Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance

The expression and activity of K V 3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice

(2017) Francesca Boscia et al.   NEUROBIOLOGY OF AGING

K v 3.1/K v 3.2 channel positive modulators enable faster activating kinetics and increase firing frequency in fast-spiking GABAergic interneurons

(2017) Kim Boddum et al.   NEUROPHARMACOLOGY

Rapid State-Dependent Alteration in K v 3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization

(2017) Matthew J.M. Rowan et al.   Cell Reports

Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating

(2016) Yalan Zhang et al.   CELL

Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons

(2016) Maile R. Brown et al.   JOURNAL OF NEUROPHYSIOLOGY

Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function

(2016) K. X. Kim et al.   JOURNAL OF NEUROSCIENCE

Fragile X mental retardation protein controls ion channel expression and activity

(2016) Laurent Ferron   JOURNAL OF PHYSIOLOGY-LONDON

Synapse-Level Determination of Action Potential Duration by K + Channel Clustering in Axons

(2016) Matthew J.M. Rowan et al.   NEURON

De novopoint mutations in patients diagnosed with ataxic cerebral palsy

(2015) Ricardo Parolin Schnekenberg et al.   BRAIN

Kv3.4 channel function and dysfunction in nociceptors

(2015) David M Ritter et al.   Channels

Biophysical characterization of KV3.1 potassium channel activating compounds

(2015) Bahar Taskin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dysregulation of Kv3.4 Channels in Dorsal Root Ganglia Following Spinal Cord Injury

(2015) D. M. Ritter et al.   JOURNAL OF NEUROSCIENCE

Intraglomerular Lateral Inhibition Promotes Spike Timing Variability in Principal Neurons of the Olfactory Bulb

(2015) M. Najac et al.   JOURNAL OF NEUROSCIENCE

Kv3.3 potassium channels and spinocerebellar ataxia

(2015) Yalan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization

(2015) Stefano Masoli et al.   Frontiers in Cellular Neuroscience

Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization

(2015) Alain J. Labro et al.   Nature Communications

Functional Analysis Helps to Define KCNC3 Mutational Spectrum in Dutch Ataxia Cases

(2015) Anna Duarri et al.   PLoS One

RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function

(2014) Gerald Thiel et al.   CELL AND TISSUE RESEARCH

Autosomal dominant cerebellar ataxias: a systematic review of clinical features

(2014) M. Rossi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Distinct Kv Channel Subtypes Contribute to Differences in Spike Signaling Properties in the Axon Initial Segment and Presynaptic Boutons of Cerebellar Interneurons

(2014) M. J. M. Rowan et al.   JOURNAL OF NEUROSCIENCE

More Than a Pore: Ion Channel Signaling Complexes

(2014) A. Lee et al.   JOURNAL OF NEUROSCIENCE

Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development

(2014) Martial A. Dufour et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy

(2014) Mikko Muona et al.   NATURE GENETICS

KCNC3R420H, a K+ channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking

(2014) Carolina Gallego-Iradi et al.   NEUROBIOLOGY OF DISEASE

Ultrafast Action Potentials Mediate Kilohertz Signaling at a Central Synapse

(2014) Andreas Ritzau-Jost et al.   NEURON

Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals

(2014) Michael B. Hoppa et al.   NEURON

Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface

(2013) Jian Zhao et al.   BIOCHEMICAL JOURNAL

Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model

(2013) Andrea H. Németh et al.   BRAIN

Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels

(2013) J. Barry et al.   JOURNAL OF CELL SCIENCE

Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

(2013) Tomohiko Irie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites

(2013) Yuanzheng Gu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Kv3.1-containing K+ channels are reduced in untreated schizophrenia and normalized with antipsychotic drugs

(2013) M Yanagi et al.   MOLECULAR PSYCHIATRY

Characterization of human auditory brainstem circuits by calcium-binding protein immunohistochemistry

(2013) R.J. Kulesza   NEUROSCIENCE

Mutation in the Kv3.3 Voltage-Gated Potassium Channel Causing Spinocerebellar Ataxia 13 Disrupts Sound-Localization Mechanisms

(2013) John C. Middlebrooks et al.   PLoS One

Kv3.3b expression defines the shape of the complex spike in the Purkinje cell

(2013) Ken Veys et al.   Frontiers in Cellular Neuroscience

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons

(2012) Elke Bocksteins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development

(2012) F. A. Issa et al.   Disease Models & Mechanisms

An evolutionarily conserved mode of modulation of Shaw-like K+ channels

(2012) Diego Cotella et al.   FASEB JOURNAL

Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain

(2012) Chia-Yi Huang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Impaired long-range synchronization of gamma oscillations in the neocortex of a mouse lacking Kv3.2 potassium channels

(2012) Michael Harvey et al.   JOURNAL OF NEUROPHYSIOLOGY

Modulation of neuronal sodium channels by the sea anemone peptide BDS-I

(2012) Pin Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13

(2012) Natali A. Minassian et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory Neurons

(2012) Leonard K. Kaczmarek   PLoS Computational Biology

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

BK and Kv3.1 Potassium Channels Control Different Aspects of Deep Cerebellar Nuclear Neurons Action Potentials and Spiking Activity

(2011) Christine M. Pedroarena   CEREBELLUM

Potassium channel modulation and auditory processing

(2011) Maile R. Brown et al.   HEARING RESEARCH

Alternative Splicing Regulates Kv3.1 Polarized Targeting to Adjust Maximal Spiking Frequency

(2011) Yuanzheng Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain Expression of Kv3 Subunits During Development, Adulthood and Aging and in a Murine Model of Alzheimer’s Disease

(2011) Enrica Boda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sparse But Highly Efficient Kv3 Outpace BKCa Channels in Action Potential Repolarization at Hippocampal Mossy Fiber Boutons

(2011) H. Alle et al.   JOURNAL OF NEUROSCIENCE

Spinocerebellar Ataxia Type 13 Mutant Potassium Channel Alters Neuronal Excitability and Causes Locomotor Deficits in Zebrafish

(2011) F. A. Issa et al.   JOURNAL OF NEUROSCIENCE

Fast Delayed Rectifier Potassium Current: Critical for Input and Output of the Circadian System

(2011) T. Kudo et al.   JOURNAL OF NEUROSCIENCE

Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons

(2011) David M. Ritter et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selective underexpression of Kv3.2 and Kv3.4 channels in the cortex of rats exposed to ethanol during early postnatal life

(2011) Daniela Tavian et al.   NEUROLOGICAL SCIENCES

Nitric Oxide Is an Activity-Dependent Regulator of Target Neuron Intrinsic Excitability

(2011) Joern R. Steinert et al.   NEURON

Targeting A-type K+ channels in primary sensory neurons for bone cancer pain in a rat model

(2011) Kai-Zheng Duan et al.   PAIN

Frequency of KCNC3 DNA Variants as Causes of Spinocerebellar Ataxia 13 (SCA13)

(2011) Karla P. Figueroa et al.   PLoS One

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

(2011) David A. Lewis et al.   TRENDS IN NEUROSCIENCES

Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels

(2010) Allan F Mock et al.   BMC NEUROSCIENCE

Kv3.3 immunoreactivity in the vestibular nuclear complex of the rat with focus on the medial vestibular nucleus: Targeting of Kv3.3 neurones by terminals positive for vesicular glutamate transporter 1

(2010) Ruth Elizabeth Brooke et al.   BRAIN RESEARCH

Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats

(2010) Luis F. Pacheco Otalora et al.   BRAIN RESEARCH

Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons

(2010) Katarina E. Leão et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method

(2010) Nagore Puente et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mechanisms of Sustained High Firing Rates in Two Classes of Vestibular Nucleus Neurons: Differential Contributions of Resurgent Na, Kv3, and BK Currents

(2010) Aryn H. Gittis et al.   JOURNAL OF NEUROPHYSIOLOGY

Kv3-Like Potassium Channels Are Required for Sustained High-Frequency Firing in Basal Ganglia Output Neurons

(2010) Shengyuan Ding et al.   JOURNAL OF NEUROPHYSIOLOGY

Kinesin I Transports Tetramerized Kv3 Channels through the Axon Initial Segment via Direct Binding

(2010) M. Xu et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b

(2010) J. G. Strumbos et al.   JOURNAL OF NEUROSCIENCE

Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture

(2010) Huaxia Tong et al.   JOURNAL OF PHYSIOLOGY-LONDON

SYMPOSIUM REVIEW: Going native: voltage-gated potassium channels controlling neuronal excitability

(2010) Jamie Johnston et al.   JOURNAL OF PHYSIOLOGY-LONDON

Distribution and role of Kv3.1b in neurons in the medial septum diagonal band complex

(2010) Z. Henderson et al.   NEUROSCIENCE

Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat

(2010) J.G. Strumbos et al.   NEUROSCIENCE

HAX-1: A multifunctional protein with emerging roles in human disease

(2009) Bengt Fadeel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Increase of Kv3.1b expression in avian auditory brainstem neurons correlates with synaptogenesis in vivo and in vitro

(2009) Thomas Kuenzel et al.   BRAIN RESEARCH

Down-regulation of delayed rectifier K+ channels in the hippocampus of seizure sensitive gerbils

(2009) Sang-Moo Lee et al.   BRAIN RESEARCH BULLETIN

The Role of Kv3-type Potassium Channels in Cerebellar Physiology and Behavior

(2009) Rolf H. Joho et al.   CEREBELLUM

Age-dependent axonal expression of potassium channel proteins during development in mouse hippocampus

(2009) Harald Prüss et al.   HISTOCHEMISTRY AND CELL BIOLOGY

KCNC3: phenotype, mutations, channel biophysics-a study of 260 familial ataxia patients

(2009) Karla P. Figueroa et al.   HUMAN MUTATION

Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex

(2009) Christine M. Constantinople et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Rescue of Motor Coordination by Purkinje Cell-Targeted Restoration of Kv3.3 Channels in Kcnc3-Null Mice Requires Kcnc1

(2009) E. C. Hurlock et al.   JOURNAL OF NEUROSCIENCE

Novel Kv3 glycoforms differentially expressed in adult mammalian brain contain sialylated N-glycans

(2008) Ruth A. Schwalbe et al.   Biochemistry and Cell Biology

Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels

(2008) Tara A. Cartwright et al.   BIOSCIENCE REPORTS

Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

(2008) J A Pratt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protein Kinase C Modulates Inactivation of Kv3.3 Channels

(2008) Rooma Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-gated Potassium Channel (Kv) Subunits Expressed in the Rat Cochlear Nucleus

(2008) Zoltán Rusznák et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Purkinje-Cell-Restricted Restoration of Kv3.3 Function Restores Complex Spikes and Rescues Motor Coordination in Kcnc3 Mutants

(2008) E. C. Hurlock et al.   JOURNAL OF NEUROSCIENCE

Kv3.3 Channels at the Purkinje Cell Soma Are Necessary for Generation of the Classical Complex Spike Waveform

(2008) E. Zagha et al.   JOURNAL OF NEUROSCIENCE

Ablation of Kv3.1 and Kv3.3 Potassium Channels Disrupts Thalamocortical Oscillations In Vitro and In Vivo

(2008) F. Espinosa et al.   JOURNAL OF NEUROSCIENCE

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

(2008) Jyh-Rong Chao et al.   NATURE

Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse

(2008) Joern R. Steinert et al.   NEURON

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON

Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons

(2008) J. Grabert et al.   NEUROSCIENCE

Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67–green fluorescent protein transgenic mice

(2008) V. Alonso-Espinaco et al.   NEUROSCIENCE

Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex

(2008) J. Grabert et al.   NEUROSCIENCE

Voltage-gated potassium currents within the dorsal vagal nucleus: Inhibition by BDS toxin

(2007) Mark L. Dallas et al.   BRAIN RESEARCH

Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

(2007) Robert K. Zahn et al.   NEUROBIOLOGY OF DISEASE