Article
Genetics & Heredity
Bohan Ma, Zhanzhu Liu, Wei Yan, Lixue Wang, Haobo He, Aijing Zhang, Zeyuan Li, Qiuzhu Zhao, Mingming Liu, Shuyan Guan, Siyan Liu, Jing Qu, Dan Yao, Jun Zhang
Summary: This study systematically identified and analyzed circRNAs in immature soybean pods, finding differentially expressed circRNAs that may be involved in fatty acid transport, suggesting a post-transcriptional regulatory role of circRNAs in soybean oil synthesis. This research provides a foundation for future exploration of circRNAs in soybean and offers novel insights for further studies on plant circRNAs.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2021)
Review
Oncology
Zheng Bian, Wei Ji, Bin Xu, Zhengyuan Huo, Hui Huang, Jin Huang, Jiantong Jiao, Junfei Shao, Xiaolu Zhang
Summary: Glioma, the most common malignant primary brain tumor in adults with poor prognosis, lacks proper clinical therapeutic targets. STAT3, involved in various processes in glioma, is considered as an ideal therapeutic target. Noncoding RNAs can regulate the ectopic expression of STAT3 in glioma.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Yi Chen, Chunrun Ling, Yansong Xu, Junjie Liu, Weizhong Tang
Summary: This study analyzed the differentially expressed circRNA in colon adenocarcinoma (COAD) and found that hsa_circ_0084927 is highly expressed and can be used as a diagnostic marker for COAD. The study also established a ceRNA network, which suggests that hsa_circ_0084927 may affect the prognosis of COAD through the regulation of cell cycle, apoptosis, and other pathways.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Medicine, General & Internal
Juan Xiao, Shija Joseph, Mengwei Xia, Feng Teng, Xuejiao Chen, Rufeng Huang, Lihong Zhai, Wenbin Deng
Summary: circRNAs, a novel type of endogenous RNAs, play important roles in cell differentiation, tissue homeostasis, and disease development. They have non-coding functions and are crucial in stem cell function. circRNAs show unique expression profiles and could serve as promising biomarkers in stem cell differentiation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Ghanbar Mahmoodi Chalbatani, Seyed Ali Momeni, Mohammad Hosein Mohammadi Hadloo, Zhina Karimi, Morteza Hadizadeh, Seyed Amir Jalali, Seyed Rouhollah Miri, Fereidoon Memari, Michael R. Hamblin
Summary: This bioinformatics analysis identified four differentially expressed circRNAs and 11 interacting miRNAs, indicating potential 1282 target genes. Among 18 hub-genes related to the survival of ccRCC patients, eight genes were found to be correlated with tumor immune cell infiltration and patient prognosis. Two potential drug candidates were suggested to play a role in ccRCC therapy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zhirong Zhao, Qiang Luo, Yi Liu, Kexin Jiang, Lichen Zhou, Ruiwu Dai, Han Wang
Summary: This study aims to explore the key gene regulation involved in the progression of chronic pancreatitis (CP) to pancreatic ductal adenocarcinoma (PDAC), with a particular emphasis on the function of long non-coding RNAs (lncRNAs). A total of 103 pancreatic tissue samples were analyzed, and two signaling axes critical in the progression of CP to PDAC were identified. These findings are important for understanding the molecular mechanism and finding novel diagnostic and therapeutic biomarkers.
Article
Genetics & Heredity
Xue-Cang Li, Zhi-Dong Tang, Li Peng, Yan-Yu Li, Feng-Cui Qian, Jian-Mei Zhao, Ling-Wen Ding, Xiao-Juan Du, Meng Li, Jian Zhang, Xue-Feng Bai, Jiang Zhu, Chen-Chen Feng, Qiu-Yu Wang, Jian Pan, Chun-Quan Li
Summary: This study identified a distinct group of circRNAs (TAH-circRNAs) with epigenomically unique features, independently transcribed via enhancers and super-enhancers by TFs and playing roles in cancer biology.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Rui He, Kaizhe Liu, Shuchang Zhang, Jun Ju, Youzhi Hu, Yamin Li, Xiaojuan Liu, Houcheng Liu
Summary: The study found that the SlHY5 gene in the purple tomato variety 'Indigo Rose' plays a key role in anthocyanin biosynthesis in plants. However, residual anthocyanins still exist in the Slhy5 mutant, indicating the presence of an anthocyanin induction pathway independent of HY5. The omics analysis showed significant differences in the expression levels of genes associated with anthocyanin biosynthesis between 'Indigo Rose' and the Slhy5 mutant, suggesting that SlHY5 plays an important role in flavonoid biosynthesis in both tomato seedlings and fruits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Wang, Xupeng Zang, Yaokun Li, Dewu Liu, Linjun Hong, Guangbin Liu
Summary: This study aims to identify potential circRNAs and regulatory mechanisms related to goat endometrial receptivity. The results show that 4666 circRNAs were identified, including 7 downregulated and 11 upregulated differentially expressed circRNAs (DE-circRNAs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggest that DE-circRNAs were significantly involved in establishing endometrial receptivity. Furthermore, circ_MYRF derived from the host gene MYRF was found to regulate the expression of ISG15, thereby promoting the formation of endometrial receptivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Pan Shu, Yujing Li, Jiping Sheng, Lin Shen
Summary: Mitogen-activated protein kinase (MAPK) cascades and ethylene play important roles in plant growth, development, and stress responses. This study focused on their potential mechanisms in cold resistance and found that SlMAPK3 transcript levels were induced by cold treatment in an ethylene-dependent manner. Overexpression of SlMAPK3 led to increased proline content and reduced ion leakage under cold stress, and upregulation of genes involved in ethylene-activated signaling, cold signaling, and heat signaling pathways. Knockout of SlMAPK3 reduced ethylene production, ACC content, and ACS activity, as well as the positive effect of ethylene in cold stress. This study provides insights into the novel mechanism of SlMAPK3 in ethylene-mediated cold tolerance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Run Zhou, Pablo Sanz-Jimenez, Xi-Tong Zhu, Jia-Wu Feng, Lin Shao, Jia-Ming Song, Ling-Ling Chen
Summary: This study comprehensively analyzed the regulatory roles of lncRNA/circRNA in tissue development of Indica rice from multiple perspectives, including methylation levels, genome structure, transposable elements, etc. The findings provide insights into the mechanisms of lncRNA and circRNA regulation in gene expression in rice.
Article
Agronomy
Begona Renau-Morata, Rosa-Victoria Molina, Eugenio G. Minguet, Jaime Cebolla-Cornejo, Laura Carrillo, Raul Marti, Victor Garcia-Carpintero, Eva Jimenez-Benavente, Lu Yang, Joaquin Canizares, Javier Canales, Joaquin Medina, Sergio G. Nebauer
Summary: This study analyzed the impact of long-term suboptimal nitrogen conditions on the metabolome and transcriptome of tomato to identify specific molecular processes and regulators. Specific responses were found in maintaining glutamate, asparagine, and sucrose synthesis in leaves for growth, while excess assimilated carbon was stored in the roots. The study identified nitrogen-responsive genes in tomato and potential targets for improving nitrogen use efficiency and fruit quality under limited nitrogen supply.
Article
Plant Sciences
Liuchun Feng, Qi Li, Dongqin Zhou, Mingyun Jia, Zhuangzhuang Liu, Zhaoqi Hou, Quanjin Ren, Shengdong Ji, Shifei Sang, Shipeng Lu, Jinping Yu
Summary: This study investigated the mechanism by which Bacillus subtilis CNBG-PGPR-1 enhances plant salt tolerance. The results showed that CNBG-PGPR-1 improves tomato leaf salt tolerance by activating complex molecular pathways, particularly the plant hormone signal transduction pathway. The study also revealed that CNBG-PGPR-1 induces methionine accumulation to regulate the ethylene pathway, thereby enhancing plant salt tolerance. Furthermore, CNBG-PGPR-1 reduces salt-induced oxidative stress by activating ROS scavenger-encoding genes.
Article
Plant Sciences
Mengxiao Jia, Jing Feng, Lina Zhang, Shikui Zhang, Wanpeng Xi
Summary: This study investigated the role of ABA in the ripening of apricots, a climacteric fruit, by analyzing transcriptome data, conducting gene expression analysis, and using transgenic tomato. The results showed that exogenous ABA treatment promoted fruit coloration and maturity, while decreasing fruit firmness and acidity. The candidate gene PYL9 was identified as potentially involved in apricot fruit ripening. The study proposed a regulatory network, highlighting the important role of ABA in climacteric fruit ripening.
HORTICULTURAL PLANT JOURNAL
(2022)
Article
Agronomy
Clara I. Mata, Jezrel Magpantay, Maarten L. A. T. M. Hertog, Bram Van de Poel, Bart M. Nicolai
Summary: Studying the transient inhibition of 1-MCP during tomato fruit ripening revealed that although 1-MCP effectively inhibited climacteric ripening, it led to higher ethylene production levels in treated fruit. Additionally, the protein abundance of ethylene receptors and CTRs decreased in 1-MCP treated fruit, potentially activating downstream ethylene signaling and gene expression, compensating for the ripening inhibition.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Neuroimaging
Dapeng Sun, Baixue Jia, Xu Tong, Peter Kan, Xiaochuan Huo, Anxin Wang, Raynald, Gaoting Ma, Ning Ma, Feng Gao, Dapeng Mo, Ligang Song, Xuan Sun, Lian Liu, Yiming Deng, Xiaoqing Li, Bo Wang, Gang Luo, Yongjun Wang, Zeguang Ren, Zhongrong Miao
Summary: This study investigated the incidence, predictors, and clinical impact of parenchymal hemorrhage (PH) after endovascular treatment (EVT) in Chinese patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (LVO). The findings showed that low admission ASPECTS, high serum glucose, and elevated neutrophil-to-lymphocyte ratio (NLR) were independent predictors of PH, while underlying intracranial atherosclerotic stenosis (ICAS) and intracranial angioplasty/stenting were associated with a lower risk of PH. Additionally, patients with PH had worse functional outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Obstetrics & Gynecology
Xiang-Lan Liu, Li Ding, Xiao Lu, Yan-Jiao Hu, Xiao-Li Zhou, Dong-Liang Lin
Summary: A cervical yolk sac tumor in a 44-yr-old woman shares similarities with adenocarcinomas with enteroblastic differentiation (AEBDs) in the digestive system. The tumor exhibits a glandular-predominant growth pattern and is positive for p16, glypican-3 (GPC3), spalt-like transcription factor 4 (SALL4), CDX-2, and p53. TP53 mutation and HPV 35 infection were detected. This aggressive tumor should be recognized for its enteroblastic component in pathology reports.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Nutrition & Dietetics
Qi Cui, Yang Xia, Yashu Liu, Yifei Sun, Kang Ye, Wenjie Li, Qijun Wu, Qing Chang, Yuhong Zhao
Summary: This study evaluated the reproducibility and validity of the Food Frequency Questionnaire (FFQ) for residents in northeast China. The findings demonstrated that the FFQ is reliable and valid for assessing the intake of most foods and nutrients.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Obstetrics & Gynecology
Sadaf Pervaz, Amin Ullah, Enoch Appiah Adu-Gyamfi, Jones Lamptey, Sanjay Kumar Sah, Mei-Jiao Wang, Ying-Xiong Wang
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Qing Chang, Qijun Wu, Yang Xia, Hehua Zhang, Shanyan Gao, Yixiao Zhang, Yuan Yuan, Jing Jiang, Hongbin Qiu, Jing Li, Chunming Lu, Chao Ji, Xin Xu, Donghui Huang, Huixu Dai, Zhiying Zhao, Hang Li, Xiaoying Li, Xiaosong Qin, Caigang Liu, Xiaoyu Ma, Xinrui Xu, Da Yao, Yuhong Zhao
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Engineering, Ocean
Zhuangcai Tian, Hanlu Liu, Shaotong Zhang, Jinran Wu, Jiahao Tian
Summary: This paper proposes a method for predicting the shear stress induced by shoaling internal solitary waves (ISWs) based on machine learning. The developed approach has been proven to be effective and accurate in predicting the shear stress and can be used to evaluate the safety and stability of ocean engineering. This method is of great significance in promoting the development of deep-water ocean engineering.
MARINE GEORESOURCES & GEOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jing Liu, Ji Lv, Zheyi Liu, Zheng Fang, Can Lai, Shan Zhao, Mingliang Ye, Fangjun Wang
Summary: In this study, it was discovered that interfacial hydrophobic hydration significantly enhances H-bond networks at the interface between a glycan-modified adsorbent and a methanol-water-acetonitrile ternary solution. This enhancement promotes the adsorbent-solution heterogeneous glycan-glycan recognition and interaction, leading to improved glycopeptide enrichment. Compared with the commonly used hydrophilic-interaction enrichment strategy, more intact N- and O-glycopeptides are identified and the enrichment recoveries are significantly increased. This study also provides in-depth profiling of N- and O-glycosylation on SARS-CoV-2 S1 and hACE2 proteins.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Psychology, Multidisciplinary
Yefeng Chen, Yiwen Pan, Haohan Cui, Xiaolan Yang
Summary: This article proposes a possible mechanism that people may have underconfidence bias in information updating due to motivated reasoning, which generates the asymmetric pattern in contagion, different from the overconfident bias observed in the literature. The study designs an experiment to relate unethical behavior to social learning, where subjects decide whether to conduct unethical behavior publicly based on private information about penalty. The results confirm that people rely more on others' decisions than their own signal, suggesting the bias facilitates the contagion.
BEHAVIORAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Mengfei Li, QianQian Yang, Lili Fan, Xiaojie Dai, Zixi Kang, Rongming Wang, Daofeng Sun
Summary: Researchers have developed alternative electrocatalysts with high stability for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The electrocatalyst, composed of hollow CoOx nanoparticles embedded in carbon nanofibers, showed excellent long-term stability and promising performance in reversible Zn-air batteries. The remarkable electrocatalytic performance is attributed to the optimized adsorption of *OOH intermediate and reduced free energy of the potential-limiting step.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Letter
Biochemistry & Molecular Biology
Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei, Wei Wang, Qing-luan Yang, Jing Wu, Yan-min Wan, Ling-ling Ge, Wen-hong Zhang, Qing-feng Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Physiology
Xinwei Wang, Jiulong Song, Peng Xia, Qiang Lin, Anliang Chen, Kai Cheng, Fane Kong, Yi Shi, Xueping Li
Summary: High-intensity interval training (HIIT) is a physical therapy that can alleviate osteoarthritis (OA)-associated hyperalgesia. Cacna2d1, a subunit protein of calcium channel, plays a crucial role in nerve cell activity. However, the effect of HIIT on OA hyperalgesia and the involvement of Cacna2d1 remains unclear. In this study, OA rat models were established using monosodium iodoacetate (MIA) injection, and different groups were compared. Pain threshold, cartilage analysis, Cacna2d1 expression, and pain neurotransmitters were measured. The results demonstrated that HIIT could attenuate OA-associated hyperalgesia, possibly through the down-regulation of Cacna2d1 expression.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Ying Hu, Yan Liu, Siqi Zhang, Ting Zhang, Bin Dai, Bo Peng, Hongbo Yang, Yakang Dai
Summary: This study proposes a cross-space convolutional neural network (CS-CNN) for the classification of four-class motor imagery-electroencephalogram (MI-EEG), aiming to improve classification accuracy and robustness. The algorithm utilizes modified customized band common spatial patterns (CBCSP) and duplex mean-shift clustering (DMSClustering) to express specific rhythms and source distribution information in cross-space, and extracts multi-view features from time, frequency, and space domains to fuse the characteristics from two spaces and classify them using CNN. Experimental results show that the proposed algorithm achieves a classification accuracy of 96.05% (with real MRI information) and 94.79% (without MRI) in the private dataset. Moreover, in the BCI competition IV-2a, CS-CNN outperforms state-of-the-art algorithms with an accuracy improvement of 1.98% and a standard deviation reduction of 5.15%.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Immunology
Zhishuo Wang, Chenghua Yan, Qizhen Du, Yuying Huang, Xuezhen Li, Dan Zeng, Ruizhi Mao, Rama Krishna Gurram, Shipeng Cheng, Wangpeng Gu, Lin Zhu, Weiguo Fan, Liyan Ma, Zhiyang Ling, Ju Qiu, Dangsheng Li, Enmei Liu, Yaguang Zhang, Yiru Fang, Jinfang Zhu, Bing Sun
Summary: This study found a negative correlation between the neurotransmitter serotonin and the cytokines IL-5 and IL-13 produced by ILC2s, which are related to depression. Serotonin can alleviate lung inflammation by suppressing ILC2 activation. The serotonin receptor HTR2A is highly expressed on ILC2s and can be targeted with an agonist called DOI to inhibit ILC2 activation and reduce type 2 immune response. Targeting HTR2A on ST2(+) ILC2s could be a potential treatment strategy for type 2 lung inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Lin, Lixing Dai, Qinqin Yang, Qizhi Yang, Hongjian He, Lingceng Ma, Jingjing Liu, Jingliang Cheng, Congbo Cai, Jianfeng Bao, Zhong Chen, Shuhui Cai, Jianhui Zhong
Summary: This study developed a real-time abdominal T-2 mapping method that does not require breath-holding or respiratory-gating. The single-shot multiple overlapping-echo detachment (MOLED) pulse sequence was used for free-breathing T-2 mapping of the abdomen. Deep learning was utilized to untangle the non-linear relationship between the MOLED signal and T-2 mapping. A synthetic data generation flow based on Bloch simulation, modality synthesis, and randomization was proposed to overcome the inadequacy of real-world training set.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Physical
Tengda Wang, Shaoying Dai, Jie Wang, Bin Liu, Meiwen Cao, Bo Guan, Yuchun Han, Yilin Wang
Summary: The large-scale use of detergents for oil-fouling removal in industry generates a significant amount of wastewater, leading to economic and environmental problems. This study presents a recyclable, efficient, and eco-friendly approach to remove oil-fouling by constructing a dynamic imine-based surfactant.
