Review
Medicine, Research & Experimental
Mahsa Bagheri, Cornelus F. van Nostrum, Robbert Jan Kok, Gert Storm, Wim E. Hennink, Michal Heger
Summary: This review investigates whether intravenous nanoformulations of curcumin improve its pharmacokinetics and whether improved pharmacokinetics leads to greater therapeutic efficacy. The study found that nanoencapsulation generally improved curcumin's pharmacokinetics, but the correlation between pharmacokinetics and pharmacodynamics was not significant.
MOLECULAR PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Yukiya Kitayama, Atsushi Harada
Summary: pH-responsive carboxy-functionalized capsule polymer particles were successfully fabricated, and controlled release was achieved by regulating the release kinetics. Shell-crosslinked hollow polymer particles were prepared by particulate interfacial photocrosslinking, and model dye was successfully encapsulated.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Rui Chen, Chenqi Zhu, Liu Xu, Yi Gu, Shujing Ren, Hua Bai, Qin Zhou, Xin Liu, Shengfeng Lu, Xiaolin Bi, Weidong Li, Xiaobin Jia, Zhipeng Chen
Summary: A self-healing elastin-mimic peptide hydrogel was developed for local drug delivery in myocardial infarction treatment, with the ability to form a high mechanical strength structure in heart tissue and prolong drug retention in the ventricular wall, thereby inhibiting ventricular remodeling and promoting angiogenesis.
Review
Pharmacology & Pharmacy
Fenting Lei, Pei Li, Tangting Chen, Qian Wang, Chenglong Wang, Yan Liu, Yiping Deng, Zongquan Zhang, Maochang Xu, Ji Tian, Wei Ren, Chunhong Li
Summary: Curcumin exhibits potent anti-inflammatory and anti-tumor activities, but its poor solubility, stability, and bioavailability limit its therapeutic potential. Nanoparticle delivery systems can improve these limitations and enhance targeting. However, the immune system easily clears exogenous nanoparticles, necessitating the development of biomimetic nanomedicines with good biocompatibility and long circulation time.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Agricultural Engineering
Weihong Li, Kedi Liu, Xingru Tao, Shi Zhao, Fei Mu, Sha Chen, Wenya Wang, Jing Li, Xinming Lu, Yang Bai, Li 'an Hou, Jialin Duan, Peifeng Wei, Miaomiao Xi
Summary: A mixture of 80% Sal-A, 10% Sal-B, and 10% DSS was found to be the most effective in cardioprotection. The inhibition of CK-MB by this mixture was even better than the treatment drugs, while there was no significant difference in the inhibition of cTnI and Myo. This study provides a basis for further research on the active monomers of Salvia miltiorrhiza in the treatment of myocardial infarction.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Chemistry, Medicinal
Thayse V. de Oliveira, Renan Stein, Diego F. de Andrade, Ruy C. R. Beck
Summary: This systematic review confirms the efficacy of curcumin-loaded polymeric nanocapsules in inhibiting tumor growth and reducing tumor weight, regardless of the solid tumor model. The analysis on bias risk suggests that nanoparticle encapsulation can enhance the anti-tumor effects of curcumin.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemical Research Methods
Manita Das, Apeksha Joshi, Ranjitsinh Devkar, Sriram Seshadri, Sonal Thakore
Summary: This article introduces an effective nanocarrier-mediated drug delivery method that overcomes limitations in the drug delivery process. By synthesizing a self-therapeutic copolymer, the nanocarrier is able to hierarchically disassemble in the tumor microenvironment, and possesses tumor specificity and improved circulation times. Experimental results demonstrate that this nanocarrier can effectively release drugs and exhibit cytotoxicity on tumor cells, suggesting its potential as an anti-tumor agent.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Physical
Alexander Zika, Mohit Agarwal, Ralf Schweins, Franziska Groehn
Summary: Quadruple-switchable nanoscale assemblies are created by combining two types of water-soluble molecular photoswitches, allowing activation through irradiation with two different wavelengths.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Biophysics
Ana Maria Salazar-Bryam, Ingrid Yoshimura, Larissa Provasi Santos, Cinthia Cristine Moura, Caio Carvalho Santos, Vinicius Luiz Silva, Roberta Barros Lovaglio, Rodrigo Fernando Costa Marques, Miguel Jafelicci Junior, Jonas Contiero
Summary: This study utilized rhamnolipids produced from glycerol to stabilize silver nanoparticles and found that different pH values during synthesis of silver nanoparticles in the presence of rhamnolipids directly influence nanoparticle size and stability. The results indicated that increasing pH enhanced the stability of silver nanoparticles and larger particles were formed at lower pH values.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Plant Sciences
Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam
Summary: The study demonstrated that Danshen water extract (DWE) and its major components, SalA and SalB, have the potential to reduce fibrillation of Aβ42 and protect neuronal cells from cell death associated with Aβ42 exposure. Furthermore, treating Drosophila melanogaster with DWE, SalA and SalB showed benefits in partially reversing degenerated eye structures, extending lifespan, and improving mobility in an Alzheimer's disease model.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Ngoc Xuan Dat Mai, Y. Thi Dang, Hanh Kieu Thi Ta, Jong-Seong Bae, Sungkyun Park, Bach Thang Phan, Fuyuhiko Tamanoi, Tan Le Hoang Doan
Summary: Biodegradable PMO nanoparticles named E4S, incorporating redox-responsive tetrasulfide bonds, were successfully synthesized with particle size smaller than 50 nm. The material exhibited high efficiency for loading the hydrophobic bioactive natural product curcumin, with the smallest particle showing the highest loading capacity.
JOURNAL OF MATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Yanan Wang, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu, Zhiyu He
Summary: This review comprehensively summarizes the application of nanomedicine in the diagnosis and monitoring of diabetes, emphasizing its potential in managing diabetes and complications, as well as its effectiveness in improving the quality of life for diabetic patients. Several critical issues regarding the application of nanomedicine-based strategies need to be addressed to ensure stability, long-term safety effects, and standard formulation administration in vivo.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
T. S. Anirudhan, Susan Varghese, V Manjusha
Summary: The study designed and evaluated Hyaluronic Acid coated Pluronic mixed micelles loaded with Paclitaxel and Curcumin for anticancer activity in MCF-7 cells, demonstrating the superior in vitro drug release and anticancer activity of the dual drug-loaded material.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Chunxian Wu, Yi Liu, Yin Zheng, Wentao Wang, Yong Liu, JieYao Yu
Summary: The co-assembly of selenium-doped carbon quantum dots and N,N-dimethyl-octylamide-propyl tertiary amine was studied, and supramolecular assemblies with multiple dimensions and novel morphologies were fabricated. Different phase behaviors were observed with increasing amine concentration, and various morphologies of aggregates were observed in cryo-TEM observations. The findings suggest that these building blocks can be used for supramolecular structures with potential applications.
Article
Biochemistry & Molecular Biology
Salahuddin Ahmed, Megan Keniry, Victoria Padilla, Narcedalia Anaya-Barbosa, Md Noushad Javed, Robert Gilkerson, Kithzia Gomez, Ali Ashraf, Acharan S. Narula, Karen Lozano
Summary: This study explores the feasibility of centrifugal spinning to produce fibrous membranes containing pul-lulan, chitosan, and danshen extract. The membranes consist of long, continuous, and uniform fibers with a few scattered beads. The nanofibers show good aqueous stability after crosslinking and exhibit potential as a bioactive chemotherapeutic drug for inhibiting colon cancer cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Giulia Vanti, Marcella Coronnello, Daniele Bani, Antonella Mannini, Maria Camilla Bergonzi, Anna Rita Bilia
Summary: The co-delivery of the P-gp inhibitor tariquidar and the cytotoxicity inducer berberine chloride using nanoliposomes shows promise in overcoming multidrug resistance by effectively reversing it and significantly increasing drug accumulation in tumor cells, potentially resensitizing resistant cells to anticancer agents.
Article
Biochemistry & Molecular Biology
Elisa Landucci, Costanza Mazzantini, Daniela Buonvicino, Domenico E. Pellegrini-Giampietro, Maria Camilla Bergonzi
Summary: Experimental evidence shows that TQ can improve cell death induced by KA, reduce excitotoxic injury, and partially rescue the decrease in apoptotic pathways.
Article
Pharmacology & Pharmacy
Giulia Vanti, Lorenzo Di Cesare Mannelli, Laura Micheli, Lorenzo Cinci, Lucia Grifoni, Maria Camilla Bergonzi, Carla Ghelardini, Anna Rita Bilia
Summary: This study demonstrated that nanovesicles loaded with khellin (K-Ves) could significantly alleviate pain and provide joint protection in a rat model of osteoarthritis through a single intra-articular injection. K-Ves exhibited good stability, high encapsulation efficiency, and potential application prospects for the treatment of osteoarthritis.
Article
Biochemistry & Molecular Biology
Giulia Vanti, Lucrezia Muti, Mario D'Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia
Summary: A novel formulation based on NLCs was developed to enhance the solubility and intestinal absorption of khellin. The K-NLCs were characterized physically and chemically, showing good stability in simulated gastric and intestinal fluids, and enhanced permeability across Caco-2 cells. This versatile formulation has the potential to improve the bioavailability and therapeutic effects of khellin.
Article
Pharmacology & Pharmacy
Elisa Landucci, Francesca Bonomolo, Chiara De Stefani, Costanza Mazzantini, Domenico Edoardo Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi
Summary: Two liposomal formulations, one of which is coated with hyaluronic acid, have been developed to enhance the solubility of Thymoquinone (TQ) and increase its absorption at the cellular level, especially in the nucleus. These formulations not only decrease TQ toxicity observed at high doses in cells, but also result in a gradual and prolonged release of TQ in both coated and uncoated liposomes.
Article
Plant Sciences
Lucia Grifoni, Giulia Vanti, Maria Giuliana Vannucchi, Maria Camilla Bergonzi, Anna Rita Bilia
Summary: Microemulsions are versatile drug delivery systems that can be administered regardless of route. In this study, a microemulsion was formulated using glycerol (2.25%), Labrasol (20.25%), vitamin E acetate (2.50%), and water (75.00%). The microemulsion showed stable globules with a size of about 17 nm and had high potential for skin care applications due to its dermatological properties.
Article
Pharmacology & Pharmacy
Giulia Vanti, Michela Capizzi, Lorenzo Di Cesare Mannelli, Elena Lucarini, Maria Camilla Bergonzi, Carla Ghelardini, Anna Rita Bilia
Summary: This study successfully addressed the low aqueous solubility and limited bioavailability of andrographolide (AG) by encapsulating it in escinosomes, nanovesicles made of escin and phosphatidylcholine. AG-loaded escinosomes exhibited favorable properties and achieved sustained release of AG. Moreover, these nanovesicles effectively alleviated thermal allodynia in a rat model of chemotherapy-induced neuropathy.
Article
Pharmacology & Pharmacy
Maria Camilla Bergonzi, Charles M. Heard, Javier Garcia-Pardo
Article
Pharmacology & Pharmacy
Chiara De Stefani, Marzia Vasarri, Maria Cristina Salvatici, Lucia Grifoni, Jose Carlos Quintela, Anna Rita Bilia, Donatella Degl'Innocenti, Maria Camilla Bergonzi
Summary: The study formulated oleanolic acid (OA) into two different microemulsions (ME-1 and ME-2) to enhance its solubility and intestinal permeability, leading to a significant increase in bioavailability. Both MEs showed enhanced intestinal permeability compared to free OA according to PAMPA assay results. The study suggests that MEs could be a promising formulation to improve the oral bioavailability of OA with potential clinical applications.
Article
Chemistry, Medicinal
Marzia Vasarri, Linda Ponti, Donatella Degl'Innocenti, Maria Camilla Bergonzi
Summary: Usnic acid is a common metabolite of lichens with various pharmacological properties. However, its poor solubility and hepatotoxicity limit its use in therapy. In this study, polymeric micelles were developed to improve the solubility and stability of usnic acid, and it was found that the micelles exhibited inhibitory action on neuroblastoma cell migration.
Article
Biochemistry & Molecular Biology
Marzia Vasarri, Emanuela Barletta, Maria Stio, Maria Camilla Bergonzi, Andrea Galli, Donatella Degl'Innocenti
Summary: Metabolic disorders and lipid dysregulation are risk factors for hepatocellular carcinoma (HCC). The marine plant P. oceanica may have potential as a treatment for HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Elisa Landucci, Costanza Mazzantini, Maura Calvani, Domenico E. Pellegrini-Giampietro, Maria Camilla Bergonzi
Summary: Dry eye disease is a common ocular disorder characterized by inadequate lubrication of the eye, leading to inflammation and ocular surface changes. Current treatments have limitations in terms of side effects and effectiveness. Thymoquinone-loaded liposomes have shown potential as a therapeutic agent for dry eye disease, improving effectiveness in reducing oxidative and inflammatory processes.
Article
Pharmacology & Pharmacy
Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Mosti, Carla Ghelardini, Anna Rita Bilia, Maria Camilla Bergonzi
Summary: The aim of this study was to test the protective and pain reliever effect of thymoquinone (TQ)-loaded formulations in a rat model of tendinopathy induced by carrageenan intra-tendon injection. The results showed that liposomes containing 2 mg/mL of TQ and covered with hyaluronic acid (HA-LP-TQ2) reduced the development of spontaneous nociception and hypersensitivity, providing a long-lasting effect as a new treatment for tendinopathies.
Article
Biochemistry & Molecular Biology
Marzia Vasarri, Donatella Degl'Innocenti, Laura Albonetti, Anna Rita Bilia, Maria Camilla Bergonzi
Summary: Olive leaves contain various pentacyclic triterpenes with pharmacological activities, including antihyperlipidemic effects. A microemulsion loading a TTP-enriched extract was developed to improve the water solubility and permeability of the triterpenes. The microemulsion formulation showed high stability, prolonged release of triterpenes, and enhanced inhibitory activity on intracellular lipid accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Manuela Leri, Marzia Vasarri, Emanuela Barletta, Nicola Schiavone, Maria Camilla Bergonzi, Monica Bucciantini, Donatella Degl'Innocenti
Summary: The extensive use of agricultural pesticides increases the risk of public exposure to pesticides over time, but little attention has been paid to prevention. This study explores the potential protective effect of OleA, a component of extra virgin olive oil, against pesticide-induced cellular toxicity. The findings suggest that OleA can maintain cellular function and prevent epigenetic modification in the presence of certain pesticides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)