P. Lopez, Maria iniguez, Emma Recio-Fernandez, Raquel Torrens, Sergio Pineiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, Jose A. Oteo, Jose G. Pichel
Summary: This study aims to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. The results showed that young IGF1R-deficient mice were insulin-resistant and had altered circulating levels of IGF1, growth hormone (GH), and IGFBP3. Middle-aged IGF1R-deficient male mice were able to counteract the negative effects induced by aging and high-fat diet (HFD) in adiposity, inflammation, and glucose metabolism, demonstrating a metabolic sexual dimorphism dependent on IGF1R.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yovita Permata Budi, Yi-Hsuan Li, Chien Huang, Mu-En Wang, Yi-Chun Lin, De-Shien Jong, Chih-Hsien Chiu, Yi-Fan Jiang
Summary: The study aims to investigate the role of autophagy in obesity-induced insulin resistance. The findings suggest that a high-fat diet promotes insulin resistance, inhibits autophagy, induces ER stress, and apoptosis in adipose tissue. Autophagy suppression may indirectly cause insulin resistance through ER stress or apoptosis.
Article
Multidisciplinary Sciences
Luis Crisostomo, Ivana Jarak, Luis P. Rato, Joao F. Raposo, Rachel L. Batterham, Pedro F. Oliveira, Marco G. Alves
Summary: The consumption of energy-dense diets has led to an increase in obesity and its associated comorbidities worldwide. Unhealthy feeding habits can start at an early age, leading to early onset of metabolic diseases with potential unknown consequences on reproductive function. Recent evidence suggests intergenerational and transgenerational effects of high-fat diets on sperm parameters and testicular metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Young-Sil Lee, Daeyoung Lee, Gun-Seok Park, Seung-Hyun Ko, Juyi Park, You-Kyung Lee, Jihee Kang
Summary: The study suggests that Lactobacillus plantarum HAC01 can alleviate hyperglycemia and type 2 diabetes by regulating glucose metabolism in the liver, protecting insulin-secreting cells, and restoring gut microbiota and short-chain fatty acids.