Review
Food Science & Technology
Ashraful Alam, Abdullah Al Arif Jahan, Md Sazzadul Bari, Labony Khandokar, Md Hasan Mahmud, Muhammed Junaid, Mohammed Salahuddin Chowdhury, Mohammad Forhad Khan, Veronique Seidel, Md Areeful Haque
Summary: This review provides an overview of the traditional uses, phytoconstituents, anti-inflammatory and anticancer activity of Allium species. These plants contain a wide range of chemical constituents and show potential for anti-inflammatory and anticancer effects. Garlic and onion, in particular, have been extensively studied, suggesting that other Allium species may also possess similar bioactive constituents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Concepcion Obon, Diego Rivera, Elena Fonolla, Francisco Alcaraz, Latifa Attieh
Summary: This study combines ethnobotany and ethnopharmacology field work techniques to study the traditional herbal mixtures with flowers in Greece and the Eastern Mediterranean countries. The botanical ingredients of these mixtures are identified and their local medicinal uses recorded, with analysis using morphological and multivariate analysis techniques.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Bahare Salehi, Cristina Quispe, Muhammad Imran, Iahtisham Ul-Haq, Jelena Zivkovic, Ibrahim M. Abu-Reidah, Surjit Sen, Yasaman Taheri, Krishnendu Acharya, Hamed Azadi, Maria del Mar Contreras, Antonio Segura-Carretero, Dima Mnayer, Gautam Sethi, Miquel Martorell, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Hafiz Ansar Rasul Suleria, Javad Sharifi-Rad
Summary: The Nigella genus, especially Nigella sativa, is well-known for its culinary and medicinal properties in regions like Eastern Europe and the Middle East. The seeds of Nigella plants contain beneficial omega-6 fatty acids and phytochemicals like thymoquinone, making them a potential source of functional ingredients. Further research, including clinical trials, is needed to standardize the use of Nigella for health benefits and culinary applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
Qiaobian He, Li Zhang, Ting Li, Changhao Li, Huina Song, Peihong Fan, Pills Pharbitidis Semem
Summary: Genus Sapium, commonly used in traditional Chinese herbal medicine, has a wide range of biological activities and high medicinal value, with terpenoids, phenylpropanoids, and tannins identified as main constituents responsible for the pharmacological effects; further extensive and in-depth research is needed to explore the medicinal potential of Sapium species.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Yuan-yuan Ren, Xiao-rui Zhang, Ting-na Li, Yi-jia Zeng, Jin Wang, Qin-wan Huang
Summary: Galla chinensis is a traditional Chinese medicine with diverse pharmacological properties used for over 1400 years. Research has focused on its traditional uses, botanical characteristics, chemical composition, pharmacology, and toxicology, showing potential therapeutic benefits for various diseases. Further studies are needed on the relationship between its components and biological activities, as well as quality control and dynamics of chemical accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Chen Wang, Hongxia Zhang, Qing Liu, Jinfeng Qi, Huifu Zhuang, Yi Gou, Hongbin Wang, Yuhua Wang
Summary: Adenosma spp. are traditionally used to treat gastrointestinal disorders, hepatitis, colds, and skin problems, and they mainly contain phenolic acids, flavonoids, and terpenoids. Research has shown that Adenosma spp. have biological activities such as antidiabetic, anticancer, and insecticidal properties, but studies are currently limited to a few species in China and Vietnam, necessitating further research to prove their health benefits.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Jian Wang, Haiqing Wang, Jian Yu, Jinglong Wang, Qinghua Cui, Lin Hou, Jingzhen Tian
Summary: The review aims to analyze the traditional uses, chemical composition, and pharmacological activities of diaphragma juglandis fructus (DJF) and provide an overview for further research and development. DJF has been traditionally used in traditional Chinese medicine to treat insomnia, nourish the kidneys, and has various pharmacological properties. Its components include flavonoids, phenolic acids, quinones, steroids, lignans, and volatile oils, which exhibit therapeutic potential for kidney diseases and have antioxidant, antitumor, antidiabetic, antibacterial, anti-inflammatory, and sedative-hypnotic properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Hammad Saleem, Atif Usman, Mohamad Fawzi Mahomoodally, Nafees Ahemad
Summary: Bougainvillea glabra is a valuable ornamental plant with traditional medicinal uses, traditionally employed against various diseases. Research has shown a wide range of pharmacological activities, but further exploration of its toxicological effects is needed.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Uche Maryann Chukwudulue, Alfred Francis Attah, Festus Basden Chiedu Okoye
Summary: The genus Psydrax, belonging to the Rubiaceae family, is an important ethno-medicinal genus with traditional applications in the management of various diseases. Despite its importance, the scientific attention given to this genus has been limited. However, phytochemical studies have identified over a hundred secondary metabolites, mainly iridoids, in a few species of Psydrax. These bioactive compounds have shown pharmacological properties such as anti-hyperglycemia, anti-inflammatory, anticonvulsant, and antimicrobial activities, supporting the traditional uses of these plants. Further research, including ethnobotanical surveys, in vivo pharmacological assays, toxicity studies, and comprehensive phytochemical investigations, is necessary to fully explore the medicinal potential of Psydrax species.
PHYTOCHEMISTRY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Stergios Pirintsos, Athanasios Panagiotopoulos, Michalis Bariotakis, Vangelis Daskalakis, Christos Lionis, George Sourvinos, Ioannis Karakasiliotis, Marilena Kampa, Elias Castanas
Summary: Ethnopharmacology has provided a framework for the therapeutic use of natural compounds, and the transition to drug discovery relies on computational methods. The significance of using computational methods to identify active substances and their plant sources is highlighted, along with the importance of in vitro and in vivo validation.
Review
Plant Sciences
Jose Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro
Summary: Cyperus rotundus is widely used in traditional medicine in Asian countries and has shown potential anticancer effects against various tumor cell lines, with its chemical compounds playing a key role.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Review
Pharmacology & Pharmacy
Panpan Wang, Zhen Wang, Zhanping Zhang, Huiyan Cao, Lingyang Kong, Wei Ma, Weichao Ren
Summary: Astragalus, also known as Huangqi, is widely distributed in the Northern Hemisphere, South America, and Africa. It has been traditionally used as ethnomedicine in several countries including Russia, Mongolia, Korea, Kazakhstan, and China. This comprehensive review summarizes the botanical characteristics, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of Astragalus, providing valuable insights for future research and the development of new drugs involving Huangqi.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Sofi Imtiyaz Ali, V. Venkatesalu
Summary: Saussurea costus is a critically endangered plant with important medicinal value, traditionally used to treat various diseases. It contains several major phytoconstituents with great drug candidate potential. Pharmacological experiments have confirmed its various medicinal properties, making it a promising candidate for drug discovery. However, further research is needed to fully understand its bioactive ingredients, physiological mechanisms, and pharmacokinetics.
PHYTOCHEMISTRY LETTERS
(2022)
Review
Plant Sciences
Sunil Kumar, Bikarma Singh, Vikas Bajpai
Summary: Andrographis paniculata is a medicinal herb used in Asian countries for various diseases. This review provides information on its traditional uses, phytochemistry, pharmacological properties, and chemical markers for quality control.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Jose Jailson Lima Bezerra, Antonio Fernando Morais de Oliveira
Summary: This study reviewed the folk medicinal use of Cyperaceae species in Brazil, distinguishing between species with and without experimental data. It found that 27 species have reports of folk medicinal use in Brazil, but only 44% have been scientifically investigated. The lack of scientific evidence to validate the traditional medicinal use of most species was highlighted.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Plant Sciences
R. Arumugam, V. Venkatesalu, R. Rajkumar
RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
(2015)
Article
Chemistry, Applied
Sofi Imtiyaz Ali, B. Gopalakrishnan, V. Venkatesalu
NATURAL PRODUCT RESEARCH
(2019)
Article
Plant Sciences
S. I. Ali, B. Gopalakrishnan, V. Venkatesalu
SOUTH AFRICAN JOURNAL OF BOTANY
(2018)
Article
Parasitology
Sofi Imtiyaz Ali, B. Gopalakrishnan, V. Venkatesalu
PARASITOLOGY INTERNATIONAL
(2018)
Article
Chemistry, Applied
Sofi Imtiyaz Ali, Venkatesalu Venugopalan
Summary: In this study, hydroxy-2-methyl-4H-pyran-4-one was isolated from the methanol root extract of Senecio laetus and evaluated for its larvicidal potential against three mosquito species. The compound showed promising results with high mortality rates, especially against Cx. quinquefasciatus. Further toxicological and field evaluations may lead to the development of this compound as a potential insecticide.
NATURAL PRODUCT RESEARCH
(2021)
Review
Chemistry, Medicinal
Sofi Imtiyaz Ali, Wajid Mohammad Sheikh, Muzafar Ahmad Rather, Venugopalan Venkatesalu, Showkeen Muzamil Bashir, Showkat Ul Nabi
Summary: Researchers are increasingly focusing on using bioactive substances in herbal medicine as antiviral drugs to combat the challenges posed by viral infections like novel coronavirus. Compounds in herbal medicine can inhibit virus replication through various mechanisms, laying the groundwork for the future development of promising antiviral treatments.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Naveed Nazir Shah, Showkat Ul Nabi, Muzafar Ahmad Rather, Qudratullah Kalwar, Sofi Imtiyaz Ali, Wajid Mohammad Sheikh, Alveena Ganai, Showkeen Muzamil Bashir
Summary: The COVID-19 pandemic has led to the urgent need for effective therapeutic protocols, with a focus on drug repurposing. Studies have identified potential targets for drug development against SARS-CoV-2, including inhibiting enzymatic proteins involved in viral replication. Clinical trials have shown inconclusive results regarding the efficacy of certain antiviral drugs, indicating a need for further research and emphasis on evidence-based approaches.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Toxicology
Showkat Ul Nabi, Sofi Imtiyaz Ali, Muzafar Ahmad Rather, Wajid Mohammad Sheikh, Mehvish Altaf, Hemant Singh, Peerzada Tajamul Mumtaz, Narayan Chandra Mishra, Sheikh Uzma Nazir, Showkeen Muzamil Bashir
Summary: Nanotechnology has revolutionized various fields, but concerns have been raised about the potential deleterious effects of nanotechnology-based products on the environment. The use of organoid technology, which bridges the gap between traditional cell cultures and in vivo models, shows promise in accurately evaluating the toxicity of nano-drug formulations by simulating tissue microenvironments.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Health Care Sciences & Services
Ahmed M. E. Elkhalifa, Naveed Nazir Shah, Zaid Khan, Sofi Imtiyaz Ali, Showkat Ul Nabi, Showkeen Muzamil Bashir, Masood Saleem Mir, Elsharif A. Bazie, Abozer Y. Elderdery, Awadh Alanazi, Fawaz O. Alenazy, Elsadig Mohamed Ahmed
Summary: This study evaluated the clinical presentation and outcome of COVID-19 patients with hypercreatinemia at the time of hospitalization. A retrospective observational study was conducted in 1668 patients confirmed positive for COVID-19 in India. The results showed that patients with hypercreatinemia had higher ICU admission rates, severe manifestations of the disease, need for mechanical ventilation, and all-cause mortality.
Article
Parasitology
Sofi Imtiyaz Ali, Venugopalan Venkatesalu
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2020)
Article
Multidisciplinary Sciences
G. Adaikala Raj, M. Jayaraman, S. Krishnamoorthy, M. Chandrasekaran, V. Venkatesalu
INTERNATIONAL LETTERS OF NATURAL SCIENCES
(2017)