Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Ruehrnoessl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Summary: The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain. Our findings reveal a general concept for stabilizing the labile receptor segments of therapeutic antiviral fusion proteins by chemical compounds.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Carina M. Mathey, Carlo Maj, Annika B. Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M. Amann, Harald Loffler, Lukas Koch, Clemens Schoffl, Heinrich Dickel, Nomun Ganjuur, Thorsten Hornung, Susann Forkel, Jens Greve, Gerda Wurpts, Par Hallberg, Anette Bygum, Christian Von Buchwald, Malgorzata Karawajczyk, Michael Steffens, Julia Stingl, Per Hoffmann, Stefanie Heilmann-Heimbach, Elisabeth Mangold, Kerstin U. Ludwig, Eva R. Rasmussen, Mia Wadelius, Bernhardt Sachs, Markus M. Nothen, Andreas J. Forstner
Summary: This study investigated the possible association between ACEi/ARB-induced angioedema and HAE genes through molecular genetic screening. The results suggest that HAE-associated mutations are, at best, a rare cause of ACEi/ARB-induced angioedema, and there was no significant association found between ACEi/ARB-induced angioedema and other variants in the investigated genes.
FRONTIERS IN GENETICS
(2022)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Summary: ACE2 is a membrane protein that regulates the cardiovascular system and acts as a receptor for human coronaviruses, including SARS-CoV-2. A newly discovered short ACE2 isoform, deltaACE2, may affect individual susceptibility to viral infection and likelihood of developing Long COVID. Research shows that deltaACE2 is more expressed in the lung and liver compared to full-length ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Peripheral Vascular Disease
Ana R. Gaspar, Beatriz Andrade, Sara Mosca, Mariana Ferreira-Duarte, Ana Teixeira, Dina Cosme, Antonio Albino-Teixeira, Fernanda A. Ronchi, Ana P. Leite, Dulce E. Casarini, Jose C. Areias, Teresa Sousa, Alberto C. Afonso, Manuela Morato, Liane Correia-Costa
Summary: This study found that childhood obesity is associated with increased activities of angiotensin-converting enzymes (ACE) and ACE2. Overweight/obese children had significantly higher ACE and ACE2 activities compared to normal weight children. In girls, ACE and ACE2 activities were associated with increased night-time systolic and diastolic blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Joshua R. Cook, John Ausiello
Summary: SARS-CoV-2 virus primarily uses ACE2 as its main receptor, associated with the renin-angiotensin system. ACE2 deficiency may contribute to the multisystem dysfunction of COVID-19, leading to angiotensin imbalance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Cell Biology
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen
Summary: Understanding the interaction between SARS-CoV-2, ACE2, bradykinin, and its metabolite des-Arg9-bradykinin is crucial in understanding the pathogenesis of COVID-19 and developing new treatment approaches.
MEDIATORS OF INFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Tomas Rajtik, Peter Galis, Linda Bartosova, Ludovit Paulis, Eva Goncalvesova, Jan Klimas
Summary: This study explores the mechanisms of alternative RAS branches under different types of hypoxic stimuli, including acute, intermittent, and chronic hypoxia, the effects on tissues like the heart, vessels, and lungs, and the clinical relevance of the studied phenomenon. Additionally, it presents future strategies for utilizing alternative RAS as a diagnostic tool and a promising pharmacological target in severe hypoxia-associated cardiovascular and cardiopulmonary diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mengqiu Ma, Yanhua Xu, Yang Su, Sang-Bing Ong, Xingdong Hu, Min Chai, Maojun Zhao, Hong Li, Xiaojuan Fan, Yingjie Chen, Dachun Xu, Xiaojiang Xu
Summary: The study found that ACE2 expression is significantly increased in both cardiomyocytes and non-cardiomyocytes in failing hearts. Brain natriuretic peptide and atrial natriuretic peptide are also significantly up-regulated in ACE2+ cardiomyocytes, consistent with other studies. Genes related to virus entry, replication, and suppression of interferon-gamma signaling are up-regulated in failing cardiomyocytes, with a higher increase in ACE2+ cardiomyocytes, indicating their vulnerability to virus infection.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Entomology
Yujiro Takano, Shin G. Goto, Tetsuo Gotoh
Summary: The facultative diapause of Eotetranychus smithi occurs at the egg stage and is induced by temperatures <= 17.5 degrees C regardless of photoperiod. The study found that the order of egg deposition affects the diapause incidence, with first eggs (males only) having a lower chance of diapause compared to second and third eggs (mostly females). The species does not exhibit thermoperiodism but relies solely on temperature for diapause induction.
PHYSIOLOGICAL ENTOMOLOGY
(2021)
Article
Multidisciplinary Sciences
Keiji Matsumoto, Toyomi Kotaki, Hideharu Numata, Tetsuro Shinada, Shin G. Goto
Summary: The study reveals that JHSB(3) is widespread in heteropteran bugs, and its evolutionary occurrence can be traced back to the common ancestor of Heteroptera.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Immunology
Mie Ikeda, Makoto Hirai, Shin-Ichiro Tachibana, Toshiyuki Mori, Toshihiro Mita
Summary: By studying parasite resistance to PPQ, a novel PbMut-PPQ-R-P9 mutant strain was identified with key genetic mutations, including the N331I mutation in PbCRT, responsible for reduced susceptibility to PPQ.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Masato Yamauchi, Makoto Hirai, Shin-Ichiro Tachibana, Toshiyuki Mori, Toshihiro Mita
Summary: The study on a transgenic rodent malaria parasite indicated that the fitness costs of sulfadoxine resistance are not significant, as the PbDHPS-A394G mutation did not impose health disadvantages during the blood stages in mice and oocyst formation in mosquitoes. This partly explains the persistence of the PfDHPS-A437G mutant in natural parasite populations.
Article
Biochemistry & Molecular Biology
Lauren Des Marteaux, Jili Xi, Genyu Mano, Shin G. Goto
Summary: Many insects survive winter by entering diapause in response to short autumnal day lengths. Glutamate signaling has been found to be involved in insect photoperiodism in Hemiptera, marking the first report of its functional involvement in this process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Correction
Biochemistry & Molecular Biology
Lauren Des Marteaux, Jili Xi, Genyu Mano, Shin G. Goto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Entomology
Shin G. Goto, Masatoshi Nagata
Summary: Most temperate multivoltine insects enter diapause in autumn, suppressing development or reproduction to synchronize with environmental changes. Photoperiodism and the circadian clock play important roles in this process, with the Clock gene possibly involved in both time measurement and downstream diapause-related processes.
EUROPEAN JOURNAL OF ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ayumu Mukai, Genyu Mano, Lauren Des Marteaux, Tetsuro Shinada, Shin G. Goto
Summary: This study found that diapause in the jewel wasp is regulated by maternal expression of the juvenile hormone (JH) and the concentration of JH in the hemolymph, which are influenced by day length.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Entomology
Shin G. Goto
Summary: This article reviews our current understanding of the physiological and molecular mechanisms underlying insect photoperiodism, with a special emphasis on photoperiodic time measurement models.
APPLIED ENTOMOLOGY AND ZOOLOGY
(2022)
Article
Entomology
Genyu Mano, Shin G. Goto
Summary: This study found that the circadian clock controls the photoperiodic response by altering the expression of key elements in two independent endocrine pathways.
APPLIED ENTOMOLOGY AND ZOOLOGY
(2022)
Article
Entomology
Aya Kodama, Keiji Matsumoto, Tetsuro Shinada, Shin G. Goto
Summary: The juvenile hormone (JH) found in Eurydema rugosa, known as a pest for crucifers, was identified as juvenile hormone III skipped bisepoxide (JHSB(3)), a bisepoxyfarnesoate compound. Topical application of JHSB(3) inhibited nymphal metamorphosis and induced nymphal-type coloration, and also effectively terminated summer and winter diapauses in females.
BULLETIN OF ENTOMOLOGICAL RESEARCH
(2023)
Article
Biodiversity Conservation
Mizuki Yoshida, Shin G. Goto
Summary: This study investigates the thermal tolerance of embryos and newly hatched larvae of the Antarctic midge. The results show that the embryos have both cold and heat tolerance, successfully hatching at temperatures ranging from -4.7 to 15 degrees C. However, the larvae only develop into the fourth instar stage at 4 degrees C, indicating their susceptibility to environmental changes.
Article
Entomology
Yuta Shimizu, Shin G. Goto
Summary: Diapause is a programmed stage-specific arrest or delay in reproduction or development and is commonly used to circumvent an adverse season. In the band-legged ground cricket Dianemobius nigrofasciatus, embryonic diapause is maternally determined, but the involvement of juvenile hormone III (JH III) and 20-hydroxyecdysone (20E) in maternal decisions and diapause entry is not supported by the study.
APPLIED ENTOMOLOGY AND ZOOLOGY
(2023)
Article
Biology
Hiroki Takekata, Shin-Ichiro Tachibana, Daisuke Motooka, Shota Nakamura, Shin G. Goto
Summary: Intertidal dwellers exhibit circatidal rhythms corresponding to tidal cycles, and the molecular mechanism behind this phenomenon is largely unknown. In this study, whole-transcriptome analysis of the mangrove cricket Apteronemobius asahinai revealed a potential link between circatidal and circadian rhythms, suggesting that physiological events in the cuticle may be controlled by the circatidal clock.
BIOLOGICAL RHYTHM RESEARCH
(2022)
