Review
Biochemistry & Molecular Biology
Han Yang, Yufang Liu, Longqing Chen, Juanjuan Zhao, Mengmeng Guo, Xu Zhao, Zhenke Wen, Zhixu He, Chao Chen, Lin Xu
Summary: Lung cancer is a prevalent and deadly disease, with limited treatment options, especially for advanced stage patients. However, recent advances in miRNA-based therapies show potential in improving prognosis and overcoming drug resistance. Clinical trials have demonstrated promising outcomes for siRNA and miRNA-based therapies. This review discusses the current state of miRNA-based therapies in lung cancer treatment and their challenges, offering new ideas for the development of novel lung cancer therapies.
Review
Cell Biology
Xianjie Jiang, Linda Oyang, Qiu Peng, Qiang Liu, Xuemeng Xu, Nayiyuan Wu, Shiming Tan, Wenjuan Yang, Yaqian Han, Jinguan Lin, Longzheng Xia, Mingjing Peng, Yanyan Tang, Xia Luo, Min Su, Yingrui Shi, Yujuan Zhou, Qianjin Liao
Summary: This paper reviews the development history of organoids, the culture methods of tumor organoids establishment, and the applications of organoids in cancer research. The standardization of cultivation methods has facilitated the large-scale production of tumor organoids. Additionally, combining tumor organoids with other cells such as immune cells, fibroblasts, and nervous cells could better mimic the microenvironment of tumor progression, which might be an important direction for the future development of tumor organoids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Rabia K. Shahid, Shahid Ahmed, Duc Le, Sunil Yadav
Summary: Diabetes is a common comorbidity in cancer patients and increases the risk for certain solid tumors. The coexistence of diabetes and cancer presents unique challenges and requires a multidisciplinary approach for better outcomes. Further studies are needed to understand the underlying mechanisms and evaluate innovative management strategies for this patient population.
Review
Physics, Applied
Marco Durante, Juergen Debus, Jay S. Loeffler
Summary: Carbon ions represent a promising combination of physical and biological advantages for radiotherapy, with clinical results showing potential breakthroughs. However, the cost-effectiveness and comparison to proton therapy centers continue to be a topic of debate in the clinical community. Research towards smaller, cheaper machines with more effective beam delivery is seen as necessary to make particle therapy more affordable and fully exploit the clinical benefits.
NATURE REVIEWS PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Review
Pharmacology & Pharmacy
Shiming He, Jian Xu, Xiujun Liu, Yongsu Zhen
Summary: Esophageal cancer is a common and deadly cancer with two histological subtypes - esophageal squamous cell carcinoma and esophageal adenocarcinoma. Available treatment strategies include surgery, chemotherapy, and molecular targeted therapy, with poor prognosis. This review discusses the latest developments in chemotherapy, molecular targeted therapy, and immunotherapy for esophageal cancer.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Multidisciplinary
Jiheon Kim, Sanghyeon Lee, Sunkyu Han, Hee-Yoon Lee
Summary: Since its discovery in 2002, conidiogenone has been extensively studied and used as a platform for the development of synthetic strategies. However, most approaches focused on the construction of the core structure, while a divergent synthetic approach for D-ring modifications remained unknown. In this study, a divergent synthesis of six conidiogenones, including three total syntheses, was achieved using a synthetic strategy that involved the use of TMM-mediated cycloaddition and subsequent D-ring diversifications.
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Editorial Material
Chemistry, Multidisciplinary
Hyung Min Chi, Pengfei Hu, Scott A. Snyder
Summary: The researchers demonstrate the construction of the tetracyclic framework of the conidiogenone family in one step using a cascade reaction starting from a material with one ring and appropriate functional groups.
Article
Medicine, General & Internal
Zhijun Zhou, Barish H. Edil, Min Li
Summary: Gastrointestinal cancers, especially pancreatic cancer, pose a significant challenge to public health. Neoadjuvant chemotherapy offers some patients the chance for radical resection. An optimal chemotherapy regimen should maximize anti-tumor efficacy while maintaining manageable safety. Surgical advancements further enhance outcomes for these patients.
Review
Chemistry, Multidisciplinary
Shahinur Acter, Michele Moreau, Robert Ivkov, Akila Viswanathan, Wilfred Ngwa
Summary: In the field of cancer treatment, multifunctional nanoparticles, specifically those made with polydopamine (PDA), are gaining attention. PDA, a nature-inspired polymer, offers various advantages such as biocompatibility, biodegradability, drug loading capability, photothermal conversion efficiency, and adhesive properties. Despite the unclear mechanism of dopamine polymerization, PDA exhibits flexibility in controlling morphology and size and is easily functionalized. It has the potential to be utilized in innovative approaches for cancer treatment. This review focuses on the application of PDA in developing multifunctional nanomaterials for photothermal therapy and discusses its potential in enhancing radiotherapy and/or immunotherapy.
Review
Oncology
Wanrong Luo, Yasser F. Ali, Chong Liu, Yuchen Wang, Caorui Liu, Xiaoni Jin, Guangming Zhou, Ning-Ang Liu
Summary: Hadron therapy using protons and carbon ions is gaining interest as a potential alternative to traditional photon radiotherapy. The precise dose distribution of charged particles allows for better tumor control and reduced damage to healthy tissues. The high-linear energy transfer characteristics of heavy ions offer biological advantages, making them a promising approach for treating breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Dor Breier, Dan Peer
Summary: Since its discovery in 2012, the CRISPR/Cas9 system has revolutionized genome editing and shown potential as a therapy for genetic diseases and cancer. However, there are challenges to be addressed before clinical testing, including the safety of in-vivo therapies and effects on genomic stability.
BIOACTIVE MATERIALS
(2023)
Review
Oncology
Darren M. C. Poon, Stephen Wu, Leon Ho, Kin Yin Cheung, Ben Yu
Summary: Although proton therapy (PT) treatment plans show superior dosimetric advantages over photon-based external beam radiotherapy (EBRT) for localized prostate cancer, the reported clinical outcomes are similar. This may be due to inadequate dose prescription, especially in high-risk cases, as indicated by the ASCENDE-RT trial. Additionally, the lack of clinical benefits with PT may be attributed to improper dose delivery, mainly due to geometric and dosimetric uncertainties during treatment planning and delivery procedures. Innovative high-precision PT technologies and treatment planning systems are being developed to address these uncertainties and aim to improve the accuracy and dose conformity of PT for localized prostate cancers, leading to better clinical outcomes.
Review
Pathology
Sina Taefehshokr, Aram Parhizkar, Shima Hayati, Morteza Mousapour, Amin Mahmoudpour, Liliane Eleid, Dara Rahmanpour, Sahand Fattahi, Hadi Shabani, Nima Taefehshokr
Summary: Cancer immunotherapy has shown promising results in inducing tumor regression, but issues like tumor resistance and relapse still exist. Different tumor types have different responses to immunotherapy, possibly due to cancer cells developing resistance mechanisms to evade treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Antonio Luiz Gomes Junior, Jana Dimitrova Tchekalarova, Keylla da Conceicao Machado, Arkellau Kenned Silva Moura, Marcia Fernanda Correia Jardim Paz, Ana Maria Oliveira Ferreira da Mata, Tiago Rocha Nogueira, Muhammad Torequl Islam, Maria Alexsandra de Sousa Rios, Antonia Maria das Gracas Lopes Cito, Shaikh Jamal Uddin, Jamil A. Shilpi, Asish K. Das, Luciano da Silva Lopes, Ana Amelia de Carvalho Melo-Cavalcante
Article
Biochemistry & Molecular Biology
Marcia Fernanda Correia Jardim Paz, Antonio Luiz Gomes Junior, Marcus Vinicius Oliveira Barros de Alencar, Shams Tabrez, Muhammad Torequl Islam, Nasimudeen R. Jabir, Mohammad Oves, Mohammad Zubair Alam, Muhammad Nadeem Asghar, Eunus S. Ali, Keylla da Conceicao Machado, Katia da Conceicao Machado, Felipe Cavalcanti Carneiro da Silva, Andre Luiz Pinho Sobral, Joao Marcelo de Castro E Sousa, Germano Pinho de Moraes, Siddhartha Kumar Mishra, Juliana da Silva, Ana Amelia de Carvalho Melo-Cavalcante
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2019)
Review
Medicine, Research & Experimental
Ana Amelia de Carvalho Melo-Cavalcante, Leonardo da Rocha Sousa, Marcus Vinicius Oliveira Barros Alencar, Jose Victor de Oliveira Santos, Ana Maria Oliveira da Mata, Marcia Fernanda Correia Jardim Paz, Ricardo Melo de Carvalho, Narcia Mariana Fonseca Nunes, Muhammad Torequl Islam, Anderson Nogueira Mendes, Juan Carlos Ramos Goncalves, Felipe Cavalcanti Carneiro da Silva, Paulo Michel Pinheiro Ferreira, Joao Marcelo de Castro e Sousaa
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Marcus Vinicius Oliveira Barros de Alencar, Muhammad Torequl Islam, Rosalia Maria Torres de Lima, Marcia Fernanda Correia Jardim Paz, Antonielly Campinho dos Reis, Ana Maria Oliveira Ferreira da Mata, Jose Williams Gomes de Oliveira Filho, Gilberto Santos Cerqueira, Paulo Michel Pinheiro Ferreira, Joao Marcelo de Castro e Sousa, Mohammad S. Mubarak, Ana Amelia de Carvalho Melo-Cavalcante
Review
Biochemistry & Molecular Biology
Muhammad T. Islam, Abul B. R. Khalipha, Rajat Bagchi, Milon Mondal, Shanita Z. Smrity, Shaikh J. Uddin, Jamil A. Shilpi, Razina Rouf
Review
Chemistry, Medicinal
Muhammad Torequl Islam
PHYTOTHERAPY RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Muhammad Torequl Islam, Sajal Biswas, Rajat Bagchi, Md. Roich Khan, Abul Bashar Ripon Khalipha, Razina Rouf, Shaikh Jamal Uddin, Jamil A. Shilpi, Sanaa K. Bardaweel, Dima A. Sabbah, Mohammad S. Mubarak
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2019)
Article
Immunology
Muhammad Torequl Islam
INFLAMMOPHARMACOLOGY
(2019)
Review
Medicine, Research & Experimental
Debora Cassia Vieira Gomes, Marcus Vinicius Oliveira Barros de Alencar, Antonielly Campinho dos Reis, Rosalia Maria Torres de Lima, Jose Victor de Oliveira Santos, Ana Maria Oliveira Ferreira da Mata, Ana Carolina Soares Dias, Joaquim Soares da Costa Junior, Maria das Gracas Freire de Medeiros, Marcia Fernanda Correia Jardim Paz, Lina Clara Gayoso e Almendra Ibiapina Moreno, Joao Marcelo de Castro e Sousa, Muhammad Torequl Islam, Ana Amelia de Carvalho Melo Cavalcante
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Rasel Ahmed Khan, Rajib Hossain, Abolghasem Siyadatpanah, Khattab Al-Khafaji, Abul Bashar Ripon Khalipha, Dipta Dey, Umma Hafsa Asha, Partha Biswas, Abu Saim Mohammad Saikat, Hadi Ahmadi Chenari, Polrat Wilairatana, Muhammad Torequl Islam
Summary: Dengue fever is a dangerous endemic disease caused by the dengue virus, resulting in millions of deaths worldwide. Some derivatives of diterpenoids exhibit anti-dengue viral properties. In silico studies showed that certain compounds have good binding affinities to viral proteins, suggesting their potential as anti-dengue medications.
Article
Chemistry, Multidisciplinary
Radoslaw Kowalski, Marek Rosochacki, Jakub Wyrostek, Muhammad Torequl Islam
Summary: The aim of this study was to compare the sensory evaluation, nutritional composition, and health-promoting ingredients of raw chocolate with commercial chocolates. The results showed that raw chocolate had lower carbohydrates, higher content of total phenolic compounds, total flavonoids, and total antioxidant activity. However, it received lower ranks in taste due to the lower carbohydrate content. On the other hand, it received the highest marks in external appearance-shape and external appearance-surface condition.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Md. Shimul Bhuia, Polrat Wilairatana, Raihan Chowdhury, Asraful Islam Rakib, Hossam Kamli, Ahmad Shaikh, Henrique D. M. Coutinho, Muhammad Torequl Islam
Summary: This study aims to summarize the botanical origins and anticancer properties of magnolin, a naturally occurring, multi-bioactive lignan molecule. Magnolin has been shown to exhibit robust anticancer activity by inhibiting cell cycle, inducing apoptosis, and modulating multiple signaling pathways in various experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.
Article
Biochemistry & Molecular Biology
Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Hossam Kamli, Fatema Akter Sonia, Md. Nayem Mia, Md. Showkoth Akbor, Md. Munnaf Hossen, Samir Awadallah, Mohammad S. S. Mubarak, Muhammad Torequl Islam
Summary: Sedatives are used for calmness or sleepiness in surgery or severe stress. Depression negatively affects emotional well-being and can be treated with anti-depressants. This study evaluated the effects of quercetin and linalool on sleeping mice induced by thiopental sodium and investigated their combined effects using in silico studies.
Review
Biochemistry & Molecular Biology
Md. Shimul Bhuia, Polrat Wilairatana, Jannatul Ferdous, Raihan Chowdhury, Mehedi Hasan Bappi, Md Anisur Rahman, Mohammad S. Mubarak, Muhammad Torequl Islam
Summary: Fruits and vegetables not only provide nutrition, but also have therapeutic effects against various diseases. Hirsutine (HSN), a natural indole alkaloid found in Uncaria species, has multiple therapeutic benefits and can be found in various foods. This study summarizes the pharmacological activities and mechanisms of HSN against different diseases, and emphasizes its potential as a promising therapeutic agent for cancer treatment.
Article
Marine & Freshwater Biology
Joao M. C. e Sousa, Vitor A. de Oliveira, Ana P. Peron, Ataide M. V. Lima, Ila B. S. Sales, Felipe C. C. da Silva, Leonardo H. G. M. Lima, Leoma Prime A. Matos, Marcus V. O. B. de Alencar, Luzia C. Rodrigues, Manik C. Shill, Muhammad T. Islam, Ana Amelia C. Melo-Cavalcante, Claudia C. Bonecker, Horacio F. J. Junior
INTERNATIONAL AQUATIC RESEARCH
(2019)
