Article
Clinical Neurology
Yinxing Huang, Meina Wang, Jianwu Wu, Kunzhe Lin, Shousen Wang, Fangfang Zhang
Summary: The aim of this study was to assess the factors influencing the occurrence of delayed hyponatremia after transsphenoidal surgery (TSS) in patients with a non-functional pituitary adenoma (NFPA). The results showed that delayed postoperative hyponatremia was independently associated with larger craniocaudal dimension, preoperative hyperprolactinemia, and larger preoperative pituitary stalk deviation angle.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Medicine, General & Internal
Xiaopeng Guo, Duoxing Zhang, Haiyu Pang, Zihao Wang, Lu Gao, Yu Wang, Wenbin Ma, Wei Lian, Bing Xing
Summary: This study demonstrates that withholding hydrocortisone during pituitary adenoma surgery is safe for patients with an intact HPA axis, and the incidence of new-onset adrenal insufficiency is noninferior to the conventional supplementation regimen.
Article
Neurosciences
Domenico Solari, Luigi Maria Cavallo, Chiara Graziadio, Sergio Corvino, Ilaria Bove, Felice Esposito, Paolo Cappabianca
Summary: Giant pituitary adenomas present a surgical challenge due to their growth patterns and locations. There is no consensus on the optimal surgical strategy, but transcranial or transsphenoidal approaches are commonly used. Endoscopic endonasal approach is preferred, but transcranial approach is more suitable when the tumor has significant intracranial extension. Accurate preoperative evaluation and individualized treatment plans are crucial for long-term effectiveness.
Article
Clinical Neurology
Janelle Cyprich, Dhiraj J. Pangal, Martin Rutkowski, Daniel A. Donoho, Mark Shiroishi, Chia-Shang Jason Liu, John D. Carmichael, Gabriel Zada
Summary: The study found that patients presenting to safety-net hospitals were more likely to be uninsured or on Medicaid, had larger and more advanced pituitary tumors, and were more likely to present with symptoms such as headaches and vision loss.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Salomon Cohen-Cohen, Desmond A. Brown, Benjamin T. Himes, Lydia P. Wheeler, Michael W. Ruff, Brittny T. Major, Naykky M. Singh Ospina, John L. D. Atkinson, Fredric B. Meyer, Irina Bancos, William F. Young Jr, Jamie J. Van Gompel
Summary: In patients with MEN1, the prevalence of pituitary adenomas is higher in females than in males. Functional adenomas, especially prolactin-secreting adenomas, are more common than nonfunctional ones. Most asymptomatic nonfunctional adenomas can be safely followed, with only a small percentage progressing to require surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Rupa G. Juthani, Anne S. Reiner, Ankur R. Patel, Aimee Cowan, Marie Roguski, Katherine S. Panageas, Eliza B. Geer, Sasan Karimi, Marc A. Cohen, Viviane Tabar
Summary: The study evaluated the safety and efficacy of iMRI for pituitary adenoma resection, comparing endoscopic transsphenoidal and microscopic transsphenoidal approaches. Results showed that iMRI can improve the extent of resection for pituitary adenomas while preserving hormone function, with low rates of postoperative complications.
JOURNAL OF NEUROSURGERY
(2021)
Review
Endocrinology & Metabolism
Mathias Brown Pedersen, Stefan Dukanovic, Jacob Bertram Springborg, Mikkel Andreassen, Jesper Krogh
Summary: The effects of transsphenoidal surgery on pituitary endocrine function in patients with NFPAs are uncertain. The chance of recovery and the risk of pituitary failure and hypopituitarism are unclear. Further systematic data collection is needed for a better understanding.
NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mayo Ono, Izumi Fukuda, Akimi Soga, Shigeyuki Tahara, Akio Morita, Hitoshi Sugihara
Summary: Incidental pituitary tumors are generally smaller, found in older patients, have a lower incidence of hormone deficiency, and show better preservation of pituitary function postoperatively. Close observation and appropriate decision-making are important to prevent incidentalomas from progressing into symptomatic tumors.
Article
Oncology
Daibo Ke, Ling Xu, Danyang Wu, Shaocheng Yang, Shun Liu, Mingxiang Xie, Shunwu Xiao
Summary: This study retrospectively reviewed the clinical records of 94 patients diagnosed with giant pituitary adenomas who underwent surgical resection between 2014 and 2022. The outcomes of the surgical and clinical procedures were analyzed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Carlos Perez-Lopez, Cristina Alvarez-Escola, Alberto Isla Guerrero
Summary: The treatment of non-functioning pituitary adenomas depends on symptoms, contact with the optic tract, and growth on imaging tests. Medical treatment is used after surgical and radiotherapy options are exhausted.
Article
Oncology
Racheal Peterson, Sandeep Kandregula, Elizabeth Jee, Bharat Guthikonda
Summary: Frailty in patients undergoing surgery for craniopharyngioma is associated with longer hospital stays, increased hospital costs, and higher risk of postoperative complications. The Hospital Frailty Risk Score (HFRS) is a valuable tool for predicting these outcomes.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Jiayin Qin, Kai Li, Xijuan Wang, Yongzhen Bao
Summary: This study aimed to investigate the differences in visual impairment caused by functioning and non-functioning pituitary adenomas. It was found that patients with functioning pituitary adenomas had better corrected visual acuity and lighter visual field defects compared to those with non-functioning pituitary adenomas. Additionally, tumor volume was correlated with visual field defects in both groups.