Review
Integrative & Complementary Medicine
Gao Ke, Zha Wen-Long, Zhu Jian-Xun, Zheng Cheng, Zi Jia-Chen
Summary: Plant-derived labdane-related diterpenoids (LRDs) are a large group of terpenoids with various pharmaceutical activities and unique properties, widely used in pharmaceutical, food and perfume industries. The biosynthesis of important LRDs and the relevant enzymes have been extensively studied.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Chemistry, Organic
Foroogh Mirzania, Javad Ghasemian Yadegari, Iraj Salimikia
Summary: This article reviews the research reports on naturally occurring diterpenoids extracted from plants with anti-leishmaniasis activity, providing an overview of the future of leishmaniasis drug discovery.
CURRENT ORGANIC CHEMISTRY
(2023)
Review
Plant Sciences
Samuel Scott, Edgar B. Cahoon, Lucas Busta
Summary: Plants have the ability to produce lineage-specific natural products from their core metabolic pathways. However, little attention has been given to natural products derived from fatty acids. Recent studies have shown that plants can produce structurally diverse compounds from fatty acids, some of which have unique structural features and novel functionalities. This review aims to summarize the current knowledge of fatty acid-derived natural products and their biosynthesis, and suggest future research priorities.
Article
Biochemistry & Molecular Biology
Xin Wang, Zongfei Zhang, Wei Peng, Jinqiu Huang, Xin Yan, Wen Yao, Jiexiu Ouyang, Shaobo Li
Summary: The functions of OsIPCSs were analyzed by CRISPR/Cas9 technology, lipidomics analysis, and transcriptomics analysis. Single-gene mutation resulted in dwarf phenotype, with osipcs3 mutant showing more severe phenotype. Multi-gene mutation led to more severe phenotypes, indicating the additive effects of OsIPCSs. A significant decrease in epidermal cell elongation and content of IPC was observed in the mutants. The results of RNA-seq showed numerous DEGs associated with cellular component organization, anatomical structure morphogenesis, and cell growth. Overall, OsIPCSs may regulate plant height through affecting cell growth and sphingolipid metabolism in rice.
Article
Chemistry, Multidisciplinary
Xinye Wang, Zhixin Wang, Guoliang Zhu, Lan Jiang, Weiyan Zhang, Yiyi Huang, Zhanren Cong, Yi-Lei Zhao, Jian-He Xu, Tom Hsiang, Lixin Zhang, Qi Chen, Xueting Liu
Summary: A key site has been identified that controls the conversion between bicyclic and polycyclic terpene skeletons. Mutation on this site can redirect the competing reactions and produce previously unknown terpenes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Plant Sciences
Miguel Ezquerro, Esteban Burbano-Erazo, Manuel Rodriguez-Concepcion
Summary: Carotenoids are important compounds in plants that play crucial roles in photoprotection and phytohormone production. By editing the PSY1 and PSY2 genes in tomato, it was found that PSY1 and PSY2 have different contributions to carotenoid production in different tissues. PSY2 is the main isoform for carotenoid biosynthesis in leaf chloroplasts, while PSY1 is important in response to high light and in fruit chromoplasts. Furthermore, the study revealed that fruit growth is controlled by ABA specifically produced from PSY1-derived carotenoid precursors, while PSY2 is associated with ABA synthesis in seeds and salt-stressed roots.
Article
Biochemistry & Molecular Biology
Li-Ting Ma, Chang-Hsin Wang, Chong-Yao Hon, Yi-Ru Lee, Fang-Hua Chu
Summary: Chamaecyparis formosensis is an endemic and precious coniferous species of Taiwan, known for its high abundance of specialized metabolites with anti-fungal and antibacterial bioactivities, which contribute to plant defense against pathogens. This species contains unique diterpenoids, including cadinene, ferruginol, and derivatives of isoabienol, which are essential for understanding diterpenoid metabolism in Cupressaceae.
Review
Chemistry, Medicinal
Fatima Vela, Abdellah Ezzanad, Alan Christy Hunter, Antonio Jose Macias-Sanchez, Rosario Hernandez-Galan
Summary: Lathyrane diterpenoids are important secondary metabolites found in Euphorbia plants, with diverse biological activities and potential clinical applications. The unique structure of lathyrane makes it a privileged structure with significant implications in medicinal chemistry.
Article
Plant Sciences
Mei Tian, Baolong Jin, Lingli Chen, Rui Ma, Qing Ma, Xiaolin Li, Tong Chen, Juan Guo, Hui Ge, Xin Zhao, Changjiangsheng Lai, Jinfu Tang, Guanghong Cui, Luqi Huang
Summary: This study investigated the diterpene synthases and their biosynthesis pathways in Aconitum genus using RNA sequencing and Iso-sequencing technologies. The results revealed the presence of different diterpene synthases in four additional Aconitum species, which have significant impact on the medicinal and toxic components of the species. These findings establish a foundation for further exploration of alkaloid biosynthetic pathways in Aconitum.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xinxin Zhang, Yan Yin, Yu Zhou, Tianliang Zhu, Miao Wang, Huiyuan Gao
Summary: Eighteen diterpenoids, including four rare cassane diterpenes, were isolated from Caesalpinia mimosoides seeds. These compounds offer insights into the evolution of plant secondary metabolism, with compounds 6 and 9 showing the best anti-renal fibrosis activity and preliminary structure-activity relationships.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Review
Plant Sciences
Elia Lacchini, Jhon Venegas-Molina, Alain Goossens
Summary: Metabolic enzymes evolve towards catalytic effectiveness, precision, and speed. Ancient and conserved enzymes involved in fundamental cellular processes have limited metabolite numbers. However, sessile organisms like plants have a vast variety of specialized metabolites, which exceed primary metabolites in number and complexity. Gene duplication, positive selection, and diversifying evolution have allowed relaxed selection and accumulation of mutations in metabolic genes, broadening substrate/product specificity and lowering activation barriers and kinetics. This study showcases the structural and functional diversity of chemical signals and products in plant metabolism using oxylipins and triterpenes.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Review
Biochemical Research Methods
Jie Shao, Yuwei Sun, Haili Liu, Yong Wang
Summary: Plant-derived diterpenoids play essential roles in plant development and stress resistance, and also have bioactivities beneficial to humans. However, these compounds are often found in limited species with low abundance. To meet the demand, it is crucial to investigate their biosynthesis in plants and engineer the biosynthetic pathway for high yield production.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Jung-Bum Lee, Tomoya Ohmura, Yoshimi Yamamura
Summary: In this study, three diterpene synthases, SdCPS2, SdKSL1, and SdKSL2, from Scoparia dulcis were functionally characterized. SdCPS2 and SdKSL1 were identified as key enzymes in the biosynthesis of scopadulcic acid B (SDB) in this plant.
Article
Multidisciplinary Sciences
Rong Chen, Qidong Jia, Xin Mu, Ben Hu, Xiang Sun, Zixin Deng, Feng Chen, Guangkai Bian, Tiangang Liu
Summary: Chimeric terpene synthases unique to fungi produce structurally diverse di-and sesterterpenes. The origin and evolution of PTTS genes in Dikarya were explored, suggesting an early gene duplication event and frequent gene loss among subsequent lineages. Biochemical characterization of 74 PTTS genes revealed 34 active enzymes producing 24 terpenes, including previously unknown sesterterpenes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Enrica Alicandri, Stefano Covino, Bartolomeo Sebastiani, Anna Rita Paolacci, Maurizio Badiani, Francesco Manti, Carmelo Peter Bonsignore, Agostino Sorgona, Mario Ciaffi
Summary: The analysis of diterpenoid composition in different organs of Calabrian pine showed that diterpene resin acids were the most abundant compounds, with species and tissue specificity. Transcript profiling confirmed differential expression across tissues and was consistent with diterpenoid profiles.
Article
Chemistry, Multidisciplinary
S. Mafu, K. C. Potter, M. L. Hillwig, S. Schulte, J. Criswell, R. J. Peters
CHEMICAL COMMUNICATIONS
(2015)
Article
Plant Sciences
Philipp Zerbe, Selina M. Rodriguez, Sibongile Mafu, Angela Chiang, Harpreet K. Sandhu, Mark O'Neil-Johnson, Courtney M. Starks, Joerg Bohlmann
Article
Biochemistry & Molecular Biology
Sibongile Mafu, Emil Fischer, J. Bennett Addison, Isabel Riberio Barbosana, Philipp Zerbe
Article
Biochemistry & Molecular Biology
Santosh Kumar, Chase Kempinski, Xun Zhuang, Ayla Norris, Sibongile Mafu, Jiachen Zi, Stephen A. Bell, Stephen Eric Nybo, Scott E. Kinison, Zuodong Jiang, Sheba Goklany, Kristin B. Linscott, Xinlu Chen, Qidong Jia, Shoshana D. Brown, John L. Bowman, Patricia C. Babbitt, Reuben J. Peters, Feng Chen, Joe Chappell
Article
Multidisciplinary Sciences
Sibongile Mafu, Meirong Jia, Jiachen Zi, Dana Morrone, Yisheng Wu, Meimei Xu, Matthew L. Hillwig, Reuben J. Peters
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Sibongile Mafu, Prema Sambandaswami Karunanithi, Teresa Ann Palazzo, Bronwyn Lee Harrod, Selina Marakana Rodriguez, Iris Natalie Mollhoff, Terrence Edward O'Brien, Shen Tong, Oliver Fiehn, Dean J. Tantillo, Jorg Bohlmann, Philipp Zerbe
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Plant Sciences
Sibongile Mafu, Yezhang Ding, Katherine M. Murphy, Omar Yaacoobi, J. Bennett Addison, Qiang Wang, Zhouxin Shen, Steven P. Briggs, Jorg Bohlmann, Gabriel Castro-Falcon, Chambers C. Hughes, Mariam Betsiashvili, Alisa Huffaker, Eric A. Schmelz, Philipp Zerbe
Review
Plant Sciences
Jiachen Zi, Sibongile Mafu, Reuben J. Peters
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65
(2014)
Article
Biochemistry & Molecular Biology
Sibongile Mafu, Matthew L. Hillwig, Reuben J. Peters
Article
Infectious Diseases
Ghislain Wabo Fotso, Bathelemy Ngameni, Thomas E. Storr, Bonaventure Tchaleu Ngadjui, Sibongile Mafu, G. Richard Stephenson
Review
Plant Sciences
Ayousha Shahi, Sibongile Mafu
Summary: This passage discusses the importance of natural products produced by plants, fungi, and bacteria in ecological adaptation and their diverse applications in industry. Ongoing research into these metabolites not only helps uncover the enzymatic diversity underlying their biosynthesis, but also delves into the physiological and mechanistic basis of their modes of action.
CURRENT OPINION IN PLANT BIOLOGY
(2021)
Article
Mycology
Ayousha Shahi, Houlin Yu, Sibongile Mafu
Summary: Plant-pathogenic fungi, including rice blast fungi, produce various specialized metabolites such as diterpenoids. In this study, two diterpene synthases were identified in rice blast fungi that produce specific diterpenoids. These synthases are functionally conserved among different pathotypes and may have expanded in some pathotypes infecting specific grass species. Understanding the terpenome of blast fungi can contribute to the development of strategies to combat harmful phytopathogens in important food crops.
FRONTIERS IN FUNGAL BIOLOGY
(2022)
Article
Plant Sciences
Yezhang Ding, Katherine M. Murphy, Elly Poretsky, Sibongile Mafu, Bing Yang, Si Nian Char, Shawn A. Christensen, Evan Saldivar, Mengxi Wu, Qiang Wang, Lexiang Ji, Robert J. Schmitz, Karl A. Kremling, Edward S. Buckler, Zhouxin Shen, Steven P. Briggs, Joerg Bohlmann, Andrew Sher, Gabriel Castro-Falcon, Chambers C. Hughes, Alisa Huffaker, Philipp Zerbe, Eric A. Schmelz
