Article
Biochemistry & Molecular Biology
Yuanpeng Hao, Xiaoqi Guo, Rui Yang, Yihao Yan, Meiyu Sun, Hui Li, Hongtong Bai, Hongxia Cui, Jingyi Li, Lei Shi
Summary: The study identified high carvacrol content with tissue-dependence in Origanum vulgare 'Hot and Spicy', shedding light on the biosynthesis of carvacrol and providing important candidate genes for metabolic engineering and breeding of Origanum cultivars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Maria Gonceariuc, Mircea Valentin Muntean, Violeta Butnaras, Marcel Matei Duda, Anna Benea, Tamara Jelezneac, Zinaida Vornicu, Ludmila Cotelea, Pantelimon Botnarenco
Summary: This study comparatively analyzed two subspecies of Origanum vulgare in climatic conditions with higher temperatures, focusing on essential oil production and polyphenol content. The research identified varieties with higher essential oil content but lower polyphenol content, as well as vice versa. The selection of two promising cultivars was based on these findings.
Article
Agricultural Engineering
Roya Emrahi, Mohammad Reza Morshedloo, Hosein Ahmadi, Abdollah Javanmard, Filippo Maggi
Summary: This study compared the effects of water deficit stress on biochemical traits and essential oil profiles of two carvacrol-rich subspecies of Oregano. The results showed that subsp. hirtum had higher dry weight, essential oil, and carvacrol content, with a positive correlation between dry weight and EO content.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Samira Hossein Jafari, Asghar Mosleh Arani, Saeed Tarkesh Esfahani
Summary: This study aimed to investigate the effects of salinity, Methyl Jasmonate (MeJA), and bacteria on the biosynthesis pathway of rosmarinic acid (RA) in O. vulgare. The results showed that salinity had a negative impact on RA induction and RAS gene expression, while the combined application of bacteria and MeJA had positive effects on biochemical and physiological traits in O. vulgare.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Plant Sciences
Zahra Azimzadeh, Abbas Hassani, Babak Abdollahi Mandoulakani, Ebrahim Sepehr, Mohammad Reza Morshedloo
Summary: This study demonstrates that both oregano subspecies can tolerate 50 mM NaCl salinity without significant reduction in essential oil yield. In subsp. vulgare, moderate salinity stress (50 mM NaCl) might increase the carvacrol content partly via increment the expression levels of DXR, Ovtps2, and CYP71D180 genes.
Article
Immunology
Na Yao, Qiong Xu, Jia-Kang He, Ming Pan, Zhao-Feng Hou, Dan-Dan Liu, Jian-Ping Tao, Si-Yang Huang
Summary: The study demonstrated that carvanol, the main component of Origanum vulgare essential oil, showed potential as a new and effective drug for treating toxoplasmosis by inhibiting the proliferation of Toxoplasma gondii.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Agricultural Engineering
Fernanda Tomiotto-Pellissier, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Ana Flavia Marques Ganaza, Ana Carolina Quasne, Beatriz Ricci, Pedro Vinicius Dolce E Carvalho, Gustavo Henrique Della Colleta, Danielle Lazarin-Bidoia, Taylon Felipe Silva, Manoela Daiele Goncalves, Renata Katsuko Takayama Kobayashi, Gerson Nakazato, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: This study investigated the leishmanicidal and immunomodulatory effects of oregano essential oil (OEO) on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. The results demonstrated that OEO containing carvacrol, thymol, gamma-terpinene, p-cymene, and beta-caryophyllene as the main components showed potential as an oral and topical drug development for the treatment of L. amazonensis. OEO exhibited leishmanicidal activity by inducing a combination of autophagic, apoptotic, and necrotic events, and had immunomodulatory effects without triggering a pro-inflammatory response.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Infectious Diseases
Letizia Angiolella, Florencia Rojas, Javier Mussin, Gustavo Giusiano
Summary: This study evaluated the effects of Origanum vulgare essential oil and carvacrol on the virulence factors of two species of Malassezia. The results showed that carvacrol had a stronger inhibitory effect and lower toxicity compared to OVEO. Both species of Malassezia exhibited reduced adherence and biofilm formation in the presence of OVEO or carvacrol, and their hydrophobicity was also decreased.
Review
Infectious Diseases
Larisa Bora, Stefana Avram, Ioana Zinuca Pavel, Delia Muntean, Sergio Liga, Valentina Buda, Daniela Gurgus, Corina Danciu
Summary: Origanum vulgare L. essential oil (OvEo) has gained attention in dermatology due to its cosmeceutical potential and pharmacological activities. It has been extensively studied for its antimicrobial and anti-inflammatory activities, showing potential in wound healing and treatment of skin disorders. Modern formulations, such as microemulsions and nanoemulsions, have also been developed for topical application.
Article
Multidisciplinary Sciences
Emel Karaca Oner, Meryem Yesil
Summary: Altitude significantly affects the essential oil content, yield, and composition of O. majorana. This study collected plant samples from different altitudes and found that the highest essential oil percentage (6.50%) was obtained at 766 m altitude. The GC-MS analyses showed that low altitude positively affected some essential oil components, such as linalool. Different altitudes also led to variations in the levels of other essential oil constituents.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Huawei Yu, Panpan Zhang, Hongbing Liu, Xiaojuan Sun, Jichao Liang, Lijuan Sun, Yong Chen
Summary: The study demonstrated the strong hypoglycemic effect of Origanum vulgare leaf extract, which inhibited alpha-glucosidase activity, promoted glucose uptake, inhibited glycosylation, and relieved oxidative stress. Mechanistic analysis showed that the extract decreased the promoter activity and the mRNA and protein expression of PEPCK and SREBP-1c, while also inhibiting the expression of CPY2E1 and enhancing the expression of GLUT2. HPLC-ESI-QTOF-MS analysis identified the main phenolic compounds in the herb, supporting its traditional use as an antidiabetic herbal medicine or dietary supplement.
Article
Agronomy
Elena Myagkikh, Svetlana Babanina, Alexander Mishnev, Ludmila Radchenko, Vladimir Pashtetskiy, Natalya Nevkrytaya, Olga Loretts
Summary: This study assessed the adaptability of different genotypes of oregano to the temperate climate of the Crimean Peninsula and found that local genotypes were more adapted in terms of essential oil accumulation. However, they were inferior to the registered cultivars bred by ARSRIMAP in terms of fresh yield.
Article
Agronomy
Xiaolu Jin, Guanggen Huang, Zheng Luo, Yongfei Hu, Dan Liu
Summary: The potential effects of oregano essential oil (OEO) on preventing necrotic enteritis (NE) caused by Clostridium perfringens (Cp) in chickens were evaluated in this study. The results showed that OEO had significant effects on increasing body weight gain and reversing the dropped feed intake. OEO also alleviated histopathological changes in the ileums of broiler chickens and had limited effects on tight junction-related gene expressions. OEO is proposed as a promising substitute for antibiotics against NE induced by Cp during poultry production.
Article
Food Science & Technology
Meltem Karagozlu, Bugra Ocak, Ozgul Ozdestan-Ocak
Summary: This study successfully developed OOEO-loaded microcapsules using complex coacervation, with 2% TA cross-linked OOEO microcapsules showing the best performance. Fourier transform infrared spectra and thermal gravimetric analysis confirmed successful encapsulation of OOEO and improved thermal stability through cross-linking. Increasing TA concentration led to reduced aggregation, increased particle size, and absolute zeta potential of the GE/GA-walled microcapsules.
FOOD AND BIOPROCESS TECHNOLOGY
(2021)
Article
Plant Sciences
Jelena Vladic, Ana Rita C. Duarte, Sanja Radman, Sinisa Simic, Igor Jerkovic
Summary: The study aimed to improve the efficiency of supercritical carbon dioxide extraction and enhance the quality of extracts obtained from Greek oregano. Microwave and enzymatic pretreatments were applied, resulting in accelerated extraction and increased antioxidant activity.
Article
Chemistry, Applied
Esfandiar Jahantab, Mohammad Reza Morshedloo, Filippo Maggi
Summary: The study on the essential oil variability among eleven wild populations of Stachys pilifera Benth in Iran showed significant chemical profile variation, indicating potential pharmaceutical and industrial applications. The findings can contribute to domestication and conservation efforts for this endemic species.
NATURAL PRODUCT RESEARCH
(2021)
Article
Agricultural Engineering
Susana Sanchez-Gomez, Rafael Pagan, Roman Pavela, Eugenia Mazzara, Eleonora Spinozzi, Oliviero Marinelli, Laura Zeppa, Mohammad Reza Morshedloo, Filippo Maggi, Angelo Canale, Giovanni Benelli
Summary: The study developed two essential oils-loaded zein nanocapsules with high toxicity on Culex quinquefasciatus larvae and limited non-target effects, indicating their potential as effective and eco-friendly formulations for mosquito control programs.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Mostafa Amani Machiani, Abdollah Javanmard, Mohammad Reza Morshedloo, Mohsen Janmohammadi, Filippo Maggi
Summary: Water deficit is a major factor affecting plant growth, and a study on applying bio-fertilizer under water stress conditions on soybean productivity and oil quality showed that inoculation with arbuscular mycorrhizal fungus (AMF) improved seed and oil yields by 22.7% and 20.1% compared to the control, while also enhancing the activity of antioxidant enzymes and improving soybean oil quality.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2021)
Article
Plant Sciences
Hasan Mumivand, Parisa Khanizadeh, Mohammad Reza Morshedloo, Edyta Sierka, Krystyna Zuk-Golaszewska, Tomasz Horaczek, Hazem M. Kalaji
Summary: The foliar application of boron and zinc significantly increased the growth, yield, and phytochemical properties of S. khuzistanica. This treatment also led to improvements in the antioxidant activity and chemical composition of the plant.
Article
Chemistry, Applied
Mohammad Reza Morshedloo, Sima Fereydouni, Hosein Ahmadi, Mohammad Bagher Hassanpouraghdam, Ahmad Aghaee, Lamia Vojodi Mehrabani, Filippo Maggi
Summary: The study investigated the oil content, fatty acid composition, and antioxidant properties of twelve Iranian sumac fruit accessions, revealing variations in oil content and fatty acid composition among different populations, with the Arasbaran population showing the highest characteristics. These findings suggest the possibility of utilizing elite populations with high ratios of unsaturated fatty acids and antioxidant compounds in the food industry.
Article
Multidisciplinary Sciences
Ghazaleh Jafari Khorsand, Mohammad Reza Morshedloo, Hasan Mumivand, Zohreh Emami Bistgani, Filippo Maggi, Abdolvahab Khademi
Summary: This study investigated the bioactive components and antioxidant capacities of seven oregano accessions, and identified the most suitable varieties for industrial use based on various analytical parameters. Rosmarinic acid was found to be the most abundant constituent and showed a significant positive correlation with antioxidant activity. Total flavonoid content was significantly correlated with total phenolic content and chicoric acid.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hosein Ahmadi, Mohammad Reza Morshedloo, Roya Emrahi, Abdollah Javanmard, Farzad Rasouli, Filippo Maggi, Manoj Kumar, Jose Manuel Lorenzo
Summary: This study compared the yield, antioxidant properties, and essential-oil (EO) quality of different mint species. The results showed that grapefruit mint had the highest yield and EO content, while ginger mint had the highest antioxidant activity. Pineapple and grapefruit mint had the highest flavonoids content and DPPH scavenging activity. Gas chromatography analysis identified specific EO types in each mint. These findings have important implications for the cultivation of mint varieties with desired characteristics for the food and drug industries.
Article
Infectious Diseases
Raffaella Campana, Mattia Tiboni, Filippo Maggi, Loredana Cappellacci, Kevin Cianfaglione, Mohammad Reza Morshedloo, Emanuela Frangipani, Luca Casettari
Summary: The antimicrobial activity of several essential oils and their related microemulsions was investigated. It was found that cumin, sea fennel, and anise essential oils were effective against various microorganisms. The antimicrobial activity was further enhanced when the essential oils were formulated into microemulsions, resulting in lower minimum inhibitory concentration and minimum bactericidal concentration values.
Article
Chemistry, Applied
Esfandiar Jahantab, Mohammad Reza Morshedloo, Vahid Karimain, Mohsen Sharafatmandrad
Summary: This study investigated the variation of essential oil composition in Boiss species among different populations in the Zagros Mountain, Iran. The results showed significant differences in chemical components among the populations, providing potential sources for industrial uses and pharmaceutical industries.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2022)
Article
Agronomy
Mohammad Bagher Hassanpouraghdam, Yadeghar Salimi, Mohammad Reza Morshedloo, Mohammad Asadi, Farzad Rasouli, Sezai Ercisli, Hafize Fidan, Crina Carmen Muresan, Romina Alina Marc
Summary: The morphological and essential oil diversity of Stachys lavandulifolia populations from the west and northwest of Iran were evaluated. The results showed significant differences between the populations for most traits. GC/MS analysis confirmed the presence of 28 components comprising up to 94.4% of the oils. Natural habitats and geo-climatological factors influenced both the morphological traits and oil composition. The populations have potential for breeding programs and future conservation and exploitation initiatives.
Article
Plant Sciences
Ali Ostadi, Abdollah Javanmard, Mostafa Amani Machiani, Amir Sadeghpour, Filippo Maggi, Mojtaba Nouraein, Mohammad Reza Morshedloo, Christophe Hano, Jose M. Lorenzo
Summary: This study evaluated the effects of arbuscular mycorrhizal fungi (AMF) and titanium dioxide (TiO2) on the yield and quality of sage plants. The results showed that the co-addition of AMF and TiO2 alleviated the effects of drought stress, increased the yield and water use efficiency of sage plants, and improved the net income index. Therefore, this integrated approach is recommended for enhancing sage production and improving its quality in drought conditions.
Article
Agricultural Engineering
Diego Romano Perinelli, Roman Pavela, Giulia Bonacucina, Cecilia Baldassarri, Eleonora Spinozzi, Jacopo Torresi, Riccardo Petrelli, Mohammad Reza Morshedloo, Filippo Maggi, Giovanni Benelli, Angelo Canale
Summary: The study demonstrates that the essential oils (EOs) and nanoemulsions (NEs) of Bunium persicum and Ziziphora clinopodioides show significant insecticidal activity against Culex quinquefasciatus mosquitoes, with the NEs exhibiting better efficacy than the EOs for Bunium persicum.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agricultural Engineering
Nickolas G. Kavallieratos, Erifili P. Nika, Anna Skourti, Diego Romano Perinelli, Eleonora Spinozzi, Giulia Bonacucina, Loredana Cappellacci, Mohammad Reza Morshedloo, Angelo Canale, Giovanni Benelli, Filippo Maggi
Summary: The encapsulation of essential oils from Pimpinella anisum and Trachyspermun ammi in nanoemulsions demonstrated effective insecticidal properties against stored product insects, providing a potential sustainable solution for the protection of durable commodities.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Farhad Behtash, Fatemeh Abedini, Hosein Ahmadi, Seyed Bahman Mosavi, Ahmad Aghaee, Mohammad Reza Morshedloo, Jose M. Lorenzo
Summary: This study investigated the effects of different concentrations of zinc and copper on the growth and biochemical indices of summer squash. High concentrations of copper intensified oxidative stress and decreased plant yield and productivity. However, the co-application of copper and zinc alleviated stress intensity and improved the plant's economic yield and physiological parameters.
Article
Horticulture
Abdollah Javanmard, Mahsa Ashrafi, Mohammad Reza Morshedloo, Mostafa Amani Machiani, Farzad Rasouli, Filippo Maggi
Summary: The co-application of chitosan nanoparticles (Cs-NPs) and Myco-Root biofertilizer can improve the physiological and biochemical properties of balangu, a medicinal plant used in Iranian traditional medicine, under different irrigation levels. This strategy enhances the essential oil quantity and quality of balangu under water deficit conditions.
Article
Plant Sciences
Wanli You, Jinglin Zhang, Xueyin Ru, Feng Xu, Zhengguo Wu, Peng Jin, Yonghua Zheng, Shifeng Cao
Summary: This study investigated the effect of calcium chloride (CaCl2) treatment on GABA accumulation in fresh-cut cantaloupe and the underlying mechanisms. The results showed that CaCl2 treatment increased GABA content and the activities of GAD and SSADH enzymes, while reducing glutamate content and GABA-T activity. Additionally, CaCl2 treatment upregulated the expressions of CmCML11 and CmCAMTA5, as well as several GABA shunt genes, through the transcriptional activation by CmCAMTA5. Furthermore, the interaction between CmCML11 and CmCAMTA5 enhanced the transcriptional activation of GABA shunt genes. Overall, this study reveals that CaCl2 treatment promotes GABA accumulation in fresh-cut cantaloupe through the combined effect of CmCML11 and CmCAMTA5 in regulating the expressions of GABA shunt genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Min Wang, Yupeng Wang, Xiaohui Wang, Guangwei Wei, Huiyi Yang, Xi Yang, Tinghai Shen, Huijie Qu, Sheng Fang, Ziming Wu
Summary: This study identified the high nitrogen use efficiency (NUE) black sesame variety 17-156 and analyzed its underlying physiological and molecular mechanisms. The results showed that 17-156 possesses a sophisticated nitrogen metabolizing machinery to uptake and assimilate higher quantities of inorganic nitrogen, simultaneously improving carbon metabolism and growth. Many important genes were up-regulated in 17-156 under high nitrogen condition. Additionally, 38 potential candidate genes were identified for future studies to improve sesame's NUE. These findings provide valuable resources for understanding the regulatory network of nitrogen metabolism and developing sesame cultivars with improved NUE.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
He Dong, Chongmei Xu, Chengtao Zhang, Li Zhang, Yaqin Yao, Suiqi Zhang
Summary: The study found that short cells in maize leaves not only improve leaf mechanical support and photosynthetic performance, enhance drought resistance, but also participate in stomatal regulation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Na Liu, Wenyan Shang, Mengxin Guan, Jibin Xiao, Guangxiang Tian, Baozhan Ma, Wenjing Shang, Xu Li, Shijia Zhao, Chuang Li, Kun Cheng, Wenming Zheng
Summary: This study cloned the full-length cDNA sequence of TaSPX3 gene in wheat and found that TaSPX3 responds to low phosphorus stress in multiple wheat genotypes. Overexpressing TaSPX3 can alleviate phosphorus deficiency symptoms and promote plant growth in Arabidopsis. The study also revealed the interaction of TaSPX3 with other genes related to the phosphorus starvation signaling pathway.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Kongyuan Wu, Lizhen Wang, Zihan Wu, Ziqing Liu, Zengfei Li, Jun Shen, Shengjie Shi, Hong Liu, Christopher Rensing, Renwei Feng
Summary: Selenium (Se) can reduce uptake and translocation of cadmium (Cd) in plants by regulating root morphology. This study investigated the effects of Se(IV) on root exudates, root morphology, root endogenous hormones, and Cd uptake efficiency in rice under Cd stress. The results showed that Se(IV) significantly reduced Cd concentrations in shoots and roots, and decreased Cd uptake efficiency via root hairs. Se(IV) also affected root morphology, root exudates, and the synthesis of hormones like IAA and JA. However, transcriptome analysis revealed no upregulated differentially expressed genes (DEGs) in IAA synthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Di Wang, Huaifang Zhang, Xuefei Hu, Haizhen Zhang, Shuang Feng, Aimin Zhou
Summary: This study identified a cell number regulator gene called SlCNR8 in willow, which enhances resistance to trace metals in transgenic poplar seedlings. SlCNR8 reduces Cd uptake and accumulation, and can be used as a candidate gene for genetic improvement of phytostabilisation of trace metals.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)