Childhood asthma is associated with mutations and gene expression differences ofORMDLgenes that can interact

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

(2015) Michaela Schedel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data

(2014) V. Sharma et al.   ALLERGY

Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controlsde NovoCeramide Synthesis in Mammalian Cells

(2014) Kerstin Kiefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DifferentFCER1Apolymorphisms influence IgE levels in asthmatics and non-asthmatics

(2013) Daniel P. Potaczek et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

(2013) T. S. Worgall et al.   Science Translational Medicine

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

(2013) Sung Gil Ha et al.   Nature Communications

The Neutrophilic Inflammatory Phenotype Is Associated With Systemic Inflammation in Asthma

(2012) Lisa G. Wood et al.   CHEST

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

(2012) Amado Carreras-Sureda et al.   HUMAN MOLECULAR GENETICS

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variants inProtocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children

(2012) Antoaneta A. Toncheva et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and genomic approaches to asthma

(2011) Youming Zhang et al.   CURRENT OPINION IN PULMONARY MEDICINE

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

(2011) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association studies for discovery of genes involved in asthma

(2011) LOUBNA AKHABIR et al.   RESPIROLOGY

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unifying Candidate Gene and GWAS Approaches in Asthma

(2010) Sven Michel et al.   PLoS One

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease

(2009) Dominique J. Verlaan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants

(2009) Kathrin Suttner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

(2009) K. Mahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of T helper and T regulatory cell responses at birth

(2008) B. Schaub et al.   ALLERGY

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE