Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew A. Badachhape, Prajwal Bhandari, Laxman Devkota, Mayank Srivastava, Eric A. Tanifum, Verghese George, Karin A. Fox, Chandrasekhar Yallampalli, Ananth V. Annapragada, Ketan B. Ghaghada
Summary: This study used contrast agents to investigate the effects of abnormal placental implantation on the retro-placental clear space (RPCS). The results showed that the RPCS in the abnormal group of mice was smaller, had a heterogeneous signal, and was significantly damaged. These findings provide a valuable method for early detection of invasive placentation.
ACADEMIC RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paolo Arosio, Davide Cicolari, Amedea Manfredi, Francesco Orsini, Alessandro Lascialfari, Elisabetta Ranucci, Paolo Ferruti, Daniela Maggioni
Summary: In this study, a linear polyamidoamine (PAA) named BAC-EDDS was successfully synthesized and showed stable nanoaggregates with negative charge, demonstrating good performance as a contrast agent in magnetic resonance imaging.
Article
Chemistry, Medicinal
Soyeon Kim, Ji-ung Yang, Jae Hun Ahn, In Ok Ko, Jung Young Kim, Yong Jin Lee, Ji-Ae Park
Summary: The study evaluated a tumor-targeting gadolinium complex Gd-TDAP, showing its potential in MR/optical imaging and therapy. The complex exhibited higher longitudinal relaxivity and tumor-targeting characteristics, as well as demonstrated potential inside the cell nucleus and for photodynamic therapy.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Medicine, General & Internal
Haiyan Wang, Yongli Wang, Jingyuan Wang, Nan Cui, Xueling Bi
Summary: Contrast-enhanced ultrasound (CEUS) is beneficial for the diagnosis and research of gynaecological diseases. However, the clinical safety of contrast doses in CEUS needs further investigation. This study observed the changes in placental ultrastructure in pregnant rats injected with SonoVueTM contrast agent and found that a low dose of SonoVueTM is safe for fetal disc imaging in late-term pregnant rats.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Reproductive Biology
C. Bertholdt, M. Dap, R. Pillot, P. Chavatte-Palmer, O. Morel, M. Beaumont
Summary: The study aimed to quantitatively characterize placental perfusion using contrast-enhanced ultrasound in pregnant rabbits and qualitatively assess the placental perfusion. The results showed that placental vascularization became gradually homogeneous as pregnancy progressed, and the wash-in and wash-out rates significantly increased. Contrast-enhanced ultrasound is feasible for qualitative and quantitative analysis of placental vascularization during pregnancy in animal models.
Article
Materials Science, Biomaterials
Vu Hoang Minh Doan, Dinh Dat Vu, Sudip Mondal, Thi Mai Thien Vo, Cao Duong Ly, Van Tu Nguyen, Sumin Park, Jaeyeop Choi, Thanh Phuoc Nguyen, Byeongil Lee, Junghwan Oh
Summary: Recently, nanomaterials based on hydroxyapatite (HAp) doped with rare-earth elements have been developed for improved bioimaging. In this study, Yb- x -Gd- x -HAp nanoparticles were synthesized using the wet precipitation method and characterized to analyze their properties. The developed FA/IR783/Yb-Gd-HAp nanomaterial showed enhanced contrast and tumor-specific properties in fluorescence imaging, and the biocompatibility of the synthesized NPs was verified. Moreover, the Yb- x -Gd- x -HAp NPs exhibited photosensitizer properties and were efficient in supporting photodynamic therapy for breast cancer cells.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
S. A. Amali S. Subasinghe, Jonathan Romero, Cassandra L. Ward, Matthew D. Bailey, Donna R. Zehner, Prakrut J. Mehta, Fabio Carniato, Mauro Botta, Jason T. Yustein, Robia G. Pautler, Matthew J. Allen
Summary: The complexes described in this study act as contrast agents for magnetic resonance imaging thermometry, enhancing contrast between 275 and 325 K. The temperature response of the fluorinated contrast complex is primarily based on the modulation of water exchange caused by trifluoromethyl groups, which can be chemically controlled.
CHEMICAL COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Viktoria Neubertova, Olga Guselnikova, Yusuke Yamauchi, Anastasia Olshtrem, Silvie Rimpelova, Erik Cizmar, Martin Orendac, Jan Duchon, Lenka Volfova, Jan Lancok, Vit Herynek, Premysl Fitl, Pavel Ulbrich, Ludek Jelinek, Patrik Schneider, Juraj Kosek, Pavel Postnikov, Zdenka Kolska, Vaclav Svorcik, Sergii Chertopalov, Oleksiy Lyutakov
Summary: This study explores the covalent functionalization of MXenes for bioimaging applications. By using a chelating agent and Gd3+ ions, the commonly diamagnetic MXenes were transformed into paramagnetic materials, enabling their use in magnetic resonance imaging. Covalent functionalization not only enhanced the stability and cytocompatibility of MXenes but also prevented the leakage of Gd3+ ions. This work expands the bioapplication of MXenes by introducing an MRI contrast and developing covalent functionalization strategies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Sellamuthu Anbu, Sabrina H. L. Hoffmann, Fabio Carniato, Lawrence Kenning, Thomas W. Price, Timothy J. Prior, Mauro Botta, Andre F. Martins, Graeme J. Stasiuk
Summary: Manganese-based contrast agents have emerged as potential alternatives to gadolinium-based ones, but their clinical application is limited due to synthetic challenges. This study successfully developed a MnCA with optimized relaxivity, MnLMe, through an innovative synthetic strategy, demonstrating promising performance in both in vitro and in vivo studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Divya Rajendran, Judith Elizabeth, Sundar Manoharan, Nagabhushan Vellala, Brahmadathan Kootallur, Abiram Angamuthu, Jebasingh Bhagavathsingh, Prince Makarios Paul
Summary: In this study, a novel Gd(III) complex was reported as a potential contrast agent for high resolution MRI images, and its molecular structure was predicted through DFT calculations. The complex displayed high relaxivity and enhanced image intensity in MRI, paving the way for higher resolution imaging.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander M. Panich, Moti Salti, Ofer Prager, Evyatar Swissa, Yuri Kulvelis, Elena B. Yudina, Alexander E. Aleksenskii, Shaul D. Goren, Alexander Ya Vul', Alexander Shames
Summary: The study demonstrates that saline suspension of PVP-coated gadolinium-grafted detonation nanodiamonds (DND) serves as a promising contrast agent in MRI, providing higher signal intensities than the commonly used gadoterate meglumin. This novel contrast agent shows potential for safer clinical use based on its performance in ex vivo and in vivo testing.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Chemistry, Organic
Alberto Lanfranco, Diego Alberti, Stefano Parisotto, Polyssena Renzi, Valentin Lecomte, Simonetta Geninatti Crich, Annamaria Deagostino
Summary: A new biotin-based BNCT-MRI theranostic probe is reported, which combines the high tumor specificity of biotin and the selectivity of BNCT. The experimental results show that the probe has a high cellular uptake rate and MRI signal intensity increase in HeLa cells, indicating its potential therapeutic application.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiaohan Zhou, Junwei Cheng, Fangfei He, Zhuo Ao, Peisen Zhang, Jing Wang, Qing Li, Weinan Tang, Yiyan Zhou, Yan Liang, Yi Hou, Wentao Liu, Dong Han
Summary: In this study, a high longitudinal relaxivity MRI contrast agent PAA-g-(DTPA-gadolinium) is designed and synthesized to track the transportation of nano-scale agents in the interstitial stream. The imaging and analysis enabled by this agent can advance the fields of physiology, pathology, and pharmacology.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Yaning Zhao, Congcong Cui, Jiahui Zhan, Guangshan Xuan
Summary: The study successfully prepared folate-chitosan/chitosan-diethylenetriaminepentaacetic acid-gadolinium nanoparticles, which exhibited good magnetic properties and specific targeting effect towards folate-overexpressing tumor cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Yuanlin Dong, Manu Banadakoppa, Madhu Chauhan, Meena Balakrishnan, Michael Belfort, Chandra Yallampalli
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Multidisciplinary Sciences
Mary C. Peavey, San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, Margeaux Wetendorf, Chandra Yallampalli, William E. Gibbons, John P. Lydon, Francesco J. DeMayo
Summary: The study revealed that overexpression of progesterone receptor PGR-B leads to relaxation of uterine muscles, prolonged gestational length, and increased incidence of labor dystocia, while overexpression of PGR-A increases uterine muscle contraction without affecting gestational length.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pathology
Amrit K. Shrestha, Renuka T. Menon, Chandrasekhar Yallampalli, Roberto Barrios, Binoy Shivanna
Summary: Adrenomedullin plays a crucial role in mitigating neonatal lung injury induced by sepsis. Lack of Adm leads to severe lung inflammation and injury in LPS-exposed neonatal mice.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Madhu Chauhan, Ancizar Betancourt, Meena Balakrishnan, Akansha Mishra, Jimmy Espinosa, Alireza A. Shamshirsaz, Karin Fox, Michael Belfort, Chandra Yallampalli
Summary: This study found that the relaxation response of the uterine artery in pregnant women to CGRP, ADM, and ADM2 is increased compared to nonpregnant women. The increase in relaxation sensitivity is mediated by the NO system and endothelium-derived hyperpolarizing factors. Additionally, the receptor system in smooth muscle cells of the uterine artery is adversely affected by vascular disruptors such as sFLT-1 and TNF-alpha.
Article
Multidisciplinary Sciences
Yuanlin Dong, Simone Hernandez Ruano, Akansha Mishra, Kathleen A. Pennington, Chandrasekhar Yallampalli
Summary: The study reveals the expression of ADM and its receptors in mouse pancreatic islets, with reduced levels in pregnant mice compared to non-pregnant mice. NIT-1-beta cells express ADM and its receptors and show glucose-dependent stimulation. ADM inhibits insulin secretion and cell growth, with effects reversed by an ADM antagonist. These findings suggest that reduced ADM and its receptors may impact beta-cell adaptation during pregnancy, while increased plasma ADM in GDM can contribute to beta-cell dysfunction.
Article
Multidisciplinary Sciences
Yuanlin Dong, Ancizar Betancourt, Michael A. Belfort, Chandrasekhar Yallampalli
Summary: This study found that certain inflammatory factors and lipid metabolic adipokines in the omental adipose tissue (OMAT) of women with gestational diabetes mellitus (GDM) were increased. The expression levels of adrenomedullin (ADM) and its receptors were also higher in OMAT of GDM women. In addition, basal lipolysis was higher in OMAT and ADM stimulated further glycerol release in OMAT. These findings suggest that the elevated expression of ADM and its receptors in OMAT may contribute to lipid metabolism dysregulation in GDM women.
Article
Nutrition & Dietetics
Vipin A. Vidyadharan, Ancizar Betancourt, Craig Smith, Chandrasekhar Yallampalli, Chellakkan S. Blesson
Summary: Gestational low-protein diet disrupts mitochondrial ultrastructure and function in skeletal muscles of female offspring, potentially leading to insulin resistance. Key genes involved in mitochondrial structure and function are dysregulated in LP-programmed female offspring.